Clinical trials: Anesthetics, Local
Pain
Randomised Trial of Eutectic Mixture of Local Anaesthetics Cream and Oral Sucrose Solution for Venepuncture
This randomized bicentric trial will investigate the efficacy of topical EMLA cream with oral sucrose solution compared to oral sucrose solution alone before venepuncture in preterm infants.
- Trial name
- VIEP (NCT00470080)
- Testing
- venepuncture
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ultrasound Imaging of Anatomical Structures
Validity of Experts and ScanNav Anatomy PNB When Identifying Sono-anatomical Structures for Ultrasound-Guided Regional Anaesthesia
This is a multi-centre, prospective, observational study, conducted under the auspices of the University of Oxford to evaluate ultrasound image analysis by human experts and an artificial intelligence device in the context of…
- Trial name
- NCT04983771
- Testing
- Annotate ultrasound scans
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- IntelligentUltrasound Limited
Postoperative Pain
Intraoperative Local Anaesthetic and Postoperative Pain
Background: Intraoperative wound infiltration with local anaesthetic is commonly used. Apart from the obvious immediate action it has been supported that a possible down regulation of pain receptors may lead to longer effects.
- Trial name
- Pain-1 (NCT02171299)
- Testing
- Wound infiltration with local anaesthetic, Ropivacaine
- Where
- Greece
- Volunteers
- 400 people
- Sponsor
- Hellenic Red Cross Hospital
Behaviour Assessment, Pain
Articaine Efficacy and Safety for Children Below Age of 4-years
Pain control is one of the significant behavior determinants in the dental office and shaping the future attitude toward dentistry, especially in children.
- Trial name
- NCT04061265
- Testing
- Articaine 4%/Epi 1:100000 Inj Cart 1.7Ml, lidocaine hydrochloride 2% and epinephrine 1:100000
- Where
- Egypt
- Volunteers
- 184 people
- Sponsor
- Minia University
Pain, Postoperative
Combined Nerve Blockade and Local Infiltration Anesthesia in Appendectomy - A Blinded Randomized Study
The purpose of this study is to assess whether the use of local anesthetic to numb the nerves that run deeper in the abdominal wall gives better post operative pain control than just infiltrating local anesthetic to the wound…
- Trial name
- NCT00508092
- Testing
- local anesthetic administration
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Royal Berkshire NHS Foundation Trust
Head and Neck Cancer
Continuous Local-anesthetic Wound Infusion for Neck Dissection
The goal of this study is to assess the efficacy of continuous local anesthetic wound infusion to improve quality of recovery following ablative surgery and neck dissection.
- Trial name
- CLAWED (NCT06201039)
- Testing
- 0.5% Lidocaine Hydrochloride, 0.9% Normal Saline
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Clubfoot
Clubfoot Tenotomy Trial
Infants undergoing Ponseti treatment for idiopathic clubfoot often require percutaneous tendoachilles lengthening (TAL) after serial casting.
- Trial name
- ClubTT (NCT04766684)
- Testing
- Jet injection of 1% lidocaine, 4% liposomal lidocaine cream
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Vanderbilt University Medical Center
Flexible Nasendoscopy
Nasal Prep for Nasendoscopy in Children
Flexible nasendoscopy involves passing a soft, thin, endoscope through the nose. This diagnostic procedure is often essential for assessment of a child by an Otolaryngologist in outpatients.
- Trial name
- NCT01351298
- Testing
- 0.05% xylometazoline hydrochloride with 1% lidocaine hydrochloride, 0.05% xylometazoline hydrochloride, Isotonic normal saline
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- Children's & Women's Health Centre of British Columbia
Pain on Propofol IV Injection
In Children, Does Using a Synera Patch Decrease Pain When Injecting Propofol at Anesthesia Induction?
The purpose of this study is to evaluate if the Synera Patch (lidocaine/tetracaine patch), used to numb the skin before IV placement, is effective in reducing pain associated with propofol IV administration when inducing general…
- Trial name
- Synera patch (NCT01576770)
- Testing
- lidocaine/tetracaine transdermal patch (NDC 43469-864-01), Gebauer's Ethyl Chloride
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas Health Science Center, Houston
Dental Fear and Anxiety
Assessing the Efficacy of Lemongrass and Lavender Aromatherapy in Reducing Dental Anxiety and Pain Associated With Local Anesthetic Injections in Pediatric Dental Patients
The goal of this clinical trial is to evaluate whether aromatherapy using lemongrass or lavender essential oils can reduce dental anxiety and pain perception in children aged 7-11 years undergoing local anesthetic administration…
- Trial name
- NCT07113080
- Testing
- lavender essential oil inhaled using face mask, lemongrass essential oil inhaled using face mask
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hiba Ahmed Eltayeb
Anesthesia, Local
Compare the Efficacy of Various Pain Alleviating Methods in Reducing Pain in Children During Intraoral Local Anaesthetic Injections
The aim of study is to compare the efficacy of various pain alleviating methods by application of Emla gel, TENS, and topical cooling of injection sites compared with 20% benzocaine gel in reducing pain in children requiring…
- Trial name
- NCT05564442
- Testing
- 20% benzocaine gel, Transcutaneous electric nerve stimuli, Emla gel
- Where
- Egypt
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Minia University
Pediatric Anesthesia
Variation of Cerebral Blood Flow in Anterior Cerebral and Basilar Artery in Neonates and Infants in Genreal Anesthesia With Caudal Block
With this study we want to see how the blood flow in the anterior cerebral artery (ACA) and the basilar artery (BA) after the caudal block changes.
- Trial name
- NCT02761954
- Volunteers
- 50 people
- Sponsor
- Bürgerhospital Frankfurt
Pain
Evaluation of Analgesia With EMLA and Glucose Oral Solution
In this randomized controlled study the investigators intended to compare analgesic effects of EMLA and/or oral glucose in 60 preterm neonate during arterial function and PICC installation.
- Trial name
- NCT00808054
- Testing
- EMLA
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Pain
Comparison of Two Different Methods of Delivering Local Analgesia During Intra-articular Corticosteroid Injections in Children With Juvenile Idiopathic Arthritis
Chronic arthritis (inflammation of joints) in children is known as Juvenile Idiopathic Arthritis (JIA). Often, to control the swelling and to help reduce the pain in the joint, medications (steroids) are injected into the joint.
- Trial name
- NCT00465504
- Testing
- iontophoresis
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of British Columbia
Post Operative Pain
Analgesic Efficacy of Genicular Nerve Block Versus (IPack Block ) in Patients Undergoing (ACL) Repair
One of the most common injuries to the knee is an anterior cruciate ligament (ACL) sprain or tear due to trauma ACL damage is crippling and often requires repair with an arthroscopic method, which is an outpatient surgery.
- Trial name
- NCT06404658
- Testing
- Genicular nerve block
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Sacral Erector Spinae Plane Block, Pediatric Regional Anesthesia
Sacral Erector Spinae Plane Block Versus Penile Block For Analgesia In Pediatric Circumcision
Circumcision is one of the most frequently performed surgical procedures in childhood and is associated with significant postoperative pain.
- Conditions
- Sacral Erector Spinae Plane Block, Pediatric Regional Anesthesia, Regional Anaesthesia
- Trial name
- NCT07321717
- Testing
- Sacral Erector Spinae Plane Block, Penile Nerve Block (PNB)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Anterior Cruciate Ligament Reconstruction
Study of Pain Management Techniques Following Anterior Cruciate Ligament Repair Surgery
Patients scheduled to undergo knee arthroscopy with anterior cruciate ligament repair with graft from the ipsilateral hamstrings and gracilis will be randomized to one of three groups.
- Trial name
- NCT01868282
- Testing
- Hamstrings block, Obturator block, Control group
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Local Anesthetic Efficacy
Effectiveness of Nitrous Oxide 50% for Reducing Pain and Distress Associated with Needle-stick in Children
Venipuncture (puncturing of a vein) through the skin in order to insert a vein catheter (also know as cannula) is one of the most common needle-related medical procedures performed in children.
- Trial name
- NCT03342079
- Testing
- Local Anesthetics,(lidocaine 70 mg/tetracaine 70 mg topical patch; Synera)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Keloid, Alopecia Areata
Pain Outcomes Following Intralesional Corticosteroid Injections
Corticosteroid therapy, including intralesional and topical applications, has many indications within the fields of Dermatology, Plastic Surgery, and Orthopedics.
- Conditions
- Keloid, Alopecia Areata, Acne, Hypertrophic Scar
- Trial name
- NCT03630198
- Testing
- Corticosteroid with lidocaine, Corticosteroid with normal saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Dental Phobia, Dental Anxiety
Assessment of Pain, Anxiety and Efficiency of NumBee Compared to Traditional Local Anesthetic Syringe
The study was conducted among a group of dental patients aged (6-8 years old) of both genders to assess the following variables in the needleless interparliamentary anesthesia (NUMBEE) compared to traditional local anesthesia: 1.
- Conditions
- Dental Phobia, Dental Anxiety, Anesthesia, Local, Needle Phobia
- Trial name
- NCT05899296
- Testing
- dental syringe ( NumBee), Traditional dental syringe
- Where
- Iraq
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duaa Kamal Naji