Clinical trials: Anesthetics, Local, open to volunteers
Laparoscopic Appendectomy
Comparing Pain Relief Between Two Methods of Freezing Injections in Children Having Their Appendix Removed
Laparoscopic appendectomies are the most common emergency surgeries performed in children. Despite being considered minimally invasive surgeries, they can result in substantial postoperative pain and 2 of 3 patients require…
- Trial name
- NCT06945263
- Testing
- Rectus Sheath Block, Local Anesthetic at the Umbilical Port Site, Intravenous Dexamethasone
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Spinal Anesthesia, Local Anesthetic
Age-Based and Weight-Based Bupivacaine Dosing for Pediatric Spinal Anesthesia for Elective Infra-Umbilical Surgeries
Pediatric anesthesia presents distinctive challenges, particularly concerning appropriate dosage administration of local anesthetics for spinal anesthesia (SA).
- Conditions
- Spinal Anesthesia, Local Anesthetic, Bupivacaine
- Trial name
- NCT06801600
- Testing
- Weight-based dosing, Age-based dosing
- Volunteers
- 60 people
- Sponsor
- Cairo University
Traditional Local Anesthesia, Computer-controlled Electronic Anesthesia
Pain and Anxiety in Pediatric Dentistry: Computer-Controlled vs. Traditional Anesthesia
The purpose of this clinical study is to evaluate how different local anesthesia techniques affect pain and anxiety levels in children undergoing dental treatment.
- Conditions
- Traditional Local Anesthesia, Computer-controlled Electronic Anesthesia, Dental Anxiety, Anxiety in Children
- Trial name
- NCT07156487
- Testing
- Digital Anesthesia with SleeperOne 5, Infiltration Anesthesia with a Metal Cartridge Syringe, Mandibular Block Anesthesia with a Metal Cartridge Syringe
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Dicle University
Dental Fear and Anxiety
Assessing the Efficacy of Lemongrass and Lavender Aromatherapy in Reducing Dental Anxiety and Pain Associated With Local Anesthetic Injections in Pediatric Dental Patients
The goal of this clinical trial is to evaluate whether aromatherapy using lemongrass or lavender essential oils can reduce dental anxiety and pain perception in children aged 7-11 years undergoing local anesthetic administration…
- Trial name
- NCT07113080
- Testing
- lavender essential oil inhaled using face mask, lemongrass essential oil inhaled using face mask
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hiba Ahmed Eltayeb
Sacral Erector Spinae Plane Block, Pediatric Regional Anesthesia
Sacral Erector Spinae Plane Block Versus Penile Block For Analgesia In Pediatric Circumcision
Circumcision is one of the most frequently performed surgical procedures in childhood and is associated with significant postoperative pain.
- Conditions
- Sacral Erector Spinae Plane Block, Pediatric Regional Anesthesia, Regional Anaesthesia
- Trial name
- NCT07321717
- Testing
- Sacral Erector Spinae Plane Block, Penile Nerve Block (PNB)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Pneumothorax, Primary Spontaneous, VATS
Optimal Postoperative Chest Tube and Pain Management in Patients Surgically Treated for Primary Spontaneous Pneumothorax (Pneumotrial)
Guidelines lack high quality evidence on optimal postoperative chest tube and pain management after surgery for primary spontaneous pneumothorax (PSP).
- Conditions
- Pneumothorax, Primary Spontaneous, VATS, Pain, Postoperative, Locoregional Anaesthesia
- Trial name
- NCT06053476
- Testing
- Thoracic epidural analgesia, Single-shot paravertebral block, Late chest tube removal
- Where
- Netherlands
- Volunteers
- 366 people
- Sponsor
- Maxima Medical Center
CHD - Congenital Heart Disease
Bilateral Ultrasound Guided Superficial Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block
Group (A): This group will receive fentanyl infusion at a dose of (0.5μg/kg/h) all through the whole operation plus ultrasound guided bilateral superficial parasternal intercostal Plane block which will be done by injecting…
- Trial name
- NCT06958120
- Testing
- superficial parasternal intercostal Plane block, Erecto spinea plane block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Regional Anaesthesia
Regional Analgesia at the Pediatric Emergency Department
Approximately two years ago, ultrasound-guided regional blocks technique was introduced into routine use in the pediatric emergency department at Hillel Yaffe Medical Center.
- Trial name
- NCT06927193
- Testing
- Regional anaesthesia
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Hillel Yaffe Medical Center
Dental Anxiety, Dental Fear
The Effect of a Kaleidoscope and Cartoons for Dental Treatment in Children
Dental fear and anxiety are among the most common challenges encountered in pediatric dental practice and may negatively affect children's cooperation and acceptance of dental treatment.
- Conditions
- Dental Anxiety, Dental Fear, Pain
- Trial name
- Pain (NCT07462364)
- Testing
- Kaleidoscope Distraction, Cartoon Distraction
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Dicle University
Surgery
Peripheral Regional Blockade and EMG
The investigators are studying a type of technology that is already used called surface electromyography (EMG). This measures and records electrical activity using sensor stickers in a non-invasive way.
- Trial name
- Electromyogram (NCT06982027)
- Testing
- BlockSynop surface electromyography device, Peripheral nerve block
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nationwide Children's Hospital
Hypertension
Assessment of Anesthetic Efficacy and Hemodynamic Stability of Two LA Drugs for Hypertensive Patients
Pain control in dentistry is an important factor for reducing the fear and anxiety associated with dental procedures. For tooth extraction, it is mandatory to use resources to manage pain and discomfort such as adequate…
- Trial name
- NCT06927726
- Testing
- 4% Articaine HCL With 1:100,000 Epinephrine, 3% plain mepivacaine HCL
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tanta University
Dental Anxiety, Local Anesthesia
Lavender vs Bitter Orange Aromatherapy to Reduce Anxiety and Pain in Pediatric Local Anesthesia
This randomized controlled clinical trial aims to evaluate and compare the effectiveness of lavender essential oil and bitter orange essential oil aromatherapy in reducing dental anxiety and pain in children during the…
- Trial name
- NCT07367594
- Testing
- Lavender essential oil in the inhaler, Bitter Orange essential oil in the inhaler
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- October University for Modern Sciences and Arts
Cleft Lip, Cleft Palate +/- Lip
Comparative Study of Regional Nerve Blocks in Primary Cleft Palate Repair
This study will evaluate whether adding a suprazygomatic maxillary nerve block to the standard palatal nerve block improves pain control after cleft palate repair surgery in children.
- Conditions
- Cleft Lip, Cleft Palate +/- Lip, Pain Management, Wound Dehiscence, Surgical
- Trial name
- NCT07892963
- Testing
- Palatal Nerve Block, Suprazygomatic Maxillary Nerve Block
- Volunteers
- 144 people
- Sponsor
- Children's National Research Institute
Laparoscopic Cholecystectomy Surgery, Analgeisa
Pain Relief Following Laparoscopic Cholecystectomy While Comparing Intra Abdominal Versus Sub Cutaneous Local Anesthetic Administration
Laparoscopic cholecystectomy involves removal of gallbladder through small incision ports resulting in faster recovery. Small incisions are less painful and hence local anesthesis administered can be effective for pain…
- Conditions
- Laparoscopic Cholecystectomy Surgery, Analgeisa, Local Anesthetic Infiltration
- Trial name
- NCT07409688
- Testing
- Intraoperitoneal local anesthetic administration, Sub cutaneous administration of local anesthetic
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Virtual Reality Simulation, Virtual Reality
RA Anatomy - VRvST Study
Primary Objective: Score out of 44 on a validated test of anatomy and sono-anatomy Secondary Objective: Before training Handedness (Edinburgh Handedness Inventory) Subjective sleepiness (Karolinska scale) Motor reaction time…
- Conditions
- Virtual Reality Simulation, Virtual Reality, Education, Medical
- Trial name
- NCT07361913
- Testing
- 3D virtual reality anatomy teaching, Standard anatomy model teaching
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Royal National Orthopaedic Hospital NHS Trust
Decayed Primary Molars
Pain Perception With Cordless Electronic Local Anesthetic Delivery System
22 children with two primary molars that need extraction or pulpotomy will be selected to compare pain perception between conventional dental syringe and cordless electronic local anesthetic delivery system.
- Trial name
- NCT07915531
- Testing
- Cordless Electronic local anesthetic delivery system, Conventional dental syringe
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Circumcision, Hydrocelectomy
Enhanced Recovery After Urologic Surgery
This clinical trial aims to investigate the analgesic efficacy of several perioperative pain management strategies-specifically, epidural analgesia, paravertebral blockade, transversus abdominis plane (TAP) block, intravenous…
- Conditions
- Circumcision, Hydrocelectomy, Hernia, Renal Cyst
- Trial name
- NCT06789744
- Testing
- General Anesthesia (GA), Epidural Analgesia( 0.2% ropivacaine), Paravertebral block ( liposomal bupivacaine 133 mg or 0.2% ropivacaine)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xiaguang Duan
Haemophilia A, Haemophilia B
Safety of Intraosseous Anaesthesia in Children With Haemophilia
Effective local anaesthesia is essential for safe and comfortable dental treatment in children with haemophilia. However, conventional nerve block techniques, particularly inferior alveolar nerve block, carry an increased risk of…
- Conditions
- Haemophilia A, Haemophilia B, Dental Caries
- Trial name
- NCT07916467
- Testing
- Intraosseous Anaesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ankara Yildirim Beyazıt University
Soft Tissue Injuries
Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in Children
Local anaesthesia is considered one of the most alarming and non-comfortable dental procedures for children. This goes back to the persisting effect of the local anaesthesia after finishing dental procedures.
- Trial name
- NCT05448807
- Testing
- OraVerse
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Phobia, Dental Anxiety
"Study of Pain Perception Using Computer-Controlled Versus Conventional Local Anaesthesia in Children Undergoing Molar Extraction
This clinical trial aims to compare pain perception in children during dental procedures when using a computer-controlled local anesthesia device versus a traditional syringe.
- Conditions
- Dental Phobia, Dental Anxiety, Dental Anesthesia, Dental Anesthesia Efficacy
- Trial name
- CCLAD-Pain (NCT07056101)
- Testing
- A conventional dental syringe, GENI High-Speed Injection, GENI Moderate-Speed Injection
- Where
- Egypt
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Tarek MHD kher al saka amini