Clinical trials: Anophthalmia
Eye Abnormalities
Modeling Ocular Developmental Diseases From 3D Cultures of Optic Vesicle Organoids Derived From hiPSCs of Patients With Ocular Malformations
Ocular morphogenesis is a complex process starting as early as the 4th week of embryonic life, involving interactions between varioustissues of different origin and conserved genes.
- Trial name
- OrganoEye (NCT06408701)
- Testing
- Blood sampling
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Microphthalmia, Coloboma
Microphthalmia, Anophthalmia, and Coloboma Genetic Epidemiology in Children
The investigators are inviting families to take part in a research study that will help us better understand the physical characteristics associated with children who have Microphthalmia, Anophthalmia, and Coloboma (MAC) and how…
- Conditions
- Microphthalmia, Coloboma, Anophthalmia
- Trial name
- MAGIC (NCT06293560)
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Anophthalmos, Orbital Implants
Prosthetic Motility and Complications in Pegged Versus Unpegged Hydroxyapatite Orbital Implants
Pegging the hydroxyapatite for increasing prosthetic motility sometimes leads to some complications for the patient. These complications ranging from discharge, granuloma formation, exposure, implant infection to socket…
- Trial name
- NCT00371280
- Testing
- orbital implant
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Anophthalmos
Molecular Analysis of Microphthalmia/Anophthalmia
This study will try to learn more about the genetic cause and symptoms of microphthalmia (small eyes) or anophthalmia (absence of one or both eyes).
- Trial name
- NCT00011843
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Anophthalmia, Microphthalmia
National Cohort on Congenital Defects of the Eye
Congenital malformations of the eye comprise various developmental defects including microphthalmia, anophthalmia, aniridia, and anterior segment anomalies (such as Peters and Axenfeld-Rieger anomalies).
- Conditions
- Anophthalmia, Microphthalmia, Aniridia, Anterior Segment Dysgenesis 6, Peters Anomaly Subtype
- Trial name
- RaDiCoACOEIL (NCT05954403)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Coloboma, Anophthalmia
Pathogenesis and Genetics of Microphthalmia, Anophthalmia and Uveal Coloboma (MAC)
Background: Uveal coloboma is a condition where the eye does not form normally. It occurs early in the fetus s development during pregnancy. It can lead to different kinds of eye problems, including blindness.
- Conditions
- Coloboma, Anophthalmia, Microphthalmia
- Trial name
- NCT01778543
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Eye Institute (NEI)