Clinical trials: Antibiotic Duration
Sepsis
PROcalcitonin to SHORTen Antibiotics Duration in PEDiatricICU Patients (ProShort-Ped) Trial
The purpose of this study is to give conclusive evidence on whether serial PCT (Procalcitonin) measurements can facilitate individual decision-making and shorten antibiotic treatment duration in patients with sepsis in the…
- Trial name
- ProShort-Ped (NCT01652404)
- Testing
- Procalcitonin-guided treatment, Conventional treatment
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Hunan Children's Hospital
Complicated Appendicitis, Perforated Appendicitis
Antibiotic Duration in Post-appendectomy Abscess
This is a randomized study of patients 2-17 years old who are diagnosed with perforated appendicitis and develop an abscess after laparoscopy that is subsequently drained.
- Trial name
- NCT03795194
- Testing
- ampicillin/clavulanate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Phoenix Children's Hospital
Primary Health Care for Children
Impact of a Real-time Mentoring Tool on Antibiotic Prescription (medAL-mentor)
The goal of this ancillary study, part of the DYNAMIC project, is to reduce antibiotic prescription and improve the quality of care for children in primary care in Tanzania using a near real-time mentoring tool (called…
- Trial name
- medAL-mentor (NCT05901155)
- Testing
- MedAL-mentor
- Where
- 40 sites in Tanzania
- Volunteers
- 37,000 people
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Sepsis
Neonatal Procalcitonin Intervention Study
In neonates, clinical signs and symptoms associated with early-onset sepsis are non-specific and currently available tests have poor positive and negative predictive values.
- Trial name
- NeoPInS (NCT00854932)
- Testing
- Procalcitonin-guided decision making
- Where
- Switzerland
- Volunteers
- 1,600 people
- Sponsor
- Luzerner Kantonsspital
Mycobacterium Avium-intracellulare Infection, HIV Infections
A Study to Evaluate the Effects of Azithromycin on MAC Disease Prevention in HIV-Positive Patients
This study is designed to find out whether HIV-positive patients whose immune systems have improved after receiving anti-HIV treatment should take azithromycin to prevent Mycobacterium avium complex (MAC) disease.
- Trial name
- NCT00000947
- Testing
- Azithromycin
- Where
- 19 sites in United States
- Volunteers
- 850 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Erythema Chronicum Migrans
Duration of Antibiotic Treatment of Erythema Migrans
The purpose of this study is to compare the efficacy of 15-day versus 10-day doxycycline treatment in patients with erythema migrans.
- Trial name
- NCT00910715
- Testing
- doxycycline
- Where
- Slovenia
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Pneumonia, Skin and Soft Tissue (SST) Infection
Trial of Reducing Inpatient Antibiotic Durations in Children
Infections like pneumonia, skin and soft tissue infection (also called SSTI or cellulitis), and urinary tract infections (UTI) are some of the most common reasons children get admitted to the hospital.
- Conditions
- Pneumonia, Skin and Soft Tissue (SST) Infection, Urinary Tract Infections (UTIs)
- Trial name
- TRIAD (NCT07322146)
- Where
- 10 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- University of California, San Francisco
Antibiotic Initiation, Antibiotic Duration
Feedback to Improve Rational Strategies of Antibiotic Initiation and Duration in Long Term Care
There is a high rate of inappropriate antibiotic use in long-term care (LTC) facilities, with both unnecessary initiation and prolongation of treatments.
- Trial name
- FIRST AID-LTC (NCT03807466)
- Testing
- Dynamic/Interactive vs. Static/Paginated Report, LTC Physicians Enrolled vs. Not Enrolled in Reports
- Where
- Canada
- Volunteers
- 356 people
- Sponsor
- Institute for Clinical Evaluative Sciences
Bacterial Infections
Compliance With AntibIotic TherapY Guidelines in French PICUs
This observational, prospective, multicenter study, conducted in nine French Pediatric and Neonatal Intensive Care Units (ICUs), will assess the antibiotic therapy for a child hospitalized in ICU and receiving systemic…
- Trial name
- COMITY (NCT04642560)
- Where
- France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Toulouse
Community Acquired Pneumonia in Children
Short Versus Standard of Care Antibiotic Duration for Children Hospitalized for CAP
The goal of this open label, randomized, non-inferiority clinical trial is to compare the treatment success of a 5 day antibiotic course versus a standard antibiotic course (usually 7-14 days of antibiotics) in hospitalized…
- Trial name
- NCT06494072
- Testing
- Ampicillin for Injection, Ceftriaxone for Injection, Amoxicillin
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Medical College of Wisconsin
Cellulitis, Abscess
Decreasing Antibiotic Duration for Skin and Soft Tissue Infection Using Behavioral Economics in Primary Care
Study the efficacy of a package of behavioral economics strategies (versus an education-only control condition) in altering clinician behavior regarding antibiotic prescription duration for skin and soft tissue infection (SSTI).
- Conditions
- Cellulitis, Abscess, Drain Abscess, Impetigo
- Trial name
- SSTIBE (NCT05226260)
- Testing
- Default Duration order Panel
- Where
- United States
- Volunteers
- 1,634 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Microbiota
Effect of Intrapartum Antibiotic Prophylaxis (IAP) on the Development of the Neonatal Gut Microbiota.
The colonization of the neonatal gastro-intestinal (GI) tract begins at birth and is influenced by several factors, such as mode of delivery, gestational age, maternal intestinal and vaginal microbiota, type of feeding…
- Trial name
- MICROBIOTA-SO (NCT02212002)
- Testing
- IAP
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Otitis, Bronchiolitis
Pediatric and Ambulatory Research in Infectious Diseases
Many ambulatory networks are mainly based on diagnoses made by first-line physicians not specifically trained to join the network.
- Conditions
- Otitis, Bronchiolitis, Influenza, Pharyngitis
- Trial name
- PARI (NCT04471493)
- Where
- France
- Volunteers
- 400,000 people
- Sponsor
- Association Clinique Thérapeutique Infantile du val de Marne
Preterm Premature Rupture of Membrane
Duration of Antibiotics Treatment With Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of Membrane
The purpose of this study is to compare the neonatal outcome and infant neurologic outcome whose mother were treated with cefazolin plus clarithromycin for one week or until delivery after preterm premature rupture of membrane.
- Trial name
- NCT01503606
- Testing
- Cefazolin, Clarithromycin
- Where
- South Korea
- Volunteers
- 151 people
- Sponsor
- Samsung Medical Center
Surgical Wound Infection
Duration of Postoperative Antibiotic Prophylaxis in Facial Fractures
Facial fractures make up a significant proportion of injuries in trauma patients. Treatment of these fractures often results in standard surgical interventions.
- Trial name
- NCT01583062
- Testing
- Amoxicillin/clavulanic acid
- Where
- Switzerland
- Volunteers
- 217 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Antibiotic Initiation, Antibiotic Duration
Feedback to Improve Rational Strategies of Antibiotic Initiation and Duration in Long Term Care (FIRST AID -LTC) - Phase 2
There is a high rate of inappropriate antibiotic use in LTC facilities, with both unnecessary initiation and prolongation of treatments.
- Trial name
- FIRST AID-LTC (NCT04187742)
- Testing
- Social Comparison Email vs. Standard Email, Maintenance Certification Email vs. Standard Email, Report Opening Status Email vs. Standard Email (among previous report openers and non-openers)
- Where
- Canada
- Volunteers
- 421 people
- Sponsor
- Institute for Clinical Evaluative Sciences
Infections
Efficacy and Safety of Antimicrobial Durations Treatment of Infections Associated With Osteosynthesis Material
Infections associated with osteosynthesis material are among the most feared and challenging complications of trauma surgery and can lead to total function loss or limb amputation when complete recovery is to be expected without…
- Trial name
- DURATIOM (NCT05294796)
- Testing
- Short course of antibiotherapy, Long course of antibiotherapy
- Where
- 29 sites in Spain
- Volunteers
- 364 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Surgical Site Infection (SSI), Spine Diseases
Efficacy of Intrawound Vancomycin in Spine Surgery
"This multicenter, prospective, time-cluster randomized controlled trial with blinded endpoint assessment (PROBE design) evaluated the efficacy of intrawound vancomycin powder (2 g) in preventing surgical site infections (SSI)…
- Trial name
- NCT07866157
- Testing
- vancomycin, Standard surgical closure
- Where
- Egypt
- Volunteers
- 416 people
- Sponsor
- Ain Shams University
Infant, Newborn, Neonatal SEPSIS
7 Days Versus 14 Days of Antibiotics for Neonatal Sepsis
The optimum duration of intravenous antibiotic therapy for culture-proven neonatal bacterial sepsis is not known. Current practices, ranging from 7 days to 14 days of antibiotics, are not evidence-based.
- Conditions
- Infant, Newborn, Neonatal SEPSIS, Anti-bacterial Agents, Recurrence
- Trial name
- NCT03280147
- Testing
- 7-day course of antibiotics, 14-day course of antibiotics
- Where
- 7 sites in India
- Volunteers
- 261 people
- Sponsor
- Indian Council of Medical Research
SURGICAL SITE INFECTION
Early Short-term Antibiotic Therapy in Penetrating Abdominal Trauma, 3 vs 7 Days
Abdominal penetrating trauma represents a frequent cause of consult into emergency rooms in Venezuela. Accidents and violence at Hospital "Miguel Perez Carreño" along april 2009 were represented by gunshots and stabbing wounds…
- Trial name
- NCT01203046
- Testing
- Ertapenem
- Volunteers
- 56 people
- Sponsor
- Silvia M. Pinango L.