Clinical trials: Antibiotic Prophylaxis
Urinary Tract Infection
Usefulness of Antimicrobial Prophylaxis in Children With Isolated Vesico-Ureteral Reflux.
Randomized, prospective, multicenter study in order to assess the usefulness of antimicrobial prophylaxis in children with isolated vesico-ureteral reflux (grade III or less).
- Trial name
- NCT00200616
- Testing
- Antimicrobial prophylaxis
- Where
- France
- Volunteers
- 232 people
- Sponsor
- Nantes University Hospital
Proven or Suspected Gram-negative Bacterial Infection, Peri-operative Prophylaxis
Pharmacokinetic and Safety Study of Ceftolozane/Tazobactam in Pediatric Participants Receiving Antibiotic Therapy for Proven or Suspected Gram-negative Infection or for Peri-operative Prophylaxis (MK-7625A-010)
The purpose of this study was to assess the pharmacokinetics, safety, and tolerability of a single intravenous dose of ceftolozane/tazobactam (MK-7625A) in pediatric participants.
- Trial name
- NCT02266706
- Testing
- Ceftolozane/Tazobactam 1000/500 mg, Ceftolozane/Tazobactam 30/15 mg/kg, Ceftolozane/Tazobactam 20/10 mg/kg
- Volunteers
- 43 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Surgical Site Infection, Antibiotics Prophylaxis
Cefuroxime vs Ceftriaxone for SSI Prevention in Neurosurgery
BACKGROUND: Surgical site infection (SSI) is potentially catastrophic in neurosurgical procedures, causing poor in-hospital outcomes in more than half of those affected and significantly increased length of hospital stay.
- Trial name
- NCT05398081
- Testing
- Cefuroxime (Zinnat®), Ceftriaxone (Rocephin®)
- Where
- Nigeria
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Dr. Promise Tamunoipiriala Jaja
Skin Transplantation, Wounds and Injuries
Do Topical Antibiotics Improve Skin Graft Results?
The goal of this study is to see if putting antibiotic ointment on a skin graft when the surgery is being done helps prevent the skin graft from getting infected after the operation.
- Conditions
- Skin Transplantation, Wounds and Injuries, Antibiotic Prophylaxis Surgery
- Trial name
- NCT07286851
- Testing
- Neomycin
- Where
- Bangladesh
- Volunteers
- 142 people
- Sponsor
- LAMB Project
Gangrenous Appendicitis
Prophylaxis With Single Versus Five Dose of Antibiotic Therapy as Treatment of Patients With Gangrenous Acute Appendicitis
A prospective, randomized controlled clinical trial was conducted at the Hospital Universitario de Santander to test the effectiveness of providing a single 1-dose therapy of antibiotic prophylaxis versus a 5-day antibiotic…
- Trial name
- NCT01115153
- Testing
- prophylaxis, therapy
- Where
- Colombia
- Volunteers
- 150 people
- Sponsor
- Universidad Industrial de Santander
Sepsis, Neonatal Mortality
Clean Trial - Chlorination to Reduce Enteric and Antibiotic Resistant Infections in Neonates
The CLEAN (ChLorine to reduce Enteric and Antibiotic resistant infections in Neonates) cluster randomized controlled trial in western Kenya will evaluate the impact of a multi-component chlorination intervention in health care…
- Conditions
- Sepsis, Neonatal Mortality, Antibiotic Resistant Infection, Enteric Infections
- Trial name
- CLEAN (NCT06824350)
- Testing
- chlorination for water disinfection and surface disinfection, infection prevention and control messaging
- Where
- 2 sites in United States, Kenya
- Volunteers
- 45,450 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Catheter-related Infections
CATCH - Catheter Infections in Children
Most children admitted to paediatric intensive care units (PICU) need to have medicines given to them into their veins using a narrow tube, so they do not need repeated injections. This tube is called a central venous catheter.
- Trial name
- NCT01029717
- Testing
- Standard polyurethane Central Venous Catheter, Antibiotic impregnated polyurethane CVC (minocycline and rifampicin), Heparin bonded polyurethane CVC
- Where
- United Kingdom
- Volunteers
- 1,859 people
- Sponsor
- Institute of Child Health
Surgical Site Infection
De-Implementation of Unnecessary Surgical Antibiotic Prophylaxis in Children
The overall objective of this study is to identify the best strategy to eliminate unnecessary antibiotic use after surgery in pediatric surgical procedures considered low-risk for an SSI.
- Trial name
- OPerAtiC (NCT04366440)
- Testing
- Order set review and modification with facilitation, Order set review and modification
- Where
- 10 sites in United States
- Volunteers
- 18,267 people
- Sponsor
- Washington University School of Medicine
Critical Illness, Antibiotic-associated Diarrhea
Probiotics For The Prevention of Antibiotics Associated Diarrhea in the Pediatric Intensive Care Unit
The goal of this prospective trial is to learn about lactobacillus use in critically ill pediatric patients. The main question[s] it aims to answer are: Is lactobacillus GG effective in preventing antibiotic associated diarrhea…
- Trial name
- NCT06109740
- Testing
- lactobacillus GG
- Volunteers
- 21 people
- Sponsor
- University of South Alabama
Antibiotic Associated Diarrhea
Effect of Lactobacillus Reuteri DSM 17938 to Prevent Antibiotic-associated Diarrhea in Children
Recent studies showed that intestinal microbiota consist more than thousand bacteria, and these microorganisms play the role as balance and continuity of the anatomical and functional integrity gastrointestinal tract.
- Trial name
- PEARL (NCT02765217)
- Testing
- Lactobacillus reuteri DSM 17938, Amoxicillin-Clavulanic Acid
- Where
- Turkey (Türkiye)
- Volunteers
- 1,325 people
- Sponsor
- Eskisehir Osmangazi University
Acute Febrile Illness
Advancing Access to Diagnostic Innovation Essential for UHC and AMR Prevention
This study aims to evaluate clinical outcomes and antibiotic prescription patterns following the use of diagnostic algorithms, point of care (PoC) rapid diagnostic tests, and behaviour change interventions in cases of acute…
- Trial name
- Accelerator (NCT04081051)
- Testing
- diagnostic algorithm+Point of care rapid diagnostic tests+ Behavior change ( assessed together as a single package of interventions)
- Where
- 8 sites in Burkina Faso, Ghana and 3 more
- Volunteers
- 17,294 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Sepsis
Using Biomarkers to Optimize Antibiotic Strategies in Sepsis
The proposed work will provide critical insights into the potential impact of a biomarker-based algorithm on reducing unnecessary antibiotic use in different adult and pediatric/neonatal ICU's.
- Trial name
- NCT02207114
- Testing
- Biomarker Algorithm Intervention
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- University of Pennsylvania
Induced Abortion, Postaboral Pelvic Inflammatory Disease
To Compare the Strategies of Universal Antibiotic Prophylaxis Versus Screen-and-treat in Reducing Infective Complications and Re-infection in Women Who Undergo Termination of Pregnancy
Screen-and-treat approach reduces postabortal pelvic inflammatory disease after induced abortion, and at the same time alters women's sexual behavior and prevents further re-infection by sexually transmitted infections when…
- Conditions
- Induced Abortion, Postaboral Pelvic Inflammatory Disease, Sexually Transmitted Infections
- Trial name
- NCT01842100
- Testing
- Universal antibiotic prophylaxis, Screen-and-treat
- Where
- China
- Volunteers
- 2,193 people
- Sponsor
- The University of Hong Kong
Burn
Comparison of Topical Antibiotics Versus Systemic Antibiotics in Preventing Burn Wound Infection in Pediatric Burn Patients
Burn wound infection is a common complication in children with burns and can delay healing and increase the risk of complications.
- Trial name
- NCT07870239
- Testing
- Silver Sulfadiazine Cream 1%, Amoxicillin and clavulanate
- Where
- Pakistan
- Volunteers
- 222 people
- Sponsor
- abdul mateen
Rheumatic Heart Disease in Children
Adapting Enhanced Supports to Improve Patient Adherence to Secondary Antibiotic Prophylaxis for Rheumatic Heart Disease
The goal of this clinical trial is to test the effectiveness and implementation of enhanced Secondary Antibiotic Prophylaxis (SAP) supports using a hybrid type 1 effectiveness-implementation design.
- Trial name
- SHIELD 3 Adapt (NCT07666048)
- Testing
- CHW Delivered SAP Adherence Supports
- Where
- United States
- Volunteers
- 308 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Surgical Site Infection
Antibiotic Prophylaxis in Clean Surgery. Impact on Surgical Site Infection
This is a randomized control study of antibiotic uses in clean non prosthetic surgeries. One group will be given antibiotic prophylaxis, other will receive a placebo.
- Trial name
- NCT03595852
- Testing
- Cefazolin
- Where
- Rwanda
- Volunteers
- 138 people
- Sponsor
- University of Rwanda
Dental Caries in Children, Dental Plaque
Targeting of Preventive Treatment for Adolescents at Risk of Oral Diseases
The aim of the study is to identify adolescent patients that are at risk of developing oral diseases, and to assess if targeted preventive oral treatment with antibacterial dual-light therapy as an adjunctive treatment method can…
- Conditions
- Dental Caries in Children, Dental Plaque, Tooth Decay, Periodontitis
- Trial name
- LumoPrevent (NCT06286501)
- Testing
- Lumoral Treatment, Standard, personalized oral health care
- Where
- Finland
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Wellbeing Services County of Pirkanmaa
Staphylococcal Infection
Safety and Efficacy of Mupirocin in Eradicating Colonization With S. Aureus in Critically Ill Infants
The objective of this trial is 1) to evaluate the safety and clinical acceptability of a 5-day course of mupirocin applied every 8 hours (± 2 hours) to the nares, umbilical and perianal areas of infants residing in the ICU.
- Trial name
- NCT01827358
- Testing
- Mupirocin calcium
- Where
- 6 sites in United States
- Volunteers
- 155 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Inflammation at Mini-screw Insertion Site, Mobility, Mini-screw
Antibiotics Prior to Mini-screw Implant Insertion
The investigators plan to use amoxicillin in capsule form, prepared by a pharmacist, for antibiotic prophylaxis to decrease the failure rate of mini-screw implants temporarily placed in the palate of patients involved in Phase II…
- Trial name
- NCT03582605
- Testing
- Amoxicillin
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- St. Louis University
Urinary Tract Infection (Diagnosis)
Comparison Between Effect of Empirical Antibiotic Prophylaxis Versus Enhanced Prophylactic Measures on Rate of Urinary Tract Infection After Flexible Ureteroscopy in Children With Pyuria
The aim of this study is to compare between effect of empirical antibiotic prophylaxis versus enhanced prophylactic measures on rate of urinary tract infection after Flexible ureteroscopy in Children.
- Trial name
- NCT07229755
- Testing
- Ceftriaxone (Rocephin®), Levofloxacin
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ain Shams University