Clinical trials: Anticholinergics
Nocturnal Incontinence
Effect of Long Acting Anticholinergic on Nocturnal Incontinence After Radical Cystectomy and Orthotopic Neobladder
It is a prospective randomized- placebo control crossover study to evaluate the effect of long acting tolterodine (anticholinergic) in improving and treating nocturnal incontinence in patient after radical cystectomy and…
- Trial name
- NCT02877901
- Testing
- long acting tolterodine 4 mg
- Volunteers
- 120 people
- Sponsor
- Mansoura University
Dystonia
Childhood Hypertonia of Central Origin: A Trial of Anticholinergic Treatment Effects
This study is an open-label trial of trihexyphenidyl in children with upper extremity dystonia due to cerebral palsy. It is hypothesized that trihexyphenidyl in doses up to 0.75mg/kg/day would be well-tolerated and show…
- Trial name
- NCT00122044
- Testing
- trihexyphenidyl
- Where
- 7 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Southern California
Male Urogenital Diseases
Early Oxybutinin Treatment for Boys With Posterior Urethral Valves
Boys with posterior urethral valves have bladder dysfunction of varying severity. Early treatment of these children with anticholinergics is recommended by some teams, although there have never been any clear studies on the…
- Trial name
- PRETIPUV (NCT04526353)
- Testing
- Oxybutynin 1 mg/ml Syrup
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Urticaria
An Efficacy and Safety Study of Desloratadine (MK-4117) in Japanese Participants With Chronic Urticaria (MK-4117-201)
This is a study to evaluate the efficacy and safety of desloratadine (MK-4117) in Japanese participants with chronic urticaria. The primary hypothesis is that the efficacy of desloratadine 10 mg and 5 mg is superior to placebo as…
- Trial name
- NCT01916967
- Testing
- Desloratadine
- Volunteers
- 239 people
- Sponsor
- Organon and Co
Fever
Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine
Anticholinergic drugs have traditionally been used for their antisialagogue properties. But use of anticholinergic drugs can interfere with thermoregulation via inhibition of the parasympathetically mediated sweat secretion.
- Trial name
- NCT02430272
- Testing
- Glycopyrrolate
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Inje University
Enuresis, Nocturnal, 2 (Disorder)
Ability to Awaken in Nonmonosymptomatic Enuresis
To evaluate the effect of controlling lower urinary tract symptoms (LUTS) with anticholinergics on improving the ability to awaken (AA) in children with nonmonosymptomatic enuresis and evaluate the potential implication of…
- Trial name
- NCT02845648
- Testing
- anticholinergic
- Volunteers
- 119 people
- Sponsor
- Seoul National University Hospital
Overactive Bladder
Comparison of Caffeine Reduction and Anticholinergic Medications for Treatment of Overactive Bladder
The purpose of this study is to assess the effects of caffeine reduction/elimination on urinary symptoms in women with overactive bladders and compare this therapeutic approach to anticholinergic therapy.
- Trial name
- NCT00780832
- Testing
- Dietary Caffeine reduction, Anticholinergic medication
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- IWK Health Centre
Idiopathic Overactive Bladder Resistant to Anticholinergic Treatment
Efficacy of 200 IU OnabotulinumtoxinA in Idiopathic Overactive Bladder Resistant to Anticholinergic Treatment
This study aimed to assess the efficacy and safety of onabotulinumtoxinA (botulinum toxin type A) in patients with idiopathic overactive bladder (OAB) and urinary incontinence who had previously failed to respond to…
- Trial name
- NCT06408051
- Testing
- Injection of onabotulinumtoxinA into the bladder wall
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hisar Intercontinental Hospital
Anticholinergic Toxicity
Rivastigmine to Prevent Recurrence of Antimuscarinic Delirium
Antimuscarinic delirium (AMD) is a common and dangerous toxicology condition caused by poisoning by medications and other chemicals that block muscarinic receptors.
- Trial name
- RIVA-AP (NCT06399679)
- Testing
- Rivastigmine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Anticholinergics Toxicity
Treatment of Adolescent Antimuscarinic (Anticholinergic) Toxidrome
Overdose of xenobiotics (antihistamines, antipsychotics, or Jimson Weed) with resulting antimuscarinic toxidrome is a common scenario in medical toxicology.
- Trial name
- TAAT (NCT03090620)
- Testing
- Physostigmine, Lorazepam
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parkinson's Disease, Overactive Bladder
Anticholinergic Therapy for Overactive Bladder in Parkinson's Disease
The purpose of this research study is to investigate the cognitive (thinking, memory, knowledge, intelligence) side effects of two medications commonly used to treat overactive bladder (OAB) symptoms in veteran patients with…
- Trial name
- NCT00892450
- Testing
- Oxybutynin and darifenacin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- US Department of Veterans Affairs
Nocturnal Enuresis in Children
Omegapres Versus Solifenacin and Mirabegron Combination Therapy in Treatment of Primary MNE
The goal of this clinical trial is to compare combination of Solifenacin and MIrabegron in treatment of primary mono-symptomatic nocturnal enuresis in children. It will also learn about the safety of that combination.
- Trial name
- NCT07199894
- Testing
- Mirabegron (beta3-adrenoceptor agonist), Anticholinergics, Desmopressin (DDAVP)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Mansoura University
Spina Bifida
Efficacy of Intravesical Oxybutynin in Children With Neurogenic Bladder Dysfunction
Malformation of the lumbosacral region (spina bifida) affects the innervation of the bladder in children. The usual evolution leads to a neurological bladder with small capacity, poor compliancy and overactivity, exposing to…
- Trial name
- POXIPEN (NCT07027020)
- Testing
- Oxybutynin Hydrochloride
- Where
- 19 sites in France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Perennial Allergic Rhinitis
A Study of the Efficacy and Safety of Desloratadine (MK-4117) in Japanese Participants With Perennial Allergic Rhinitis (MK-4117-200)
This is a study to evaluate the efficacy and safety of desloratadine (MK-4117) in Japanese participants with perennial allergic rhinitis.
- Trial name
- NCT01918033
- Testing
- Desloratadine 5 mg
- Volunteers
- 608 people
- Sponsor
- Organon and Co
Overactive Bladder
Dose-Escalating Study of Propiverine Hydrochloride in Children Suffering From Overactive Bladder
The open-label dose-escalating two-centre study was designed to assess the pharmacokinetics as well as safety, tolerability and efficacy parameters of propiverine in patients 5-10 years of age suffering from…
- Trial name
- NCT00795925
- Testing
- propiverine hydrochloride
- Volunteers
- 30 people
- Sponsor
- APOGEPHA Arzneimittel GmbH
Anticholinergic Side Effects
Reduction of Adverse Events of Anticholinergic Drugs by Multidisciplinary Medical Reviews in Norwegian Nursing Homes
Thesis: Is drug-induced anticholinergic activity additive resulting in a total anticholinergic load causing harmful side effects in old, fragile patients? Is it possible to reduce the anticholinergic load by multidisciplinary…
- Trial name
- PRADA (NCT00854438)
- Testing
- Multidisciplinary drug reviews by pharmacist and physician
- Where
- Norway
- Volunteers
- 87 people
- Sponsor
- Ullevaal University Hospital
Overactive Bladder
Treatment of Overactive Bladder With Anticholinergic Agents
This study aims to evaluate the efficacy and adverse effect incidence of three different anticholinergics (oxybutinin, propiverine, and tolterodine) that are used in children with overactive bladder.
- Trial name
- NCT07046156
- Testing
- Oxybutynin Cl, propiverine, Tolterodine
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Asthma, Depression
Defining and Treating Depression-related Asthma
Depression is seen more often in people with asthma, and may lead to increased development and severity of asthma. This study will investigate whether children with depression and asthma have less allergic disease and less…
- Conditions
- Asthma, Depression, Childhood Asthma
- Trial name
- NCT04617015
- Testing
- Ipratropium Bromide
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- State University of New York at Buffalo
Anticholinergic Toxicity
Rivastigmine for Antimuscarinic Delirium
Antimuscarinic delirium (AMD) is a common and dangerous toxicology condition caused by poisoning by medications and other chemicals that block muscarinic receptors.
- Trial name
- RIVA-AM (NCT06382649)
- Testing
- Rivastigmine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity
Reversibility of Bronchial Obstruction in Children Born Preterm
This observational study aims to compare responses to different, commonly used inhaled bronchodilators in children born preterm with bronchial obstruction at spirometry.
- Conditions
- Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity, Chronic Lung Disease of Newborn, Preterm Birth Complication
- Trial name
- NCT06110481
- Where
- Czechia
- Volunteers
- 73 people
- Sponsor
- Charles University, Czech Republic