Clinical trials: Antimicrobial Effectiveness
Cystic Fibrosis
Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis Patients With P. Aeruginosa
The purpose of this study was to evaluate the safety and efficacy of aztreonam for inhalation solution (AZLI) in patients with cystic fibrosis (CF) and lung infection due to Pseudomonas aeruginosa (PA).
- Trial name
- AIR-CF2 (NCT00104520)
- Testing
- AZLI 75 mg two times a day (BID)/three times a day (TID)
- Where
- 56 sites in United States
- Volunteers
- 211 people
- Sponsor
- Gilead Sciences
Impacted Wisdom Tooth, Pain
Investigation of Effectiveness of Local Antibiotic With Platelet Rich Fibrin on Third Molar Surgery Outcomes In Vivo
The aim of this study was investigate the effectiveness of Local Antibiotic Applications With Platelet Rich Fibrin on Third Molar Surgery Outcomes In Vivo and In Vitro.
- Conditions
- Impacted Wisdom Tooth, Pain, Staphylococcus Aureus
- Trial name
- NCT05678296
- Testing
- Diagnosis, Analgesic, traditional osteotomies
- Where
- Cyprus
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ceren Melahat Donmezer
Antibiotic Associated Diarrhea, Clostridium Difficile Infection
Probiotic Lactobacillus Reuteri to Prevent Antibiotic-associated Diarrhea and Clostridium Difficile-related Infections in Hospitalized Children
The purpose of this study is to determine if the daily intake of the probiotic Lactobacillus reuteri prevents antibiotic-associated diarrhoea and related Clostridium difficile infections in children and adolescents.
- Conditions
- Antibiotic Associated Diarrhea, Clostridium Difficile Infection, Gastroenteritis
- Trial name
- AADreuter (NCT01295918)
- Testing
- L reuteri in children on antibiotics
- Where
- 2 sites in Bulgaria
- Volunteers
- 100 people
- Sponsor
- St Marina University Hospital, Varna, Bulgaria
Chronic Cough
Finnish Children´s Protracted Cough
Prolonged cough lasting more than four weeks is common in children, but the best treatment is often unclear when no underlying disease can be found.
- Trial name
- FINNCHICO (NCT07582549)
- Testing
- Fluticasone propionate inhalation, Amoxicillin-clavulanic acid oral suspension
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Tampere University Hospital
Candidiasis, Oral, HIV Infections
The Safety and Effectiveness of Peridex in Preventing or Delaying Fungal Infections of the Mouth in HIV-Infected Patients
To evaluate the safety and effectiveness of Peridex (an oral rinse containing chlorhexidine gluconate) for preventing the occurrence of clinically-evident microbiologically-documented oral candidiasis in HIV-positive patients…
- Trial name
- NCT00002431
- Testing
- Chlorhexidine gluconate
- Where
- 5 sites in United States
- Sponsor
- Procter and Gamble
Acute Bronchitis
The Sublimated Mare Milk Supplement's Effect on Gut Mucosal Lining After Antibiotics
This clinical trial studies the effect of sublimated mare milk supplement on gut microbiome of patients with acute bronchitis.
- Trial name
- NCT03657836
- Testing
- Sublimated mare milk supplement, Standard antibiotic therapy
- Where
- Kazakhstan
- Volunteers
- 12 people
- Sponsor
- Nazarbayev University Medical Center
Cystic Fibrosis, Lung Infection
Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Patients With Cystic Fibrosis, Mild Lung Disease, and P. Aeruginosa
The purpose of this study was to evaluate the safety and efficacy of a 28-day course of aztreonam for inhalation solution (AZLI) in patients with cystic fibrosis (CF), mild lung disease (forced expiratory volume in 1 second…
- Conditions
- Cystic Fibrosis, Lung Infection, Pseudomonas Aeruginosa
- Trial name
- AIR-CF4 (NCT00712166)
- Testing
- AZLI 75 mg three times daily (TID)
- Where
- 40 sites in United States, Australia and 1 more
- Volunteers
- 160 people
- Sponsor
- Gilead Sciences
Posterior Urethral Valves
Efficacy and Safety of Circumcision Alone on Risk of Febrile Urinary Tract Infections in Boys With Posterior Urethral Valves: a Prospective Randomized Open-label Multicentric Trial Enriched With Historic Controls.
Boys with posterior urethral valves (PUV) are at increased risk of developing febrile urinary tract infections (fUTIs). As shown in the CIRCUP trial, circumcision plus antibiotic prophylaxis reduces the risk of FUTIs compared…
- Trial name
- CIRCUP 2 (NCT07527442)
- Testing
- Antibiotics strategy, Circumcision
- Where
- 13 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bordeaux
Staphylococcus Aureus Bacteremia, Staphylococcus Aureus Endocarditis
Direct Lysis of Staph Aureus Resistant Pathogen Trial of Exebacase
The purpose of this superiority study is to evaluate the efficacy and safety of exebacase in addition to standard of care antibiotics (SoCA) compared with SoCA alone for the treatment of patients with Staphylococcus aureus (S.
- Trial name
- DISRUPT (NCT04160468)
- Testing
- Exebacase
- Where
- 55 sites in United States
- Volunteers
- 259 people
- Sponsor
- ContraFect
Tracheostomy Infection
Infection Control Program in Tracheostomized Patients
Healthcare-associated infections are infections that patients acquire during the course of receiving treatment for other conditions within a healthcare setting and are not present at the time of admission.
- Trial name
- NCT05113329
- Volunteers
- 52 people
- Sponsor
- Assiut University
Inguinal Hernia
Effectiveness of Topical Antibiotic Prophylaxis in Inguinal Hernia Repair
Aim of this study is to measure the effectiveness of topical gentamicin to prevent post-operative infection in inguinal tension-free hernia repair operation.Secondary aim is, if it is effective as a prophylactic agent, to compare…
- Trial name
- NCT01273818
- Testing
- Gentamicin and cefazolin, Cefazolin, Gentamicin
- Where
- Turkey (Türkiye)
- Volunteers
- 276 people
- Sponsor
- Diskapi Teaching and Research Hospital
Community-Acquired Pneumonia (CAP)
Lefamulin Post-Market Surveillance Study
Community-acquired pneumonia (CAP) refers to infectious parenchymal lung inflammation acquired outside hospital settings. In China, its incidence is 7.13 per 1000 person-years, with over 10 million new cases annually.
- Trial name
- NCT07697885
- Testing
- This is a multicenter, single-arm, non-interventional study. No interventional measures will be adopted.
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Marubeni Pharmaceuticals (Suzhou) Co., Ltd.
Otitis Media With Effusion
Efficacy and Cost Analysis of Steroids in Treatment of Otitis Media With Effusion
We intend to study the cost of treatment, efficacy and adverse effects for Otitis media with effusion.
- Trial name
- NCT03590912
- Testing
- Mometasone 50 Mcg/Inh Nasal Spray, Antibiotics + Antihistamine (levocetirizine) + Nasal decongestants (Oxymetazoline 0.025%), Steroid Drug (prednisolone)
- Where
- Nepal
- Volunteers
- 160 people
- Sponsor
- Lumbini Medical College
Appendicitis
Appendectomy Versus Non-Operative Treatment For Acute Non-Perforated Appendicitis in Children
Rationale and Aim: The standard treatment for acute appendicitis in children is appendectomy. An increasing body of evidence from the adult literature suggests that acute appendicitis may be treated effectively with antibiotics…
- Trial name
- APPY (NCT02687464)
- Testing
- Non-operative treatment, Appendectomy
- Where
- United States
- Volunteers
- 978 people
- Sponsor
- Children's Mercy Hospital Kansas City
Antibiotic-associated Diarrhea
Efficacy and Safety of BB-12 Supplemented Strawberry Yogurt For Healthy Children on Antibiotics
Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. One of the most common indications for probiotic treatment is the prevention of antibiotic-associated diarrhea…
- Trial name
- PLAY ON (NCT03181516)
- Testing
- Bifidobacterium animalis subsp. lactis BB-12, Control
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- Georgetown University
Acute Respiratory Infections
C Reactive Protein (CRP) Intervention to Reduce Inappropriate Antibiotic Prescriptions in the Primary Healthcare Setting
Many studies have showed that rapid point-of-care (POC) c-reactive protein (CRP) test can reduce inappropriate use of antibiotic at primary health care level.
- Trial name
- CRP (NCT01918579)
- Testing
- Patients will be tested by rapid POC CRP test
- Where
- Vietnam
- Volunteers
- 2,037 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Probiotic
Heat-Inactivated Lactobacillus Salivarius HM-6 in Preschool Children With ECC
This study aims to evaluate whether a short, 14-day administration of chewable tablets containing heat-inactivated Lactobacillus salivarius HM-6 Paradens can influence selected salivary parameters related to oral health in…
- Trial name
- AEPRO (NCT07825324)
- Testing
- Children in the intervention group received commercially available chewable tablets containing 10 mg of heat-inactivated Lactobacillus salivarius HM-6 Paradens.
- Where
- Poland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Obesity
Short- and Long-Term Effects of Antibiotics on Childhood Growth
The objectives of the proposed study are to assess the effects of different types, timing, and amount of antibiotic use in the first two years of life with (Specific Aim 1) body mass index (BMI) and obesity at ages 5 and 10 years…
- Trial name
- ABX (NCT02744846)
- Testing
- Antibiotics exposure
- Volunteers
- 681,739 people
- Sponsor
- Harvard Pilgrim Health Care
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Coronavirus Disease 2019 (COVID-19)
A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People With Weakened Immune Systems or at Increased Risk for Poor Outcomes Who Are Hospitalized Due to Severe COVID-19
A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People with Weakened Immune Systems or at Increased Risk for Poor Outcomes who are Hospitalized Due to Severe COVID-19
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Coronavirus Disease 2019 (COVID-19), Immunocompromised, Hospitalization
- Trial name
- EPIC-HOS (NCT05545319)
- Testing
- Nirmatrelvir, Ritonavir
- Where
- 11 sites in United States, Bulgaria
- Sponsor
- Pfizer
Empyema, Pleural
Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema
To evaluate the impact of using different antibiotic regimens including single and combined agents as the empirical therapy and evaluate the clinical outcomes regarding safety, efficacy, and pharmacodynamics parameters.
- Trial name
- NCT06787885
- Testing
- Levofloxacin + clindamycin, Levofloxacin + cefipime
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Fayoum University