Clinical trials: Antimicrobial Stewardship
Prematurity, Infections
Antibiotic Stewardship to Prevent Early Sepsis in Preterm Infants
Early onset sepsis (EOS) occurs in newborns within the first 72 hours of life, and is rare, about 0.8 cases per 1000 births (1).
- Trial name
- BACTINEO (NCT06930911)
- Testing
- Antibiotic therapy
- Where
- France
- Volunteers
- 711 people
- Sponsor
- Hospices Civils de Lyon
VAP - Ventilator Associated Pneumonia
Ventilator-associated Pneumonia (VAP) Diagnostic Stewardship Trial
This is a prospective pilot/feasibility trial of a bundled diagnostic stewardship intervention at the level of the microbiologic testing pathway in ventilator-associated pneumonia (VAP).
- Trial name
- NCT05176353
- Testing
- VAP diagnostic stewardship bundle
- Where
- United States
- Volunteers
- 4,892 people
- Sponsor
- University of Michigan
Pneumonia Childhood, Pneumonia
Lung Ultrasound for Guiding Antibiotic Use in Pediatric Pneumonia
Pneumonia is a major cause of illness and death in children, with an annual incidence of about 3.3 per 1,000 in those under five years old, many requiring hospitalization.
- Conditions
- Pneumonia Childhood, Pneumonia, Lung Ultrasound, Antibiotic Stewardship
- Trial name
- LUSCAP (NCT06921993)
- Testing
- LUNG ULTRASOUND
- Where
- 18 sites in United States, Israel and 1 more
- Volunteers
- 659 people
- Sponsor
- Meyer Children's Hospital IRCCS
Child Health
Dynamic CDSA to Manage Sick Children in Tanzania
This study aims to reduce morbidity and mortality among children and mitigate antimicrobial resistance using a novel clinical decision support algorithm, enhanced with point-of-care technologies to help health workers in primary…
- Trial name
- DYNAMIC-TZ (NCT05144763)
- Testing
- ePOCT+
- Where
- 40 sites in Tanzania
- Volunteers
- 92,331 people
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Neonatal Sepsis, Early-Onset, Culture Positive Neonatal Sepsis
Molecular Culture for the Diagnosis of Neonatal Sepsis
Rationale: Early diagnosis of sepsis in neonates is complicated as the signs and symptoms are nonspecific. Although blood culture is the gold standard for the diagnosis, false-negative results and long incubation period of 36-72…
- Conditions
- Neonatal Sepsis, Early-Onset, Culture Positive Neonatal Sepsis, Culture Negative Neonatal Sepsis, Clinical Sepsis
- Trial name
- NCT05763680
- Testing
- Molecular Culture
- Where
- Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Jip Groen
Otitis Media, Antimicrobial Stewardship
Digital Otoscope Versus Education and Feedback for Otitis Media in Young Children
Randomized controlled trial involving 40 pediatric primary care clinicians with high rates of diagnosing and treating middle ear infections.
- Trial name
- NCT06731660
- Testing
- Education with personalized performance feedback, Use of digital otoscope
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Children's Hospital
Drug Resistance, Microbial, Antimicrobial Stewardship
Gonorrhoea Resistance Assessment by Nucleic Acid Detection (GRANDII)
Three sexual health clinical services across Australia and their associated pathology testing laboratories are implementing a new management program for gonorrhoea infection.
- Conditions
- Drug Resistance, Microbial, Antimicrobial Stewardship, Gonorrhea
- Trial name
- GRANDII (NCT04268342)
- Testing
- Resistance guided treatment for gonorrhoea infection
- Where
- Australia
- Volunteers
- 1,626 people
- Sponsor
- The University of Queensland
Antimicrobial Stewardship, Antibiotics Causing Adverse Effects in Therapeutic Use
A Multimodal Intervention to Optimise Antimicrobial Use in Residential Aged Care Facilities (ENGAGEMENT Study)
The antimicrobial stewardship ENGAGEMENT study aims to deliver a bundle of interventions, including education of GPs and nursing staff, guideline implementation and telehealth support for 18 residential aged care facilities…
- Trial name
- ENGAGEMENT (NCT04705259)
- Testing
- Antimicrobial Stewardship ENGAGEMENT bundle
- Where
- 4 sites in Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Antibiotic Prescription
Impact of a Communication Toolkit on Antibiotic Prescribed by General Practitioners: a Randomised Trial
This study is a pragmatic, randomised, controlled, before-after interventional study conducted in one region in France in primary care.
- Trial name
- NCT04562571
- Testing
- Charter & patient information leaflets
- Where
- France
- Volunteers
- 349 people
- Sponsor
- Central Hospital, Nancy, France
Communicable Diseases
Computerized Antibiotic Stewardship Study
Prescribing antibiotics frequently poses problems in practice, since patients don't always receive the right dosage of the right antibiotic for the right period of time.
- Trial name
- COMPASS (NCT03120975)
- Testing
- Computerized decision support and audit & feedback, Audit & Feedback, Standard antibiotic stewardship
- Where
- 3 sites in Switzerland
- Volunteers
- 16,176 people
- Sponsor
- Benedikt Huttner
Respiratory Syncytial Virus Infections, Antibiotic Stewardship in Community Hospitals
RSV Antibiotic Drivers And Resource-use
This study retrospectively evaluated the clinical, laboratory, and radiologic factors that influence the decision to prescribe antibiotics in children under 2 years of age hospitalized with RSV-positive acute lower respiratory…
- Trial name
- RADAR (NCT06977971)
- Where
- Turkey (Türkiye)
- Volunteers
- 209 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Drug Resistance, Bacterial
Epidemiology of Antimicrobial-use and Antimicrobial-resistant Infections in Four Hospitals in Thailand
The main goal of this retrospective observational study is to understand how stepping down antibiotic treatment (called antibiotic de-escalation) affects patients who receive it compared to those who don't after received a…
- Conditions
- Drug Resistance, Bacterial, Bacteremia
- Trial name
- NCT07082465
- Where
- 4 sites in Thailand
- Volunteers
- 108,000 people
- Sponsor
- University of Oxford
Bloodstream Infection Multidrug-resistant Gram-negative Bacteria
Combating Multidrug-resistant Gram-negative Bacteria in Africa Through Diagnostic and Antimicrobial Stewardship
Antimicrobial resistance (AMR) is a major threat to public health and the well-being of humans, with high mortality rates of infections caused by MDR GNB.
- Trial name
- ComBac (NCT07820332)
- Testing
- Treatment according to AMR algorithm
- Volunteers
- 1,320 people
- Sponsor
- Universität des Saarlandes
Acute Respiratory Infection, Influenza-like Illness
Effectiveness and Implementation of a National Guideline for Acute Respiratory Tract Infections to Reduce Antibiotic Prescribing in Swiss Primary Care
The ImpProGUIDE study aims to find out whether implementing new Swiss national guidelines for acute respiratory infections (ARI) can help to reduce antibiotic prescribing in primary care.
- Trial name
- ImpProGUIDE (NCT07396428)
- Testing
- Training Session on acute respiratory infection guideline within a multifaceted implementation strategy
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Respiratory Infections in Children
Improving Antibiotic Stewardship for Children With Respiratory Illness Presenting to Village Health Workers in Uganda
This is a stepped wedge, cluster randomized study of a clinical algorithm that includes point-of-care C-reactive protein testing to inform antibiotic treatment decisions by village health workers for children presenting with…
- Trial name
- STAR (NCT05294510)
- Testing
- STAR Sick Child Job Aid
- Where
- Uganda
- Volunteers
- 1,280 people
- Sponsor
- University of North Carolina, Chapel Hill
Surgical Site Infection
De-Implementation of Unnecessary Surgical Antibiotic Prophylaxis in Children
The overall objective of this study is to identify the best strategy to eliminate unnecessary antibiotic use after surgery in pediatric surgical procedures considered low-risk for an SSI.
- Trial name
- OPerAtiC (NCT04366440)
- Testing
- Order set review and modification with facilitation, Order set review and modification
- Where
- 10 sites in United States
- Volunteers
- 18,267 people
- Sponsor
- Washington University School of Medicine
Hematologic Diseases, Bacteremia Sepsis
Effect of dRAST on Treatment for Bacteremia in Patients With Hematologic Diseases
The purpose of this study is to evaluate whether the use of direct rapid antibiotic susceptibility test (dRAST), in addition to the current standard antibiotic susceptibility test, can increase the proportion of patients with…
- Trial name
- NCT03611257
- Testing
- dRAST, Current standard method
- Where
- South Korea
- Volunteers
- 116 people
- Sponsor
- Seoul National University Hospital
Antibiotic Prescribing Audit and Feedback
Providing Antibiotic Prescribing Feedback to Primary Care Physicians: The Ontario Program To Improve AntiMicrobial USE
Antibiotic overuse occurs in multiple jurisdictions and is associated with rising rates of antimicrobial resistance. Mailing letters to the highest antibiotic prescribing physicians is a potentially effective method to optimize…
- Trial name
- OPTIMISE (NCT03776383)
- Testing
- Antibiotic use feedback letter
- Where
- Canada
- Volunteers
- 3,500 people
- Sponsor
- Ontario Agency for Health Protection and Promotion
Sepsis, Bacteremia
Blood Culture Improvement Guidelines and Diagnostic Stewardship for Antibiotic Reduction in Critically Ill Children
This study will test the hypothesis that reliable implementation of an evidence-based clinical practice guideline for evaluation of patients with signs and symptoms of sepsis will decrease antibiotic use in pediatric intensive…
- Trial name
- Bright STAR (NCT03441126)
- Testing
- Multicenter Quality Improvement program
- Where
- 5 sites in United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Otitis Media
Improving Knowledge Translation Upon Emergency Department Discharge
The amount and speed of emergency department (ED) discharge instructions often make it difficult for patients/caregivers to know the final diagnosis and to remember instructions.
- Trial name
- NCT02703389
- Testing
- Video, Pamphlet
- Where
- Canada
- Volunteers
- 136 people
- Sponsor
- Hamilton Health Sciences Corporation