Clinical trials: Antioxidant Effect
Cystic Fibrosis
Effects of an Antioxidant-Enriched Multivitamin Supplement on Inflammation and Oxidative Stress in Cystic Fibrosis
The purpose of this study will be to evaluate the effects of a modified formulation of AquADEKs (AquADEKs-2) on markers of inflammation, antioxidant levels and oxidative stress.
- Trial name
- AquADEKs-2 (NCT01859390)
- Testing
- AquADEKs-2, control multivitamin
- Where
- 15 sites in United States
- Volunteers
- 73 people
- Sponsor
- University of Colorado, Denver
Critical Illness
Lactoferrin Use in ICU Patients
Introduction: Lactoferrin has several uses due to its effects. It has anti-inflammatory, antioxidant, immunomodulatory, antibacterial, antifungal, and antiviral effects. Its safety is proven by food and drug administration.
- Trial name
- RCT (NCT05936528)
- Testing
- Lactoferrin, Antioxidant therapies, Dexamethasone
- Where
- Egypt
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Mansoura University Hospital
Obesity, Nonalcoholic Fatty Liver Disease
Fatty Liver Disease in Obese Children
Although weight reduction through physical activity-based interventions is the mainstay therapy for nonalcoholic fatty liver disease (NAFLD), its maintenance is difficult and typically unsuccessful.
- Conditions
- Obesity, Nonalcoholic Fatty Liver Disease, Cardiovascular Disease
- Trial name
- NCT02117700
- Testing
- N-acetyl cysteine 600 mg once/day, N-acetyl cysteine 600mg twice/day
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Nemours Children's Clinic
Chronic Periodontitis
Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis
Periodontal disease is an immune-inflammatory disease which consists of connective tissue breakdown, loss of attachment, and alveolar bone loss.In normal physiology, there is an equilibrium maintained between reactive oxygen…
- Trial name
- NCT03533972
- Testing
- Ashwagandha
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tatyasaheb Kore Dental College
Autoimmune, Lupus Erythematosus, Systemic
Effect of Green Tea on Treatment of Lupus
This randomized double blind clinical trial performed on 68 patients (32 in intervention and 36 in control group) diagnosed with SLE.
- Trial name
- NCT02875691
- Testing
- green tea extract
- Where
- Iran
- Volunteers
- 68 people
- Sponsor
- Ahvaz Jundishapur University of Medical Sciences
Cyanotic Congenital Heart Disease, Pediatric HD
Propofol vs Sevoflurane in Cyanotic Congenital Heart Disease
The stress response to surgery compromises a series of humoral, metabolic, or cellular reactions. Cardiac surgery with use of cardiopulmonary bypass (CPB) is a major activator of the systemic inflammatory response (SIRS).
- Trial name
- PSI (NCT04125550)
- Testing
- Propofol, Sevoflurane
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Cukurova University
Postoperative Pain, Oxidative Stress Response
Analgesic and Antioxidant Effects of Melatonin in Pediatric Surgery
Background. Long-term consequences of postoperative pain are detrimental in children. We tested the hypothesis that melatonin reduces postoperative pain and oxidative stress involving sirtuin pathway in children undergoing…
- Trial name
- NCT06724432
- Testing
- oral melatonin
- Where
- 2 sites in Italy
- Volunteers
- 44 people
- Sponsor
- University of Parma
Malaria
Antioxidant Micronutrients in Malaria
In the last decade, the prevalence of malaria has been escalating at an alarming rate, especially in Africa. An estimated 300 to 500 million cases each year cause 1.5 to 2.7 million deaths, more than 90% occur in children under 5…
- Trial name
- AMM (NCT01152931)
- Testing
- Amodiaquine + Artesunate, Lumefantrine + Artemether, Artesunate + vitamin A
- Where
- 2 sites in Nigeria
- Volunteers
- 10 people
- Sponsor
- University of Lagos, Nigeria
Disorder Related to Renal Transplantation
Study of the Effect of N-acetyl Cysteine on the Renal Graft Function Biomarkers (IL18, NGAL)
The purpose of this study is to investigate the effect of (NAC) N-Acetyl Cysteine on biomarkers of Delayed Graft Function (DGF), including Neutrophil Gelatinase Associated Lipocalin (NGAL) and Intereleukin 18 (IL18).
- Trial name
- NCT01403506
- Testing
- N-acetyl Cysteine
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Immune Thrombocytopenia
Oxidant Status and Effect of Antioxidant in Immune Thrombocytopenia
Oxidative stress occurs as a result of increased activity of free radical-producing enzymes, decreased activity of free radical-removing enzymes, and insufficient levels of antioxidants.
- Trial name
- ITP (NCT01763658)
- Testing
- Antox tablets(Mepaco), drug therapy for ITP
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Chronic Renal Failure, Hemodialysis
The Effect of CoQ10 Administration on Hemodialysis Patients
The purpose of this study is to examine whether CoQ10 administration is effective as an antioxidant in hemodialysis patients.
- Trial name
- NCT00307996
- Testing
- Coenzyme Q10 (drug)
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- University of Shizuoka
Cystic Fibrosis in Children
Effect of Antioxidant Docosahexaenoic Acid (DHA) in Cystic Fibrosis Patients
This study evaluates the effect of antioxidant docosahexaenoic acid (DHA) in patients with cystic fibrosis. Half of participants will receive DHA, while the other half will receive placebo.
- Trial name
- NCT04987567
- Testing
- ANTIOXIDANT DHA TRIGLYCERIDE (TRIDOCOSAHEXAENOINE-AOX®)
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Corporacion Parc Tauli
Cystic Fibrosis (CF)
Antioxidant Supplements in Cystic Fibrosis Children
This randomized controlled clinical trial included 60 pediatric patients with cystic fibrosis (CF) assigned randomly into two arms; Arm 1(extra care arm):received a tailored dietary plan following Mediterranean diet to cover…
- Trial name
- NCT06875050
- Testing
- Mediterranean diet, Fat soluble vitamins supplementation, Antioxidant Supplement
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Asthma, Pulmonary Function
VCSIP Follow-up Study
The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function and decrease wheeze at 5 years of age in their offspring.
- Conditions
- Asthma, Pulmonary Function, Wheezing, In Utero Nicotine
- Trial name
- VCSIPRenewal (NCT03203603)
- Testing
- No active intervention
- Where
- 2 sites in United States
- Volunteers
- 242 people
- Sponsor
- Oregon Health and Science University
Autism Spectrum Disorder
Effect of Increasing Total Antioxidant Capacity in Autism Spectrum Disorder
This double-blind, randomized, controlled trial (RCT) has the aim to evaluating the effectiveness of increasing Total Antioxidant Capacity (TAC) as add-on intervention in two cohorts of patients with Autism Spectrum Disorder…
- Trial name
- TACASD (NCT06623227)
- Testing
- Vitamin E and C
- Where
- Indonesia
- Volunteers
- 50 people
- Sponsor
- Rinvil Renaldi
ADHD
Therapeutic Effects of Pine Bark Extracts in Attention Deficit Hyperactivity Disorder
In this study, the investigators will investigate the effects of polyphenolic extract from pine bark on the inattention and hyperactivity in patients with attention deficit hyperactivity disorder (ADHD) based on antioxidative…
- Trial name
- NCT03368690
- Testing
- Oligopin®
- Where
- 2 sites in Taiwan
- Volunteers
- 32 people
- Sponsor
- Taipei Medical University
Fatty Liver
Omega 3 Supplementation in Children With Non Alcoholic Fatty Liver
this is a prospective, interventional, open-label, randomized study on the efficacy of omega 3 fatty acids supplementation in Egyptian children with non-alcoholic fatty liver disease who had been selected from nutrition and…
- Trial name
- omega 3 (NCT04281121)
- Testing
- omega 3 fatty acids
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Type 2 Diabetes Mellitus
Dietary Antioxidants, Redox Tone and Health Promotion: an Orthomolecular Study of Interactions
Aging is associated with increased risk of various diseases, and much attention is given to the use of natural products (like herbs) and 'functional food', such as teas, for healthy aging.
- Trial name
- NCT01315977
- Testing
- Green tea
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Retinopathy of Prematurity
Effect of Vitamin E for Prevention of Retinopathy of Prematurity: A Randomized Clinical Trial.
The retinopathy of prematurity (ROP) is a public health problem, the main causes of ROP are prematurity, use of oxygen, malnutrition and oxidative stress.
- Trial name
- NCT03274596
- Testing
- Vitamin E
- Volunteers
- 90 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Obesity
Fruit and Vegetable Juice Concentrate Effects on RBP4 and Antioxidant Capacity in Lean and Overweight 6-10 Year Old Boys
Our study aims to evaluate if the consumption of a Fruit and Vegetable Juice Concentrate (FVJC) vs. placebo can exert changes in the serum levels of Retinol Binding Protein 4 (RBP4), carotenoids, tocopherol, antioxidant capacity…
- Trial name
- FVJC (NCT00842543)
- Testing
- Fruit and Vegetable Juice Concentrate (FVJC)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic