Clinical trials: Antithrombotic Therapy
Traumatic Intracranial Hemorrhage, Brain Injuries
Mild Traumatic Brain Injury and the Risk for Traumatic Intracranial Hemorrhage
Management of traumatic brain injuries causes significant efforts on emergency departments (ED) and overall health care. Patients on antithrombotic treatment with even minor trauma to the head, although without significant…
- Trial name
- NCT05609721
- Testing
- no intervention, only observational study
- Where
- Sweden
- Volunteers
- 2,044 people
- Sponsor
- Umeå University
Terminal Cancer
Towards Cancer Patient Empowerment for Optimal Use of Antithrombotic Therapy at the End of Life
Despite the fact that antithrombotic therapy (ATT) has little or even negative effects on the well-being of cancer patients during their last year of life, stopping ATT is rare in clinical practice.
- Trial name
- SERENITY (NCT05706740)
- Testing
- Physician survey on antithrombotic medication during end-of-life care in cancer patients
- Where
- 12 sites in Denmark, France and 6 more
- Volunteers
- 467 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Acute Coronary Syndrome, Myocardial Infarction
Outcome of Longterm Antithrombotic Therapy in Acute Coronary Syndrome Patients
This observational study will based on the Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA) and the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) which since 2009 are…
- Trial name
- NCT01623700
- Where
- Sweden
- Volunteers
- 78,000 people
- Sponsor
- Uppsala University
Nonvalvular Atrial Fibrillation, Aspirin
Non-antithrombotic Versus. Single Antiplatelet Therapy Following Left Atrial Appendage Closure
The goal of this clinical trial is to verify that Non-Antithrombotic Therapy (NAPT) followed by Oral Anticoagulants (OAC) monotherapy for 45 days after Left Atrial Appendage Closure (LAAC) is non-inferior to Single Antiplatelet…
- Conditions
- Nonvalvular Atrial Fibrillation, Aspirin, Non-Antithrombotic Therapy, High Bleeding Risk
- Trial name
- NCT07125417
- Testing
- Single Antiplatelet Therapy or No Therapy (Control), Non-Antithrombotic Therapy
- Where
- 21 sites in Japan
- Volunteers
- 500 people
- Sponsor
- OCEAN-SHD Study Group
Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients
Perioperative Ischemia Versus Perioperative Bleeding During Non-cardiac Surgery in Cardiac Patients
The aim of the study is to analyze the present use of antithrombotic therapy on a large cohort of consecutive cardiacs undergoing non-cardiac surgery.
- Conditions
- Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients, Perioperative Period
- Trial name
- PRAGUE-14 (NCT01897220)
- Where
- 2 sites in Czechia
- Volunteers
- 1,200 people
- Sponsor
- Charles University, Czech Republic
Acute Myocardial Infarction, Coronary Stent Thrombosis, Antithrombotic Therapy
The MATRIX OCT Substudy
Residual thrombosis of stent struts may occur after the end of primary angioplasty and determine distal embolization and further myocardial damage.
- Trial name
- NCT01971788
- Testing
- Optical Coherence Tomography of the infarct related artery
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- S.M. Misericordia Hospital
Antithrombotic Therapy, Perioperative Care
Protocol-based Management and Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy
The purpose of this pragmatic interventional study is to evaluate whether a protocol-based management of antithrombotic drugs can reduce a composite of perioperative outcomes in patients with chronic antithrombotic therapy before…
- Conditions
- Antithrombotic Therapy, Perioperative Care, Perioperative Outcomes
- Trial name
- NCT04852406
- Testing
- Protocol-based management of perioperative antithrombotic therapy, Routine management of perioperative antithrombotic therapy
- Where
- China
- Volunteers
- 526 people
- Sponsor
- Peking University First Hospital
Cerebrovascular Disease
Individualized Antithrombotic Therapy for Patients With Ischemic Cerebrovascular Disease
To investigate the therapeutic effect of individualized treatment of antiplatelet in secondary prevention of ischemic stroke.
- Trial name
- NCT03471169
- Testing
- Desirable TEG, Undesirable TEG
- Where
- China
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Coronary Artery Disease
SAfety and EFficacy of Bridging Antithrombotic Therapy During Elective Non-cardiac Surgery
Patients with coronary artery disease, especially after PCI, require long-term oral antiplatelet therapy. However, this patient population may inevitably require non-cardiac surgery for a variety of conditions.
- Trial name
- SAFE (NCT04675801)
- Where
- China
- Volunteers
- 950 people
- Sponsor
- Beijing Anzhen Hospital
Venous Thrombosis
Evaluation of the Duration of Therapy for Thrombosis in Children
The Kids-DOTT trial is a randomized controlled clinical trial whose primary objective is to evaluate non-inferiority of shortened-duration (6 weeks) versus conventional-duration (3 months) anticoagulation in children with…
- Trial name
- Kids-DOTT (NCT00687882)
- Testing
- Shortened duration (6 weeks) of anticoagulant therapy, Conventional duration (3 months) of anticoagulant therapy, No Intervention
- Where
- 63 sites in United States, Australia and 4 more
- Volunteers
- 532 people
- Sponsor
- Johns Hopkins All Children's Hospital
Non-valvular Atrial Fibrillation (NVAF), Venous Thromboembolism (VTE)
Precision Antithrombotic Therapy
The goal of this observational study is to systematically analyze the relationship between trough/peak concentrations of novel oral anticoagulants (NOACs) and antiplatelet drugs with clinical events, aiming to provide high-level…
- Conditions
- Non-valvular Atrial Fibrillation (NVAF), Venous Thromboembolism (VTE), MI(Myocardial Infarction), Ischemic Stroke
- Trial name
- NCT07654634
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Atrial Fibrillation, Anticoagulant Therapy
ReAl-life multIceNter Outcomes Registry for Better antithrOmbotic Strategies in Patients With AF (RAINBOW-AF)
Anticoagulation therapy is the most important part of the treatment strategy for atrial fibrillation. Previous studies have confirmed that both warfarin and new oral anticoagulants can effectively prevent stroke in patients with…
- Trial name
- NCT05361889
- Volunteers
- 5,000 people
- Sponsor
- Henan Provincial People's Hospital
Atrial Fibrillation, Coronary Artery Disease
LAAO With DAPT Versus Antithrombotic Therapy
This study will retrospectively review and compare clinical outcomes between left atrial appendage occlusion with dual antiplatelet therapy versus conventional antithrombotic therapy in patients with atrial fibrillation…
- Trial name
- NCT03310801
- Testing
- ACP or Watchman
- Volunteers
- 480 people
- Sponsor
- Korea University Anam Hospital
Intracranial Aneurysm, Natural History
The Prospective Cohort Study on the Benefit-risk of Antithrombotic or Anticoagulant Therapy in Patients With Unruptured Intracranial Aneurysms Associated With Ischemic Heart Disease or Ischemic Cerebrovascular Disease
This is a registry study of the natural course of unruptured intracranial aneurysms (UIA). In addition, the investigators will analyze the benefit-risk of antithrombotic or anticoagulant therapy in patients with unruptured…
- Conditions
- Intracranial Aneurysm, Natural History, Ischemic Heart Disease, Ischemic Cerebrovascular Disease
- Trial name
- NCT03153878
- Volunteers
- 1,800 people
- Sponsor
- Liu Zhiyong
Mitral Regurgitation
STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients Without an Indication for Oral Anticoagulant
Mitral regurgitation (MR) is the most common valvular heart disease, affecting approximately 24.2 million people worldwide (with a higher prevalence in older age groups).
- Trial name
- STAR-TEER Ⅱ (NCT07007143)
- Testing
- Experimental: Aspirin monotherapy, Active Comparator: Aspirin+Clopidogrel
- Where
- China
- Volunteers
- 1,032 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Acute Ischemic Stroke, Active Cancer
Acute Ischemic Stroke in Patients With Active Cancer
The goal of this multicenter prospective observational study, conducted at 24 hospitals in Japan, is to learn about recurrent ischemic stroke in people with active cancer who develop acute ischemic stroke.
- Trial name
- CAT-AIS (NCT07819526)
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Osaka University
Peripheral Arterial Disease
Genotype-guided Strategy for Antithrombotic Treatment in Peripheral Arterial Disease.
Rationale: Peripheral arterial disease (PAD) is a common presentation of atherosclerosis. For the prevention of adverse events related to arterial thrombosis in PAD patients, clopidogrel is recommended.
- Trial name
- GENPAD (NCT04619927)
- Testing
- Direct CYP2C19 genotyping, CYP2C19 genotyping at the end of the study, Poor metabolisers
- Where
- 11 sites in Netherlands
- Volunteers
- 2,276 people
- Sponsor
- Radboud University Medical Center
Cerebrovascular and Cardiovascular Diseases
The Bleeding With Antithrombotic Therapy Study 2
The purpose of this study is to determine the incidence and severity of bleeding complications in patients with cerebrovascular and cardiovascular diseases treated with oral antithrombotic therapy.
- Trial name
- BAT2 (NCT02889653)
- Testing
- Any oral antithrombotics (antiplatelets or anticoagulants)
- Where
- 9 sites in Japan
- Volunteers
- 5,306 people
- Sponsor
- National Cerebral and Cardiovascular Center, Japan
Acute Coronary Syndrome, Atrial Fibrillation
Ongoing WARfarin and Coronary STENTing
Patients on warfarin treatment pose particular problems when undergoing percutaneous coronary intervention with stent implantation (PCI-S), because of the poor definition of the optimal antithrombotic strategies to be adopted…
- Trial name
- WAR-STENT (NCT00722319)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- War-Stent Investigators
Palliative Care
Complex Decisions Regarding Antithrombotic Therapy: the QUIET Study
"Complex decisions regarding antithrombotic therapy: the QUIET study" is a monocentric observational study without drug intervention, conducted through the administration of a questionnaire (survey).The aim of this study is to…
- Trial name
- QUIET (NCT07486154)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS