Clinical trials: Apnea, Obstructive Sleep
Obstructive Sleep Disordered Breathing
Prediction of Tongue Base Obstruction During Sleep
This study investigates the hypothesis that, in children, tongue motor functions can predict both the anatomical site and the degree of upper airway obstruction contributing to obstructive sleep-disordered breathing.
- Trial name
- PTOS (NCT06792045)
- Testing
- Physiotherapist assessment, ENT assessment, Drug-Induced Sleep Endoscopy
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Université Catholique de Louvain
Infrared-thermal-imaging
Evaluation of Infrared Thermal Imaging in Diagnosis of OSAHS in Children
OSAHS is a common sleep breathing disorder in children, with the same incidence as childhood asthma, and is mainly caused by upper airway stenosis caused by tonsil/adenoid hyperplasia.
- Trial name
- NCT05830227
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- State Key Laboratory of Respiratory Disease
Sleep Apnea, Home Respiratory Polygraphy Sleep Study
Home Respiratory Polygraphy in Childhood Sleep Apnea-Hypopnea Syndrome (CHILDSLEEP).
The aims of the study is to assess the diagnostic utility of home respiratory polygraphy (HRP) complemented with polysomnography (PSG) in childhood Obstructive Sleep Apnea-Hypopnea Syndrome (OSAS), as well as its usefulness in…
- Conditions
- Sleep Apnea, Home Respiratory Polygraphy Sleep Study, Childhood Sleep Apnea, Polysomnography
- Trial name
- CHILDSLEEP (NCT04340310)
- Testing
- Home respiratory polygraphy
- Where
- Spain
- Volunteers
- 125 people
- Sponsor
- Hospital Universitario San Juan de Alicante
Obstructive Sleep Apnea
BASET Scoring: A Novel Simple Biometric Score and Potential Tool for Diagnosis and Grading of Obstructive Sleep Apnea Syndrome (OSAS) Patients
this study aims to assess the validity of BASET scoring as a new potential tool for diagnosis and grading the severity of OSAS patients and as screening of the risk factors of OSAS.
- Trial name
- BASET (NCT05511974)
- Testing
- BASET score
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Mansoura University
Sleep Apnea
Controlled Trial on Effect of Montelukast Treatment in Children With Obstructive Sleep Apnea Syndrome
Oral therapy with montelukast may lead to improved polysomnographic findings in children with mild to moderate OSAS with and without allergic rhinitis who a priori require T\&A for OSAS.
- Trial name
- NCT00599534
- Testing
- Montelukast
- Where
- 2 sites in United States
- Sponsor
- University of Louisville
Obstructive Sleep Apnea
Precision Sleep Medicine
This retrospective observational study aims to characterize the prevalence and clinical features of obstructive sleep apnea (OSA) phenotypes and develop a rater-independent algorithm for automated OSA phenotyping, improving…
- Trial name
- NCT06903481
- Where
- 2 sites in Switzerland
- Volunteers
- 1,055 people
- Sponsor
- University Hospital, Basel, Switzerland
Obstructive Sleep Apnea of Child, Sleep-Disordered Breathing
Comparison of Two Reeducation Methods in Children With Persistent Sleep Apnea, a Randomized Controlled Trial
Myofunctional therapy has been shown to be effectively reduce symptoms of paediatric obstructive sleep apnea, usually performed after adenotonsillectomy.
- Conditions
- Obstructive Sleep Apnea of Child, Sleep-Disordered Breathing, Adenotonsillar Hypertrophy
- Trial name
- PERSIST-B-RCT (NCT06634264)
- Testing
- Soft Oral Appliance
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Université de Montréal
Anesthesia, General Anesthesia
Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
The objective of this trial is to determine whether an opioid-free general anesthetic (OFA) technique utilizing ketamine, dexmedetomidine, lidocaine, and gabapentin can help reduce postoperative respiratory depression in the…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Postoperative Complications
- Trial name
- NCT02987985
- Testing
- Acetaminophen, gabapentin, Acetaminophen, Ketamine , Lidocaine , Dexmedetomidine
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Saskatchewan
Down Syndrome, Obstructive Sleep Apnea
Computer Models of Airways in Children and Young Adults With Sleep Apnea and Down Syndrome
The purpose of this research study is to develop a way of predicting with computers how surgery on the airway will affect night time breathing called Obstructive Sleep Apnea (OSA) in children with Down Syndrome.
- Trial name
- DYMOSA (NCT01902407)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Obesity, Obstructive Sleep Apnea
Treatment of Obstructive Sleep Apnea in Children: An Opportunity for Cardiovascular Risk Modification
Heart disease is a major cause of ill-health and death in adults. The risk factors for heart disease, if present in children, carry over into adult life.
- Conditions
- Obesity, Obstructive Sleep Apnea, Sleep Disorders, Cardiovascular Disease
- Trial name
- TREAT (NCT02403492)
- Testing
- cPAP, cPAP, Continuation, cPAP, Discontinuation
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- The Hospital for Sick Children
Obstructive Sleep Apnea
Effects of Positive Airway Pressure (PAP) in Children With Obstructive Sleep Apnea (OSA)
Obstructive sleep apnea is a problem for a large number of children and can result in problems with thinking patterns, behaviors and sleep if left untreated.
- Trial name
- OSA (NCT01156649)
- Testing
- PAP therapy
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- University of Tennessee
Sleep Apnea Syndromes, Sleep Apnea
Management of Sleep Apnea Patients by a Clinical Nurse (Supernurse)
Sleep apnea is a prevalent problem and references for the evaluation of this condition often exceeds the sleep clinic's capacity thus creating important delays in the patients' care.
- Conditions
- Sleep Apnea Syndromes, Sleep Apnea, Multidisciplinary Communication, Sleep Apnea, Obstructive
- Trial name
- NCT03455920
- Testing
- Clinical nurse (supernurse) evaluation, Pulmonologist evaluation
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Annie C Lajoie
Sleep Apnea
Hepatic Drug Biotransformation in Children With Obstructive Sleep Apnea
The purpose of this research study is to determine the effect of chronic nighttime low oxygen saturations on selected body systems (liver) that break down drugs in children with obstructive sleep apnea syndrome (OSAS).
- Trial name
- NCT00310323
- Testing
- Dextromethorphan, Caffeine
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Virginia Commonwealth University
Obstructive Sleep Apnea of Child
Endoscopic Classification and DISE-Guided Surgery in Pediatric Obstructive Sleep-Disordered Breathing.
Pediatric obstructive sleep apnea (OSA) can lead to severe health issues if untreated. While polysomnography is the gold standard for diagnosis, current surgical treatment in Denmark relies on caregiver reports and clinical…
- Trial name
- DISE (NCT06093802)
- Testing
- Drug-induced Sleep Endoscopy findings (identified obstruction sites)
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Regional Hospital West Jutland
Pediatric Obstructive Sleep Apnea, Cognition
Observational Study on the Impact of Obstructive Sleep Apnea on Executive Function and Empathy Development in Children
This study aims to investigate the effects of obstructive sleep apnea (OSA) on executive function and empathy development in children aged 3-12 years.
- Conditions
- Pediatric Obstructive Sleep Apnea, Cognition, Empathy, EEG
- Trial name
- OSA-EFED (NCT06850220)
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Soochow University
Obstructive Sleep Apnea
Knowledge, Attitude, and Practice of Pediatric Dentists Toward Obstructive Sleep Apnea Among Children
The main objective of this study is to assess the knowledge, attitude, and practice of Egyptian pediatric dentists toward obstructive sleep apnea among children.
- Trial name
- NCT06970873
- Testing
- Evaluation of Knowledge, Attitude, and Practice of Pediatric Dentists
- Volunteers
- 362 people
- Sponsor
- Cairo University
Non Alcoholic Fatty Liver Disease
The Role of Obstructive Sleep Apnea in Children With Fatty Liver Disease
The purpose of this study is to examine whether CPAP therapy can reduce or eliminate hepatic fat accumulation in obese children and adolescents.
- Trial name
- NCT02134522
- Testing
- Continuous positive airway pressure (CPAP).
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Yale University
Pediatric Sleep Disordered Breathing, Obstructive Sleep Apnea
Pediatric/Adolescent WatchPAT 400 Reliability Pilot Study
The goal of this clinical trial is to learn whether a newer sleep-testing device gives results that closely match the standard overnight sleep study, in children and adolescents ages 6-18 who are being evaluated for possible…
- Trial name
- NCT07851402
- Testing
- WatchPAT 400
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Milton S. Hershey Medical Center
Enlargement of Tonsil or Adenoid
Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population
Adenotonsillar hypertrophy is the principal cause of obstructive sleep apnea of childhood, yet little is known with regard to its pathophysiologic and molecular mechanisms.
- Trial name
- NCT03541434
- Testing
- Complete Blood Count, Tympanometry, Tonsillectomy and/or adenoidectomy
- Where
- 2 sites in Greece
- Volunteers
- 134 people
- Sponsor
- University of Patras
Hypertension, Obstructive Sleep Apnea
Hypertension and Sleep Disordered Breathing in Pediatrics
The primary objective is to determine the prevalence of sleep disordered breathing in children with primary hypertension or pre hypertension.
- Trial name
- NCT00990899
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- NYU Langone Health