Clinical trials: Appendicitis Perforated
Appendicitis, Appendix Mass
Identification of the Optimal Treatment Strategy for Complex Appendicitis in the Pediatric Population
Aim of this study is to evaluate the effect of different treatment strategies on overall complications, health related-Quality of Life (hr-QOL) and costs among two subtypes of complex appendicitis in children (<18 years old).
- Conditions
- Appendicitis, Appendix Mass, Appendicitis Perforated
- Trial name
- CAPP (NCT04755179)
- Testing
- Laparoscopic appendectomy, Open appendectomy, Non-operative treatment
- Where
- 32 sites in Netherlands
- Volunteers
- 1,308 people
- Sponsor
- Ramon Gorter
Appendicitis
Single Incision Laparoscopic Surgery (SILS) Versus Laparoscopic Appendectomy
This is a prospective trial of single incision versus standard 3-port laparoscopic appendectomy. The hypothesis is that there may a difference in wound infection rates, operative time, doses of analgesics post-operatively, and…
- Trial name
- NCT00981136
- Testing
- Single Incision Laparoscopic Appendectomy, 3 port laparoscopic appendectomy
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Children's Mercy Hospital Kansas City
Perforated Appendicitis, Postoperative Infection
Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis
After appendix has been removed for perforated appendicitis, patients will receive postoperative antibiotics. In the last 5 years, the literature has transitioned from a 3 -drug therapy to 2-drug therapy.
- Trial name
- NCT03289351
- Testing
- Piperacillin, Tazobactam Drug Combination
- Where
- 2 sites in United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Phoenix Children's Hospital
Perforated Appendicitis
Diagnostic Value of Hyperbilirubinaemia as a Predictive Factor for Appendiceal Perforation in Acute Appendicitis
The values of laboratory examinations which are useful for the diagnoses of appendicitis are white blood cell count (WBC), C-reactive protein (CRP) and erythrocyte blood sedimentation rate (ESR).
- Trial name
- NCT00677417
- Volunteers
- 538 people
- Sponsor
- Ruhr University of Bochum
Perforated Appendicitis
Study on Laparoscopic Operation for Perforated Appendicitis
The purpose of this study is to conduct a prospective observational study for the open approach and laparoscopic approach for perforated appendicitis.
- Trial name
- NCT00677989
- Testing
- Laparoscopic appendectomy, Open appendectomy
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Perforated Appendicitis
Irrigation Versus No Irrigation for Perforated Appendicitis
The purpose is to quantify the effect of irrigation during laparoscopic appendectomy for perforated appendicitis.
- Trial name
- NCT00854815
- Testing
- Irrigation, No Irrigation
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Children's Mercy Hospital Kansas City
Appendicitis, Perforated Appendicitis
Optimal Care of Complicated Appendicitis
When the appendix becomes infected and inflamed, it is called appendicitis. Sometimes, if the infection and inflammation get worse, the appendix can die or burst, leading to a larger infection or even pus pockets around the…
- Conditions
- Appendicitis, Perforated Appendicitis, Ruptured Appendicitis, Complicated Appendicitis
- Trial name
- NCT03159754
- Testing
- Early Appendectomy, Interval Appendectomy, Antibiotics
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Perforated Appendicitis, Covid19
Frequency of Perforated Appendicitis in Times of COVID-19
Appendicitis is one of the most common clinical conditions in general surgery. The diagnosis is usually made from clinical examination, imaging (sonography or CT) and laboratory parameters.
- Trial name
- NCT04472052
- Testing
- appendectomy
- Where
- Germany
- Volunteers
- 143 people
- Sponsor
- University Hospital Tuebingen
Abscess, Intra-Abdominal, Abdominal Abscess
A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections
The purpose of the study is to evaluate the safety and tolerability of doripenem compared with meropenem in children hospitalized with complicated intra-abdominal infections.
- Conditions
- Abscess, Intra-Abdominal, Abdominal Abscess, Abdomen, Acute, Abdominal Pain
- Trial name
- NCT01110382
- Testing
- Doripenem, Meropenem, Amoxicillin/clavulanate potassium
- Where
- 19 sites in United States, Argentina and 6 more
- Volunteers
- 41 people
- Sponsor
- Janssen Research & Development, LLC
Perforated Appendicitis
Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation
It has recently been published that hyperbilirubinemia is a reliable marker for the preoperative diagnosis of perforated acute appendicitis.
- Trial name
- NCT00528138
- Testing
- Laboratory Test
- Where
- Chile
- Volunteers
- 132 people
- Sponsor
- Cirujanos la Serena
Appendicitis
Appendectomy Versus Non-Operative Treatment For Acute Non-Perforated Appendicitis in Children
Rationale and Aim: The standard treatment for acute appendicitis in children is appendectomy. An increasing body of evidence from the adult literature suggests that acute appendicitis may be treated effectively with antibiotics…
- Trial name
- APPY (NCT02687464)
- Testing
- Non-operative treatment, Appendectomy
- Where
- United States
- Volunteers
- 978 people
- Sponsor
- Children's Mercy Hospital Kansas City
Acute Appendicitis, Appendicitis Perforated
Bilirubin Levels to Diagnose Appendicitis and Predict Appendiceal Perforation
The goal of this study is to learn if serum bilirubin levels can aid in the diagnosis of acute appendicitis and predict appendiceal perforation
- Trial name
- NCT06956638
- Testing
- Non-interventional
- Where
- Nepal
- Volunteers
- 98 people
- Sponsor
- Nepalese Army Institute of Health Sciences
Perforated Appendicitis
The Management of Perforated Acute Appendicitis in Adult and Pediatric Populations
Patients admitted at Marshall Health - Cabell Huntington Hospital with the diagnosis of acute perforated appendicitis or appendicular abscess larger than 3cm will be admitted and treated with percutaneous drainage and the IV…
- Trial name
- NCT04253899
- Testing
- Appendectomy, Observation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Marshall University
Acute Appendicitis, Acute Appendicitis With Rupture
Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children
Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery.
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Abdominal Pain (AP)
- Trial name
- NCT07008092
- Testing
- Blood specimen collection, Urine collection
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KBC Split
Appendicitis Perforated
Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA)
This study is an internal pilot for a multicenter, blinded randomized controlled trial. The purpose of the multicenter trial is to determine whether post-operative piperacillin/tazobactam is more effective than ceftriaxone and…
- Trial name
- ALPACA (NCT05943223)
- Testing
- Piperacillin/tazobactam, Normal saline, CefTRIAXone Injection
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- McMaster Children's Hospital
Appendicitis
Diagnostic Accuracy of Serum Bilirubin in the Prediction of Perforated Appendicitis
Hyperbilirubinemia is reported to be a positive predictor in diagnosing perforated appendicitis. Therefore we analysed the diagnostic accuracy of serum bilirubin in discriminating between perforated and simple/no appendicitis.
- Trial name
- NCT01698099
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital Tuebingen
Perforated Appendicitis
Role of Intravenous Versus Home Oral Antibiotics in Perforated Appendicitis
To compare the effect of a single-agent home intravenous (IV) versus oral antibiotic therapy on complication rates and resource utilization following appendectomy for perforated appendicitis
- Trial name
- NCT02724410
- Testing
- home intravenous ertapenem, home oral amoxicillin-clavulanate, peripheral inserted central Catheter
- Volunteers
- 82 people
- Sponsor
- Wake Forest University Health Sciences
Appendicitis
Perforated Appendicitis With Delayed Presentation
There is no consensus among pediatric surgeons regarding the optimal treatment for children with complicated appendicitis with delayed diagnosis.
- Trial name
- NCT01068288
- Testing
- Laparoscopic or open appendectomy, Expectant Management
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- The Hospital for Sick Children
Acute Appendicitis
Patient Time and In-hospital Delay of Surgery Association With Complicated Appendicitis
This is a retrospective observational study with its main aim of evaluating possible factors associated with complicated appendicitis.
- Trial name
- NCT04689906
- Testing
- surgery
- Volunteers
- 3,137 people
- Sponsor
- Rambam Health Care Campus
Acute Appendicitis
Non-operative Treatment of Acute Non-perforated Appendicitis
Gold Standard treatment of appendicitis is appendectomy but non-operative treatment of non-perforated appendicitis with antibiotics is also under trial.
- Trial name
- NCT04030741
- Testing
- Meronem and flagyl, Appendectomy
- Where
- Pakistan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- King Edward Medical University