Clinical trials: Arm
Acute Liver Failure, Fulminant Hepatic Failure
TReatment for ImmUne Mediated PathopHysiology
TReatment for ImmUne Mediated PathopHysiology (TRIUMPH) is a multi-center, three arm, randomized, controlled trial of immunosuppressive therapy for children with acute liver failure.
- Conditions
- Acute Liver Failure, Fulminant Hepatic Failure, Hepatic Encephalopathy, Acute Liver Injury
- Trial name
- TRIUMPH (NCT04862221)
- Testing
- High-dose methylprednisolone, Equine anti-thymocyte globulin, Prednisolone
- Where
- 17 sites in United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Anxiety, Sedation
Preparing Kids for MRI Using VR
Children frequently exhibit pre-MRI anxiety that can cause motion, repeated sequences, prolonged room time, and exposure to sedation.
- Conditions
- Anxiety, Sedation, Child, Virtual Reality
- Trial name
- NCT07203716
- Testing
- Virtual Reality Orientation (Home+Booster), Virtual Reality Orientation (Pre-Scan Only), Usual Care (No VR)
- Volunteers
- 150 people
- Sponsor
- Haseki Training and Research Hospital
Relapsed or Refractory Medulloblastoma (MB), Neuroblastoma (NB), Ewing Sarcoma (ES) and Alveolar Rhabdomyosarcoma (ARMS)
A Study of TB-403 in Pediatric Subjects With Relapsed or Refractory Medulloblastoma
The purpose of this study is to assess the safety and tolerability profile of TB-403 (humanized monoclonal antibody against placental growth factor (PlGF)) in pediatric subjects with relapsed or refractory Medulloblastoma.
- Trial name
- NCT02748135
- Testing
- TB-403 20mg/kg, TB-403 50mg/kg, TB-403 100mg/kg
- Where
- 10 sites in United States
- Volunteers
- 18 people
- Sponsor
- Oncurious NV
Female Breast Cancer Patients, Histopathologically Confirmed Advanced HR +/HER2-invasive Breast Cancer
Adebrelimab Combined With Fluzoparib in HRD-positive HR +/HER2- Advanced Breast Cancer
This is an open-label, single-arm, exploratory study planned to include 40 patients with HRD-positive HR +/HER2- advanced breast cancer treated with Adebrelimab in combination with fluzoparib.
- Conditions
- Female Breast Cancer Patients, Histopathologically Confirmed Advanced HR +/HER2-invasive Breast Cancer, HRD Positive Advanced Breast Cancer
- Trial name
- NCT06254066
- Testing
- Adebrelimab plus Fluzoparib
- Volunteers
- 40 people
- Sponsor
- Zhejiang Cancer Hospital
Obstetric; Injury
Modified Constraint Induced Movement Therapy in Children With Obstetric Brachial Plexus Injury
The aim of this study was to increase and improve the use of affected extremity in obstetric brachial plexus palsy children while restricting the use of less affected arm and the purpose was to improve the function, Range of…
- Trial name
- NCT05411731
- Testing
- Conventional physical therapy treatment, Constraint induced movement therapy
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Riphah International University
Neurofibromatosis 2
Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients
The purpose of the study is to determine if RAD001 treatment will shrink or slow the growth of the vestibular schwannoma(s) in Neurofibromatosis 2 (NF2) patients.
- Trial name
- AFINF2 (NCT01490476)
- Testing
- RAD001
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
T-Cell Non-Hodgkin Lymphoma, T-cell Lymphoma (PTCL and CTCL)
CD5 CAR T-Cell Therapy for r/r T-cell Lymphomas
This is a multi-center, open-label, non-randomized, single-arm clinical trial. Refractory/relapse T-NHL patients are treated with autologous and allogeneic CD5 CAR T-cell therapy.
- Trial name
- NCT07022964
- Testing
- CD5 CAR-T cells infusion
- Where
- 3 sites in China
- Volunteers
- 36 people
- Sponsor
- Beijing GoBroad Hospital
Hemiplegic Cerebral Palsy
Electromyography Biofeedback Training Versus Mirror Therapy on Muscle Activity, Range of Motion and Function of Upper Limb in Children With Hemiplegia
One of the main motor control issues in hemiplegic CP is spasticity, which affects the flexor muscles of the upper limb. This spasticity causes the limb to adopt a flexed posture, limiting the range of motion and contributing to…
- Trial name
- NCT07818616
- Testing
- Neurotrac Simplex electromyography biofeedback device, Mirror, a designed physical therapy program
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Bronchopulmonary Dysplasia
Efficacy and Safety of Zelpultide Alfa in Preterm Neonates at High Risk of Developing Bronchopulmonary Dysplasia (BPD)
This is a randomized, parallel-group, double-blind, placebo-controlled multicenter phase 2b/3 study with an adaptive seamless design.
- Trial name
- ZELA (NCT06897839)
- Testing
- Zelpultide alfa
- Where
- 49 sites in Argentina, Belgium and 6 more
- Volunteers
- 366 people
- Sponsor
- Airway Therapeutics, Inc.
Cerebrovascular Accident
Ischemic Nerve Block to Improve Hand Function in Stroke Patients
This study will determine whether impaired hand function due to stroke can be improved by blocking nerve impulses to the unaffected arm.
- Trial name
- NCT00056706
- Testing
- Transient deafferentation
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pediatric Cancers, Hematologic Malignancies
Follow-Up Evaluation for Gene-Therapy-Related Delayed Adverse Events After Participation in Pediatric Oncology Branch Clinical Trials
Background: Gene therapy involves changing the genes inside the body s cells to stop disease. It is very closely regulated. People who have had this therapy may have problems months or even years later.
- Conditions
- Pediatric Cancers, Hematologic Malignancies, Solid Tumors
- Trial name
- NCT02315599
- Testing
- anti-CD19 CAR
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Cancer Institute (NCI)
Orthodontic Brackets
Digital Bonding vs. Direct Bonding Study
This is a prospective, 2-armed, randomized, multi-site clinical study to demonstrate that digital bonding is a more efficient treatment method than direct placement of brackets.
- Trial name
- NCT06266130
- Testing
- Treatment Group Digital Bonding Tray, Control Group Direct Bonding
- Where
- 5 sites in United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Solventum Orthodontics Corporation
Systemic Lupus Erythematosus (SLE), Lupus Nephritis (LN)
A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis
This Phase IIa, open-label, single-arm study includes an initial Safety Run-In followed by dose expansion to evaluate the safety, tolerability, cellular kinetics, pharmacodynamics, and preliminary clinical activity of a single…
- Trial name
- NCT07328581
- Testing
- ICG318, BCMA-CD19-IL-15/IL-15 sushi Compound CAR T following lymphodepletion
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- iCell Gene Therapeutics
Fusion Imaging for EVAR
Fusion Imaging for EVAR With Mobile C-arm
Fusion imaging is a technique that facilitates endovascular navigation but is only available in hybrid rooms. The goal of this study is to evaluate the feasibility of fusion imaging with a mobile C-arm in a conventional operating…
- Trial name
- FUTUR (NCT04008212)
- Testing
- Fusion imaging
- Volunteers
- 59 people
- Sponsor
- Rennes University Hospital
Low Back Pain, Knee Arthritis Osteoarthritis
How Patient Education Helps Patients With Chronic Musculoskeletal Disorders Stick to Home Exercise for Pain Relief.
The study aims to evaluate the effectiveness of a structured patient education program in enhancing adherence to prescribed home exercise regimens in individuals with chronic low back pain, knee osteoarthritis, and shoulder pain.
- Conditions
- Low Back Pain, Knee Arthritis Osteoarthritis, Shoulder Disease, Shoulder and Upper Arm Injury
- Trial name
- NCT07764354
- Testing
- Educational with musculoskeletal condition, Standard physical therapy program
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Hemiplegia
Constraint Induced Movement Therapy on Infantile Hemiplegia
The purpose of this study is to assess the functionality of the affected upper limb in infantile hemiplegia by applying a protocol of modified constraint-induced movement therapy.
- Trial name
- NCT02178371
- Testing
- mCIMT, Unimanual therapy without constraint UTWC
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- CEU San Pablo University
Cerebral Palsy
The Effects of Virtual Reality on Upper Extremity Function in Hemiplegic Cerebral Palsy
The investigators have planned a research on the effects of virtual reality therapy and home exercise program on hand functions in children with hemiplegic cerebral palsy in Istanbul University Istanbul Faculty of Medicine in the…
- Trial name
- NCT02841319
- Testing
- Virtual Reality Exercises using Hand Tutor
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Istanbul University
Cerebrovascular Accident
Effects of Perfetti's Method on Cognition, Dexterity and Sensory Motor Function of the Upper Extremity in Stroke Patients
Null Hypothesis (HO) There is no difference between the effects of Perfetti's Method versus routine physical therapy on cognition, dexterity, and sensory motor function of the upper extremity in stroke patients.
- Trial name
- NCT05167006
- Testing
- routine physical therapy, Perfetti's method
- Where
- Pakistan
- Volunteers
- 88 people
- Sponsor
- University of Lahore
Duchenne Muscular Dystrophy
Safety and Efficacy of P-188 NF in DMD Patients
This is an open-label study to evaluate the safety, tolerability and efficacy of daily, subcutaneous dosing with P-188 NF (Carmeseal-MD™) in non-ambulatory boys with Duchenne Muscular Dystrophy (DMD).
- Trial name
- NCT03558958
- Testing
- P-188 NF
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Phrixus Pharmaceuticals, Inc.
Cerebral Palsy, Upper Extremity Problem
Effects of Action Observation Therapy and Video-Based Play Therapy on Children With Unilateral Cerebral Palsy
Cerebral Palsy (CP) defines a group of permanent disorders in the development of movement and posture, which occur in the developing fetal and newborn brain, due to non-progressive disorders, leading to activity limitations.
- Trial name
- NCT05327179
- Testing
- Action Observation Treatment, Virtual Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Sinem Erturan
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