Clinical trials: Aspirin
Coronary Artery Disease, CABG
The 10-Year Extended Follow-up of the DACAB Trial
The goal of this observational study is to learn about the very long-term effects of different antiplatelet strategies in patients who underwent coronary artery bypass grafting (CABG) and participated in the original DACAB trial.
- Conditions
- Coronary Artery Disease, CABG, Antiplatelet Therapy of Coronary Artery Bypass
- Trial name
- DACAB-FE-10Y (NCT07480629)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ruijin Hospital
Gastric Ulcer, Duodenal Ulcer
Rabeprazole Specific Clinical Experience Investigation for the Long-term Combination Therapy With Low-dose Aspirin
To investigate the safety and efficacy of long-term combination therapy with rabeprazole and low-dose aspirin.
- Trial name
- NCT02423187
- Testing
- No Intervention
- Where
- 3 sites in Japan
- Volunteers
- 1,568 people
- Sponsor
- Eisai Co., Ltd.
Congenital Heart Disease
Antiplatelet Activity of Aspirin in Infants After Aortopulmonary and Cavopulmonary Shunts
Background: Blood clots cause poor outcomes, including death, in babies with heart defects that require a surgical connection ("shunt") to provide blood flow to their lungs.
- Trial name
- NCT01656993
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Utah
Preeclampsia
Antenatal Platelet Response on Aspirin: a Pharmacokinetic Study Through Pregnancy
Longitudinal pharmacokinetic and pharmacodynamic study in first and third trimester of pregnancy
- Trial name
- APROACH-PK (NCT04645004)
- Testing
- Aspirin 81Mg Non-enteric coated Tab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Thomas Jefferson University
Coronary Artery Disease
(EASY)-IMProving Adherence to Clopidogrel Trial (IMPACT))
The purpose of this study is to test the impact of a multidisciplinary approach to improve the adhesion and persistence to Clopidogrel therapy.
- Trial name
- EASY-IMPACT (NCT01134679)
- Testing
- Multi-disciplinary disease management approach
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Laval University
Colorectal Cancer
Aspirin and/or Folic Acid in Preventing Recurrent Colorectal Polyps
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of aspirin and/or folic acid may be effective in preventing recurrent polyps in patients who have…
- Trial name
- NCT00033319
- Testing
- folic acid, acetylsalicylic acid
- Where
- 32 sites in United Kingdom
- Sponsor
- Queen's Medical Center
Pre-eclampsia, Intra-uterine Growth Restriction
Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers
The objective of this study is to test the efficacy of low-dose aspirin (160 mg/day), given bedtime and started early during pregnancy (≤ 15 +6 weeks of gestation) in nulliparous pregnant women selected as "high-risk" by the…
- Trial name
- PERASTUN (NCT01729468)
- Testing
- Aspirin
- Where
- 17 sites in France, Martinique
- Volunteers
- 1,106 people
- Sponsor
- University Hospital, Tours
Low Birth Weight, Small for Gestational Age (SGA)
Improving Aspirin Prescription Rates in Outpatient Clinic
Ρrееςlаmpѕia is a syndrome characterised by the new onset of hуреrtеnѕion plus proteinuria, end-organ dysfunction, or both after 20 weeks of gestation. It complicates 3-5% of pregnancies.
- Conditions
- Low Birth Weight, Small for Gestational Age (SGA), Preeclampsia (PE), Prevention &Amp; Control
- Trial name
- NCT06694233
- Testing
- Aspirin prescription on outpatient basis
- Where
- Kuwait
- Volunteers
- 300 people
- Sponsor
- Cairo University
Prostate Cancer
A Study to Examine the Effectiveness of Aspirin and/or Vitamin D3 to Prevent Prostate Cancer Progression
To demonstrate the acceptability and feasibility of recruitment to a randomised chemoprevention study of standard (300mg) or low dose (100mg) aspirin vs. placebo and/or Vitamin D3 vs.
- Trial name
- PROVENT (NCT03103152)
- Testing
- High dose Aspirin & Vitamin D, Low dose Aspirin , Vitamin D
- Where
- 7 sites in United Kingdom
- Volunteers
- 104 people
- Sponsor
- Queen Mary University of London
Coronary Artery Disease
Trained Immunity by Dual-pathway Inhibition in Coronary Artery Disease
Coronary artery disease (CAD) is a manifestation of systemic atherosclerosis for which single antiplatelet therapy (SAPT) is indicated if patients are stable.
- Trial name
- DUALCAD (NCT05210725)
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Preeclampsia Severe, Cardiovascular Diseases
Postpartum Low-Dose Aspirin After Preeclampsia for Optimization of Cardiovascular Risk (PAPVASC)
Women who develop preeclampsia (PE) in pregnancy are at a greater risk for adverse cardiovascular health outcomes. PE is associated with vascular remodeling and functional changes in the postpartum, reflective of its systemic…
- Conditions
- Preeclampsia Severe, Cardiovascular Diseases, Primary Prevention
- Trial name
- PAPVASC (NCT04243278)
- Testing
- Low-dose aspirin
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Dr. Graeme Smith
Preeclampsia
Aspirin (ASA) Therapy and Preeclampsia Prevention
According to U.S. Pharmacist® "low-dose aspirin refers to dosages between 81 mg and 325 mg taken every day to prevent heart attacks, strokes, and colon cancer." It has been found through research that low-dose aspirin also…
- Trial name
- NCT04158830
- Testing
- Aspirin 81 mg Enteric Coated Tab - 1 tablet, Aspirin 81 mg Enteric Coated Tab - 2 tablets
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Tennessee
Infertility
Does Low-Dose Aspirin Improve Outcome in In Vitro Fertilisation/Intra Cytoplasmatic Sperm Injection (IVF/ICSI)?
To investigate the effect of daily administration of low-dose aspirin, compared to placebo, on IVF and ICSI outcome.
- Trial name
- NCT00644085
- Testing
- aspirin
- Where
- Belgium
- Volunteers
- 201 people
- Sponsor
- University Hospital, Ghent
Hypertensive Disorder of Pregnancy
Thriving Hearts: Healing-Centered, Integrated, Community Maternity Care
The overarching goal of Thriving Hearts is to implement a multi-level program through Local Health Departments (LHDs) that cultivates conditions for mothers and birthing people to not only survive pregnancy, but to thrive.
- Trial name
- NCT06744231
- Testing
- Usual Care, Thriving Hearts
- Where
- United States
- Volunteers
- 17,500 people
- Sponsor
- University of North Carolina, Chapel Hill
Venous Thromboembolism (VTE), Total Joint Arthroplasty
Efficacy of Aspirin in Preventing Venous Thromboembolism
Efficacy of aspirin and enoxaparin in preventing venous tromboembolism was compared after total knee or hip arthroplasty.
- Conditions
- Venous Thromboembolism (VTE), Total Joint Arthroplasty, Total Hip Arthroplasty (THA)
- Trial name
- NCT06635317
- Testing
- Aspirin, enoxaparin
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Bleeding Complication During Colon Polypectomy
Postpolypectomy Bleeding in Patients With Antiplatelet Therapy
The purpose of this study is to determine if the use of aspirin prior to colonoscopy increases the risk of post polypectomy bleeding.
- Trial name
- NCT01465256
- Testing
- Aspirin
- Where
- South Korea
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Soonchunhyang University Hospital
Complications Due to Heart Valve Prosthesis
Cost Effectiveness Analysis In Patients With Heart Valve Prosthesis
The combined Antiplatelet and Anticoagulant treatment decreased thrombus formation and overall mortality. Also the initiation of an efficacious early anticoagulation protocol is important because of its potential impact on the…
- Trial name
- HVP (NCT02022527)
- Testing
- Acetyl Salicylic Acid, Warfarin
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Pharmacoeconomic Unit, Egypt
Neurodevelopmental Abnormality
ASPIRIN: Neurodevelopmental Follow-up Trial
A total of 620 children will be enrolled in this study from six sites in sub-Saharan Africa, South Asia, and Latin America. Half of the children's mothers will have taken aspirin and half will have taken placebo.
- Trial name
- NCT04888377
- Testing
- Aspirin
- Where
- 14 sites in United States, Democratic Republic of the Congo and 4 more
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Sickle Cell Disease, Pregnancy Related
LEARNER- Low dosE AspiRiN prEterm tRial (Angola)
This study is being conducted to evaluate the safety and effect of starting daily use of low dose (100 mg) aspirin in pregnant women with sickle cell disease, who are being followed in two county hospitals in Angola, in the first…
- Conditions
- Sickle Cell Disease, Pregnancy Related, Pregnancy Complications, Pre-Eclampsia
- Trial name
- LEARNER (NCT06417411)
- Testing
- Aspirin 100mg
- Where
- Angola
- Volunteers
- 450 people
- Sponsor
- Instituto Nacional de Investigacao em Saude, Angola
Drugs, Investigational
Evaluate Analgesic Efficacy of Fast Release Aspirin
The objective of the study is to evaluate the analgesic efficacy of a single, oral dose of fast release aspirin tablets, 650 mg (2 x 325 mg) compared to regular aspirin tablets, 650 mg (2 x 325 mg) and placebo in subjects with…
- Trial name
- TAROT (NCT01122602)
- Testing
- Acetylsalicyclic acid (Fast acting Aspirin, BAY1019036), Acetylsalicyclic acid (Aspirin, BAYE4465)
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Bayer