Clinical trials: Aspirin Prophylaxis
Gastric or Duodenal Ulcers
Long-term Use of Takepron Capsules on the Prevention of Recurrence of Gastric/Duodenal Ulcer in Patients Receiving Low-dose Aspirin
The purpose of this study is to investigate the safety and efficacy of long-term administration of lansoprazole (Takepron) for up to 12 months in the routine clinical setting in patients receiving low-dose aspirin
- Trial name
- NCT02099682
- Testing
- Lansoprazole
- Volunteers
- 3,366 people
- Sponsor
- Takeda
Bleeding Peptic Ulcer
Prevention of Gastric Ulcer Bleeding by Using "Computer-alert" in General Practice
The purpose of this study is to investigate if a computerised decision-support tool used in general practice, can reduce the frequency of peptic ulcer bleeding related to the use of NSAIDs (Non-Steroidal-antiinflammatory-drug)…
- Trial name
- NCT01845168
- Testing
- Computer-alert, A computer alerts which pops up when the GP presribes NSAID/ASA to a patient with risk-factors
- Where
- 2 sites in Denmark
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Habitual Abortion
Low Molecular Weight Heparin and/or Aspirin in Prevention of Habitual Abortion
1 % of all pregnancies end in habitual/recurrent abortion. In about half of women with habitual abortions (HAB) hereditary or acquired (antiphospholipid antibodies) thrombophilia are observed.
- Trial name
- HABENOX (NCT00959621)
- Testing
- Aspirin, Klexane, Klexane and ASA
- Where
- Finland
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Venous Thromboembolism
Comparative Study of Prophylactic Agent for Venous Thromboembolism After Total Knee Arthroplasty
The purpose of this study is to compare the efficacy of two prophylactic agent(aspirin 300mg/day and rivaroxaban 10mg/day) for venous thromboembolism after total knee arthroplasty.
- Trial name
- NCT02271399
- Testing
- acetylsalicylic acid, rivaroxaban
- Where
- South Korea
- Volunteers
- 156 people
- Sponsor
- Hanyang University Seoul Hospital
Preeclampsia
162 mg of Aspirin for Prevention of Preeclampsia
This is a study to assess if 162 mg of aspirin will decrease rates of preeclampsia in pregnant patients compared to 81 mg of aspirin.
- Trial name
- NCT05221164
- Testing
- Aspirin 162 mg
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Methodist Medical Center of Illinois
Preeclampsia
Aspirin (ASA) Therapy and Preeclampsia Prevention
According to U.S. Pharmacist® "low-dose aspirin refers to dosages between 81 mg and 325 mg taken every day to prevent heart attacks, strokes, and colon cancer." It has been found through research that low-dose aspirin also…
- Trial name
- NCT04158830
- Testing
- Aspirin 81 mg Enteric Coated Tab - 1 tablet, Aspirin 81 mg Enteric Coated Tab - 2 tablets
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Tennessee
Acute Coronary Syndrome
Secondary Prevention in Acute Coronary Syndromes: A CALIBER Study
All contemporary guidelines for secondary prevention in acute coronary syndromes recommend a combination of aspirin, beta-blockers, ACE-inhibitors and statins. Yet underutilisation of these drugs is common.
- Trial name
- NCT01162187
- Volunteers
- 400,000 people
- Sponsor
- University College, London
Gastric or Duodenal Ulcers
Special Drug Use Surveillance of Vonoprazan for "Prevention of Recurrence of Gastric/Duodenal Ulcer in Patients Receiving Low-dose Aspirin: Long-term Use"
The purpose of this survey is to investigate the safety and effectiveness of long-term administration of vonoprazan tablets for up to 12 months in the routine clinical setting in patients receiving low-dose aspirin.
- Trial name
- NCT03214094
- Testing
- Vonoprazan
- Where
- Japan
- Volunteers
- 1,119 people
- Sponsor
- Takeda
Pre-eclampsia, Intra-uterine Growth Restriction
Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers
The objective of this study is to test the efficacy of low-dose aspirin (160 mg/day), given bedtime and started early during pregnancy (≤ 15 +6 weeks of gestation) in nulliparous pregnant women selected as "high-risk" by the…
- Trial name
- PERASTUN (NCT01729468)
- Testing
- Aspirin
- Where
- 17 sites in France, Martinique
- Volunteers
- 1,106 people
- Sponsor
- University Hospital, Tours
Hypertensive Disorders of Pregnancy, Preeclampsia
Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL
The overall goal of this large, pragmatic, comparative effectiveness trial is to test the hypothesis that among at-risk individuals, 162 mg/day aspirin is superior to 81 mg/day in preventing Hypertensive disorders of pregnancy…
- Conditions
- Hypertensive Disorders of Pregnancy, Preeclampsia, Gestational Hypertension
- Trial name
- ASPIRIN (NCT06468202)
- Testing
- Aspirin 81 mg, Aspirin 162 mg
- Where
- 20 sites in United States
- Volunteers
- 10,742 people
- Sponsor
- Ohio State University
Preterm Delivery, Obstetrical Complications
Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial
This is a phase-III multi-center double-blind randomized clinical trial of 1,800 individuals with a history of prior preterm birth at less than 35 weeks gestation who are randomized to either 162 mg aspirin or 81 mg aspirin…
- Trial name
- ADEPT (NCT06980025)
- Testing
- 162mg Aspirin, 81mg Aspirin
- Where
- 14 sites in United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Prostate Cancer
A Study to Examine the Effectiveness of Aspirin and/or Vitamin D3 to Prevent Prostate Cancer Progression
To demonstrate the acceptability and feasibility of recruitment to a randomised chemoprevention study of standard (300mg) or low dose (100mg) aspirin vs. placebo and/or Vitamin D3 vs.
- Trial name
- PROVENT (NCT03103152)
- Testing
- High dose Aspirin & Vitamin D, Low dose Aspirin , Vitamin D
- Where
- 7 sites in United Kingdom
- Volunteers
- 104 people
- Sponsor
- Queen Mary University of London
Reflux Esophagitis, Gastric Ulcer
A Study of Esomeplazole (D961H) in Japanese Paediatric Patients With Reflux Esophagitis, Gastric Ulcer or Duodenal Ulcer
This is an open label, parallel group, multi-centre, phase III study to assess the safety and efficacy of D961H in maintenance therapy following initial healing therapy in Japanese paediatric patients with reflux esophagitis, and…
- Conditions
- Reflux Esophagitis, Gastric Ulcer, Duodenal Ulcer
- Trial name
- NCT03553563
- Testing
- D961H capsule 10mg, D961H sachet 10mg
- Where
- 15 sites in Japan
- Volunteers
- 50 people
- Sponsor
- AstraZeneca
Colorectal Cancer
Aspirin and/or Folic Acid in Preventing Recurrent Colorectal Polyps
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of aspirin and/or folic acid may be effective in preventing recurrent polyps in patients who have…
- Trial name
- NCT00033319
- Testing
- folic acid, acetylsalicylic acid
- Where
- 32 sites in United Kingdom
- Sponsor
- Queen's Medical Center
Preeclampsia
Early Prevention of Preeclampsia Study
This is a randomized controlled trial to estimate the efficacy of low dose aspirin for preventing preeclampsia in women identified as high risk.
- Trial name
- EPAPP (NCT01547390)
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Gastric Ulcer, Duodenal Ulcer
Nexium Capsules LDA Specific Clinical Experience Investigation
The purpose of this investigation is to collect following data in patients given Nexium capsule (Nexium) for long term in usual-post-marketing therapy to prevention of recurrence of gastric ulcer or duodenal ulcer with Low dose…
- Trial name
- NCT01729182
- Where
- 47 sites in Japan
- Volunteers
- 2,363 people
- Sponsor
- AstraZeneca
Thrombosis
Antiaggregation in Primary Prevention of Vascular Access for Hemodialysis
This is a prospective study consisting in testing whether systematic use of aspirin is beneficial for primary prevention of vascular access for hemodialysis attested by doppler ultrasound exam.
- Trial name
- NCT02055131
- Testing
- aspirin
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- Tunis University
Recurrent Acute Pancreatitis, Prevention
The Effect of Aspirin on Recurrent Acute Pancreatitis
Recurrent acute pancreatitis (RAP) was defined as two or more occurrences of acute pancreatitis, which was associated with higher percentages of morbidities and mortalities, lower patients' life quality and increased health-care…
- Conditions
- Recurrent Acute Pancreatitis, Prevention, Aspirin
- Trial name
- NCT06185621
- Testing
- 100mg aspirin
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Air Force Military Medical University, China
Prostate Cancer
Combination Statin, Acetylsalicylic Acid and Dutasteride Use in Prostate Cancer
The purpose of this study is to assess whether there is any interaction between statins, acetylsalicylic acid (ASA) and dutasteride on protection from prostate cancer, the development of high grade prostate cancer, or lower…
- Trial name
- NCT01428869
- Where
- Canada
- Volunteers
- 8,231 people
- Sponsor
- University Health Network, Toronto
Preterm Birth
Comparative Study Between Vaginal Progesterone Alone or Combined With Aspirin in Prevention of Recurrent Preterm Birth
This is a double blinded randomized placebo controlled clinical trial to detect the efficacy and safety of vaginal progesterone alone or combined with aspirin in prevention of recurrent PTB.
- Trial name
- prematurity (NCT05319834)
- Testing
- Aspirin tablet
- Where
- Egypt
- Volunteers
- 256 people
- Sponsor
- Menoufia University