Clinical trials: Asthma; Status
Status Asthmaticus
Pleth Variability and Asthma Severity in Children
Research has shown that pleth variability can be used to assess asthma severity in children with status asthmaticus. The investigators would like to use an FDA-cleared monitor (Masimo Radical 7) which measures Pleth Variability…
- Trial name
- NCT02302261
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Northwell Health
Asthma (Diagnosis), Adolescent - Emotional Problem
Research on Disease Control and Mental Health Status of Adolescent Asthma Patients
Background: Currently in China, adolescent asthma care is characterized by both undertreatment and overtreatment. Patients in this age group may exhibit negative emotions toward disease treatment and long-term control.
- Trial name
- NCT07412119
- Testing
- Eligible participants will complete a battery of assessment questionnaires
- Volunteers
- 460 people
- Sponsor
- Beijing Children's Hospital
Asthma
Using Mobile Phones to Improve Adherence to Inhaled Steroids
This study has two main goals. The first goal is to test whether a mobile phone intervention can increase adherence to daily inhaled steroid medications in African American adolescents prescribed this type of medication by…
- Trial name
- ADEPT4 (NCT01710059)
- Testing
- Asthma Supervision, Mobile Phone, Inhaled Corticosteroid Mobile Phone Application
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rush University Medical Center
Pediatric, Asthma, Acute Exacerbation, Pediatric ICU
Use of High Frequency Chest Compression in Pediatric Status Asthmaticus
Asthma is a disease resulting in mucus hypersecretion and airways obstruction. This causes difficulty breathing. The High Frequency Chest Compressor (HFCC) is a device that has been shown to decrease respiratory complications in…
- Trial name
- NCT00552448
- Testing
- High Frequency Chest Compression VEST
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Texas Tech University Health Sciences Center
Pediatric Obesity, Asthma in Children
Steroid Metabolism in Obese and Non-Obese Pediatric Patients Hospitalized for Status Asthmaticus
Single center, open-label, non-randomized study to assess the pharmacokinetic profile of methylprednisolone in healthy children 2-20 years of age admitted for asthma exacerbation.
- Trial name
- NCT04874610
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Status Asthmaticus
The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room
Asthma is the most common chronic illness of childhood. About 10% of children are affected. Not surprisingly, acute asthma exacerbations are one of the common reasons to visit pediatric emergency rooms (ER).
- Trial name
- NCT01524198
- Testing
- Budesonide, Normal saline
- Where
- Saudi Arabia
- Volunteers
- 945 people
- Sponsor
- King Saud University
Hypersensitivity, Psychologic Factors in Physical Conditions Classified Elsewhere
Interaction Effect of Asthma and Aeroallergen Category on the Psychological Status in Allergic Rhinitis Patients
Allergic rhinitis (AR) and asthma are considered as "one airway, one disease". Although there is increasing evidence for an association between allergy and depression, it remains unknown if the relationship between AR and asthma…
- Conditions
- Hypersensitivity, Psychologic Factors in Physical Conditions Classified Elsewhere, Respiratory Tract Diseases, Allergic Rhinitis
- Trial name
- NCT01295255
- Volunteers
- 524 people
- Sponsor
- Beijing Tongren Hospital
Vitamin D Deficiency
Vitamin D Status in Pediatric Asthma
The purpose of this study is to evaluate level of vitamin D in pediatric asthma and relationship between vitamin D and level control of asthma.
- Trial name
- NCT01432678
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Asthmatic Crisis, Wheezing
Optimizing Vitamin D Status in Children With Wheeze / Asthma (OPTIVIT)
Vitamin D deficiency is highly prevalent in the UK. Research shows that vitamin D enhances the immune system and may help protect against chest infections that can cause wheezing illness or worsen asthma symptoms.
- Trial name
- OPTIVIT (NCT02880930)
- Testing
- Fultium-D3 drops (Internis)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Queen Mary University of London
Pulmonary Function Tests
Iron Status and Lung Function in Pediatric Asthma
Iron has a variable role regarding asthma and respiratory function. In addition, iron deficiency may affect spirometry results in asthmatic children.
- Trial name
- NCT05277610
- Testing
- iron studies
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Asthma Childhood
Ideal Steroids for Asthma Treatment in the PICU
Determine if differences in (1) pediatric intensive care unit length of stay, (2) continuous nebulized albuterol duration, and (3) a composite outcome of advanced asthma therapy incidence including use of non-invasive ventilation…
- Trial name
- iSTAT PICU (NCT03900624)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Johns Hopkins All Children's Hospital
Secondhand Exposure, Smoking Status
An Integrated Intervention to Reduce Secondhandsmoke in Children
This is a community essay to assess the effectiveness of a multi-level (individual, family, and school) school-based intervention to prevent the exposure to secondhand smoke (SHS) in a population of 1,734 schoolchildren (12-14…
- Trial name
- RESPIR·NET (NCT01881607)
- Testing
- RESPIRNET Program
- Where
- Spain
- Volunteers
- 1,779 people, healthy volunteers welcome
- Sponsor
- Institut Català d'Oncologia
Childhood Asthma With Status Asthmaticus
Status Asthmaticus on the PICU; Intravenous Salbutamol
Although IV salbutamol is frequently used in children in a wide range, pharmacodynamic data are scarce. To date, there is an insufficient evidence base to guide initial and subsequent dosing recommendation for its IV use in…
- Trial name
- STATIC IV (NCT03493503)
- Testing
- Salbutamol, Sodium Chloride 0.9%
- Where
- Netherlands
- Volunteers
- 58 people
- Sponsor
- Erasmus Medical Center
Asthma
Protocol CAUSE-03 / CHEETAH
This is a one-year longitudinal, observational study of 250 urban children and adolescents with asthma and 60 without asthma, ages 6-17 years old.
- Trial name
- CHEETAH (NCT06136091)
- Where
- 8 sites in United States
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma; Status, Asthma in Children
Pragmatic RCT of High-dose Oral Montelukast for Moderate and Severe Pediatric Acute Asthma Exacerbations
Objective: To determine the extent to which high-dose (30mg) oral montelukast, added to standard treatment in children with moderate and severe acute exacerbations improves outcomes.
- Conditions
- Asthma; Status, Asthma in Children, Asthma Acute, Asthma Attack
- Trial name
- NCT03277170
- Testing
- Montelukast Oral Granules
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Asthma, Status Asthmaticus
Bilevel Positive Airway Pressure (BiPAP) for the Treatment of Moderate to Severe Acute Asthma Exacerbations
Bilevel Positive Airway Pressure (BiPAP) is increasingly being reported as an effective and safe method of respiratory support for children with severe asthma exacerbations unresponsive to standard therapies and with impending…
- Trial name
- NCT02347462
- Testing
- Bilevel Positive Airway Pressure (BiPAP) (Trilogy BiPAP, Philips Respironics), Standard care
- Where
- Canada
- Sponsor
- University of British Columbia
Pediatric Asthma
Humidity Asthma Interventions for Low Socioeconomic Status Children
The goal of this intervention study is to assess the effectiveness of low-cost humidity and mold reduction interventions in the home for reducing pediatric asthma.
- Trial name
- INHALE (NCT07453667)
- Testing
- Healthy home intervention
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Case Western Reserve University
Asthma in Children
Respiratory Outcome of Children From the FEPED Cohort
Early lung function deficits represent a significant risk factor for the evolution toward chronic obstructive pulmonary disease later in life.
- Trial name
- RESPIFEPED (NCT03229317)
- Testing
- Plethysmography
- Where
- 3 sites in France
- Volunteers
- 142 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Status Asthmaticus
Early Noninvasive Positive Pressure Ventilation in Children With Status Asthmaticus
Status asthmaticus is recognized as a common cause of morbidity in children in the United States. In recent years, hospitalization rates have reached an all time high.
- Trial name
- NCT01188473
- Testing
- NPPV plus standard of care
- Where
- United States
- Sponsor
- Southern Illinois University
Acute Severe Asthma
Compare Efficacy Nebulized and Intravenous Magnesium Sulphate in Thai Children
The purpose of this study is to determine whether nebulized magnesium sulphate is effective in the treatment of acute severe asthma when comparison with intravenous magnesium sulphate
- Trial name
- NCT02112305
- Testing
- isotonic magnesium sulphate, 50% magnesium sulphate
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Queen Sirikit National Institute of Child Health