Clinical trials: Autism Spectrum Disorders
Cerebral Palsy, Mental Retardation
Development and Application of a Diagnosis and Treatment System for Children's Brain Diseases Based on Knowledge Graphs and Large Models
Using the knowledge graph and big model technology of combining Chinese and Western medicine we construct a popularization and prevention system for childhood encephalopathy an assisted decision-making system for childhood…
- Conditions
- Cerebral Palsy, Mental Retardation, Tourette's Syndrome, Attention Deficit Hyperactivity Disorder
- Trial name
- NCT06848959
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Yun Liu,PhD
Executive Dysfunction, Autism Spectrum Disorder
Intervention-Induced Plasticity of Flexibility and Learning Mechanisms in ASD
This project explores the association between learning and cognitive flexibility by testing whether a cognitive behavioral intervention designed to improve flexibility in ASD changes learning and associated neural activation…
- Conditions
- Executive Dysfunction, Autism Spectrum Disorder, Adolescent Behavior
- Trial name
- NCT05131659
- Testing
- Executive function group therapy
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Children's National Research Institute
Autism
Clinical and Genetic Study of Autism Spectrum Disorder
The purpose of this study is to prepare instruments for Autism Spectrum Disorder (ASD), to collect clinical, neuropsychological, and genetic data of ASD probands and their family, and to identify the genetic variants close to…
- Trial name
- NCT00494754
- Where
- 4 sites in Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorder
LEGO-Based Play Therapy for Children With Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by difficulties in social communication and interaction, as well as restricted and repetitive patterns of behavior.
- Trial name
- LEGO-ASD (NCT07751679)
- Testing
- LEGO®-Based Play Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University
Autism Spectrum Disorder
Executive Function Intervention for Children With ASD Combining a Digital App and Parent Coaching
The purpose of this randomized controlled study is to develop and evaluate a digital cognitive control intervention that integrates a digital application-based child training program with an online parent coaching program for…
- Trial name
- NCT07376356
- Testing
- ChuckChuck Step, ChuckChuck Step (Shortened Parent Coaching)
- Volunteers
- 40 people
- Sponsor
- Korea University
Childhood Autism
Melatonin Dose-effect Relation in Childhood Autism
Melatonin is a neurohormone produced from serotonin which promotes sleep. The alterations in central and peripheral serotonin neurobiology and in circadian sleep-wake rhythms observed in autistic disorder suggest abnormalities in…
- Trial name
- MELADOSE (NCT01780883)
- Testing
- melatonin
- Where
- 4 sites in France
- Volunteers
- 34 people
- Sponsor
- Rennes University Hospital
Mental Retardation, Autism Spectrum Disorder
A Cross-sectional Study to Evaluate Speech and Language Development in Chinese Children Aged 2-6 Years
The purpose of this study is to establish a new Chinese children's speech and language norm by obtaining the latest data of speech and language development of children aged 2 ~ 6 from different regions in China.
- Conditions
- Mental Retardation, Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder
- Trial name
- NCT05442229
- Testing
- establish a new Chinese children's speech and language norm
- Volunteers
- 5,744 people
- Sponsor
- Tongji Hospital
Child Autism
Effect of Modified Dental Visual Aids on Behavior Management During Dental Treatment in Children With Autism Spectrum Disorder
There is a need to find an approach that is appropriate for managing children with Autism Spectrum Disorder in the dental clinic, to manage their behaviour and decrease their anxiety in this research we will apply our modified…
- Trial name
- NCT04576559
- Testing
- Modified dental visual aids, Regular dental visual aids
- Where
- Saudi Arabia
- Volunteers
- 64 people
- Sponsor
- King Abdulaziz University
Autism Spectrum Disorder, Theta Burst Stimulation
Explore the Impacts of Theta Burst Stimulation Over the Right Inferior Frontal Gyrus in Autism Spectrum Disorder: Combination of Clinical Symptoms, Neuropsychological Function and MRI
Exploring the therapeutic efficacy of Theta Burst Stimulation (TBS) over the right inferior frontal gyrus (RIFG) in autism, including changes in core symptoms, adaptive functioning, neuropsychological performance, and…
- Conditions
- Autism Spectrum Disorder, Theta Burst Stimulation, Right Inferior Frontal Gyrus
- Trial name
- NCT07579494
- Testing
- intermittent theta burst stimulation
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Autism Spectrum Disorder
Autism Registry for French Guiana
The objective of the autism registry is to estimate the prevalence of autism in French Guiana in the cohort of children aged 8 years.
- Trial name
- REGUYAUT (NCT02903732)
- Testing
- observational
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier de Cayenne
Autism Spectrum Disorder
The Effects and Mechanism of Parent Intervention for Autism Sprectrum Disorder
Purpose of the Research: The goal of this clinical study is to investigate if a parent training program called "Project IMPACT" (Improving Parents as Communication Teachers) can help improve the core challenges in social…
- Trial name
- ImPACT (NCT07393893)
- Testing
- Parents conducted interventions based on project ImPACT., General behavioral interventions
- Where
- China
- Volunteers
- 80 people
- Sponsor
- University of Electronic Science and Technology of China
Autism Spectrum Disorder
The Effect of High Antioxidant Cacao on Behaviors in Children With Autism Spectrum Disorder
The purpose of this study is to determine if routine consumption of high antioxidant cacao can have an effect on the behaviors of children with Autism Spectrum Disorder.
- Trial name
- NCT03195465
- Testing
- Dark Chocolate
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Loma Linda University
Autism Spectrum Disorder, Adhd
A+ Treatment/Feasibility of Adapted ESDM-informed Caregiver Coaching Delivered Remotely for Children With ASD (Autism Spectrum Disorder) and ADHD (Attention Deficit Hyperactivity Disorder)
This study will evaluate the feasibility of adapted ESDM-informed caregiver coaching in children with comorbid ASD and ADHD, who are between 36 and <132 months of age.
- Trial name
- NCT05417607
- Testing
- P-ESDM informed caregiver coaching
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Duke University
Autism Spectrum Disorder
Aquatic Therapy and Autism Spectrum Disorders
To compare the efficacy of one-on-one versus group-based aquatic therapy on the social interactions, behaviors and physical activities of children with autism spectrum disorders (ASDs).
- Trial name
- AT&ASD (NCT03195244)
- Testing
- Aquatic Physical Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sloan W. Rush, MD
Autism Spectrum Disorder, Mitochondrial Pathology
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders
The study involves up to 5 visits for a fasting blood draw, behavioral assessments, and/or questionnaires. Other samples may be collected when appropriate. This study is currently recruiting.
- Conditions
- Autism Spectrum Disorder, Mitochondrial Pathology, Epilepsy, Brain Tumor
- Trial name
- NCT04322734
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Southwest Autism Research & Resource Center
Autism Spectrum Disorder
Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Open Label
The goal of this study is to target the neurobiology of restricted and repetitive behaviors in children with autism spectrum disorder using N-acetylcysteine (NAC), a well-tolerated nutritional supplement that has shown promise…
- Trial name
- NCT05494398
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Stanford University
Autism, Inflammation
Intestinal Inflammation and Carbohydrate Digestion in Autistic Children
The purpose of the study is to find correlations between non-invasive fecal tests of intestinal inflammation and macro- and microscopic evaluation of duodenal and colonic histology, disaccharidase activity, and intestinal…
- Trial name
- NCT00227487
- Testing
- Stool collection, Administration of carbohydrate solution during clinically indicated endoscopy, Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 115 people
- Sponsor
- Massachusetts General Hospital
Equine-Assisted Therapy, Autism Spectrum Disorder
Equine Assisted Therapy in Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder that negatively affects social interaction, communication, and behavior. Various animals have started to be used for therapeutic purposes by those in need.
- Trial name
- AUTISM-EAT (NCT06057311)
- Testing
- Hippotherapy, Equine-Assisted Activities Therapy, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Izmir Democracy University
CTNNB1 Gene Mutation
Genotype-phenotype Correlations in Children and Adults With CTNNB1 Mutation
The aim of this study is to explore and define the correlations between genotype and phenotype in patients with CTNNB1 mutations as well as monitor and survey the natural history of the CTNNB1 syndrome.
- Trial name
- Gen-Phe CTNNB1 (NCT04812119)
- Testing
- The Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F), The Autism Spectrum Quotient-Children's Version (AQ-Child), The Autism-Spectrum Quotient (AQ)-Adolescent Version (AQ-Adolescent)
- Where
- 3 sites in Australia, Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Irritability Associated With Autism Spectrum Disorder
A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism
The purpose of this study is to assess KarXT + KarX-EC for the treatment of irritability associated with autism in children and adolescents.
- Trial name
- NCT07284745
- Testing
- KarXT, KarX-EC
- Where
- 39 sites in United States, Australia and 2 more
- Volunteers
- 176 people
- Sponsor
- Bristol-Myers Squibb
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