Clinical trials: Autotransplantation
Anterior Cruciate Ligament Rupture
Arthroscopic ACL Reconstruction: Quadriceps Tendon vs Hamstring Tendon Autograft - A Prospective RCT
A prospective randomized controlled trial comparing functional outcomes of arthroscopic anterior cruciate ligament reconstruction using quadriceps tendon autograft versus hamstring tendon autograft at SMS Medical College, Jaipur.
- Trial name
- NCT07470944
- Testing
- Arthroscopic ACL Reconstruction
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Sawai Mansingh Medical College
Autografts, Blood Flow Restriction Therapy
Blood Flow Restriction Following ACLR w/Quad Autograft
This project is intended to acquire objective measurements of implementing BFR rehabilitation in ACL reconstructions to show any changes upon completion of the BFR protocol.
- Conditions
- Autografts, Blood Flow Restriction Therapy, Rehabilitation Outcome, Quadriceps Muscle Strength
- Trial name
- BFR Quad Delay (NCT06636045)
- Testing
- Not applicable- observational study
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Kansas Medical Center
Leukemia
Chemotherapy and Biological Therapy With or Without Bone Marrow or Peripheral Stem Cell Transplant in Treating Patients With Chronic Myelogenous Leukemia
RATIONALE: Giving chemotherapy, such as hydroxyurea, cytarabine, idarubicin, and etoposide before a donor bone marrow transplant or stem cell transplant helps stop the growth of cancer cells.
- Trial name
- NCT00025402
- Testing
- filgrastim, recombinant interferon alfa, busulfan
- Where
- 188 sites in Czechia, Germany and 3 more
- Volunteers
- 1,000 people
- Sponsor
- III. Medizinische Klinik Mannheim
Adenosine Deaminase Deficiency, ADA-SCID
Treatment of SCID Due to ADA Deficiency With Autologous Transplantation of Cord Blood or Hematopoietic CD 34+ Cells After Addition of a Normal Human ADA cDNA by the EFS-ADA Lentiviral Vector
This is a clinical gene transfer study that aims to verify the safety and efficacy of the use of the EFS-ADA lentiviral vector to introduce the human adenosine deaminase (ADA) gene into the hematopoietic progenitors of patients…
- Trial name
- NCT02022696
- Testing
- Lentiviral Gene Transfer
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Lymphoma
Rituximab in Addition to Autologous Transplantation With BEAM for Patients With Lymphoid Malignancies
Cohort 1: Patients who are less than or equal to 65 years of age. 1. To determine the disease-free survival (DFS) in the 2 arms (standard dose versus high dose rituximab) Cohort 2: Patients who are older than 65 years of age 1.
- Trial name
- NCT00472056
- Testing
- Carmustine, Etoposide, Cytarabine
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- M.D. Anderson Cancer Center
Bone Loss, Alveolar, Tooth Loss
Tooth Autotransplantation and Bone Dimension Changes
Tooth autotransplantation is a treatment option to replace tooth with imposible prognosis. In several cases the receipt site has a reduced bone dimension.
- Conditions
- Bone Loss, Alveolar, Tooth Loss, Bone Atrophy, Alveolar
- Trial name
- NCT03927937
- Testing
- AUTOTRANSPLANTATION TOOTH
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Full-thickness Skin Defects, Degloving Injuries
RECELL® System Combined With Meshed Autograft for Reduction of Donor Skin Harvesting in Soft Tissue Reconstruction
A prospective randomized within-subject controlled study to compare the clinical performance of conventional autografting with and without the RECELL system on acute non-burn full-thickness skin defects.
- Conditions
- Full-thickness Skin Defects, Degloving Injuries, Crush Injuries, Laceration of Skin
- Trial name
- NCT04091672
- Testing
- Control Intervention (Conventional Autograft), Investigational Intervention (RECELL + more widely meshed autograft)
- Where
- 18 sites in United States
- Volunteers
- 65 people
- Sponsor
- Avita Medical
Anterior Cruciate Ligament Reconstruction
Transtibial Versus Anteromedial Femoral Tunnel Technique in ACL Reconstruction
The anteromedial (AM) portal technique was introduced to position the femoral tunnel in anterior cruciate ligament (ACL) reconstruction to more closely replicate the original footprint compared to the transtibial (TT)…
- Trial name
- NCT02633410
- Testing
- Femoral tunnel creation
- Volunteers
- 96 people
- Sponsor
- Panam Clinic
Lymphoma
Filgrastim and Chemotherapy Followed by Peripheral Stem Cell Transplant in Treating Patients With Hodgkin's Lymphoma or Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplant may allow the doctor to give higher doses of…
- Trial name
- NCT00005985
- Testing
- filgrastim, carmustine, cyclophosphamide
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Chronic Myelogenous Leukemia
Autologous Transplantation for Chronic Myelogenous Leukemia
The goal of this clinical research is to learn if treatment with high-dose busulfan and cyclophosphamide plus autologous bone marrow transplantation followed by treatment with Gleevec (imatinib mesylate) is effective in treating…
- Trial name
- NCT01003054
- Testing
- Busulfan, Cyclophosphamide, Imatinib Mesylate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Anterior Cruciate Ligament Injuries
All-Inside Single-Bundle for Anterior Cruciate Ligament Reconstruction With Full Thickness of the Peroneus Longus Tendon Compared to the Six-strand-hamstring Autograft (ACL)
Anterior cruciate ligament reconstruction is the current gold standard for restoring knee stability. Hamstring tendon (HT) autograft is the most popular graft choice for ACL reconstruction worldwide.
- Trial name
- ACL (NCT05580133)
- Testing
- anterior cruciate ligament reconstruction
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mongi Slim Hospital
Pterygium
Manifestations of Ocular Irritation Following Pterygium Excision With Sutures Fixed Conjunctival Autograft
In this work, the manifestations of ocular irritation associated with vicryl 8/0 sutures fixed conjunctival auto-graft in pterygium patients were evaluated.
- Trial name
- NCT05164900
- Testing
- pterygium excision with sutures fixed conjunctival auto-graft
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Tanta University
Anterior Cruciate Ligament Reconstruction Rehabilitation, Dry Needling
Dry Needling and Quad Strength After Anterior Cruciate Ligament Reconstruction
Dry needling is a skilled intervention provided by trained physical therapists to treat pain, myofascial dysfunction, and a variety of other diagnosis.
- Conditions
- Anterior Cruciate Ligament Reconstruction Rehabilitation, Dry Needling, Strength
- Trial name
- ACLR (NCT07657195)
- Testing
- Dry Needling
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Pterygium, Primary
Conjunctival Autologous Transplantation Using Fibrin Glue in Primary Pterygia
To evaluate the recurrence and postoperative complications rates after conjunctival autograft surgery using fibrin adhesive for primary pterygium
- Trial name
- NCT00949728
- Testing
- Conjunctival autograft using fibrin glue
- Where
- Brazil
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Hospital de Olhos Sadalla Amin Ghanem
Anterior Cruciate Ligament (ACL) Tear
Sciatic Technique Comparison of Nerve Blockade for Pain Control Following Hamstring Autograft Harvest in Adolescents
The purpose of this research is to compare the effect of single-injection sciatic PNB to continuous sciatic PNB on 1) postoperative pain control as measured by self-reported pain scores, pain medication use, and unplanned…
- Trial name
- NCT02947633
- Testing
- Single-injection sciatic PNB, Continuous sciatic PNB
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hyperparathyroidism, Secondary
Subtotal Parathyroidectomy or Total Parathyroidectomy With Autograft in Chronic Kidney Disease Patients Under Dialysis
This study evaluates the metabolic and clinical results of two well recognized and accepted surgical techniques in the management of severe hyperparathyroidism in patients under regular dialysis treatment.
- Trial name
- NCT02464072
- Testing
- Subtotal Parathyroidectomy, Total Parathyroidectomy + 45 autografts, Total Parathyroidectomy + 90 autografts
- Where
- Brazil
- Volunteers
- 133 people
- Sponsor
- University of Sao Paulo General Hospital
Genovarum
Results of Opening-wedge High Tibial Osteotomy Using Iliac Crest Allograft Compared to Iliac Crest Autograft
The purpose of this RCT is to determine the results of opening-wedge high tibial osteotomy in patients with genovarum deformity using iliac crest allograft compared to the results when using iliac crest autograft.
- Trial name
- NCT00595712
- Testing
- Iliac crest allograft, Iliac crest autograft
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
ACL Injury
BFR Therapy for Post-Op Rehab of ACL Reconstruction With Quadriceps Tendon Autograft
The overall objective of the proposed research is to conduct a prospective, randomized controlled trial to investigate whether the addition of BFR therapy to standard post-operative rehabilitation regimen significantly improves…
- Trial name
- NCT04519801
- Testing
- Blood Flow Restriction (BFR) therapy, Standard REHAB
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brooke Army Medical Center
Traumatic Dental Injury, Tooth Aplasia
Premolar Autotransplantation in Juvenile Dentition: Quantitative Assessment of Vertical Bone and Soft Tissue Growth
Objective: Premolar autotransplantation represents an effective therapeutic option for the treatment of juvenile dentition in traumatic dental injury with tooth loss.
- Trial name
- NCT02740907
- Testing
- premolar autotransplantation
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- MKG-Praxisklinik
Pes Planovalgus
New Bone Grafting Technique in Paediatric Foot Surgery. Validation of Outcome Measures
The purpose of this study is to determine whether structural calcium ceramic bone graft substitute (ReproBone™) is non-inferior compared to autologous tricortical iliac crest bone graft in lateral calcaneal lengthening…
- Trial name
- NCT01770574
- Testing
- ReproBone, calcaneal lengthening
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus