Clinical trials: BPD
Bronchopulmonary Dysplasia (BPD)
Late Low-Dose Dexamethasone in Preterm Neonates Using DART Protocol
Premature babies, especially those who need breathing support for many days, are at risk of developing a long-term lung condition called bronchopulmonary dysplasia (BPD).
- Trial name
- NCT07904104
- Testing
- Dexamethasone
- Where
- Pakistan
- Volunteers
- 93 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Severe Bronchopulmonary Dysplasia
PNEUMOSTEM for the Prevention and Treatment of Severe BPD in Premature Infants
This study is to evaluate the efficacy and safety of PNEUMOSTEM® for the Prevention and Treatment of Severe Bronchopulmonary Dysplasia (Severe BPD) in Premature Infants.
- Trial name
- NCT03392467
- Testing
- PNEUMOSTEM
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Medipost Co Ltd.
Bipolar Disorder, Mood Disorders
Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study
This research protocol seeks to learn more about bipolar disorder in children and adolescents ages 6-17. Researchers will describe the moods and behaviors of children with bipolar disorder and use specialized testing and brain…
- Conditions
- Bipolar Disorder, Mood Disorders, Attention Deficit Hyerpactivity Disorder
- Trial name
- NCT00006177
- Where
- United States
- Volunteers
- 1,303 people
- Sponsor
- National Institute of Mental Health (NIMH)
Bronchopulmonary Dysplasia
Biomarkers and Volumetric Capnography in BPD
The purpose of this study is to assess the association of biomarkers on day 7 of life with the development of bronchopulmonary dysplasia in very preterm infants.
- Trial name
- BPD-2014 (NCT02083562)
- Where
- 2 sites in Switzerland
- Volunteers
- 210 people
- Sponsor
- University Hospital, Basel, Switzerland
Bronchopulmonary Dysplasia
Clinic Features and Outcome of BPD (SGBPD)
This study described the perinatal high-risk factors and clinical manifestations of the children, and compared the high-risk factors, clinical manifestations and prognosis of BPD among different clinical subtypes by comparison…
- Trial name
- NCT04237844
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Wang Jianhui
Healthy, Cystic Fibrosis (CF)
MRI for Non-Invasive Imaging in Neonates and Children
The purpose of this study is to develop rapid MRI techniques for imaging the lung with hyperpolarized helium-3 gas as an inhaled contrast agent.
- Conditions
- Healthy, Cystic Fibrosis (CF), Asthma, Bronchopulmonary Dysplasia (BPD)
- Trial name
- NCT02163681
- Testing
- Hyperpolarized Helium-3 MRI of the chest
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Bronchopulmonary Dysplasia, Neurally Adjusted Ventilatory Assist
NAVA vs. CMV Crossover in Severe BPD
This prospective, unblinded, pilot randomized cross-over trial of 2 modes of mechanical ventilation will compare measures of pulmonary mechanics, respiratory gas exchange, and patient comfort between conventional flow triggered…
- Conditions
- Bronchopulmonary Dysplasia, Neurally Adjusted Ventilatory Assist, Mechanical Ventilation
- Trial name
- NCT04821453
- Testing
- NAVA, CMV
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Children's Hospital of Philadelphia
Retinopathy of Prematurity (ROP)
IGF-1/IGFBP3 Prevention of Retinopathy of Prematurity
To compare the severity of retinopathy of prematurity (ROP) among treated infants with an untreated control population, matched for gestational age at birth while confirming the dose of rhIGF-1/rhIGFBP-3 is safe and efficacious.
- Trial name
- NCT01096784
- Testing
- rhIGF-I/rhIGFBP-3
- Where
- 24 sites in United States, Italy and 4 more
- Volunteers
- 121 people
- Sponsor
- Shire
Bronchopulmonary Dysplasia
Efficacy and Safety of Zelpultide Alfa in Preterm Neonates at High Risk of Developing Bronchopulmonary Dysplasia (BPD)
This is a randomized, parallel-group, double-blind, placebo-controlled multicenter phase 2b/3 study with an adaptive seamless design.
- Trial name
- ZELA (NCT06897839)
- Testing
- Zelpultide alfa
- Where
- 49 sites in Argentina, Belgium and 6 more
- Volunteers
- 366 people
- Sponsor
- Airway Therapeutics, Inc.
Bronchopulmonary Dysplasia
A Clinical Safety Study of AT-100 (rhSP-D) in Preterm Neonates at High Risk for Bronchopulmonary Dysplasia (BPD)
The purpose of this study is to determine if an investigational drug, AT-100, can reduce the occurrence of Bronchopulmonary Dysplasia (BPD) in babies born premature, as compared to babies born premature who receive an air-sham…
- Trial name
- NCT04662151
- Testing
- AT-100
- Where
- 19 sites in United States, Spain
- Volunteers
- 37 people
- Sponsor
- Airway Therapeutics, Inc.
Bronchopulmonary Dysplasia (BPD)
Efficacy of Intrathecal Administration of Budesonide to Prevent Bronchopulmonary Dysplasia
The goal of this clinical trial is to learn if budesonide works to prevent bronchopulmonary dysplasia in newborn less than 32 weeks gestational age or birth weight less than 1500 g with respiratory distress syndrome who needs…
- Trial name
- NCT07725575
- Testing
- Experimental
- Where
- Indonesia
- Volunteers
- 86 people
- Sponsor
- Universitas Indonesia
Bronchopulmonary Dysplasia, Right Ventricular Dysfunction
Right vEntricular Function Prediction mOdel to Identify pReterm infanTs With Early BronchoPulmonary Dysplasia.
Short title REPORT-BPD feasibility study Design A mixed methods observational cohort feasibility study Study Setting Neonatal Intensive Care Unit at University Hospitals Plymouth NHS Trust Aim To explore the feasibility of…
- Conditions
- Bronchopulmonary Dysplasia, Right Ventricular Dysfunction, In the Perinatal Period
- Trial name
- REPORT-BPD (NCT05235399)
- Testing
- Echo scans
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University Hospital Plymouth NHS Trust
BPD - Bronchopulmonary Dysplasia
Randomized Control Trial: Synchronized Non-invasive Positive Pressure Ventilation Versus Non Synchronized Non Invasive Positive Pressure Ventilation in Extremely Low Birth Weight Infants
Infants delivered weighing less than 1 kg at birth (ELBW) are at high risk for the development of bronchopulmonary dysplasia (BPD) and Ventilator-Induced Lung Injury (VILI), in part because of the need for mechanical ventilation…
- Trial name
- NCT03613987
- Testing
- NAVA technology to synchronize NIPPV
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- New York Medical College
BPD
Effect of Autologous Cord Blood Mononuclear Cells for Treatment of Bronchopulmonary Dysplasia in Extremely Preterm Neonates
This is a non-randomized, case-controlled trial that evaluates the efficacy of autologous cord blood mononuclear cells(ACBMNC) infusion as a Treatment for BPD.
- Trial name
- NCT05071638
- Testing
- autologous cord blood mononuclear cells
- Where
- 2 sites in China
- Volunteers
- 76 people
- Sponsor
- Guangdong Women and Children Hospital
Premature Birth, Infant, Very Low Birth Weight
The Efficacy and Safety of Montelukast Sodium in the Prevention of Bronchopulmonary Dysplasia
This study is multicentered, prospective, randomized, opened, parallel, intervention study. The aim of this study is to evaluate the efficacy and safety of Montelukast sodium in the prevention of bronchopulmonary dysplasia (BPD)…
- Conditions
- Premature Birth, Infant, Very Low Birth Weight, Bronchopulmonary Dysplasia
- Trial name
- BPD (NCT01717625)
- Testing
- Montelukast
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Ajou University School of Medicine
Tracheomalacia, Bronchopulmonary Dysplasia (BPD)
Enhancing Lung Health in Kids With Structural Lung Damage and Malformations: Azithromycin (AZI) for Airway Infection Prevention
Children with lung and airway malformations or early structural lung damage face significant challenges, often leading to recurrent respiratory infections, hospitalizations, and decreased quality of life.
- Conditions
- Tracheomalacia, Bronchopulmonary Dysplasia (BPD), Vascular Ring, Cystic Lung Disease
- Trial name
- TRALULALA-AZI (NCT06409299)
- Testing
- Azithromycin 40 MG/ML
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Bronchopulmonary Dysplasia
Ultrasound Assessment of Diaphragmatic Function in Infants With BPD
Preterm infants have high and prolonged exposure to positive pressure ventilation, which contributes to acute lung injury and the development of bronchopulmonary dysplasia (BPD).
- Trial name
- NCT04941963
- Testing
- Chest ultrasound
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Mount Sinai Hospital, Canada
BPD - Bronchopulmonary Dysplasia
Safety and Efficacy of Umbilical Cord-derived Mesenchymal Stem Cell(MSC) Transplantation in the Treatment of Bronchopulmonary Dysplasia(BPD) in Premature Infants
Bronchopulmonary dysplasia (BPD) is a chronic lung disease, which is a major complication of very low and ultra-low preterm infants.
- Trial name
- MSC，BPD (NCT06788470)
- Testing
- MSC
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Bronchopulmonary Dysplasia
129Xe MRI in Pediatric Population With BPD
Hyperpolarized (HP) gas magnetic resonance imaging (MRI) of the lungs offers additional information that cannot be obtained with CT scan, the current gold standard for imaging this disorder.
- Trial name
- NCT04035629
- Testing
- MagniXene, hyperpolarized 129Xe MRI
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Xemed LLC
Severe Bronchopulmonary Dysplasia
Aerosolized Albuterol Use in Severe BPD
Currently several dose schedules of Albuterol are administered via nebulization to infants in the neonatal and infant intensive care unit (N/IICU).
- Trial name
- NCT02766673
- Testing
- Albuterol Sulfate, Sterile Saline
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Children's Hospital of Philadelphia