Clinical trials: Bacterial Ulcer
Buruli Ulcer
Thermotherapy of Buruli Ulcer at Community Level in the Health District of Akonolinga
The project rolls out combined innovative low-tech thermotherapy of Buruli ulcer (BU) with heat packs and WHO recommended wound management in a BU endemic district of Cameroon.
- Trial name
- UB Thermo (NCT03969940)
- Sponsor
- Swiss Tropical & Public Health Institute
Acne, Bites
Implementation of a Minor Ailment Service in Community Pharmacy Practice
Self-care and self-medication are commonly the treatments of choice for the management of minor ailments. Minor ailments can be treated through community pharmacy using a Minor Ailment Service (MAS).
- Conditions
- Acne, Bites, Burns, Cold
- Trial name
- INDICA+PRO (NCT05247333)
- Testing
- Minor ailment service
- Where
- Spain
- Volunteers
- 20,987 people
- Sponsor
- Universidad de Granada
Helicobacter Pylori Infection, Peptic Ulcer
The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy
Helicobacter pylori (HP) is a gram-negative bacillus responsible for one of the most common infections found in humans worldwide.
- Conditions
- Helicobacter Pylori Infection, Peptic Ulcer, Bile Reflux, Gastritis
- Trial name
- NCT00441831
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- Mackay Memorial Hospital
Mycobacterium Ulcerans Infection
WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8
This is a WHO-sponsored trial. Combination therapy with streptomycin and rifampicin has been the standard antibiotic treatment for M. ulcerans infection since 2004.
- Trial name
- NCT01659437
- Testing
- Clarithromycin Extended Release, Streptomycin intramuscular injection
- Where
- 5 sites in Benin, Ghana
- Volunteers
- 310 people
- Sponsor
- University Medical Center Groningen
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Helicobacter Infections, Gastritis
Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori
The eradication rate of the standard H. pylori eradication therapy (such as the triple therapy with a proton pump inhibitor [PPI], amoxicillin and clarithromycin) depends on bacterial susceptibility to clarithromycin and…
- Conditions
- Helicobacter Infections, Gastritis, Gastric Ulcer, Duodenal Ulcer
- Trial name
- NCT00149084
- Testing
- Lansoprazole, clarithromycin, amoxicillin
- Where
- Japan
- Volunteers
- 296 people
- Sponsor
- Hamamatsu University
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Ulcerative Colitis
Role of Bile Acids and Microbiota in Clostridioides Difficile Infection in Ulcerative Colitis
Ulcerative Colitis (UC) is a chronic Inflammatory Bowel Disease characterized by chronic inflammation of the colon. Composition of gut microbiota of UC patients is abnormal (dysbiosis).
- Trial name
- ABRICO (NCT06228352)
- Testing
- Feces collection
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Clostridium Difficile Infection, Ulcerative Colitis
Fecal Microbial Transplantation for C. Difficile and/or Ulcerative Colitis or Indeterminate Colitis
Fecal Microbiota Transplantation will be offered to eligible C. difficile patients (does not require Investigational New Drug designation) and to eligible ulcerative colitis or indeterminate colitis patients as Investigational…
- Conditions
- Clostridium Difficile Infection, Ulcerative Colitis, Indeterminate Colitis
- Trial name
- FMT (NCT03268213)
- Testing
- Fecal Microbial Transplantation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stony Brook University
Skin and Connective Tissue Diseases, Neglected Tropical Diseases
Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers
Skin-related Neglected Tropical Diseases (Skin NTDs) affect about 1.8 billion people worldwide, particularly in poor and rural communities where healthcare access is limited.
- Conditions
- Skin and Connective Tissue Diseases, Neglected Tropical Diseases, Leprosy, Buruli Ulcer
- Trial name
- SkincAIr (NCT07506967)
- Testing
- A mobile app with AI functionality for diagnosing skin-related NTDs
- Where
- 5 sites in Democratic Republic of the Congo, Ethiopia and 3 more
- Volunteers
- 2,420 people
- Sponsor
- Kenya Medical Research Institute
Helicobacter Infections, Gastritis
Risk Factors for Gastric Disease in Pediatric Helicobacter Pylori (H. Pylori)
Helicobacter pylori (Hp) is a major cause of chronic-active gastritis and primary duodenal ulcers, and is strongly linked to gastric cancer. Most Hp infections worldwide are acquired in childhood.
- Conditions
- Helicobacter Infections, Gastritis, Peptic Ulcer
- Trial name
- NCT00212225
- Where
- 3 sites in United States
- Volunteers
- 755 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Infected Corneal Ulcers, Bacterial Keratitis
A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers
Bacterial corneal ulcers are a leading cause of pediatric blindness in underdeveloped countries due to a lack of antibiotic availability and affordability, among other reasons.
- Conditions
- Infected Corneal Ulcers, Bacterial Keratitis, Corneal Ulcer, Childhood Blindness
- Trial name
- NCT00386958
- Testing
- Povidone-Iodine
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Pressure Ulcers
Evaluate the Efficacy of a Silk-Like Fabric for the Prevention of Pressure Sores in a Long Term Care Setting
The primary purpose of this research study is to evaluate if DermaTherapy® bedding will significantly reduce pressure ulcer incidence by decreasing maceration, friction, and shearing among residents of Nursing Homes.
- Trial name
- NCT01403272
- Testing
- DermaTherapy® Linen and underpads.
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Precision Fabrics Group, Inc.
Corneal Ulcer, Eye Infections, Bacterial
Steroids for Corneal Ulcers Trial
The purpose of this study is to determine whether adding topical steroids improves the outcomes of bacterial corneal ulcers, especially visual acuity.
- Trial name
- SCUT (NCT00324168)
- Testing
- Antibiotics, Topical corticosteroid
- Where
- 5 sites in United States, India
- Volunteers
- 500 people
- Sponsor
- Thomas M. Lietman
Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease
Natural History of Trisomy 8-Associated Autoinflammatory Disease (TRIAD) and Related Disorders
Background: Trisomy 8 mosaicism is a genetic disorder that can increase inflammation in the body. Symptoms include fevers; sores or ulcers in the mouth, digestive tract, or genital area; skin rashes; problems in organs or…
- Conditions
- Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease, Mucosal Ulcerations
- Trial name
- NCT07683104
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Leprosy
The Use of Low Level Laser Therapy for Wound Healing in Leprosy Patients
Neuropathic ulcers are common sequelae of leprosy. The objectives of this study are to analyze the clinic-epidemiological characteristics of patients attended at one specialized dressing service from a leprosy-endemic region of…
- Trial name
- NCT00860717
- Testing
- Routine treatment, Low level laser therapy (LLLT)
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Para Federal University
Buruli Ulcer, Mycobacterium Ulcerans Disease
Pathogenesis and Management of M. Ulcerans Disease, Buruli Ulcer
Buruli ulcer is a neglected tropical disease caused by infection with Mycobacterium ulcerans (Mu) in rural parts of West Africa. It causes large skin ulcers mainly in children aged 5 to 15 years.
- Trial name
- Buruli_Path (NCT02153034)
- Where
- 3 sites in Ghana
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Kwame Nkrumah University of Science and Technology
Yaws, Cutaneous Ulcer
Repurposing Clinically Approved Drugs for Yaws With an Insight Into the Cutaneous Ulcer Disease Syndrome (Trep-AByaws)
The goal of this clinical trial is to test the non inferiority of linezolid compared with azithromycin as a treatment for yaws .
- Trial name
- Trep-AByaws (NCT05764876)
- Testing
- Linezolid Oral Tablet, Azithromycin Oral Tablet
- Where
- Papua New Guinea
- Volunteers
- 383 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Buruli Ulcer, Mycobacterium Ulcerans
BURULICO Drug Trial Study Protocol: RCT SR8/SR4+CR4, GHANA
The standard for treatment Buruli ulcer disease (BUD) used to be surgery but the WHO now advises streptomycin (S, 15 mg/kg daily, intramuscularly) and rifampicin (R,10 mg/kg daily) along with surgery.
- Trial name
- BURULICO (NCT00321178)
- Testing
- SR4 - switch to CR4
- Where
- 2 sites in Ghana
- Volunteers
- 151 people
- Sponsor
- University Medical Center Groningen
Corneal Ulcer, Eye Infections, Fungal
The Mycotic Ulcer Treatment Trial II: A Randomized Trial Comparing Oral Voriconazole vs Placebo
The purpose of this study is to determine if the addition of oral voriconazole to topical treatment regimens results in lower rates of perforation in severe fungal corneal ulcers.
- Trial name
- MUTTII (NCT00997035)
- Testing
- Voriconazole
- Where
- 7 sites in United States, India and 1 more
- Volunteers
- 240 people
- Sponsor
- University of California, San Francisco