Clinical trials: Basic Science
Opioid-Dependence Among Adolescents
Science-Based Treatment for Opioid-Dependent Adolescents
The purpose of this study is to evaluate ways to optimize outcomes from combined behavioral-pharmacological treatment for opioid-dependent youth.
- Trial name
- NCT00182572
- Testing
- buprenorphine, naltrexone, behavior therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Development and Research Institutes, Inc.
Substance Use, Substance-Related Disorders
Clinician Practice Companion to Address Youth Substance Use
Substance use, including the use of opioids, cannabis, and other drugs, is common among adolescents and young adults, and overdose has become a leading cause of death among youth in Canada and the United States.
- Conditions
- Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use
- Trial name
- NCT07725289
- Testing
- Practice Companion
- Where
- 5 sites in United States, Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Team-effectiveness Research, School-based Interventions
Enhancing Team Effectiveness for a Collaborative School-based Intervention for ADHD
The proposed project aims to integrate team-based implementation strategies with an established school-based intervention for children with ADHD, the Collaborative Life Skills Program (CLS), to enhance its implementation and…
- Conditions
- Team-effectiveness Research, School-based Interventions, Attention Deficit/ Hyperactivity Disorder, Implementation Science
- Trial name
- NCT06180681
- Testing
- Team-Enhanced Collaborative Life Skills Program, Standard Collaborative Life Skills Program
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of California, San Diego
Parent-Child Relations, Behavioral Intervention
Mobile Health (mHealth) Tools to Improve Delivery Quality of a Family Home Visiting Intervention
This study will pilot a family-focused, behavioral health intervention while also developing and piloting mHealth tools to support Community Health Workers (CHWs) in Sierra Leone.
- Conditions
- Parent-Child Relations, Behavioral Intervention, Exposure to Violent Event, Child Development
- Trial name
- NCT04481399
- Testing
- Family Strengthening Intervention for Early Childhood Development, Community Health Worker Routine
- Where
- Sierra Leone
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Boston College
Vaccine Refusal
Clinic-based HPV and COVID-19 Vaccine Promoting Intervention for AfAm Adolescents in Alabama
In this 30-month study, the investigators propose to develop a culturally appropriate vaccine confidence intervention, targeting positive change related to HPV vaccine uptake behavior and reducing sentiments of hesitancy towards…
- Trial name
- NCT04604743
- Testing
- Intervention, TBN
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Grief, Post Traumatic Stress Disorder
Building and Sustaining Interventions for Children: Task-sharing Mental Health Care in Low-resource Settings
The BASIC study will take place in Kanduyi/Bungoma South Sub-County, in western Kenya, and focuses on children orphaned by one or two parents.
- Conditions
- Grief, Post Traumatic Stress Disorder, Depression
- Trial name
- BASIC (NCT03243396)
- Testing
- Trauma-Focused Cognitive Behavioral Therapy
- Where
- Kenya
- Volunteers
- 956 people
- Sponsor
- Duke University
Humans, Simulation Training
Using 'Guided-Discovery-Learning' to Optimize and Maximize Transfer of Surgical Simulation
The study is a randomized experimental study comparing two forms of learning; guided-discovery-learning and traditional instructional learning.
- Conditions
- Humans, Simulation Training, Problem-Based Learning, Clinical Competence
- Trial name
- GDLEFFICACY (NCT03684720)
- Testing
- Discover followed by direct instruction [DD]
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Healthy
Developing and Validating Food-based Dietary Guidelines and a Healthy Eating Index
Among several factors contributing to the occurrence of undernutrition, micronutrient deficiencies, overnutrition, and chronic disease, unhealthy diet is one of the most important factors that need to be addressed to tackle the…
- Trial name
- NCT03394963
- Testing
- Food-based dietary guidelines for healthier diet
- Where
- Ethiopia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ethiopian Public Health Institute
Normal Healthy Embryos
Derivation of New Human Embryonic Stem Cell Lines: Identification of Instructive Factors for Germ Cells Development
The purpose of this study is 1. To generate human embryonic stem cells lines (hESC) lines 2. Study of the factors that contribute to differentiation towards germ cell.
- Trial name
- NCT01165918
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Mental Health, Parenting Stress
SBIR/ STTR Family Check-up Online
The Family Check-Up Online, a digital health intervention, was designed to improve child mental health through family-centered intervention.
- Conditions
- Mental Health, Parenting Stress, Academic Achievement, Parenting Skills
- Trial name
- NCT06876246
- Testing
- Family Check-Up Online, FCU Online with Telehealth Coaching
- Where
- United States
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Osteoarthritis, Knee, Cruciate Ligament Injury
Basic Research Projects Related to Sports Injuries
Biological samples are important human genetic resources, which can provide great value for medical research, and how to protect and rationally utilize them is of great importance.However, at present, the blood samples after…
- Conditions
- Osteoarthritis, Knee, Cruciate Ligament Injury, Patella Dislocation, Discoid Meniscus of Knee
- Trial name
- NCT04958551
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Obesity, Child
Scaling up Building Healthy Families
Evidence-based interventions for childhood obesity (EBI-CO) can improve children's weight status, but families in rural areas and small cities have limited access to the interdisciplinary healthcare teams recommended to deliver…
- Trial name
- NCT07404839
- Testing
- Building Healthy Families Program
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Utah
Covid19
Community-engaged Approaches to Testing in Community and Healthcare Settings for Underserved Populations
The pandemic caused by the novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has resulted in substantial global morbidity and mortality including in Oklahoma and caused unprecedented interruptions…
- Trial name
- CATCH-UP (NCT04870307)
- Testing
- Dissemination and Implementation Research
- Where
- United States
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Alcohol Use, Underage Drinking
Parent-Focused Alcohol Prevention Program for Hispanic Families in Faith-Based Settings
The goal of this clinical trial is to determine whether Guiando Buenas Decisiones, a parent-focused alcohol prevention program, can help prevent or delay alcohol initiation and use among Hispanic immigrant adolescents ages 12 to…
- Conditions
- Alcohol Use, Underage Drinking, Parenting Intervention, Prevention
- Trial name
- NCT07869550
- Testing
- Guiando Buenas Decisiones (GBD)
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Unplanned Hospitalizations
Sustainable Improvement of INTERprofessional Care for Better Resident Outcomes
INTERCARE is an interprofessional nurse-led care model developed specifically for long-term care facilities (LTCFs) in Switzerland that has been shown to successfully reduce unplanned transfers for residents.
- Trial name
- INTERSCALE (NCT06473051)
- Testing
- Original set, Adapted set
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Basel
Child Behavior Disorders
Teachers Leading the Frontlines (Tealeaf) - a Hybrid Effectiveness, Implement, and Context Trial
Purpose: The overall aim of this study is to evaluate the effectiveness, implementation, and contextual influences of a teacher-delivered transdiagnostic model of child mental health care (Tealeaf) for school-aged children in…
- Trial name
- Tealeaf (NCT05179759)
- Testing
- Tealeaf, Enhanced Usual Care
- Where
- India
- Volunteers
- 20,160 people
- Sponsor
- University of North Carolina, Chapel Hill