Clinical trials: Biliary Condition
Biliary Tract Cancer
Irinotecan, Gemcitabine, Chemotherapy for Biliary Tract Cancer
The study hypothesis is that chemotherapy of irinotecan and gemcitabine will improve local control of cancer and prolong survival in patients with inoperable biliary tract cancer.
- Trial name
- NCT00832689
- Testing
- Irinotecan and Gemcitabine
- Where
- South Korea
- Volunteers
- 39 people
- Sponsor
- Yonsei University
Cholestasis
Omegaven® as Parenteral Nutrition
The purpose of this study is to determine if a fat emulsion comprised of omega-3 fatty acids, Omegaven, would be beneficial in the management of steatotic liver injury in parenteral nutrition (PN) by its inhibition of de novo…
- Trial name
- NCT02334293
- Testing
- Omegaven
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Carle Foundation Hospital
Biliary Atresia, Kasai Portoenterostomy Status, Cholangitis
Cholangitis Definition and Treatment After Kasai Hepatoportoenterostomy for Biliary Atresia: TRACK-BA Study (TRacking Cholangitis Post Kasai in Biliary Atresia)
Biliary atresia is a rare liver disease affecting newborns. In those babies bile ducts are blocked, and bile cannot flow from the liver to the intestines.
- Trial name
- TRACK-BA (NCT07129655)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University Hospital, Geneva
Bile Duct Neoplasms Malignant
Stenting Malignant Jaundice for Quality of Life
Endoscopic stent insertion is considered the method of choice for palliation of malignant bile duct obstruction (MBDO). However, it can cause complications and requires periodic stent exchanges.
- Trial name
- NCT01459965
- Testing
- ERCP with 10 French biliary plastic stent placement, ERCP with 11.5 French biliary plastic stent
- Volunteers
- 164 people
- Sponsor
- Indiana University
Alagille Syndrome, Cholestasis
Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver Disease
OBJECTIVES: I. Determine the role of magnesium deficiency in the pathogenesis of decreased serum vitamin D and reduced bone density in children with chronic cholestatic liver disease.
- Conditions
- Alagille Syndrome, Cholestasis, Biliary Atresia
- Trial name
- NCT00007033
- Testing
- magnesium gluconate, magnesium sulfate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Center for Research Resources (NCRR)
Helicobacter Pylori Infection, Peptic Ulcer
The Revolutions of Helicobacter Pylori Infection, Bacterial Density, and Histological Features After Antrectomy
Helicobacter pylori (HP) is a gram-negative bacillus responsible for one of the most common infections found in humans worldwide.
- Conditions
- Helicobacter Pylori Infection, Peptic Ulcer, Bile Reflux, Gastritis
- Trial name
- NCT00441831
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- Mackay Memorial Hospital
Choledocholithiasis
Choledochotomy Techniques During LCBDE
complications after laparoscopic common bile duct exploration (LCBDE) regarding the choledochotomy technique have not been adequately studied in the literature.
- Trial name
- NCT04463381
- Testing
- choledochotomy techniques during LCBDE
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Sohag University
Acute Cholecystitis
Magnetic Resonance Cholangiography and Intraoperative Cholangiography in Acute Cholecystitis
The treatment of choice for acute cholecystitis is cholecystectomy performed as soon as possible after onset of symptoms. Up to 9-22% of patients undergoing cholecystectomy due to cholecystitis have common bile duct stones.
- Trial name
- NCT04059601
- Testing
- Magnetic resonance cholangiography, Intraoperative cholangiography
- Where
- Finland
- Volunteers
- 180 people
- Sponsor
- Jyväskylä Central Hospital
Primary Sclerosing Cholangitis, Elastography
Disease Status in Primary Sclerosing Cholangitis by Elastography
Primary sclerosing cholangitis (PSC) is a chronic liver disease that can lead to liver cirrhosis, liver failure and liver cancer.
- Conditions
- Primary Sclerosing Cholangitis, Elastography, Hepatic Fibrosis, Magnetic Resonance Imaging
- Trial name
- NCT02446665
- Testing
- MR Elastography (MRE) and FibroScan
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- University Health Network, Toronto
Biliary Disease
Common Bile Duct Pressures in Patients With and Without Cholelithiasis
Objective. To measure the pressures of the common bile duct in patients with and without cholelithiasis and relating them to the presence of pancreatobiliary reflux. Summary Background Data.
- Trial name
- NCT04025645
- Testing
- MEASUREMENT OF COMMON BILE DUCT PRESSURES
- Volunteers
- 87 people
- Sponsor
- Hospital de La Serena
Alagille Syndrome
Long-term Safety and Efficacy of Odevixibat in Patients With Alagille Syndrome
The purpose of this study is to assess the long-term safety and effectiveness of odevixibat in participants with Alagille syndrome (ALGS).
- Trial name
- ASSERT-EXT (NCT05035030)
- Testing
- Odevixibat
- Where
- 35 sites in United States, Belgium and 8 more
- Volunteers
- 62 people
- Sponsor
- Albireo, an Ipsen Company
Cholelithiasis, Inflammatory Response
Study of the Inflammatory Reaction in Standard vs Single Port Cholecystectomy for Uncomplicated Cholelithiasis
This is a study of the inflammatory reaction in standard 4 port laparoscopic cholecystectomy vs Single Port Laparoscopic (SIL) cholecystectomy.
- Trial name
- Lap vs SILS (NCT01116492)
- Testing
- Single incision laparoscopic cholecystectomy, Laparoscopic cholecystectomy
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- G. Hatzikosta General Hospital
Congenital Biliary Dilatation
Clinical Spectrum and Long-term Outcomes of Congenital Biliary Dilatation
Congenital biliary dilatation affects children and adults and can cause biliary complications and malignancy. Large multicenter data on its clinical characteristics and long-term outcomes are limited.
- Trial name
- NCT07903077
- Where
- China
- Volunteers
- 4,341 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Alagille Syndrome
A Study to Observe the Long-term Safety of Odevixibat in Patients With Alagille Syndrome (ALGS) Who Are Receiving Ongoing Treatment
This study will collect information from patients with ALGS who are using odevixibat in their daily lives. Odevixibat is a medication that helps patients with ALGS, a rare disease that affects the liver and causes itching.
- Trial name
- NCT07585097
- Where
- 14 sites in France, Italy
- Volunteers
- 30 people
- Sponsor
- Ipsen
Choledochal Cyst Resection, Biliary Atresia, Kasai Portoenterostomy Status
ERAS in Choledochal Cyst & Biliary Atresia
This study aims to compare two feeding approaches after surgery for biliary atresia and choledochal cyst in children. Traditionally, children are kept without oral feeding for more than 48 hours after these operations until bowel…
- Trial name
- NCT07709702
- Testing
- Enhanced Recovery After Surgery, Post-operative care
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Muhammad Zubair Shoukat
Portal Hypertension, Biliary Atresia
Primary Prophylaxis for Variceal Bleed in Biliary Atresia
Biliary atresia is the commonest etiology of neonatal cholestasis and is the most common indication for pediatric liver transplantation world-wide.
- Trial name
- BA-BB (NCT04494763)
- Testing
- Propanolol
- Where
- India
- Volunteers
- 92 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8
Pharmacogenomics Testing in the Optimal Use of Supportive Care Medications in Stage III-IV Cancer
This early phase I trial studies how well a genetic test called pharmacogenomics works in directing the optimal use of supportive care medications in patients with stage III-IV cancer.
- Conditions
- Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Anatomic Stage IIIC Breast Cancer AJCC v8
- Trial name
- NCT04067960
- Testing
- Biospecimen Collection, Genetic Testing, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Biliary Atresia, Cholangitis
Preventive Effect of Prophylactic Oral Antibiotics Against Cholangitis After Kasai Portoenterostomy
This study is non-inferiority trial design. This study aimed to investigate the effect of prophylactic oral antibiotics on preventing cholangitis in biliary atresia (BA) patients after Kasai portoenterostomy (KP) by comparing the…
- Conditions
- Biliary Atresia, Cholangitis, Anti-Bacterial Agents
- Trial name
- NCT05925309
- Testing
- Basic treatment: sulperazone + ursodeoxycholic acid + compound glycyrrhizin + methylprednisolone + vitamin AD , D , E , K + imipenem or meropenem, Prophylactic oral antibiotics: compound sulfamethoxazole tablet (SMZ/TMP) + cefaclor
- Where
- China
- Volunteers
- 356 people
- Sponsor
- Children's Hospital of Fudan University
Liver Cirrhosis, Biliary
Autologous Bone Marrow Mononuclear Stem Cell for Children Suffering From Liver Cirrhosis Due to Biliary Atresia
The aim of this study was to evaluate the safety and effectiveness of autologous bone marrow mononuclear stem cell transplantation for Children Suffering from Liver Cirrhosis Due to Biliary Atresia
- Trial name
- NCT03468699
- Testing
- Autologous BMMC transplantation
- Where
- 2 sites in Vietnam
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Anesthesia, Pediatrics
Norepinephrine for Prevention of Intraoperative Hypotension in Infants Undergoing Kasai Portoenterostomy
This study aims to assess the efficacy and safety of prophylactic intraoperative norepinephrine infusion versus the standard technique on decreasing the incidence of intraoperative hypotension in infants undergoing Kasai…
- Conditions
- Anesthesia, Pediatrics, Biliary Atresia
- Trial name
- NCT05521152
- Testing
- Norepinephrine Bitartrate
- Where
- Egypt
- Volunteers
- 31 people
- Sponsor
- Kasr El Aini Hospital