Clinical trials: Biofilm Formation
Multidrug Resistant Klebsiella Pneumoniae Infection
Phenotypic and Genotypic Detection of Biofilm Formation and Efflux Pump Activity in Multi-drug Resistant Klebsiella Pneumoniae
1. Sample: urine, pus and sputum samples. 2. Culture: the samples will be inoculated on the MacConkey agar and subcultured on eosine methylene blue agar. 3. Identification of isolates will be done by: Colony morphology.
- Trial name
- Klebsiella (NCT07541690)
- Testing
- Genotypic Detection of Biofilm Formation and Efflux Pump Activity.
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Dental Plaque
A Protocol for the Use of Chlorhexidine Gluconate Saturation for the Reduction of Dental Biofilm Formation on Polymethylmethacrylate Restoration
Chlorhexidine gluconate (CHX), as an anti plaque agent, is commonly used with a variety of products. In this study we, the investigators at Hadassah Medical Organization, intend to examine the efficacy of a single dip in CHX of…
- Trial name
- NCT00259181
- Testing
- saturation of polymethylmethacrylate with chlorhexidine gluconate to reduce in vivo plaque formation
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Orthodontic Aligner Material, Enamel Demineralization
Development of Biofunctional 3D-Printed Orthodontic Aligners With Antimicrobial and Remineralizing Properties
Clear orthodontic aligners are widely used due to their esthetics and patient comfort; however, prolonged wear may promote biofilm accumulation and enamel demineralization.
- Conditions
- Orthodontic Aligner Material, Enamel Demineralization, Dental Biofilm Formation, Clear Aligner Material Properties
- Trial name
- 3D-BIOALIGN (NCT07603427)
- Testing
- Modified 3D-Printed Orthodontic Aligner Resin
- Where
- Iraq
- Volunteers
- 400 people
- Sponsor
- University of Baghdad
Oral Disease
Effect of Different Cleaning Regimes on Biofilm Formation of Acrylic Based Removable Orthodontic Appliance
This study is to evaluate the effects of different cleaning regimes i.e. chemical and mechanical on biofilm formation of an acrylic based removable orthodontic appliance and to find out if surface modification i.e.
- Trial name
- NCT05707221
- Testing
- cleaning removable acrylic appliance with denture brush and chlorhexidine toothpaste, cleaning removable acrylic appliance with cleansing tablet, combination of mechanical and chemical cleaning
- Where
- Iraq
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Candida Infection
Biofilm Formation and Antifungal Resistance in Candida Species
1. To determine the susceptibility pattern of our local isolated Candida strains which is essential for optimal management of fungal infection. 2. Detection of biofilm formation by conventional and molecular methods 3.
- Trial name
- NCT07245563
- Volunteers
- 300 people
- Sponsor
- Assiut University
Healthy
Collection of Dental Plaque and Saliva for Studies of Bacterial Colonization of Teeth
This study will explore how bacteria colonize human teeth and how this process changes over the lifetime of individuals. It will include an investigation of transmission of bacteria that initiate colonization between adults and…
- Trial name
- NCT00098267
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Dental Plaque, Dental Caries
Probiotic Treatment of Orthodontic Patients
The purpose of this study is to examine the effect of treatment with a lozenge containing the probiotic strain S. salivarius M18 on the formation, composition and virulence of dental plaque and in healthy orthodontic patients…
- Trial name
- NCT06751979
- Testing
- Probiotic treatment
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Mandibular Prosthesis User
Assessment of the Impact of Probiotics on Biofilm Formation on Removable Acrylic Dentures
The aim of this study is to evaluate the effect of PIP toothbrush cleaner® on the microbial composition and Candida albicans colonization of denture biofilm formation.
- Trial name
- NCT02736994
- Testing
- PIP toothbrush cleaner® (Chrisal, Lommel, Belgium)., Corega Tabs Anti-bacteria®, Water
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pseudomonas Aeroginosa
mexB Efflux Pump Gene Expression, Activity and Biofilm Formation in Clinical Isolates of Pseudomonas Aeruginosa
1. Detection of expression level of mexB efflux pump gene in multidrug resistant clinical isolates of Pseudomonas aeruginosa by real time PCR(QRT-PCR). 2.
- Trial name
- NCT07469436
- Testing
- Real time PCR
- Volunteers
- 80 people
- Sponsor
- Assiut University
Bacterial Colonization
Bacterial Colonization on Nails Covered With a Methacrylic Coating
In the research, the investigators will monitor the bacterial colonization of nails coated with a methacrylic coating
- Trial name
- NCT06831305
- Testing
- Comparison of microbiological sampling on natural nails, Comparison of microbiological sampling on methacrylic nails
- Where
- Slovenia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Chronic Serous Otitis Media, Simple or Unspecified
Prevalence of Mucosal Biofilm Formations in Adenoidectomy Specimens
Rationale: Bacterial biofilms are defined as an assemblage of bacterial cells enclosed in a self-produced glycocalyx matrix. Adherence on surfaces, and resistance to both antibiotic treatments and host defenses are ones of the…
- Trial name
- BOLERO (NCT01022944)
- Testing
- With chronic middle ear effusion, Without chronic middle ear effusion
- Where
- France
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Staphylococcal Aureus Infection, Surgical Site Infection (SSI)
Gene Expression Analysis of Biofilm Formation and Antimicrobial Resistance in Clinical Methicillin-Resistant Staphylococcus Aureus
Staphylococcus aureus are Gram-positive cocci that asymptomatically colonize the skin and mucosal surfaces of approximately 20-30% of healthy individuals . Although they commonly exist as a harmless commensal organisms, S.
- Trial name
- NCT07796555
- Testing
- swab from lesion, Biochemical reactions, Antibiotic sensitivity
- Volunteers
- 100 people
- Sponsor
- Sohag University
Orthopedic Surgery
Biofilm Formation and Antibiotic Sensitivity Patterns
Detection of bacteria that form biofilm and its sensitivity to antibiotics in patients with surgical site infection after orthopedic surgery.
- Trial name
- NCT05181163
- Testing
- swab
- Volunteers
- 100 people
- Sponsor
- Sohag University
Detection of Type VI Secretion System in K.Pneumoniae, Detection of Relation to Ab Resistance, Biofilm
Type VI Secretion System in Klebsiella Pneumoniae
Klebsiella pneumoniae (K. pneumoniae) is an important opportunistic pathogen contributing to nosocomial and antimicrobial-resistant infections. The increasing prevalence of infections caused by multidrug-resistant K.
- Trial name
- Klebsiella (NCT05516654)
- Testing
- Routine bacteriological cultures, Identification of the organism and antibiotic sensitivity will be done by VITEK II, Detection of biofilm formation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Sohag University