Clinical trials: Bleeding
Scoliosis; Spinal Fusion; Blood Transfusion; Operative Blood Loss
Blood Transfusion Risk Factors and Cell Saver Impact in Pediatric Scoliosis Surgery
Spine surgery for scoliosis correction in pediatric patients is a major procedure associated with a high risk of perioperative blood loss.
- Trial name
- NCT07661589
- Testing
- posterior Instrumented Spinal Fusion, Intraoperative Cell Saver Autologous Reinfusion
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Mehdi Trifa
Aneurysm, Vasospasm
Balloon Prophylaxis of Aneurysmal Vasospasm
The purpose of this study is to determine if early transluminal ballooning of the major cerebral arteries prevents severe vasospasm and improves neurological outcome in patients with Fisher Grade III aneurysmal subarachnoid…
- Trial name
- NCT00282893
- Testing
- transluminal ballooning, currently existing therapies for the treatment of vasospasm
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 170 people
- Sponsor
- University of California, Davis
Congenital Bleeding Disorder, Glanzmann's Disease
Observational Registry of the Treatment of Glanzmann's Thrombasthenia
This observational registry is conducted in Europe, Asia, Africa and the United States of America (USA). The purpose of the registry is to evaluate the efficacy and safety of activated recombinant human factor VII (rFVIIa) during…
- Trial name
- NCT01476423
- Testing
- activated recombinant human factor VII
- Where
- 15 sites in United States, Algeria and 13 more
- Volunteers
- 218 people
- Sponsor
- Novo Nordisk A/S
Cirrhosis
Primary Prophylaxis of Gastric Varix Bleed
In patients who have never bled from gastric varix (GOV2 and IGV1), cyanoacrylate injection will be better than both beta-blocker therapy and no treatment in prevention of gastric variceal bleed.
- Trial name
- NCT00905996
- Testing
- Endoscopic cyanoacrylate injection, Beta-blocker (propranolol)
- Where
- India
- Volunteers
- 74 people
- Sponsor
- Govind Ballabh Pant Hospital
Idiopathic Scoliosis
Study of DDAVP Combined With TXA on the Blood Loss and Transfusion Need During and After Scoliosis Correction Surgery
Intraoperative administration of tranexamic acid (TXA,T) reduces significantly blood loss and blood transfusion requirements during spinal posterior fusion in adolescents with scoliosis.
- Trial name
- NCT02084342
- Testing
- tranexamic acid and sodium chloride injection, normal saline, desmopressin acetate injection
- Volunteers
- 60 people
- Sponsor
- Liu Weifeng
Renal Disease, End Stage, Anticoagulant-induced Bleeding
Safety and Efficacy of Apixaban in Severe Renal Impairment
Despite emergence of new anticoagulants over the last few years, patients with advanced chronic kidney disease still have limited options and are usually managed with warfarin after venous thromboembolism or diagnosis of atrial…
- Trial name
- NCT03399305
- Where
- United States
- Sponsor
- Albert Einstein College of Medicine
Intracranial Hemorrhages, Acute Ischemic Stroke
AI Assisted Reader Evaluation in Acute Computed Tomography (CT) Head Interpretation
This study has been added as a sub study to the Simulation Training for Emergency Department Imaging 2 study (ClinicalTrials.gov ID NCT05427838).
- Conditions
- Intracranial Hemorrhages, Acute Ischemic Stroke, Hydrocephalus, Cerebral Infarction
- Trial name
- AI-REACT (NCT06018545)
- Testing
- Ground truthing, Reading
- Where
- 4 sites in United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Abnormal Uterine Bleeding
Patient Satisfaction With Initial Phone Call Versus Office Visit Following Minimally Invasive Hysterectomy, a Randomized Controlled Trial.
Patients will be randomized to clinic or telephone follow up after outpatient TLH. surveys will document patient satisfaction.
- Trial name
- NCT03809468
- Testing
- phone call follow up
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Dipeptidyl-peptidase-4, STEMI
Plasma Dipeptidyl-peptidase-4 Activities With No-reflow and Bleeding
Dipeptidyl-peptidase-4 (DPP4) is an important regulator of incretins and inflammation, and participates in the pathophysiological process of acute myocardial infarction (AMI).
- Conditions
- Dipeptidyl-peptidase-4, STEMI, PCI, No-reflow
- Trial name
- NCT02849691
- Volunteers
- 747 people
- Sponsor
- Chinese PLA General Hospital
Hematuria, Urothelial Neoplasm
Safely Reduce Cystoscopic Evaluations for Hematuria Patients
The SeARCH-trial assess the clinical impact of a molecular urine test as a 'urine-first' strategy in the diagnostic workup of patients presenting with microscopic hematuria.
- Conditions
- Hematuria, Urothelial Neoplasm, Urothelial Carcinoma, Bladder Cancer
- Trial name
- SeARCH (NCT06026189)
- Testing
- urine-first strategy
- Where
- Netherlands
- Volunteers
- 1,100 people
- Sponsor
- Erasmus Medical Center
Minor Head Injury, Intracranial Bleeding
Risk Factors of Minor Head Injury
Introduction and Aims: The objective of this prospective study is to evaluate the risk factors of minor head injury in all consecutive patients of one year.
- Conditions
- Minor Head Injury, Intracranial Bleeding, Traumatic Brain Injury
- Trial name
- NCT00451789
- Where
- Austria
- Volunteers
- 12,500 people
- Sponsor
- Medical University of Vienna
Uterine Leiomyoma
Study on the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women With Uterine Myoma
The investigators want to know whether the intravenous ascorbic acid would reduce the blood loss during laparoscopic myoma surgery.
- Trial name
- NCT01715597
- Testing
- ascorbic acid, Normal saline
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Haemophilia B
A Research Study Investigating Nonacog Beta Pegol (N9-GP) for Treatment and Prevention of Bleedings in Chinese People With Haemophilia B
The study investigates how well the medicine called nonacog beta pegol (N9-GP) works in Chinese people with haemophilia B. Participants will be treated with N9-GP.
- Trial name
- Paradigm9 (NCT05365217)
- Testing
- Nonacog beta pegol
- Where
- 15 sites in China
- Volunteers
- 30 people
- Sponsor
- Novo Nordisk A/S
Enamel Demineralization
Comparative Assessment of Adhesive PreCoated (APC) Flash-free and Conventional Brackets and the Effects on Enamel Demineralization and Periodontal Health
Adhesive PreCoated (APC) flash-free brackets have been recently introduced, with no need of flash removal step. Evaluation of APC and conventional brackets and their effects on enamel demineralization and periodontal health.
- Trial name
- NCT07752290
- Testing
- Group A, Group B
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Respiratory Distress Syndrome In Premature Infants
Safety and Efficacy Study of the Draeger Babylog VN500 Device in HFOV Mode in VLBW Neonates
The purpose of this study is to determine the safety and effectiveness of the Babylog VN500 in high frequency oscillatory ventilation (HFOV) mode as a method for treating very low birth weight (VLBW) neonates requiring invasive…
- Trial name
- NCT02445040
- Testing
- Babylog VN500 in HFOV Mode
- Where
- 14 sites in United States
- Volunteers
- 225 people
- Sponsor
- Draeger Medical Systems, Inc.
Acquired Bleeding Disorder, Cardiac Surgery Requiring Cardiopulmonary Bypass
Activated Recombinant Human Factor VII Following Cardiac Bypass Surgery for Paediatric Congenital Heart Disease
This trial is conducted in Oceania. The aim of this trial is to investigate the efficacy of activated recombinant human factor VII and standard treatment compared with standard haemostatic replacement therapy in cardiopulmonary…
- Trial name
- NCT01562574
- Testing
- activated recombinant human factor VII
- Where
- Australia
- Volunteers
- 82 people
- Sponsor
- Novo Nordisk A/S
Vaginal Bleeding
Long-Term Outcome Following Laparoscopic Supracervical Hysterectomy Performed With and Without Excision of the Endocervix in a Reverse Cone Pattern
The occurrence of persistent vaginal bleeding following laparoscopic supracervical hysterectomy (LSH) is reported in the wide range of 0 % - 25 %.
- Trial name
- LSH-LAPCONE (NCT00921778)
- Testing
- Lapcone, laparoscopic supracervical hysterectomy
- Where
- Norway
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Cardiac Surgical Procedures, Blood Coagulation Disorders
Fibrinogen Concentrate In Children After Cardiac Surgery
The purpose of this study is to evaluate prospectively whether concentrate fibrinogen reduces blood losses, transfusion requirements and occurrence of clinical complications compared to cryoprecipitate in children after cardiac…
- Conditions
- Cardiac Surgical Procedures, Blood Coagulation Disorders, Fibrinogen, Cryoprecipitate
- Trial name
- FiCCS (NCT01187225)
- Testing
- Fibrinogen concentrate, Cryoprecipitate
- Where
- Brazil
- Volunteers
- 63 people
- Sponsor
- University of Sao Paulo
Vessel Puncture Site Bleeding
Ultrasound-guided In-plane Puncture of the Femoral Artery
In Germany almost 1 million cardiac catheterizations are performed each year. These procedures can be done either by a transradial or a transfemoral approach. Today, the transradial approach is the recommended default strategy.
- Trial name
- PARFEM (NCT06065943)
- Testing
- Palpation and Fluoroscopy, Ultrasound guidance
- Where
- Germany
- Volunteers
- 286 people
- Sponsor
- Wuerzburg University Hospital
Pregnancy of Unknown Location (PUL)
Expediting Pregnancy of Unknown Location Risk Stratification Using the ROM-Plus Point of Care Test
The goal of this study is to learn if the ROM-Plus bedside test can effectively triage patients who present with pregnancy of unknown location (PUL) and vaginal bleeding as high or low risk for ectopic pregnancy.
- Trial name
- NCT07519954
- Testing
- ROM-Plus bedside test
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
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