Clinical trials: Bleeding Disorder
Hemophilia
Safety and Efficacy of FVIIa to Prevent Excessive Bleeding in Hemophilia Patients With Inhibitors Undergoing Major Surgery
This is an interventional, prospective, international, multicenter, single-arm, Phase 3, and sequential efficacy and safety study in adolescents and adults with congenital hemophilia A or B with inhibitors to factor VIII (FVIII)…
- Trial name
- SCOPE HIM (NCT05695391)
- Testing
- Coagulation Factor VIIa (Recombinant)
- Where
- 15 sites in United States, Malaysia and 4 more
- Volunteers
- 2 people
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Coagulation Defect; Bleeding
ROTEM Versus aPTT/PT in Pediatric Surgery
Hemocoagulation management in perioperative bleeding is nowadays based on standard coagulation testing: activated partial thromboplastin time (aPTT), prothrombin time (PT), fibrinogen, D-dimers, platelets.
- Trial name
- NCT03699813
- Testing
- Comparison of two approaches to bleeding management
- Volunteers
- 45 people
- Sponsor
- University Hospital, Motol
Dysplasia, Congenital Hip
Efficacy of Tranexamic Acid for Reducing Blood Loss and Blood Transfusion After Periacetabular Osteotomy
The goal of this randomized controlled, double-blinded trial is to assess the efficacy of intravenous tranexamic acid, a drug, in reducing blood loss and transfusion in patients undergoing periacetabular osteotomy, an elective…
- Trial name
- NCT02253810
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Hospital for Special Surgery, New York
Anxiety, Postoperative Pain
Evaluation of the Postoperative Agitation Prevention and Analgesic Efficacy of Perioperative Dexmedetomidine Infusion in a Pediatric Patient Group to Undergo Tonsillectomy and Adenoidectomy
Dexmedetomidine is a drug known for its pain-relieving and restlessness-reducing effects. The purpose of this run is to use the association between this use during surgery and the attrition of post-operative pain and discomfort.
- Conditions
- Anxiety, Postoperative Pain, Bleeding
- Trial name
- NCT05986942
- Testing
- Fentanyl, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Burak Omur
Hemophilia B
Gene Therapy for Hemophilia B Patients Aged 12-18 Years Old
This is a Phase 1, open- label, non- randomized, uncontrolled, single dose pilot study to evaluate the safety, tolerability and efficacy of a single intravenous infusion of BBM-H901 in hemophilia B subjects with ≤2IU/dl residual…
- Trial name
- NCT05709288
- Testing
- BBM-H901
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Thrombocytopenia
Optimal Platelet Dose Strategy for Management of Thrombocytopenia
The primary objective of this study is to compare the three study arms of lower, medium, and higher dose platelet therapy with respect to the percentage of patients experiencing at least one episode of Grade 2 or higher bleeding…
- Trial name
- PLADO (NCT00128713)
- Testing
- Medium Dose Prophylactic Platelet Transfusions, Lower Dose Prophylactic Platelet Transfusions, Higher Dose Prophylactic Platelet Transfusions
- Where
- 21 sites in United States
- Volunteers
- 1,351 people
- Sponsor
- Carelon Research
Hemophilia A
Extension at 10 Years of the: "Observational Study Evaluating Efficacy and Costs of Secondary Prophylaxis vs On-demand Therapy With Kogenate Bayer in Patients With Severe Haemophilia A."
Following the performance of the POTTER observational study, whose primary objective was to collect data on the benefits of secondary prophylaxis versus on demand treatment in terms of prevention of bleeding episodes, the present…
- Trial name
- POTTER 10 (NCT02581969)
- Testing
- Recombinant Factor VIII (Kogenate FS, BAY14-2222)
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- Bayer
Congenital Bleeding Disorder, Haemophilia B
Safety, Efficacy and Pharmacokinetics of NNC-0156-0000-0009 in Previously Treated Children With Haemophilia B.
This trial is conducted in Asia, Europe and North America. The aim of the trial is to evaluate safety, efficacy and pharmacokinetics (the exposure of the trial drug in the body) of NNC-0156-0000-0009 (nonacog beta pegol, N9-GP)…
- Trial name
- paradigm™5 (NCT01467427)
- Testing
- nonacog beta pegol
- Where
- 51 sites in United States, Brazil and 10 more
- Volunteers
- 25 people
- Sponsor
- Novo Nordisk A/S
HIV Infections, Hepatitis C
Treatment of Hepatitis C in Hemophilic Patients With HIV
Pegylated interferon (PEG-interferon) and ribavirin are accepted treatments for hepatitis C virus (HCV) infection. However, HCV infection progresses differently in patients who are coinfected with HIV and in hemophiliacs.
- Conditions
- HIV Infections, Hepatitis C, Hemophilia
- Trial name
- NCT00055341
- Testing
- Peginterferon alfa-2a, Ribavirin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Scoliosis; Spinal Fusion; Blood Transfusion; Operative Blood Loss
Blood Transfusion Risk Factors and Cell Saver Impact in Pediatric Scoliosis Surgery
Spine surgery for scoliosis correction in pediatric patients is a major procedure associated with a high risk of perioperative blood loss.
- Trial name
- NCT07661589
- Testing
- posterior Instrumented Spinal Fusion, Intraoperative Cell Saver Autologous Reinfusion
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Mehdi Trifa
Aneurysm, Vasospasm
Balloon Prophylaxis of Aneurysmal Vasospasm
The purpose of this study is to determine if early transluminal ballooning of the major cerebral arteries prevents severe vasospasm and improves neurological outcome in patients with Fisher Grade III aneurysmal subarachnoid…
- Trial name
- NCT00282893
- Testing
- transluminal ballooning, currently existing therapies for the treatment of vasospasm
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 170 people
- Sponsor
- University of California, Davis
Congenital Bleeding Disorder, Glanzmann's Disease
Observational Registry of the Treatment of Glanzmann's Thrombasthenia
This observational registry is conducted in Europe, Asia, Africa and the United States of America (USA). The purpose of the registry is to evaluate the efficacy and safety of activated recombinant human factor VII (rFVIIa) during…
- Trial name
- NCT01476423
- Testing
- activated recombinant human factor VII
- Where
- 15 sites in United States, Algeria and 13 more
- Volunteers
- 218 people
- Sponsor
- Novo Nordisk A/S
Hemophilia B
BAX 326 Surgery Study in Hemophilia B Patients
The purpose of the study is to assess the hemostatic efficacy and safety of BAX 326 in subjects with severe (FIX level < 1%) or moderately severe (FIX level 1-2%) hemophilia B undergoing major or minor elective or emergency…
- Trial name
- NCT01507896
- Testing
- Recombinant factor IX
- Where
- 14 sites in Argentina, Bulgaria and 8 more
- Volunteers
- 30 people
- Sponsor
- Baxalta now part of Shire
Hemophilia B, Factor IX Deficiency
Phase I/II Study of Monoclonal Factor IX Concentrate for Factor IX Deficiency
OBJECTIVES: Assess the safety and long-term efficacy of monoclonal factor IX concentrate in patients with factor IX deficiency.
- Trial name
- NCT00004801
- Testing
- monoclonal factor IX replacement therapy
- Volunteers
- 3 people
- Sponsor
- National Center for Research Resources (NCRR)
Renal Disease, End Stage, Anticoagulant-induced Bleeding
Safety and Efficacy of Apixaban in Severe Renal Impairment
Despite emergence of new anticoagulants over the last few years, patients with advanced chronic kidney disease still have limited options and are usually managed with warfarin after venous thromboembolism or diagnosis of atrial…
- Trial name
- NCT03399305
- Where
- United States
- Sponsor
- Albert Einstein College of Medicine
Hemophilia A
Pharmacokinetics and Safety of a Single Intravenous Infusion of BAY 79-4980
The primary objective of this study is to determine the pharmacokinetic profile after single administration of two doses of BAY 79-4980 (high and low: 35 IU FVIII/Kg reconstituted in 22 mg and 13 mg of liposomes/Kg, respectively)…
- Trial name
- NCT00629837
- Testing
- Recomb. Factor VIII (Kogenate FS Liposome, BAY79-4980), Recombinant Factor VIII (Kogenate FS, BAY14-2222)
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Bayer
Intracranial Hemorrhages, Acute Ischemic Stroke
AI Assisted Reader Evaluation in Acute Computed Tomography (CT) Head Interpretation
This study has been added as a sub study to the Simulation Training for Emergency Department Imaging 2 study (ClinicalTrials.gov ID NCT05427838).
- Conditions
- Intracranial Hemorrhages, Acute Ischemic Stroke, Hydrocephalus, Cerebral Infarction
- Trial name
- AI-REACT (NCT06018545)
- Testing
- Ground truthing, Reading
- Where
- 4 sites in United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Abnormal Uterine Bleeding
Patient Satisfaction With Initial Phone Call Versus Office Visit Following Minimally Invasive Hysterectomy, a Randomized Controlled Trial.
Patients will be randomized to clinic or telephone follow up after outpatient TLH. surveys will document patient satisfaction.
- Trial name
- NCT03809468
- Testing
- phone call follow up
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Dipeptidyl-peptidase-4, STEMI
Plasma Dipeptidyl-peptidase-4 Activities With No-reflow and Bleeding
Dipeptidyl-peptidase-4 (DPP4) is an important regulator of incretins and inflammation, and participates in the pathophysiological process of acute myocardial infarction (AMI).
- Conditions
- Dipeptidyl-peptidase-4, STEMI, PCI, No-reflow
- Trial name
- NCT02849691
- Volunteers
- 747 people
- Sponsor
- Chinese PLA General Hospital
Hematuria, Urothelial Neoplasm
Safely Reduce Cystoscopic Evaluations for Hematuria Patients
The SeARCH-trial assess the clinical impact of a molecular urine test as a 'urine-first' strategy in the diagnostic workup of patients presenting with microscopic hematuria.
- Conditions
- Hematuria, Urothelial Neoplasm, Urothelial Carcinoma, Bladder Cancer
- Trial name
- SeARCH (NCT06026189)
- Testing
- urine-first strategy
- Where
- Netherlands
- Volunteers
- 1,100 people
- Sponsor
- Erasmus Medical Center
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