Clinical trials: Bloodstream Infections
Infection
Continuous Antibiotic Infusion In Children
Continuous intravenous antibiotic infusion using elastomeric pumps is well established in adult care and has been shown to be effective, safe, and cost-efficient, particularly for beta-lactams and vancomycin.
- Trial name
- NCT07575009
- Testing
- Benzylpenicillin
- Where
- Finland
- Volunteers
- 150 people
- Sponsor
- Tampere University Hospital
Infant, Newborn, Infant, Low Birth Weight
Intravenous Immune Globulin (IVIG) to Prevent Neonatal Infection
A controlled clinical trial was conducted at eight participating centers between January 1, 1988, and March 31, 1991. Patients were randomly assigned to an intravenous immune globulin group or a control group.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- IVIG (NCT01203345)
- Testing
- IVIG
- Where
- 8 sites in United States
- Volunteers
- 2,416 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Sepsis
Establishment of Early Diagnosis and Monitoring Model for Sepsis Patients
In recent years, although the clinical treatment of sepsis has been greatly improved, it is still an important cause of death in ICU patients, and seriously threatens human health.
- Trial name
- EDAMMFS (NCT04974411)
- Testing
- infection, sepsis
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Sepsis
nSeP: Detecting Neonatal Sepsis by Immune-Metabolic Network Analysis
Diagnosis of neonatal sepsis remains a challenge due to non-specific signs and diagnostic inaccuracies. Studies have shown that this could lead to overdiagnosis and overuse of antibiotic treatment, with potential long-term…
- Trial name
- nSeP (NCT03777670)
- Testing
- Blood test
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Cardiff and Vale University Health Board
Neonatal Sepsis
White Blood Cells and Platelets Indices as a Prognostic Factor in Neonatal Sepsis
Sepsis is a complex condition initiated by a pathogen and mediated by cytokines followed by immune, inflammatory, and coagulation homeostasis disturbances, its evolution being dictated by a complicated balance between pro…
- Trial name
- NCT03880305
- Testing
- complete blood count
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Sepsis, Bacteremia
Safety and Efficacy of MBI 226 for the Prevention of Central Venous Catheter-Related Bloodstream Infections
Central venous catheters (CVCs) are used in patient care for such purposes as the administration of medication, fluids, blood products and for functions such as hemodialysis and plasmapheresis.
- Conditions
- Sepsis, Bacteremia, Fungemia
- Trial name
- NCT00027248
- Testing
- MBI 226
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- BioWest Therapeutics Inc
Necrotizing Enterocolitis, Sepsis
The Role of Lactobacillus Reuteri in Preventing Necrotizing Enterocolitis (NEC) in Pre-term Infants
The purpose of this study is to compare the effectiveness of L. Reuteri with placebo in prevention of NEC in children, as according to my knowledge, there is limited work is done nationally and internationally.
- Trial name
- NEC (NCT04541771)
- Testing
- Lactobacillus Reuteri DSM 17938
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital and Institute of Child Health, Multan
Premature Intestinal Microbiota, Necrotizing Enterocolitis
Defining the Intestinal Microbiota in Premature Neonates
The investigators will collect daily faecal samples from premature (<32 weeks) infants in the intensive care unit from the day of birth until they are discharged.
- Conditions
- Premature Intestinal Microbiota, Necrotizing Enterocolitis, Late Onset Bloodstream Infection
- Trial name
- NCT01102738
- Where
- 3 sites in United Kingdom
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Parasitemia
Parasitic Clearance and Recurrence Rates Among Patients With Vivax Malaria
This research is intended to study the efficacy of CQ alone for P.vivax infection and also to study the recurrence rate among patients with P.vivax on standard dose of CQ and PQ.
- Trial name
- BCAPES (NCT01784315)
- Testing
- Artemisinin combination therapies (ACT)will be used for Chloroquine resistant P.vivax, Chloroquine and Primaquine
- Where
- 3 sites in Bhutan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Bhutan
Acute Myeloid Leukemia, Neutropenia
Home Away From Home - Medical Outcomes
Treatment for pediatric acute myeloid leukemia (AML) involves intensive chemotherapy regimens that result in periods of profound neutropenia leaving patients susceptible to severe infectious complications.
- Conditions
- Acute Myeloid Leukemia, Neutropenia, Bacteremia
- Trial name
- Aim 1 (NCT02774850)
- Where
- 17 sites in United States
- Volunteers
- 610 people
- Sponsor
- Children's Hospital of Philadelphia
Sepsis, Liver Injury
Sepsis Associated Liver Injury in Pediatric Sepsis at Assiut University Children's Hospital - 2026
This prospective cohort study aims to determine the incidence of sepsis-associated liver injury (SALI) among pediatric patients with sepsis admitted to Assiut University Children's Hospital and to evaluate its association with…
- Trial name
- NCT07832890
- Volunteers
- 158 people
- Sponsor
- Assiut University
Early-Onset Sepsis, Neonatal, EOS
Safely Reduce Newborn Antibiotic Exposure With the Early-onset Sepsis Calculator
Newborns are at risk for early-onset sepsis (EOS), which occurs within 72 hours after birth. The incidence of proven EOS is 0.5-2.0 per 1000 live births.
- Trial name
- NCT05274776
- Testing
- EOS calculator
- Where
- 10 sites in Netherlands
- Volunteers
- 1,830 people
- Sponsor
- prof. dr. Frans B. Plötz
Postpartum Period, Sepsis
Correlation of Survival in Puerperae by Electrical Impedance Tomography
Introduction: Electrical Impedance Tomography (TIE) consists of an equipment that enables the visualization / quantification in real time of the regional distribution of ventilation and pulmonary perfusion, as well as of…
- Conditions
- Postpartum Period, Sepsis, Respiratory Distress Syndrome,Adult, HELLP Syndrome
- Trial name
- COSIPBEIT (NCT03715647)
- Testing
- Sepsis, HELLP Syndrome, Respiratory Distress Syndrome Adult
- Volunteers
- 30 people
- Sponsor
- Amazon University
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Bacteremia, Periodontal Diseases
Bacteremia From Periodontal Treatment to Elucidate the Underpinnings of Sepsis
Approximately 40,000 Swedes suffer from sepsiseach year, about 20% die. Biomarkers that are sensitive to current or previous bacteremia are needed in the treatment of sepsis.
- Conditions
- Bacteremia, Periodontal Diseases, Sepsis, Heart Diseases
- Trial name
- NCT04565691
- Testing
- Non-surgical periodontal treatment
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Malmö University
Neonatal Sepsis, Refractory Shock
Methylene Blue Versus Vasopressin Analogue for Treatment of Septic Shock in Preterm Neonate
A randomized, prospective study comparing methylene blue versus terlipressin in treatment of catecholamines resistant shock in preterm neonate
- Trial name
- NCT04110418
- Testing
- Methylene Blue
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Ain Shams University
Sepsis, Septic Shock
Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock
Patients with severe infection can develop very low blood pressure. There are many mechanisms leading to this, and one of them appears to involve a hormone called vasopressin.
- Trial name
- VaCoSS (NCT00698048)
- Where
- Singapore
- Volunteers
- 136 people
- Sponsor
- Jan Hau Lee