Clinical trials: Bone Age Assessment
Bone Age Assessment
Validation Sonic Bone's Ultrasound System for Bone Age Assessment
The selection of talents in junior sports is strongly influenced by the current physical conditions of the athletes. However, the physical abilities, for example in junior football, are largely dependent on the maturation and…
- Trial name
- BAUS (NCT04301570)
- Testing
- Ultrasound device, XR
- Where
- Switzerland
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Sport Magglingen
Growth Hormone Deficiency
Use of miRNAs in Growth Hormone Deficiency (GHD)
This study aims at improving knowledge about the diagnosis of growth hormone deficiency (GHD) and treatment with growth hormone (GH), with the goal of providing information on the presence of new biomarkers, such as miRNAs, for…
- Trial name
- GH-miRNA2 (NCT06455956)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University of Parma
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Study to Assess the Pharmacokinetics, Safety, and Tolerability of Iptacopan in Pediatric PNH Patients
The purpose of this open-label, single arm, multicenter, phase 3 study is to assess the pharmacokinetics of iptacopan in pediatric patients and to assess whether iptacopan is safe and well tolerated when used for the treatment of…
- Trial name
- NCT06934967
- Testing
- LNP023
- Where
- 15 sites in United States, Brazil and 4 more
- Volunteers
- 12 people
- Sponsor
- Novartis Pharmaceuticals
Achondroplasia
A Clinical Trial to Evaluate Efficacy and Safety of Navepegritide in Adolescents (12 - 18 Years of Age) With Achondroplasia.
The purpose of this clinical trial is to evaluate efficacy and safety of once weekly subcutaneous (SC) doses of navepegritide 100 μg/kg compared to placebo (inactive drug) in adolescents aged 12 to 18 years with Achondroplasia.
- Trial name
- teACH (NCT06732895)
- Testing
- Navepegritide
- Where
- 5 sites in Canada, Denmark and 3 more
- Volunteers
- 25 people
- Sponsor
- Ascendis Pharma A/S
Idiopathic Scoliosis
Assessment of Skeletal Maturity Using Proximal Femoral Epiphysis in Patients With Scoliosis
This study aims to explore the use of proximal femoral head for the assessment of skeletal maturity in patients with idiopathic scoliosis.
- Trial name
- NCT04746417
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- The University of Hong Kong
Osteoporosis, Age-Related
Persistence With Prolia® (Denosumab) in Postmenopausal Women With Osteoporosis
The objective of this study was to describe persistence with Prolia® 60 mg administered subcutaneously (SC) every 6 months (Q6M) at 12 and 24 months.
- Trial name
- NCT02732210
- Where
- 89 sites in United States, Canada
- Volunteers
- 935 people
- Sponsor
- Amgen
Growth Hormone Deficiency, Small-for-gestational Age
Growth and Asymmetric diMethylArginine
Principal objective : Validation of a handy biochemical parameter, plasma concentration of Asymmetric DimethylArginine (ADMA), based on a recognize biochemical parameter, the dilation of the brachial artery, at ultrasound…
- Trial name
- GAMMA (NCT03422081)
- Testing
- arterial doppler ultrasound
- Where
- 2 sites in France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Lille
Bone Diseases, Developmental
Developing a COMputerised Bone Age Tool
The Greulich and Pyle technique (G\&P) is that most commonly used to assess bone age in children, particularly in the context of suspected skeletal dysplasia.
- Trial name
- COMBAT1 (NCT02617901)
- Testing
- Left hand DXA
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Ewing Sarcoma
A Study of KC1036 in Adolescents With Advanced Ewing Sarcoma
This open-label, single-arm clinical trial is to evaluate the safety and effectiveness of KC1036 in treating adolescents aged 12 and above with advanced Ewing sarcoma.
- Trial name
- NCT06564272
- Testing
- KC1036
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Konruns Pharmaceutical Co., Ltd.
Rickets
Ultrasound Imaging and Quantitative Vibro-Acoustic Assessment of Rickets Under the Age of Ten
The goal of this study is to find out if the use of ultrasound pictures of bones can spot changes in the growth areas of children with rickets, a condition that affects how bones harden.
- Trial name
- NCT06385938
- Testing
- Ultrasound with quantitative vibro-acoustic assessment
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Bone Age
Validation of an Artificial Intelligence-based Algorithm for Skeletal Age Assessment
The purpose of this study is to understand the effects of using an Artificial Intelligence algorithm for skeletal age estimation as a computer-aided diagnosis (CADx) system.
- Trial name
- NCT03530098
- Testing
- BoneAgeModel
- Where
- 6 sites in United States
- Volunteers
- 1,903 people
- Sponsor
- Stanford University
Fracture Fixation, Internal, Distal Radius Fracture
RemeOs™ DrillPin for Fixation of Distal Radius Fractures in Children
This is a pre-market, single-arm, open-label, monocenter clinical investigation evaluating the safety and performance of the magnesium (Mg)-based bioresorbable RemeOs™ DrillPin for surgical fixation of distal radius fractures in…
- Trial name
- NCT07028541
- Testing
- Magnesium-based bioresorbable DrillPin for fixation of distal radius fractures in children
- Volunteers
- 20 people
- Sponsor
- Bioretec Ltd.
Genu Varum, Genu Valgus
IMU-based Assessment of Motor Control in a Population of Young Subjects With Paramorphisms and Dysmorphisms
While various complex pathologies of the developmental age, such as Infantile Cerebral Palsy or Neuromuscular Diseases, are notoriously considered causes of alteration of locomotor development, it is scarcely known whether…
- Conditions
- Genu Varum, Genu Valgus, Flat Feet, Cavus Foot
- Trial name
- MOTOR-CHILD (NCT05763901)
- Testing
- Clinical tests and motor control evaluation using Inertial Measurement Units
- Where
- Italy
- Volunteers
- 151 people
- Sponsor
- Istituto Ortopedico Rizzoli
Rib Fractures, Rib Trauma
Investigation of the Effect of Age and Injury Severity on Short-term Intra-hospital Outcomes After Surgical Stabilized Rib Fractures
The study aims to investigate the effect of surgical stabilisation of rib fractures (SSRF) on clinical outcomes measured during the hospital stay (mortality, days on a mechanical ventilator, intensive care unit and hospital…
- Conditions
- Rib Fractures, Rib Trauma, Rib Fracture Multiple, Thorax; Fracture
- Trial name
- NCT06464302
- Testing
- Surgical stabilisation of rib fractures (SSRF), Non-operative management of rib fractures
- Where
- Germany
- Volunteers
- 1,064 people
- Sponsor
- University Hospital Muenster
Slipped Capital Femoral Epiphysis
Evaluation of Skeletal Maturity for Slipped Capital Femoral Epiphysis
This study is being done for two reasons: 1) to evaluate growth problems in the hip in patients with Slipped Capital Femoral Epiphysis (SCFE) as they continue to grow into adults, and 2) to help doctors determine which patients…
- Trial name
- NCT01220882
- Testing
- Radiographic skeletal age assessment
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rutgers, The State University of New Jersey
Achondroplasia
A Clinical Trial to Evaluate the Safety and Efficacy of BMN 111 in Infants and Young Children With Achondroplasia
Study 111-206 is a Phase 2 randomized, double-blind, placebo-controlled clinical trial of BMN 111 in infants and young children with a diagnosis of achondroplasia.
- Trial name
- NCT03583697
- Testing
- BMN 111
- Where
- 16 sites in United States, Australia and 2 more
- Volunteers
- 75 people
- Sponsor
- BioMarin Pharmaceutical
Short Stature, Idiopathic, Infant, Small for Gestational Age
Evaluation of the Ease of Use, Preference, and Safety of EutropinPen Inj.
The purpose of this study is to assess the ease of use, preference, and safety after 8 weeks subcutaneous administration of EutropinPen Inj. in patients pretreated with recombinant human growth hormone by reusable device.
- Conditions
- Short Stature, Idiopathic, Infant, Small for Gestational Age, Growth Hormone Deficiency, Chronic Renal Failure
- Trial name
- NCT03015909
- Testing
- Somatropin
- Where
- South Korea
- Volunteers
- 116 people
- Sponsor
- LG Life Sciences
Overweight and Obesity, Body Composition
Aerobic Exercise and Body Composition in Overweight and Obese Boys.
Overweight and obesity are unhealthy fat accumulations. children aged 2-18 are deemed overweight if their body mass index (BMI)/Age is ≥ 85th - <95th percentile and obese if >95th percentile.
- Conditions
- Overweight and Obesity, Body Composition, Body Fat, Lean Body Mass
- Trial name
- NCT07586579
- Testing
- aerobic exercise
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitas Sriwijaya
Endocrine Diseases
Performance of the Diagnostic Value of Bone Age Assessment Software Based on Deep Learning in Chinese Children
High accuracy and precision bone age assessment is very important for the diagnosis and treatment monitoring of various pediatric diseases.
- Trial name
- NCT05137301
- Testing
- X-ray bone age instrument
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Scoliosis
Evaluation of the Surface Topography for Monitoring Scoliosis Patients Aged 10-13 Years
The main objective of the study is to investigate the correlation between the measurement of the Cobb angle (angle of scoliosis) by conventional radiography and angle measured by surface topography.
- Trial name
- SCOBIOMOD (NCT02531945)
- Testing
- Use of Biomod device
- Where
- France
- Volunteers
- 125 people
- Sponsor
- University Hospital, Toulouse