Clinical trials: Bone Injury
Bone Fractures, Radius Fractures
Management of Distal Radius Fractures in Children Younger Than 11 Years Old.
This fractures have been managed with anatomical reduction performed under anesthesia or using sedatives. In our institution this means prolonged hospital stay, involvement of an anesthesiologist and the use of an special room in…
- Conditions
- Bone Fractures, Radius Fractures, Closed Fractures
- Trial name
- NCT02670629
- Testing
- Partial reduction with overriding position, Closed anatomic reduction
- Volunteers
- 58 people
- Sponsor
- Carlos A Acosta-Olivo
Brain Tumor, Central Nervous System Tumor
Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy
RATIONALE: Sodium thiosulfate may reduce or prevent hearing loss in young patients receiving cisplatin for cancer. It is not yet known whether sodium thiosulfate is more effective than no additional treatment in preventing…
- Conditions
- Brain Tumor, Central Nervous System Tumor, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
- Trial name
- NCT00716976
- Testing
- sodium thiosulfate, examination
- Where
- 76 sites in United States, Australia and 1 more
- Volunteers
- 131 people
- Sponsor
- Children's Oncology Group
Spinal Cord Injury
The Effect of FES on Children With Spinal Cord Injury
Regular exercise is strongly recommended to help maintain a healthy lifestyle. Unfortunately, children and young adults with damaged spinal cords may not be able to exercise regularly.
- Trial name
- NCT00291317
- Testing
- RT 300-P FES Cycle
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Children's Specialized Hospital
Fractures, Bone, Deformity; Bone
Virtual Reality Distraction During Outpatient Pediatric Orthopedic Procedures
Virtual Reality(VR) has had promising applications in science and medicine, including intervention delivery. The use of VR interventions has been studied in a wide range of medical conditions, including anxiety, phobias, obesity…
- Trial name
- NCT05510232
- Testing
- A treatment group that will watch a non-VR video via an iPad, A treatment group that will have headset on and will watch a non-VR video, A treatment group that will be immersed in the VR game (Bear Blast) via the headset.
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Hospital for Special Surgery, New York
Stomatitis
Evaluation of Efficacy and Mechanisms of an Antiinflammatory Intervention for Chemotherapy Related Mucosal Injury
This study consisted of two parts: the pilot study and the main study. The purpose of the pilot study is to demonstrate the effectiveness of planned laboratory techniques to assess for TNF-alpha gene expression from unstimulated…
- Trial name
- NCT00031551
- Testing
- Etanercept
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- National Institute of Nursing Research (NINR)
Deformity, Defect, Congenital
Observational Study on JuniOrtho Plating System for Deformities and Fractures Treatment in Lower Limb
Orthofix Srl put the JPS on the European market (2019) by the mean of a pre-market clinical evaluation made under the Medical Device Directive (MDD) requirements that were based on the analysis of the scientific literature of…
- Conditions
- Deformity, Defect, Congenital, Trauma
- Trial name
- JPS (NCT05245617)
- Testing
- JuniOrtho™ Plating System™
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Orthofix s.r.l.
Trauma, Fractures, Closed
Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures
This a randomized clinical trial involving children with non-operative fractures presenting the emergency department randomized either to intranasal or intravenous ketamine.
- Conditions
- Trauma, Fractures, Closed, Children, Only, Deep Sedation
- Trial name
- NCT03781817
- Testing
- Intravenous Ketamine, Intranasal Ketamine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Osteoporosis
Safety and Efficacy of Alendronate (Fosamax) in Children With Osteoporosis
We have previously evaluated the safety and efficacy of Alendronate in 10 patients with juvenile osteoporosis during a 12-month clinical trial.
- Trial name
- NCT00259857
- Testing
- Alendronate
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Medical University of South Carolina
Abscess, Fracture
Study to Find the Dose of Rapidly Administered Ketamine for Brief Painful Procedures in Children
The purpose of the study is to find the dose of rapidly administered ketamine in 3 different pediatric age groups (2-5, 6-11 and 12-17) for abscess drainage and fracture reduction.
- Trial name
- NCT01669642
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Washington University School of Medicine
Tibial Fractures, Intra-Articular Fractures
Management of Traumatic Bone Defects in Tibial Plateau Fractures With Antibiotic-Impregnated Biodegradable Calcium Sulfate Beads: A Prospective Clinical Trial
This is a prospective clinical trial of tibial plateau fractures treated with internal fixation and a calcium sulfate graft which can be mixed with antibiotics and molded into various bead sizes for implantation into bone…
- Conditions
- Tibial Fractures, Intra-Articular Fractures, Fracture Fixation, Internal
- Trial name
- NCT02456194
- Testing
- Calcium Sulfate + Antibiotics + Internal Fixation
- Where
- 5 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Ross Leighton
Osteoporosis, Achlorhydria
Does Omeprazole Decrease Intestinal Calcium Absorption?
The purpose of this study is to measure the effect of omeprazole on intestinal calcium absorption in postmenopausal women.
- Conditions
- Osteoporosis, Achlorhydria, GERD, Hip Fracture
- Trial name
- NCT00582972
- Testing
- Omeprazole
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cartilage Loss, Microfracture
Effects of Unloader Bracing in Clinical Outcome and Cartilage Physiology Following Microfracture of Chondral Defects
The study will examine clinical and radiographic outcomes of microfracture surgery (a common technique to address isolated areas of cartilage loss) in the knee used with or without unloader bracing.
- Trial name
- Mfxbracing (NCT02016300)
- Testing
- Unloader Bracing, Non-Bracing
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Stanford University
Vitamin D Receptor Defect
Association Between Vitamin D Receptor Polymorphism and Serum Vitamin D Levels in Children With Low-Energy Fractures
This study was designed to determine the impact of vitamin D serum levels and vitamin D receptor (VDR) polymorphisms on the occurrence of low energy fractures in children.
- Trial name
- NCT02805647
- Where
- Poland
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Fractures
The Effect of NSAID Use in the Acute Phase of Skeletally Immature Bone Healing: A Prospective Study
Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are excellent medications for providing pain control in children with fractures or those who have surgery to correct bony deformity requiring the bone to be cut…
- Trial name
- NCT02076321
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Missouri-Columbia
Bone Fracture, Radius Fracture
Study on Wood-plastic Composite for Circumferential Casting
The purpose of study is to verify that WOODCAST Circular system performs safely and effectively in its intended use.
- Conditions
- Bone Fracture, Radius Fracture, Ankle Fracture
- Trial name
- WOODCAST (NCT01493167)
- Testing
- limb casting/splinting
- Where
- Finland
- Volunteers
- 97 people
- Sponsor
- Onbone Oy
Osteosarcoma, Nephrotoxicity
Preventing Nephrotoxicity and Ototoxicity From Osteosarcoma Therapy
Osteosarcoma is the most common type of bone cancer in children, adolescents and young adults. Treatment with surgery and a combination of three conventional chemotherapy drugs can cure nearly two-thirds patients with…
- Conditions
- Osteosarcoma, Nephrotoxicity, Ototoxicity
- Trial name
- NCT01848457
- Testing
- Pantoprazole, High-dose methotrexate infusion duration
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospital of Philadelphia
Humeral Fractures
The Outcomes of Proximal Humerus Fractures in Children
To date, the clinical benefits and harms of surgical intervention in proximal humerus fractures in children remain debatable. The practical question raised by orthopaedic surgeons is: for children and adolescent, are the clinical…
- Trial name
- NCT02863289
- Volunteers
- 118 people
- Sponsor
- NHS Tayside
Metatarsal Stress Fracture, Stress Fracture of Tibia
Photobiomodulation Therapy for the Treatment of Lower Extremity Stress Fractures in a Military Training Setting
The goal of this clinical trial is to compare photobiomodulation therapy (PBMT) in addition to standard of care in the treatment of tibial and metatarsal bone stress injuries in a military training setting.
- Trial name
- PM12 (NCT05843864)
- Testing
- Photobiomodulation Therapy with Standard Physical Therapy
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Brooke Army Medical Center
Breast Cancer, Osteoporosis
Do Aromatase Inhibitors (AIs) Decrease Intestinal Calcium Absorption?
Research Question: Do Aromatase Inhibitors Decrease Intestinal Calcium Absorption? Study Design: Postmenopausal women with early stage breast cancer initiating aromatase inhibitor adjuvant therapy will participate in this…
- Conditions
- Breast Cancer, Osteoporosis, Osteopenia, Fracture
- Trial name
- NCT00766532
- Testing
- Aromatase Inhibitor
- Volunteers
- 12 people
- Sponsor
- University of Wisconsin, Madison
Femoral Fractures
A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Distal Femur Fractures
This study looks at two (2) types of surgical treatments and hopes to answer the question, "which is the best way to surgically treat a distal femur fracture?" Both procedures being studied are standard of care (used routinely)…
- Trial name
- NCT00429663
- Testing
- reamed, interlocking intramedullary nail, locking periarticular plate
- Where
- 22 sites in United States
- Volunteers
- 160 people
- Sponsor
- Boston Medical Center