Clinical trials: Bone Resorption
Maxillofacial Bone Defect, Alveolar Bone Loss
Bone Marrow Mononuclear Cells for the Repair of Severe Maxillofacial Bone Defects
This is a single-center, single-arm, open-label clinical study conducted at the Department of Stomatology, Nanjing Drum Tower Hospital.
- Trial name
- NCT07852806
- Testing
- Autologous bone marrow-derived mononuclear cells (BMMNCs), Bio-Oss bone graft material with collagen membrane
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Bone Atrophy, Alveolar
Piezo-assisted Expansion of Narrow Ridges
the goal of the study was the evaluation of the clinical and histological performance of delayed inserted implants in augmented sites with a shaped solid graft inserted in an originally narrow alveolar edentulous ridge.
- Trial name
- PRIDE (NCT07401238)
- Testing
- Alveolar Ridge Reconstruction
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Root Resorption, Orthodontic Appliance
Three-dimensional CBCT Analysis of Root Volume Changes Following Tooth-bone and Bone-borne Maxillary Expansion: A Pilot Study.
External root resorption (ERR) is an undesired side effect observed after rapid maxillary expansion (RME). This study aimed to investigate changes in the root volume of maxillary permanent first molars after RME using tooth-borne…
- Conditions
- Root Resorption, Orthodontic Appliance, CBCT Segmentation
- Trial name
- NCT06912568
- Testing
- Miniscrew insertion, Expander, CBCT
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- University of Roma La Sapienza
Alveolar Bone Resorption, Preserving the Alveolar Ridge
Radiographic Evaluation in Alveolar Preservation Using Platelet-rich Fibrin. Randomized Controlled Trial
This randomized controlled trial is designed to assess the use of platelet-rich fibrin (PRF), a biomaterial derived from a participant's own blood, in alveolar ridge preservation following premolar extraction for orthodontic…
- Trial name
- NCT06900036
- Testing
- Platelet-Rich Fibrin (PRF) Application for Alveolar Preservation
- Where
- Ecuador
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Universidad Católica de Cuenca
Gorham Disease, Lymphatic Diseases
Imaging of Lymphatic Anomalies
Lymphatic Anomalies (LA) is characterized by proliferation of lymphatic tissue causing deterioration of pulmonary function. Understanding changes in lymphatic anatomy in these patients is hindered by the difficulty of imaging the…
- Conditions
- Gorham Disease, Lymphatic Diseases, Lymphangiomatosis
- Trial name
- NCT02744027
- Testing
- Dynamic Contrast Enhanced Magnetic Resonance Lymphangiography (DCMRL), Heavy Weighted T2 Imaging (T2W), Lymph Node Access
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
Osteoporosis, Postmenopausal
Soluble Corn Fiber Effect on Bone Resorption in Post Menopausal Women
This study is designed to study the dose response effect of continuous Soluble Corn Fiber (SCF) intake over a 50 day period on bone resorption in healthy post menopausal women using the 41Calcium methodology.
- Trial name
- NCT02416947
- Testing
- 0 g SCF, 10g SCF, 20g SCF
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Purdue University
Bone Resorption, Symptoms
Microsurgery Using a Bioceramic Root End Filling Material
Endodontic failures are not uncommonly encountered despite improvements in routine root canal therapy. Endodontic microsurgery is one way to manage such failure.
- Trial name
- microsurgery (NCT03733938)
- Testing
- endodontic microsurgery
- Where
- Jordan
- Volunteers
- 50 people
- Sponsor
- Jordan University of Science and Technology
Periodontal Disease, Periodontal Bone Loss
Laser Assisted Open Flap Debridement
The study involves the surgical treatment of patients with Stage I to III of periodontitis. Following completion of Steps 1 and 2 of periodontal therapy according to the EFP guidelines for the treatment of periodontitis, sites…
- Trial name
- LaserOpen (NCT07807215)
- Testing
- Mechanical Open Flap debridement, Laser assisted open flap debridement
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Bari Aldo Moro
Arthroplasty, Replacement, Knee
Outcome Study of Highly-cross Linked Polyethylene vs. Standard Polyethylene for Primary Posterior Stabilized (PS) Total Knee
Polyethylene wear and osteolysis remain a concern with the use of modular, fixed bearing total knee arthroplasty. A variety of highly cross-linked polyethylenes have been introduced to decrease this problem, but there is little…
- Trial name
- NCT02178020
- Testing
- knee arthroplasty, standard polyethylene, knee arthroplasty, XLP polyethylene
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Chapel Hill Orthopedics Surgery & Sports Medicine
Malocclusion of Anterior Teeth, Malocclusion; Displaced Teeth
Effects of Three Orthodontic Archwire Protocols on Root and Bone Changes
This randomized controlled clinical trial compares the effects of three orthodontic archwire protocols used during the alignment phase on anterior tooth roots and the supporting alveolar bone.
- Trial name
- NCT07688655
- Testing
- Square-shaped cross-sectional archwire, Rectangular-shaped cross-sectional archwire, Traditional sequence of archwires
- Where
- Syria
- Volunteers
- 53 people
- Sponsor
- Damascus University
Bone Regeneration, Periodontal Bone Loss
Effect of Nitroglycerin Hydrogel on Repairing Critical Bone Defects
Due to their osteoconductive, osteoinductive, and osteogenic qualities, autologous bone grafts are the gold standard for augmenting bone, (1).
- Conditions
- Bone Regeneration, Periodontal Bone Loss, Healing Fracture of Bone
- Trial name
- Nitro- Bone (NCT06925763)
- Testing
- Nitroglycerin
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Minia University
Osteoporosis, Prostate Cancer
Effect of Androgen Suppression on Bone Loss in Patients With or Without Bone Metastases Secondary to Prostate Cancer
RATIONALE: Assessing the effect of androgen suppression on bone loss in prostate cancer patients may improve the ability to plan treatment, may decrease the risk of fractures and bony pain, and may help patients live more…
- Trial name
- NCT00003903
- Testing
- management of therapy complications
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Rochester
Alveolar Bone Loss
Minimally Invasive Ridge Splitting Versus the Conventional Open Flap Technique
The goal of this clinical trial is to compare implant stability, and crestal bone loss, when using minimal invasive ridge splitting versus convenient open flap technique.
- Trial name
- NCT06329362
- Testing
- Minimally invasive implantation, Open flap procedure for ridge expansion.
- Where
- 2 sites in Egypt, Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Royal College of Surgeons of Edinburgh
Osteopenia
Optimal Meals to Reduce Bone Resorption in Women With Osteopenia
The goal of this clinical trial is to investigate whether different types of small meals can help reduce bone loss in postmenopausal women with osteopenia, a condition where bone density is lower than normal and may lead to…
- Trial name
- NCT07056322
- Testing
- 200 ml dairy, 100 ml milk, 100 g banana
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- University of Aarhus
Lymphatic Diseases, Lymphatic Abnormalities
A Prospective Natural History Study of Lymphatic Anomalies
Background: The lymphatic system is a network of vessels that carry a clear fluid called lymph through the body. Problems in the lymphatic system can cause pain, fluid buildup, and issues with immunity.
- Trial name
- NCT05731141
- Where
- 2 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Sever Mandibular Bone Resorption, Sensory Defect
Inferior Alveolar Nerve Translocation With Dental Implant Placement in Severely Resorbed Mandibles
This study investigates the effects of inferior alveolar nerve lateralization on the post-implant insertion sensory outcome for patients with severe mandibular bone resorption.
- Conditions
- Sever Mandibular Bone Resorption, Sensory Defect, Implant Failure
- Trial name
- NCT07104994
- Testing
- Dental implant
- Where
- Yemen
- Volunteers
- 9 people
- Sponsor
- University of Science and Technology, Yemen
Alveolar Bone Loss
Subperiosteal Implants Constructed With Digital Technology
Atrophied jaw is a condition where there is insufficient bone quantity to place root form implants. Several treatment plans are available for treating atrophied jaws, including subperiosteal implants.
- Trial name
- NCT06012643
- Testing
- The purpose of this systematic review of case reports and case series was to evaluate the spectrum of subperiosteal implants for severely atrophied jaws using digital technology.
- Where
- Egypt
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Bone Loss, Alveolar, Tooth Loss
Tooth Autotransplantation and Bone Dimension Changes
Tooth autotransplantation is a treatment option to replace tooth with imposible prognosis. In several cases the receipt site has a reduced bone dimension.
- Conditions
- Bone Loss, Alveolar, Tooth Loss, Bone Atrophy, Alveolar
- Trial name
- NCT03927937
- Testing
- AUTOTRANSPLANTATION TOOTH
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Lymphatic Malformation, Generalized Lymphatic Anomaly (GLA)
Lymphatic Anomalies Registry for the Assessment of Outcome Data
Lymphatic anomalies are a rare subset of vascular anomalies that are poorly understood. the understanding of the natural history, long-term outcomes, risk factors for morbidity and mortality, and the relative benefit of medical…
- Conditions
- Lymphatic Malformation, Generalized Lymphatic Anomaly (GLA), Central Conducting Lymphatic Anomaly, CLOVES Syndrome
- Trial name
- NCT02399527
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Boston Children's Hospital
Dental Implant Failure, Periodontal Bone Loss
A Retrospective Analysis of Failures of Oral Implants
The purpose of this retrospective study is to investigate and identify factors associated with the failure of dental implants within the population rehabilitated with dental implants at the Folktandvården Specialistklinik in…
- Trial name
- NCT02369562
- Testing
- Evaluation of the failure rate of dental implants
- Where
- Sweden
- Volunteers
- 2,670 people, healthy volunteers welcome
- Sponsor
- Malmö University