Clinical trials: Bowel Dysfunction
Colitis, Ulcerative
A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis
The purpose of this study is to evaluate efficacy of golimumab in inducing clinical remission as assessed by the Mayo score, in pediatric participants with moderately to severely active ulcerative colitis (UC).
- Trial name
- PURSUIT 2 (NCT03596645)
- Testing
- Golimumab, Infliximab
- Where
- 58 sites in United States, Belgium and 9 more
- Volunteers
- 84 people
- Sponsor
- Janssen Research & Development, LLC
Colorectal Cancer, Metastatic Cancer
Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002692
- Testing
- fluorouracil, isolated perfusion, leucovorin calcium
- Where
- United Kingdom
- Volunteers
- 312 people
- Sponsor
- Medical Research Council
Ulcerative Colitis
A Study of Mirikizumab (LY3074828) in Children and Teenagers With Ulcerative Colitis (UC)
This study was designed to evaluate how the body processes and removes mirikizumab. The study also evaluated safety and disease response in pediatric participants with UC taking mirikizumab.
- Trial name
- SHINE-1 (NCT04004611)
- Testing
- Mirikizumab
- Where
- 37 sites in United States, Canada and 3 more
- Volunteers
- 26 people
- Sponsor
- Eli Lilly and Company
Crohn's Disease
Study of Antibiotics in the Treatment of Colonic Crohn's Disease
Crohn's disease (CD) is a form of inflammatory bowel disease that can affect any part of the digestive system. Symptoms of this chronic illness include abdominal pain, bloating, nausea, vomiting, and diarrhea.
- Trial name
- NCT00257699
- Testing
- ciprofloxacin, metronidazole
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Mount Sinai Hospital, Canada
Pelvic Organ Prolapse, Constipation
Cohort Study of Bowel Function Following Robotic-assisted Laparoscopic Sacrocolpopexy
Compare changes in bowel function before, 6 months and one year after Robotic-assisted laparoscopic sacral colpopexy. Compare objective anatomic outcomes before, 6 months and one year after Robotic-assisted laparoscopic sacral…
- Conditions
- Pelvic Organ Prolapse, Constipation, Bowel Dysfunction, Irritable Bowel Syndrome
- Trial name
- NCT01618292
- Testing
- Robotic sacral colpopexy
- Where
- United States
- Volunteers
- 393 people
- Sponsor
- Atlantic Health System
Appendicitis, Polymer Clips
Polymer Clips Vs Endoloop for Appendicular Stump Ligation
laparoscopic appendectomy is the gold standard procedure now a days for the treatment of appendicitis. Polymer clips are new modality used for the ligation of appendicular stump.
- Conditions
- Appendicitis, Polymer Clips, Surgitie
- Trial name
- NCT03591419
- Testing
- polymer clip, endoloop
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Services Hospital, Lahore
Lymphatic Diseases, Lymphatic Abnormalities
A Prospective Natural History Study of Lymphatic Anomalies
Background: The lymphatic system is a network of vessels that carry a clear fluid called lymph through the body. Problems in the lymphatic system can cause pain, fluid buildup, and issues with immunity.
- Trial name
- NCT05731141
- Where
- 2 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Anal Fistula
Randomized Trial on the Effect of Topical Phenytoin on Healing After Fistulotomy
Patients with anal fistula who will undergo anal fistulotomy will be randomized into one of two groups; the first group will receive topical phenytoin therapy postoperatively and the second group will not receive such topical…
- Trial name
- NCT03096522
- Testing
- Phenytoin 2% spray, Anal fistulotomy
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Mansoura University
Celiac Disease
Can a Very High Result From a Screening Test for Celiac Disease be Used to Diagnose Celiac Disease?
This study is to see if a high response to the TTG screening test for celiac disease is as accurate as the current method of diagnosing celiac disease which entails a general anesthetic and upper endoscopy to obtain biopsies of…
- Trial name
- NCT00175760
- Testing
- Diagnosis of Celiac Disease
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes
Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT
The objective of this study is to evaluate the efficacy of using a reduced-intensity condition (RIC) regimen with umbilical cord blood transplant (UCBT), double cord UCBT, matched unrelated donor (MUD) bone marrow transplant…
- Conditions
- Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes, Inherited Metabolic Disorders (IMD), Hereditary Anemias
- Trial name
- HSCT+RIC (NCT01962415)
- Testing
- Hydroxyurea, Alemtuzumab, Fludarabine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Paul Szabolcs
Appendicitis Acute
Low vs Medium Pressure Pneumoperitoneum
The purpose of this study is to asses whether the pressure used for the pneumoperitoneum during laparoscopic surgery in children affects their postoperative pain levels.
- Trial name
- LoMePneu (NCT04949659)
- Testing
- Laparoscopic appendectomy
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- University Children's Hospital, Zurich
Crohn's Disease, Ulcerative Colitis
Treatment With the Specific Carbohydrate Diet for Children With Active Crohns Disease and Ulcerative Colitis
The aim of this study is to determine the tolerability and potential efficacy of dietary therapy, the Specific Carbohydrate Diet (SCD), in pediatric patients with Crohn's disease (CD) and Ulcerative Colitis (UC).
- Trial name
- SCD (NCT02213835)
- Testing
- Specific Carbohydrate diet (SCD)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- David Suskind
Colorectal Neoplasms
Diagnostic Value of Endocytoscopy for Colorectal Lesions
Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related death worldwide. Colonoscopy is considered the preferred method of screening for colorectal cancer, and resection of…
- Trial name
- NCT06324097
- Testing
- endocytoscopy
- Where
- China
- Volunteers
- 463 people
- Sponsor
- Hong Xu
Colon Adenocarcinoma, DNA Repair Disorder
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair
This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid…
- Conditions
- Colon Adenocarcinoma, DNA Repair Disorder, Lynch Syndrome, Stage III Colon Cancer AJCC v8
- Trial name
- NCT02912559
- Testing
- Atezolizumab, Biospecimen Collection, Computed Tomography
- Where
- 1,049 sites in United States, Germany and 1 more
- Volunteers
- 712 people
- Sponsor
- National Cancer Institute (NCI)
Inflammatory Bowel Diseases
Efficacy and Mechanism of Fecal Microbiota Transplantation of the Bai Ethnicity in the Treatment of UC
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), affects over 2 million people worldwide .
- Trial name
- NCT06591013
- Testing
- Fecal microbiota transplantation
- Where
- China
- Volunteers
- 102 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Rheumatoid Arthritis, Crohn's Disease
The RATIO: Registry of Infections and Lymphoma in Patients Treated With TNF-a Antagonists
The RATIO registry is a French registry designed by a multidisciplinary group to collect data on opportunistic and severe bacterial infections and lymphoma in patients treated with TNF-a antagonists ( infliximab, etanercept and…
- Conditions
- Rheumatoid Arthritis, Crohn's Disease, Ankylosing Spondylitis, Psoriasis
- Trial name
- NCT00224562
- Testing
- TNF-alpha antagonists
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Newly-diagnosed Crohn's Disease
Development and Validation of a Nomogram for Predicting Surgery in Newly-diagnosed Crohn's Disease: a Retrospective Cohort Study
A majority of patients with Crohn's disease undergo surgery during the disease course. We aimed to develop an easily available nomogram to predict the risk of surgery at diagnosis.
- Trial name
- NCT06457035
- Testing
- immunosuppressant
- Volunteers
- 490 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
NEC, Atresia
Safety and Feasibility of Indocyanine Green Fluorescence for Intraoperative Assessment of Intestinal Perfusion in Young Infants and Neonates
The goal of this clinical trial is to test the use of the SPY-PHI device for the purpose of ICG-mediated intestinal perfusion visualization during gastrointestinal surgery in neonates and young infants (<3 months old) undergoing…
- Conditions
- NEC, Atresia, Malrotation, Intestinal Perforation
- Trial name
- IMAGINE (NCT05734118)
- Testing
- Perfusion assessment by means of the SPY-PHI camera
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Inflammatory Bowel Diseases
Receptor for Advanced Glycation End Products (RAGE) Polymorphisms In Inflammatory Bowel Disease
The inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract that manifests as Crohn's disease (CD) and Ulcerative colitis (UC .
- Trial name
- NCT04286659
- Volunteers
- 180 people
- Sponsor
- Assiut University
Appendicitis
Is Acute Appendicitis Still a Clinical Diagnosis?
This study aims to investigate the use of preoperative diagnostic imaging before appendectomy in Denmark and whether it has changed over time during the period from 2000-15.
- Trial name
- NCT04477824
- Testing
- Diagnostic imaging
- Volunteers
- 82,000 people
- Sponsor
- Claus Anders Bertelsen, PhD, MD
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