Clinical trials: Bowel Dysfunction
Colitis, Ulcerative
A Study of How the Medicine Called "Etrasimod" Works in Children With the Gut Disease Called Ulcerative Colitis
The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in pediatrics participants (≥ 2 years up to < 12 years…
- Trial name
- ELEVATE-UCkids (NCT07470879)
- Testing
- Etrasimod
- Where
- 46 sites in United States, Australia and 8 more
- Volunteers
- 24 people
- Sponsor
- Pfizer
Dyspepsia, Malabsorption Syndrome
Evaluation of Topical Lidocaine Spray as Adjuvant to Upper Gastrointestinal Endoscopy in Children
There is some controversy in the medical literature regarding the effectiveness of topical lidocaine in children as an adjuvant drug to upper gastrointestinal endoscopy.
- Conditions
- Dyspepsia, Malabsorption Syndrome, Gastroesophageal Reflux Disease, Abdominal Pain
- Trial name
- NCT00521703
- Testing
- Lidocaine, Tannic acid
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Hospital Infantil Cândido Fontoura
Irritable Bowel Syndrome (IBS), Pediatrics
Pentabiocel in Pediatric IBS
Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits, including diarrhea, constipation, or a combination of both.
- Trial name
- NCT06720805
- Testing
- Pentabiocel
- Where
- 4 sites in Italy
- Volunteers
- 56 people
- Sponsor
- University of Roma La Sapienza
Preterm Birth, Pediatric Cancer
eHealth as an Aid for Facilitating and Supporting Self-management in Families With Long-term Childhood Illness
The overall aim is twofold: 1) to stretch the borderline regarding the present knowledge of clinical and economic cost-effectiveness of eHealth as an aid for facilitating and supporting self-management in families with long-term…
- Conditions
- Preterm Birth, Pediatric Cancer, Hirschsprung Disease, Congenital Malformation
- Trial name
- eChildHealth (NCT04150120)
- Testing
- e-health device with application, Mobile phone text messaging, early detection of cerebral palsy using a mobile phone application
- Where
- 7 sites in Denmark, Ethiopia and 1 more
- Volunteers
- 720 people
- Sponsor
- Lund University
Necrotising Enterocolitis Neonatal
Calprotectin Levels in Necrotizing Enterocolitis
Necrotizing enterocolitis (NEC) is a serious condition that can affect premature babies, leading to complications like intestinal damage and infection.
- Trial name
- NCT06693154
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Ankara Yildirim Beyazıt University
Irritable Bowel Syndrome (IBS), Functional Abdominal Pain
Peer Mentorship: An Intervention To Promote Effective Pain Self-Management In Adolescents
This protocol matches child subjects with peer mentors of similar age who have learned to function successfully with a chronic pain disorder.
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Abdominal Pain, Fibromyalgia, Complex Regional Pain Syndrome (CRPS)
- Trial name
- NCT01118988
- Testing
- Mentorship
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Los Angeles
Colo-rectal Cancer, Recurrence
F-18 FDG- PETCT in Staging and Recurrent Colorectal Cancer
Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cause of cancer death in the United States.
- Trial name
- NCT03572595
- Testing
- F-18 FDG-PET/CT
- Volunteers
- 45 people
- Sponsor
- Assiut University
Crohn's Disease, Vitamin D Deficiency
Exploring the Effects of Caltrate Supplement on the Chronic Course of Crohn's Disease Patients With Vitamin D Deficiency
Aims:Prospectively observe the effects of Caltrate supplementation on the chronic course of Crohn's disease patients, analyze whether the effect of Caltrate on CD patients is affected by factors such as disease site, disease…
- Conditions
- Crohn's Disease, Vitamin D Deficiency, Vitamin D Supplement
- Trial name
- NCT04276636
- Testing
- Caltrate Pill
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Acute Appendicitis, Superficial SSI
Laparoscopic vs Open Appendectomy
his randomized controlled trial was conducted to compare the frequency of superficial surgical site infections (SSIs) following laparoscopic appendectomy and open appendectomy in patients undergoing surgical treatment for acute…
- Trial name
- NCT07841444
- Testing
- Laparoscopic appendectomy, Open Appendectomy
- Where
- Pakistan
- Volunteers
- 276 people
- Sponsor
- Quaid-e-Azam Medical College
Fecal Incontinence, Urinary Incontinence
Safety and Efficacy of Concurrent MACE and Mitrofanoff Procedures
This was a prospective study. The study period was from January 2022 to July 2025. The study included 30 patients suffering from combined fecal and urinary incontinence submitted for concurrent Malone Antigrade continent Enema…
- Trial name
- MitroMACE (NCT07206719)
- Testing
- Malone Antegrade Continent Enema (MACE) and Mitrofanoff procedures
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mohammad Daboos
Hirschsprungs Disease
Electrophysiological Activity of the Anorectum in Children Suspected of Hirschsprung Disease
Children with chronic constipation, suspected of having hirschsprungs disease, who are admitted for rectal biopsy will be included in the study.
- Trial name
- NCT02342457
- Testing
- Child suspected of Hirschsprung disease
- Volunteers
- 20 people
- Sponsor
- Rabin Medical Center
Postnatal Growth Restriction, Necrotizing Enterocolitis
Human Milk-derived Fortification in Preterm Infants
Human Milk alone is unable to meet the high nutritional requirements of preterm infants. The American Academy of Pediatrics recommends fortification of human milk as a standard practice in all very low birth weight (VLBW)…
- Trial name
- NCT05228847
- Testing
- Human milk-derived HMF, bovine milk-derived HMF
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University of Calgary
Colorectal Cancer, Diarrhea
Biomarker-Guided Fluorouracil in Treating Patients With Colorectal Cancer Receiving Combination Chemotherapy
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, oxaliplatin, and leucovorin calcium, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Colorectal Cancer, Diarrhea, Neutropenia
- Trial name
- NCT01164215
- Testing
- fluorouracil, leucovorin, oxaliplatin
- Where
- 5 sites in United States
- Volunteers
- 76 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Neonatal Sepsis, Necrotizing Enterocolitis
Bovine Lactoferrin and Neonatal Survival in Low Birth Weight Babies.
Pakistan has the third highest number of neonatal deaths worldwide. During the last two decades (1990-2013), neonatal mortality rate in the country has declined by only 1.0% per year.
- Trial name
- NCT03431558
- Testing
- bLF (Bovine lactoferrin)
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Peritoneal (Metastatic) Cancer, Colorectal Cancer
Biopsy-Resection Agreement of Peritoneal Histopathological Growth Patterns in Colorectal Peritoneal Metastases: A Prospective Observational Pilot Study
his prospective, single-center observational pilot study evaluates whether peritoneal histopathological growth patterns can be assessed on limited excisional biopsies obtained during staging laparoscopy in adults with suspected…
- Conditions
- Peritoneal (Metastatic) Cancer, Colorectal Cancer, Colorectal (Colon or Rectal) Cancer, Histopathological Growth Patterns (HGPs)
- Trial name
- PROCPHGP (NCT07474025)
- Where
- 2 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Jules Bordet Institute
Crohn Disease
Bowel Preparation for Magnetic Resonance Enterography
Adequate bowel preparation is required for magnetic resonance enterography (MRE) which can be achieved by two methods including administering contrast solution after mid-gut tubing and taking contrast solution orally.
- Trial name
- NCT03541733
- Testing
- mid-gut tubing
- Where
- China
- Volunteers
- 102 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Irritable Bowel Disease, Functional Abdominal Pain - Not Otherwise Specified (FAP-NOS)
Pain in Pediatric Patients - Internet Interventions for Disorders of Gut-brain Interaction
Many children and adolescents often experience long-lasting stomach pain. In many cases, this is due to disorders of gut-brain interaction (DGBI), such as irritable bowel syndrome (IBS), functional abdominal pain, and functional…
- Conditions
- Irritable Bowel Disease, Functional Abdominal Pain - Not Otherwise Specified (FAP-NOS), Functional Dyspepsia
- Trial name
- PIPPI (NCT07319078)
- Testing
- Gut-directed hypnotherapy, Cognitive-behavioral therapy
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Appendicitis
Structured Management of Patients With Suspicion of Appendicitis Using a Clinical Score and Selective Imaging
Patients with acute abdominal pain and suspicion of appendicitis are common. The management of these patients is controversial with large variations between hospitals.
- Trial name
- STRAPPSCORE (NCT00971438)
- Testing
- Diagnostic imaging
- Where
- Sweden
- Volunteers
- 1,312 people
- Sponsor
- Ryhov County Hospital
Colorectal Cancer
Fluorouracil and Leucovorin and/or Levamisole After Surgery In Treating Patients With Dukes' B Or Dukes' C Colon Cancer
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00425152
- Testing
- fluorouracil, leucovorin calcium, levamisole hydrochloride
- Volunteers
- 2,151 people
- Sponsor
- NSABP Foundation Inc
Ulcerative Colitis
A Study of Symptom Improvement of Ulcerative Colitis After an Induction Dose of Ustekinumab in Japanese Clinical Practice
The purpose of this study is to describe the initial response to ustekinumab induction treatment for ulcerative colitis (UC) in Japan.
- Trial name
- NCT04963725
- Testing
- Ustekinumab
- Where
- 23 sites in Japan
- Volunteers
- 137 people
- Sponsor
- Janssen Pharmaceutical K.K.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.