Clinical trials: Bowel Dysfunction
Prematurity, Necrotizing Enterocolitis
Collaborative Research Group for Necrotizing Enterocolitis
This proposal will test the hypothesis that synthesis and catabolism of epidermal growth factor (EGF), the genotype of the EGF gene, and the microbiome interact to influence EGF expression in infants at risk for necrotizing…
- Trial name
- NCT00828451
- Testing
- [5,5,5-2H3]leucine (stable isotope labeled leucine)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Washington University School of Medicine
Ulcerative Colitis
Effects of WB-EMS in Ulcerative Colitis Patients
The purpose of this study is to determine the effect of 12 weeks of WB-EMS either applicated passive in a supine resting position or active during slight movements compared with a non-training control group on body composition…
- Trial name
- NCT02144129
- Testing
- active Whole Body Electromyostimulation, Passive WB-EMS, WB-EMS application
- Where
- Germany
- Sponsor
- University of Erlangen-Nürnberg Medical School
Chronic Granulomatous Disease, Inflammatory Bowel Disease
Elemental Diet for Treatment of Inflammatory Bowel Disease in Patients With Chronic Granulomatous Disease
Background: Bacteria that live inside the stomach and intestines are important for health. Chronic granulomatous disease (CGD) and inflammatory bowel disease (IBD) can make people have unhealthy bacteria.
- Trial name
- NCT03983837
- Testing
- Neocate Splash
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Crohn's Disease
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease
This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study, comprised of 3 sub-studies, to evaluate the efficacy and safety of duvakitug in participants with moderately to severely…
- Trial name
- STARSCAPE-1 (NCT07184931)
- Testing
- Duvakitug
- Where
- 461 sites in United States, Argentina and 34 more
- Volunteers
- 980 people
- Sponsor
- Sanofi
Irritable Bowel Syndrome
The Effect of Shigyakusan Used for IBS and MUPS Diagnosed by Abdominal N Line Tenderness
Abstract Background \& Aims: Abdominal N line tenderness for diagnosis and shigyakusan for treatment of irritable bowel syndrome ( IBS ) and medically unexplained physical symptoms ( MUPS ) were studied.
- Trial name
- NCT02653937
- Testing
- Tsumura's shigyakusan
- Volunteers
- 1 people
- Sponsor
- Nakatani Clinic
Appendicitis
The Hasselt APPendicitis Immunology and Environmental Cohort STudy
The Hasselt Appendicitis Immunology and Environmental Study (HAPPIEST) aims at characterizing factors that influence the development and severity of acute appendicitis.
- Trial name
- HAPPIEST (NCT02391675)
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Acute Myeloid Leukemia, Anatomic Stage III Breast Cancer AJCC v8
National Cancer Institute "Cancer Moonshot Biobank"
This trial collects multiple tissue and blood samples, along with medical information, from cancer patients. The "Cancer Moonshot Biobank" is a longitudinal study.
- Conditions
- Acute Myeloid Leukemia, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Clinical Stage IV Esophageal Adenocarcinoma AJCC v8
- Trial name
- NCT04314401
- Testing
- Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging
- Where
- 150 sites in United States, Puerto Rico
- Volunteers
- 1,600 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Neoplasms
Artificial Intelligence for Diminutive Polyp Characterization
Artificial intelligence is a promising tool that may have a role in characterizing colon epithelial lesions (CADx), helping to get a reliable optical diagnosis regardless of the endoscopist experience.
- Trial name
- NCT05391477
- Testing
- GI-Genius artificial intelligence
- Where
- Spain
- Volunteers
- 643 people
- Sponsor
- Hospital Universitario La Fe
Clinical and Nutritional Safety.
Oat Products in the Treatment of Coeliac Disease in Children
In many Northern European countries oat-based products have been used in the dieto-therapy of coeliac disease for many years. The purpose of this study is to evaluate clinical tolerance and liking of gluten-free products…
- Trial name
- NCT00808301
- Testing
- Gluten-free products
- Where
- 7 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Heinz Italia SpA
Crohn Disease, Pediatric Crohns Disease
PediCRaFT: Pediatric Crohn's Disease Fecal Transplant Trial
The objective of this study is to assess the feasibility of a novel colonic and oral fecal microbiota transplantation protocol for the treatment of active pediatric Crohn's disease (CD).
- Conditions
- Crohn Disease, Pediatric Crohns Disease, Inflammatory Bowel Diseases, Colitis
- Trial name
- PediCRaFT (NCT03378167)
- Testing
- MICROBIOTA
- Where
- 2 sites in Canada
- Volunteers
- 17 people
- Sponsor
- McMaster Children's Hospital
Colorectal Cancer, Surgery
CPET in Colorectal Surgery
The present study is a retrospective analysis of prospectively collected clinical data. Anonymized data from patients collected during routine clinical care from 7 major colorectal units in the UK who perform pre-operative…
- Trial name
- NCT02298907
- Where
- United Kingdom
- Volunteers
- 170 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Inflammatory Bowel Diseases
Ganglioside and IBD
Context. Inflammatory bowel disease (IBD) is a chronic and debilitating disorder. Novel treatment strategies aimed to resolve intestinal inflammation and induce disease remission are necessary.
- Trial name
- NCT04782544
- Testing
- Buttermilk Powder, Anhydrous Milk Fat
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Children's Hospital of Orange County
Obesity, Stress
Brain-Gut Interactions in Overweight and Normal Weight Patients With Chronic Abdominal Pain
About 15 to 20 percent of individuals living in the United States have chronic abdominal pain, often of unknown origin, which is often difficult to diagnose and treat.
- Conditions
- Obesity, Stress, Irritable Bowel Syndrome, Women
- Trial name
- NCT00824941
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Ulcerative Colitis
Phase III Study of MLN0002 (300 mg) in the Treatment of Ulcerative Colitis
The purpose of this study is to evaluate efficacy, safety and pharmacokinetics of the vedolizumab (MLN0002) induction and maintenance therapy in Japanese participants with moderate or severe ulcerative colitis (UC).
- Trial name
- NCT02039505
- Testing
- Vedolizumab
- Where
- 59 sites in Japan
- Volunteers
- 292 people
- Sponsor
- Takeda
Celiac Disease
Safety and Tolerability of Oat Containing Gluten-free Diet
The purpose of this study is to determine the safety and tolerability of oats in gluten free diet.
- Trial name
- SafeOatDiet (NCT02612766)
- Testing
- Pure, uncontaminated oats
- Where
- Romania
- Volunteers
- 25 people
- Sponsor
- Alfred Rusescu Institute for Mother and Child Care
Crohn Disease (CD)
Impact of Ultra-Processed Food Reduction on Remission Duration in Pediatric Crohn's Disease
Crohn's disease is a chronic inflammatory bowel disease. This study will investigate whether reducing the intake of ultra-processed foods through regular consultations with a registered dietitian can help children and adolescents…
- Trial name
- Up4-CD (NCT07884045)
- Testing
- Ultra-Processed Food Reduction Counseling, Standard Dietary Counseling
- Where
- 2 sites in Czechia
- Volunteers
- 124 people
- Sponsor
- University Hospital, Motol
Cancer, Breast Cancer
Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid Tumors
This Phase 1/2 study evaluates the safety, feasibility, and preliminary anti-tumor activity of allogeneic donor-derived CAR-NK cells in participants with advanced solid tumors.
- Conditions
- Cancer, Breast Cancer, Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (Locally Advanced or Metastatic)
- Trial name
- SELECT-CAR-NK (NCT07410494)
- Testing
- EB-SELECT Single-Target CAR-NK Cells, Dual-Target Antigen-Selected CAR-NK
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Essen Biotech
Stage II Colon Cancer, Stage III Colon Cancer
Fluorouracil Plus Leucovorin With or Without Oxaliplatin in Treating Patients With Stage II or Stage III Colon Cancer
Randomized phase III trial to compare the effectiveness of fluorouracil plus leucovorin with or without oxaliplatin in treating patients who have stage II or stage III colon cancer.
- Trial name
- NCT00004931
- Testing
- leucovorin calcium, fluorouracil, oxaliplatin
- Where
- United States
- Volunteers
- 2,472 people
- Sponsor
- National Cancer Institute (NCI)
Body Image Disorder
Prevention of Body Image Disorder by Nurse Intervention on the Patient and Family Prior to Breast and Colon Surgery
This is a non-blinded, randomized, controlled clinical trial consisting of 64 participants, which aims to assess the effectiveness of a nursing intervention for family members and patients prior to surgery to prevent body image…
- Trial name
- NCT03726801
- Testing
- HEALTH EDUCATION
- Where
- Spain
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Appendicitis
The Role of Imaging in the Diagnosis of Acute Appendicitis During the COVID-19 Pandemic
This is a retrospective observational study in the form of a cohort study evaluating the use of pre-operative imaging for the diagnosis of acute appendicitis in a tertiary centre during the first and second waves of the COVID-19…
- Trial name
- NCT05205681
- Testing
- Pre-operative imaging
- Where
- United Kingdom
- Volunteers
- 313 people
- Sponsor
- University College London Hospitals
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