Clinical trials: Brain Disorder
DIPG Brain Tumor, Diffuse Intrinsic Pontine Glioma
Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG
A Phase 1 clinical trial to evaluate the safety and early efficacy of CAR T-cell with IL-7Ra signal targeting B7H3 in children with diffuse intrinsic pontine glioma (DIPG) patients after complete standard treatments.
- Trial name
- CMD03DIPG (NCT06221553)
- Testing
- B7H3 specific CAR T cell with IL-7Ra signaling domain
- Where
- Thailand
- Volunteers
- 9 people
- Sponsor
- Chulalongkorn University
Persistent Pulmonary Hypertension of Newborn
N-Terminal Pro-brain Natriuretic Peptide Hormone and Persistent Pulmonary Hypertension
Babies who are suspected of having persistent pulmonary hypertension (PPHN) will be included in this study. PPHN is a condition in which the blood is restricted from flowing to the lungs in a normal way making it hard for babies…
- Trial name
- NCT00443859
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Stroke
Turkish Validity and Reliability of the Expanded Rehabilitation Complexity Scale
The RCS is a tool that can assess the need for complex rehabilitation and objectively indicate that a patient may have difficulty functioning well at home or in the community if their medical needs are still high.
- Trial name
- NCT06573359
- Testing
- questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Cardiovascular Diseases, Heart Diseases
Stroke and MI in Users of Estrogen/Progestogen
To estimate the relative risks of acute myocardial infarction (MI) and of stroke in postmenopausal users of estrogen/progestogen (E/P) combinations and to estimate the relative risks of MI and of stroke in users of estrogen alone.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Cerebrovascular Accident
- Trial name
- NCT00005466
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Down Syndrome
Effects of (tDCS) Combined With Virtual Reality Versus CPT on Brain, Cognitive, and GMS in Children With DS.
This randomized controlled trial aims to compare the effects of transcranial direct current stimulation (tDCS) combined with virtual reality-based training versus conventional physical therapy on brain activity, cognitive…
- Trial name
- NCT07385066
- Testing
- Conventional Physical Therapy, Experimental group (tDCS + Virtual Reality)
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Superior University
Cerebral Palsy (CP), Spastic Diplegia Cerebral Palsy
Comparison of Synchronous and Asynchronous Action Observation Therapy in Children With Cerebral Palsy
The aim of this study is to compare the effects of synchronous and asynchronous action observation therapy (AOT) on balance, gait, and functional capacity in children with cerebral palsy (CP).
- Conditions
- Cerebral Palsy (CP), Spastic Diplegia Cerebral Palsy, Spastic Hemiplegic Cerebral Palsy, Neurodevelopmental Disorder (Diagnosis)
- Trial name
- NCT07114731
- Testing
- Synchronous Action Observation Therapy, Asynchronous Action Observation Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Istanbul University - Cerrahpasa
Diabetic Ketoacidosis, Uncontrolled Type 1 Diabetes Mellitus
DKA Optic Ultrasound
Diabetic ketoacidosis (DKA) is a complication of type 1, or "insulin-dependent," diabetes (T1DM) and is defined by a high blood glucose level (over 200 mg/dL) coupled with severe acidosis.
- Trial name
- DKA Optic US (NCT02130180)
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Migraine
Prescription of Triptans in the Grand Est Region, France
The high frequency of migraine contrasts with the disparity of its management. The FRAMIG 3 study, carried out in France on the basis of the definition criteria of migraine of the IHS 2004 classification, identified, on the basis…
- Trial name
- PASENREGE (NCT05780580)
- Where
- France
- Volunteers
- 4,275,652 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Stroke, Dehydration
Neuroprotective Therapy and Therapeutic Target in Emergency Department
The investigators studied laboratory measurements and previously identified risk factors to identify factors predictors of early deterioration following stroke.
- Trial name
- NCT02143596
- Testing
- normal saline
- Where
- Taiwan
- Volunteers
- 159 people
- Sponsor
- Chang Gung Memorial Hospital
Amblyopia, VEP
Possible Beneficial Effects Of Combined Fluoxetine And Occlusion Therapy In Improving And Maintaining Vision In Amblyopia Using Optical Coherence Tomography Angiography (OCTA) And Visual Evoked Potential (VEP). The Aim Of The Study Is To Evaluate Possible Beneficial Effects For Different Age Groups.
Amblyopia is described as a limitation of the visual function of one or both eyes with no pathological cause, with a prevalence of about 1-5% of the total world population.
- Trial name
- VA; OCTA; VEP; (NCT07417046)
- Testing
- Flouxetine, Patching therapy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Minia University
Premature Childbirth
Evaluation of Brain Plasticity in Premature Infants at School Age After Cognitive Remediation
Infantile brain plasticity is still a poorly known phenomenon. However, neuropsychological disorders and behavioral deficits are common disorders that can have serious consequences for school enrollment, family and social…
- Trial name
- EPIREM (NCT03972761)
- Testing
- Magnetic Resonance Imaging (MRI) 3 tesla
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Blindness, Cerebrovascular Accident
Mechanisms of Human Plasticity in the Human System
The purpose of this study is to investigate the physiology associated with plasticity of the motor system. Plasticity refers to the process by which neighboring brain cells assume the responsibilities of damaged or diseased brain…
- Conditions
- Blindness, Cerebrovascular Accident, Spinal Cord Injury
- Trial name
- NCT00001661
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke, Cognitive Impairment
The Treatment Effectiveness of Combined tDCs and Neurofeedback (NF) for Patients With Cognitive Deficits After Stroke
This is a double blinded, randomized control trial with a pretest-posttest control and interventional groups design. Both the assessor and participants are blinded to all assessments and evaluations.
- Trial name
- NCT03093142
- Testing
- tDCS & neurofeedback, neurofeedback
- Where
- Hong Kong
- Volunteers
- 45 people
- Sponsor
- Kowloon Hospital, Hong Kong
Cerebral Palsy
Pully System Exercise Role in Management of Spasticity
The goal of this clinical trial is to investigate the effect of pully system exercise in in management of spasticity in cerebral palsy children Does pully system exercise has role in management of spasticity in cerebral palsy…
- Trial name
- NCT06927869
- Testing
- designed physical therapy , pully system exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Pompe's Disease
Prevalence of Heterozygote Mothers for Pompe's Disease Among Mothers Having Delivered in French Guiana
Given the high incidence of Pompe's Disease in French Guiana (100 times higher than in mainland France) the aim is to determine the prevalence of heterozygotes among women having just delivered in French Guiana who accepted that…
- Trial name
- DEPIPOMP2 (NCT02903654)
- Testing
- observational
- Volunteers
- 925 people
- Sponsor
- Centre Hospitalier de Cayenne
Hemiparetic Cerebral Palsy
Using Neurotechology to Help Children With Physical Disability Due to Cerebral Palsy
Hemiparetic cerebral palsy is a condition in which one side of a child's body becomes weak due to brain injury occurring around birth, often caused by stroke.
- Trial name
- NCT07269353
- Testing
- Brain Computer Interface - Functional Electrical Stimulations
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Alberta
Cerebral Palsy
Effect of Rhythmic Auditory Stimulation on Balance in Children With Cerebral Palsy.
To evaluate the effect of Rhythmic Auditory Stimulation (RAS) on balance in children with cerebral palsy.
- Trial name
- NCT05455970
- Testing
- Rhythmic auditory stimulation (RAS)
- Where
- Thailand
- Volunteers
- 22 people
- Sponsor
- Mahidol University
Tourette Syndrome
Safety, Tolerability, Pharmacokinetic, and Efficacy Study of AZD5213 in Adolescents With Tourette's Disorder
This is a two-part, randomized, multi-center, blinded study in adolescents with Tourette's Disorder. There will be an up to 21-day screening period in which subject eligibility will be determined.
- Trial name
- NCT01904773
- Where
- 7 sites in United States
- Volunteers
- 29 people
- Sponsor
- AstraZeneca
Amblyopia, Strabismus
Screening for 3-D Visual Disorders in Preschool Children
Visual screening is necessary among pre-school children as they found themselves in a critical period of visual developement. To date, there are no national vision screening program that has been implemented nationwide.
- Conditions
- Amblyopia, Strabismus, Anisometropia
- Trial name
- VISION (NCT05204069)
- Testing
- Instillation of cyclopentolate
- Where
- France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epilepsy
Ketogenic Diet Program for Epilepsy
This study will assess the effectiveness of the ketogenic diet (high-fat, low-carbohydrate, and moderate protein) in treating epilepsy.
- Trial name
- NCT02497105
- Testing
- Ketogenic Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
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