Clinical trials: Brain Disorders
Parkinson Disease
The Alouette Test in Parkinson Disease
Reading disorders in Parkinson's Disease (PD) are poorly evaluated due to the lack of validated tests to screen for them. They are often attributed to hand tremors associated with the disease.
- Trial name
- REPEAT (NCT03958175)
- Testing
- Alouette test (reading test)
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon
Amblyopia, Amblyopia Occlusion
Monocular Action Video Game Treatment of Amblyopia
This study evaluates the effectiveness of the monocular treatment with action video-games in comparison with the occlusion therapy alone in amblyopic patients, and the satisfaction with the different evaluated treatments.
- Conditions
- Amblyopia, Amblyopia Occlusion, Unilateral Amblyopia, Anisometropic Amblyopia
- Trial name
- NCT04313257
- Testing
- Monocular Active Occlusion, Monocular Passive Occlusion
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Universitat Politècnica de Catalunya
Stroke
Mobile Terminal Based Management of Stroke Secondary Prevention Adminstration Effect Research
The investigators want to verify whether mobile application based on stroke strengthen prevention management is more effective than traditional management model or open stroke management platform.
- Trial name
- NCT02618265
- Testing
- Mobile terminal, traditional management, website platform management
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Multiple Sclerosis, Clinically Isolated Syndrome
AT RISK FOR MS - Clinical Conversion of Female Monozygotic Twins Discordant for CIS/MS
The definition of the most 'at-risk' population within highly susceptible groups would provide an opportunity for preemptive therapeutics.
- Trial name
- ARMS (NCT00617383)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Brain Tumor Recurrent
Infusion of 5-Azacytidine (5-AZA) Into the Fourth Ventricle in Children With Recurrent Posterior Fossa Ependymoma
The goal of this clinical research study is to establish the safety of direct administration of 5-Azacytidine into the fourth ventricle of the brain or resection cavity in patients with recurrent posterior fossa ependymoma.
- Trial name
- 5-AZA (NCT02940483)
- Testing
- 5-Azacytidine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cerebral Palsy (CP)
Oral Motor Facilitation Technique And Traditional Exercises on Children With Cerebral Palsy
Cerebral palsy is a motor disorder caused by the damage to the developing brain. Feeding and swallowing difficulties are common in children with cerebral palsy (CP).
- Trial name
- NCT06343922
- Testing
- oral motor facilitation technique group, traditional oral motor exercises group
- Where
- Pakistan
- Volunteers
- 10 people
- Sponsor
- Riphah International University
Cerebral Palsy
Effect of Low Level Laser Therapy on Hamstring Muscle Tightness and Calf Muscle Spasticity in Cerebral Palsy Children.
Background :Spasticity is a motor disorder in children with cerebral palsy (CP) Cp is a non progress lesion in unmature brain lead to a group of chronic disorders that affect movement and posture development, may be accompanied…
- Trial name
- cp (NCT04789629)
- Testing
- low level laser therapy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- National Institute of Laser Enhanced Sciences
Cerebral Palsy (CP), Sleep Disordered Breathing (SDB)
Epidemiology of Sleep Disordered Breathing in Children and Young People With Cerebral Palsy
Cerebral palsy (CP) refers to a non-progressive movement disorder, which occurs due to damage to the developing brain around the time of birth.
- Conditions
- Cerebral Palsy (CP), Sleep Disordered Breathing (SDB), Respiratory Support
- Trial name
- UK_CPSSS (NCT06737302)
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Edinburgh
Tourette Syndrome, Tic Disorder, Chronic Motor or Vocal
Open-label MNS for Tourette Syndrome
A recent report (Morera Maiquez et al 2020) described reduced tic severity in people with Tourette syndrome during 1-minute epochs of median nerve stimulation (MNS) at 10 Hz.
- Trial name
- NCT05016765
- Testing
- Active, self-directed electrical stimulation of the median nerve
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Acute Disseminated Encephalomyelitis
ADAM'S Prognostic Markers
Acute Disseminated Encephalomyelitis (ADEM) is an immune-mediated demyelinating disorder of the central nervous system that predominantly affects children.
- Trial name
- NCT07188194
- Volunteers
- 32 people
- Sponsor
- Assiut University
Parkinson Disease
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for Parkinson's Disease
This trial will study the safety and efficacy of intranasal instillation of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of Parkinson's Disease
- Trial name
- NCT05152394
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Cerebral Palsy
Amantadine in Treating Cognitive & Motor Impairments in Adolescents and Adults With Cerebral Palsy
Cerebral palsy (CP) is a common childhood-onset disability associated with motor and cognitive impairments, however most research is focused on motor outcomes.
- Trial name
- NCT04273737
- Testing
- Amantadine Hydrochloride
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Columbia University
Cerebral Palsy
Allogeneic Umbilical Cord Blood Therapy in Children With CP
This open-label study aims to analyze cytokines related to clinical outcomes of allogeneic umbilical cord blood therapy for children with cerebral palsy.
- Trial name
- NCT02025972
- Testing
- Allogeneic umbilical cord blood therapy
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- MinYoung Kim, M.D.
Epilepsy
Trial to Evaluate the Safety and Efficacy of Keppra After Conversion to Mono-therapy in Subjects With Partial Epilepsy
A cohort of patients who became seizure-free during add-on treatment to one standard AED with Keppra in a previous trial (N01031) were followed to assess whether seizure freedom was maintained. Tolerability was documented.
- Trial name
- NCT00630357
- Testing
- Levetiracetam (Keppra)
- Volunteers
- 14 people
- Sponsor
- UCB Pharma
Cerebral Palsy, Spastic
Investigation of Motor Imaging Skills in Children With Spastic Cerebral Palsy
The aim of this study was to investigate implicit and explicit motor imagery skills in children with spastic cerebral palsy and typically developing children.
- Trial name
- NCT06343701
- Testing
- Implicit motor imagery, Explicit motor imagery
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Dementia, Paratonia
Safety and Effectiveness of Botulinum Toxin in Elderly Patients With Dementia and Muscle Stiffness
Aim of the study is to perform a pilot study to assess the impact of Botulinum toxin on muscle tone, and caregiver burden in individuals who are cognitively impaired and who are fully dependent.
- Trial name
- NCT02212119
- Testing
- Botulinum Toxin, Saline
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Assistive Technology Clinic, Canada
Hypoxic-Ischemic Encephalopathy, Pain
Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial)
Management of neonatal pain and sedation often includes opioid therapy. A growing body of evidence suggests long-term harm associated with neonatal opioid exposure.
- Trial name
- DICE (NCT04772222)
- Testing
- Dexmedetomidine Hydrochloride, Morphine Sulfate
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Binge Eating Disorder, Obesity
Binge Eating Disorder and Obesity : Functional MRI Study
Obesity, defined as BMI> 30kg / m2, is a major public health problem, with devastating medical and psychological consequences. 30% of obese suffer from BED type of eating disorders.
- Trial name
- BED (NCT02868619)
- Testing
- Functional MRI, ADO-BEDS scale, R-CMAS scale
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Concussion, Mild
Impact of a Paced Breathing Exercise Intervention on Autonomic Nervous System Function After Pediatric Concussion
The goal of this pilot clinical trial is to assess the feasibility of administering a paced breathing exercise intervention program to children and adolescents in the sub-acute period after concussion, and to document the…
- Trial name
- Breathe (NCT06559865)
- Testing
- Breathing exercises
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Troublesome Sialorrhea, Cerebral Palsy
Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability
The objective of this study is to investigate the efficacy and safety of NT 201 compared with placebo for the treatment of chronic troublesome sialorrhea associated with neurological disorders (e.g.
- Conditions
- Chronic Troublesome Sialorrhea, Cerebral Palsy, Stroke, Traumatic Brain Injury
- Trial name
- SIPEXI (NCT02270736)
- Testing
- NT 201
- Where
- 31 sites in Georgia, Hungary and 4 more
- Volunteers
- 256 people
- Sponsor
- Merz Pharmaceuticals GmbH
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