Clinical trials: Brain Injuries, Acute
Brain Injuries, Acute, Brain Trauma
BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence
The purpose of this research study is to prospectively collect biospecimens, imaging, and clinical data from patients with penetrating brain injuries across high-volume PBI sites in the US (including UChicago).
- Conditions
- Brain Injuries, Acute, Brain Trauma, Penetrating Head Injury, Traumatic Brain Injury
- Trial name
- BRIDGE-US (NCT07636213)
- Testing
- Blood Sample Collection
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Chicago
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Acute Coronary Syndrome, Atrial Fibrillation
Short- and Long-term Health Effects of Air Pollution in Poland
The effects of air pollution on the frequency of hospital admissions and mortality due to acute coronary syndromes, atrial fibrillation, and renal disfunction are noted also in areas perceived as pollution-free (due to the lack…
- Conditions
- Acute Coronary Syndrome, Atrial Fibrillation, Kidney Diseases, Particulate Matter Inhalation Injury
- Trial name
- EP-PARTICLES (NCT05198492)
- Testing
- Impact of air pollution
- Where
- Poland
- Volunteers
- 8,300,000 people
- Sponsor
- Medical University of Bialystok
Rhabdomyolysis, Myopathy
Study of the Causes of the Breakdown of Muscle Fibers in Hospitalized Patients
1. Analyze the various causes of breakdown of muscle fibers in hospitalized patients. 2. Analyze the characteristics of these patients in Taiwan (including the drugs history, risk factors and the incidence of complications).
- Conditions
- Rhabdomyolysis, Myopathy, Acute Renal Failure, Neuroleptic Malignant Syndrome
- Trial name
- NCT01022450
- Where
- Taiwan
- Volunteers
- 2,500 people
- Sponsor
- National Taiwan University Hospital
Acute Kidney Injury, Children
Renal Oxygen Saturation and Its Association With Acute Renal Injury
Peri-operative renal dysfunction is a major mortality and morbidity cause following cardiac and major vascular surgery. Although several intra-operative strategies are proposed for better outcomes, no effective and fast resulting…
- Conditions
- Acute Kidney Injury, Children, Cardiac Surgery
- Trial name
- NCT03608956
- Where
- Turkey (Türkiye)
- Sponsor
- Marmara University
Acute Brain Injury, Traumatic Brain Injury
Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain Injury
Acute brain injury (ABI) is a leading cause of death and long-term disability in children. Diagnosis depends on fast neuroimaging, and head computed tomography (CT) is the bedside reference standard despite exposing the…
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Hydrocephalus
- Trial name
- CUPID-Peds (NCT07772323)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Virginia Commonwealth University
Brain Injuries, Traumatic
Multiomic Analysis of Body Fluid in Acute Traumatic Brain Injury
The goal of this experimental observation study is to figure out differently expressed biomarkers in body fluid in traumatic brain injury patients.
- Trial name
- MOSS-FAST (NCT05778123)
- Testing
- Type of disease
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Brain Injuries, Traumatic, Cerebrovascular Trauma
A Multidimensional Inpatient Balance Training Class to Improve Functional Outcomes in Rehabilitation Inpatients With ABI
Many survivors of acquired brain injury (ABI) suffer from decreased balance and increased risks of falls. Previous studies indicate that balance training improves balance, reduces falls, and increases walking speed and balance…
- Conditions
- Brain Injuries, Traumatic, Cerebrovascular Trauma, Acute Brain Injuries
- Trial name
- NCT03110237
- Testing
- Control Balance Training (BT) class, Fallproof Balance Training (BT) class
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Concussion, Mild, Concussion, Brain
Acute Concussion and Melatonin
In this study, the investigator plans a randomized trial of melatonin versus placebo post acute pediatric concussion. The investigator hypothesizes that patients with acute concussions managed with melatonin will have improved…
- Conditions
- Concussion, Mild, Concussion, Brain, Pediatric ALL
- Trial name
- NCT04731974
- Testing
- Melatonin 3 MG
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Brain Injuries, Traumatic, Injuries, Acute Brain
The EPIC Project: Impact of Implementing the EMS Traumatic Brain Injury Treatment Guidelines
Evaluation of the impact (on survival and other outcomes) of implementing the Brain Trauma Foundation/National Association of EMS Physicians Traumatic Brain Injury (TBI) guidelines in the prehospital EMS systems throughout the…
- Conditions
- Brain Injuries, Traumatic, Injuries, Acute Brain, TBI (Traumatic Brain Injury)
- Trial name
- EPIC (NCT01339702)
- Testing
- The National Prehospital TBI Management Guidelines
- Where
- United States
- Volunteers
- 26,873 people
- Sponsor
- University of Arizona
Post-Concussion Syndrome
Craniosacral Therapy for Concussion Symptoms
This study investigated the utilization of CranioSacral Therapy (CST) in patients with Post-Concussion Syndrome (PCS) and capture patient-reported perceptions of their lived experiences of treatment effect upon their symptoms.
- Trial name
- NCT04820192
- Testing
- Craniosacral Therapy
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Special Therapies, Inc.
Cervical Artery Dissection, Carotid Artery Dissection
To Determine the Feasibility of a Clinical Trial Comparing Anticoagulants Versus Antiplatelets in the Acute Treatment of Patients With Cervical Artery Dissection
This is a feasibility study to determine if a sufficient number of patients can be recruited throughout the United Kingdom and whether sufficient endpoints can be generated for a full scale therapeutic trial of anticoagulants…
- Conditions
- Cervical Artery Dissection, Carotid Artery Dissection, Vertebral Artery Dissection, Stroke
- Trial name
- CADISS (NCT00238667)
- Testing
- Antiplatelet (Aspirin, Dipyridamole, clopidogrel), Anticoagulant (Unfractionated Heparin, LMW Heparin, Warfarin)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- St George's, University of London
Pediatric Acute Neurologic Disease, Traumatic and Non-traumatic
RCT: Early Rehabilitation Protocol vs. Usual Care in the Pediatric ICU for Children With Acute Brain Injury
Background. Early rehabilitation programs (ERP) that include physical, occupational, and speech therapies lessens debilitation and promotes return to previous physical and cognitive functioning and have been successfully applied…
- Trial name
- NCT02209935
- Testing
- Early Rehabilitation Protocol, Usual care
- Where
- 3 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of Pittsburgh
Alzheimers Disease, Inflammation
Alzheimers Disease and Neuromarkers in Patients With Acute Hip Fractures
The investigators explore the presence of AD factors beta-amyloid and tau in CSF and plasma to verify AD diagnosis in patients with acute hip fracture. Clinical dementia test is performed prior to operation.
- Conditions
- Alzheimers Disease, Inflammation, Hip Fracture
- Trial name
- ADhipfract (NCT02409082)
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Sahlgrenska University Hospital
Traumatic Brain Injury
Pediatric Autologous Bone Marrow Mononuclear Cells for Severe Traumatic Brain Injury
Pediatric severe traumatic brain injury (TBI) is the leading cause of death and disability in children ages 1-14 years old. There are no effective therapies to treat secondary brain injury and the post-injury response of CNS…
- Trial name
- NCT01851083
- Testing
- autologous bone marrow mononuclear cells
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- The University of Texas Health Science Center, Houston
Brain Injury Traumatic Mild, Brain Injuries
Screening Emotions in Adolescents at the Hospital for mTBI
The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an increased risk for developing…
- Conditions
- Brain Injury Traumatic Mild, Brain Injuries, Brain Injuries, Acute, Head Injury With Intracranial Hemorrhage
- Trial name
- SEARCH-mTBI (NCT06370520)
- Testing
- Validated Questionnaires, Questionnaires, Clinician / Medical Record Variables
- Where
- 6 sites in United States
- Volunteers
- 2,592 people
- Sponsor
- University of California, Davis
Hypoxic-Ischemic Encephalopathy, Acute Kidney Injury
Renal and Cerebral NIRS and Early Acute Kidney Injury in Cooled Neonates With Birth Asphyxia
This prospective, single-center observational cohort study evaluated whether continuous cerebral and bilateral renal near-infrared spectroscopy (NIRS) monitoring during therapeutic hypothermia distinguishes term neonates with…
- Conditions
- Hypoxic-Ischemic Encephalopathy, Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy, Neonatal, Asphyxia Neonatorum
- Trial name
- NCT07743099
- Testing
- 1- Continuous Cerebral Near-Infrared Spectroscopy, 2- Continuous Bilateral Renal Near-Infrared Spectroscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Agah Bahadır Öztürk,MD
Acute Kidney Injury, Hypoxia-Ischemia, Brain
Tissue Oxygenation During Treatment of Infant Congenital Heart Defects
Background: Acute kidney injury (AKI) is a common and serious postoperative complication in children with congenital heart disease.
- Conditions
- Acute Kidney Injury, Hypoxia-Ischemia, Brain, Mesenteric Ischemia
- Trial name
- NCT03941015
- Where
- China
- Volunteers
- 245 people
- Sponsor
- Beijing Anzhen Hospital
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Mild Traumatic Brain Injury, Acute Brain Injury
Aerobic Exercise for Concussion
The use of aerobic exercise treatment in the chronic phase of concussion recovery is well-described in the literature but there are limited existing data on the effect of exercise treatment in the acute phase after sport-related…
- Conditions
- Mild Traumatic Brain Injury, Acute Brain Injury, Brain Concussion
- Trial name
- NCT02959216
- Testing
- Aerobic Exercise, Stretching Exercise
- Where
- 3 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia