Clinical trials: Brain Injuries
Cerebral Palsy Spastic Diplegia
Investigation of the Effects of Diaphragm Exercises in Children With Cerebral Palsy
The aim of this study is to examine the effects of diaphragmatic myofascial relaxation exercise and diaphragmatic breathing exercises added to the conventional physiotherapy and rehabilitation program in children with diplegic…
- Trial name
- NCT05559346
- Testing
- Diaphragmatic exercises, conventional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Uskudar University
Cerebral Palsy Infantile, Pre-Term
Motor-voice Assessment in Infants (MAMI)
The goal of this observational study is to discover features of normal and disordered motor-voice profiles that are biobehavioral markers of physical disability in infants..
- Conditions
- Cerebral Palsy Infantile, Pre-Term, Motor Delay, Neurodevelopmental Disorders
- Trial name
- MAMI (NCT06807203)
- Testing
- Behavioral observation
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Ohio State University
Cerebral Palsy, Quality of Life
Relationship Between Trunk Control and Hand Function and Quality of Life
Increasing quality of life and improving hand functions are very substantial treatment goals for physiotherapy and rehabilitation.
- Conditions
- Cerebral Palsy, Quality of Life, Hand
- Trial name
- NCT05206461
- Testing
- Trunk Control Measurement Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- KTO Karatay University
Cerebral Palsy, Neuromuscular Disease
Calibration and Validation of the PROMIS and Neuro-QOL Questionnaires in Cerebral Palsy and Congenital Muscular Dystrophy
Background: Neuromuscular diseases (NMDs) do not have cures. But future treatments will try to improve the health-related quality of life (HRQoL) in people with NMD. Computer questionnaires can help test HRQoL in people with NMD.
- Trial name
- NCT02153970
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- National Institute of Nursing Research (NINR)
Dystonia, Drug Induced Dystonia
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
- Conditions
- Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT05317390
- Testing
- DystoniaNet-based diagnosis of isolated dystonia
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Mild Traumatic Brain Injury; Concussion
Seeing-Moving-Playing: Early Rehabilitation Utilizing Visual and Vestibular Technology Following Traumatic Brain Injury
The aim of this research program is to 1) Evaluate potential problems with vision, inner ear-eye reflexes and deficits of processing eye information that occur following TBI; and 2) Evaluate treatment programs for individuals…
- Trial name
- SiMPlyRehab (NCT03215082)
- Testing
- Vestibular-Visual Intervention, standard care
- Where
- 4 sites in Canada, France and 1 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Bacterial Vaginosis, Premature Birth
Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity
The trial intends to evaluate the efficacy of specially designed probiotics to prevent premature birth and related neonatal morbidity associated to intra-uterine infection.
- Conditions
- Bacterial Vaginosis, Premature Birth, Sepsis, Periventricular Leukomalacia
- Trial name
- NCT00303082
- Testing
- Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
- Where
- 2 sites in Brazil
- Volunteers
- 645 people
- Sponsor
- Oswaldo Cruz Foundation
Cerebral Palsy
Stem Cells in Umbilical Blood Infusion for CP
This study will investigate the safety of single dose intravenous infusion of cord blood cells which were cryopreserved after the birth of a brother or sister to a child with cerebral palsy.
- Trial name
- SCUBI-CP (NCT03087110)
- Testing
- Matched sibling donor cord blood cell infusion
- Where
- 2 sites in Australia
- Volunteers
- 12 people
- Sponsor
- Murdoch Childrens Research Institute
Executive Function Deficits (EFD), Developmental Coordination Disorder
Let's CO-OPerate! Together we Are Stronger
The goal of this replicated single case experimental study using a randomized multiple baseline design across participants and goals is to enable children/adolescents (aged 8-16 years) with developmental coordination disorders…
- Conditions
- Executive Function Deficits (EFD), Developmental Coordination Disorder, Acquired Brain Injury (Including Stroke), Brain Injury, Fetus and Neonate
- Trial name
- NCT07085403
- Testing
- Cognitive Orientation to daily Occupational Performance (CO-OP) is a cognitive problem-solving approach
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Hopitaux de Saint-Maurice
Premature Birth, Brain Injury
Melatonin As A Novel Neuroprotectant In Preterm Infants- Dosage Study
Preterm babies are at risk of brain injury. Melatonin, a naturally occurring hormone, may reduce this risk. The unborn baby receives melatonin from the mother but following premature delivery there maybe a period of prolonged…
- Trial name
- MIND (NCT00649961)
- Testing
- Melatonin injection
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- Imperial College London
Cerebral Palsy
Early Childhood Constraint Therapy in Cerebral Palsy
This is a prospective interventional study involving young children who will all receive non-invasive, passive assessments of sensory and motor function.
- Trial name
- APPLES (NCT02567630)
- Testing
- Soft Mitt Constraint Therapy for Sensory/Motor Impairment in Cerebral Palsy
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Acquired Brain Injury
Checking the Usability of a Virtual Reality System in Children With Brain Injury
The purpose of this study is to check the usability of Virtual Reality (VR) Video Capture Projected System in children with acquired brain injury(ABI)and comparing their performance to the performance of normally developing…
- Trial name
- NCT00358865
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cerebral Palsy, GORD
Gastro-oesophageal Reflux and NeuroDisability (Cerebral Palsy) in CHILDren
This study assesses the content validity of the PGSQ for parents/carer of children with cerebral palsy and GORD, including features such as readability, face validity and acceptability for completion.
- Conditions
- Cerebral Palsy, GORD, Pediatrics, GERD in Children
- Trial name
- GRANDCHILD (NCT04293107)
- Where
- 2 sites in United Kingdom
- Volunteers
- 26 people
- Sponsor
- Poole Hospital NHS Foundation Trust
Traumatic Brain Injury, Cerebral Palsy
Validity and Reliability of Perceived Exertion Rating Scale in Children With Brain Damage
The purpose of this study is to examine the reliability and validity of the rating of perceived exertion scale in children post severe traumatic brain injury during treadmill exercise.
- Trial name
- NCT01840644
- Testing
- Walking on treadmill, different velocities and incline
- Where
- Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Alyn Pediatric & Adolescent Rehabilitation Hospital
Spastic Diplegia Cerebral Palsy, Quality of Lifte
Additional Effects of Cuevas Medek Exercises Along With Conventional Physical Therapy on Gross Motor Proficiency and Quality of Life, in Children With Spastic Diplegic Cerebral Palsy
Cerebral palsy (CP) is a prevalent pediatric neurological disorder hindering movement and posture development due to non-progressive disruptions in brain development.
- Conditions
- Spastic Diplegia Cerebral Palsy, Quality of Lifte, Motor Function
- Trial name
- NCT06966609
- Testing
- Control Group, Experimental Group
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Foundation University Islamabad
Cerebral Palsy, Cerebral Palsy (CP)
Validity Assessment of Sensors for Movement Tracking With Children/Youth With Diverse Neuromotor Abilities
The overall goal of this study is to establish the clinical utility and accuracy of markerless motion captures systems for tracking therapy exercises and movement during game play. Specific aims are: 1.
- Trial name
- MOCAP (NCT07360171)
- Testing
- Validity Assessment of Sensors for Movement Tracking With Children/Youth With Diverse Neuromotor Abilities
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Cerebral Palsy
Functional and Neuroplastic Effects of HABIT-ILE in Children With Bilateral Cerebral Palsy
This randomized controlled trial will compare the effects of neuroplastic and functional changes of Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) when presented in two periods (2HG; n=24) versus a…
- Trial name
- FuN HABIT-ILE (NCT06428032)
- Testing
- Hand-Arm Bimanual Intensive Therapy Including Lower Extremities
- Where
- Chile
- Volunteers
- 48 people
- Sponsor
- Universidad Nacional Andres Bello
Concussion, Brain
Evaluating a Novel Method of EEG Evoked Response Potential Analysis in Concussion Assessment, Young Adults and Adults
Concussion is widely recognized as a major public health concern in the United States and worldwide. Although many concussions resolve completely and spontaneously, almost 1 in 4 patients will go on to experience post-concussion…
- Trial name
- NCT03249675
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Diplegic Spastic Cerebral Palsy
Effects OF NMES With and Without Dynamic Bracing on Spasticity and Movement Quality in CP
The study aims at comparing Neuromuscular electrical Stimulation with and without dynamic bracing on spasticity and movement quality of lower limb in Children with Cerebral Palsy
- Trial name
- NCT06303336
- Testing
- NMES with Dynamic Bracing, NMES without Dynamic Bracing, Dynamic Bracing Only
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Disorders of Consciousness
mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of Consciousness
The goal of this clinical trial is to test how effective the mindBEAGLE device is in allowing people who are unconscious (due to a brain injury or other condition) to communicate using brain waves to answer Yes/No questions.
- Trial name
- NCT06426602
- Testing
- mindBEAGLE daily device use
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Amy Wagner
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