Clinical trials: Brain Injury Traumatic Moderate
Traumatic Brain Injury
Transcranial Doppler on Admission of Patients With Mild to Moderate Traumatic Brain Injury
Patients with mild to moderate traumatic brain injury (TBI) are at risk for secondary neurological deterioration. Their outcome within the first week after injury could be predicted by clinical signs, brain CT scan and…
- Trial name
- TCD (NCT01291706)
- Testing
- Transcranial Doppler
- Where
- 21 sites in France
- Volunteers
- 369 people
- Sponsor
- University Hospital, Grenoble
Craniocerebral Trauma, Hypothalamic-pituitary Disorders
Long-term Follow-up of Pituitary and Hypothalamic Dysfunction in Children Who Have Suffered Moderate to Severe Head Trauma Included in the ENDOC TC Cohort
The annual incidence of traumatic brain injury (TBI), all causes combined, varies between 180 and 300 per 100,000. TBI increases the risk of death or serious sequelae by a factor of 8.
- Conditions
- Craniocerebral Trauma, Hypothalamic-pituitary Disorders, Pediatric, Endocrinology
- Trial name
- ENDOC TC 2 (NCT07533435)
- Testing
- Telephone questionnaire
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Biomarkers
Role of Concentration of Biomarkers S100B and NSE in Serum in Mild and Moderate Head Trauma
In pediatric age groups communication difficulties very sometimes may present further obstacles in obtaining a detailed injury history and early identification of TBI symptoms.
- Trial name
- NCT02988102
- Testing
- Following S100B and NSE in head trauma
- Where
- Albania
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Clinical Centre of Kosova
Brain Injuries
Tranexamic Acid for Preventing Progressive Intracranial Haemorrhage in Traumatic Brain Injury
The study's objective is to evaluate the effectiveness and safety of tranexamic acid for adult patients with moderate to severe TBI.With the research question as "Does TXA reduce the incidence of progressive intracranial…
- Trial name
- NCT00755209
- Testing
- tranexamic acid
- Where
- Thailand
- Volunteers
- 238 people
- Sponsor
- Khon Kaen University
Traumatic Brain Injury
Prediction of Neurological Outcome of Children After a Traumatic Brain Injury Based on an Integrated Predictive Model
This study aims to develop a integrated predictive model based on serum biomarkers, HRV, and an innovative computerized classifier output, to predict the patient long term neurological outcome after a moderate or severe TBI in…
- Trial name
- NCT04157634
- Testing
- Prognostication model
- Volunteers
- 70 people
- Sponsor
- St. Justine's Hospital
Cerebral Palsy, Traumatic Brain Injury
Targeted Training for Trunk Control_case Series Cerebral Palsy
If a child with cerebral palsy does not develop independent sitting balance by 4 years of age, their prognosis for walking is very poor.
- Trial name
- CP_TT (NCT02097836)
- Testing
- Targeted Training
- Volunteers
- 11 people
- Sponsor
- University of Oregon
Traumatic Brain Injury
Respiratory Treatment of Patients With Moderate and Severe Traumatic Brain Injury
Intracranial pressure (ICP) in patients with traumatic brain injury (TBI) is influenced by several factors of which one is arterial CO2 tension.
- Trial name
- NCT01955785
- Testing
- pressure controlled ventilator, Pressure Regulated Volume Controlled Ventilator
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- Norwegian University of Science and Technology
Traumatic Brain Injury
A Phase 2a Dose Escalation Study With SLV334 in Patients With Traumatic Brain Injury.
A Randomized, Double Blind, Placebo Controlled, Phase 2 Dose Escalation Study to Investigate the Safety and Pharmacokinetics after Single and Multiple I.V.
- Trial name
- NCT00735085
- Testing
- SLV334
- Where
- 14 sites in United States, Israel and 2 more
- Volunteers
- 57 people
- Sponsor
- Abbott Products
Traumatic Brain Injury
Growth Hormone and Insulin Growth Factor 1 Deficiencies in Children/Adolescents Following Traumatic Brain Injury: The Impact on Growth and Neuropsychological Development
The purpose of this study is to look at the relationship between growth hormones, and recovery from a TBI - traumatic brain injury. It is believed that a TBI may interfere with the body's ability to produce growth hormones.
- Trial name
- NCT00929045
- Testing
- Growth Hormone Replacement
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Brain Injuries, Traumatic
Validation of the Scandinavian Guidelines for Minor and Moderate Head Trauma in Children
Head injuries are common among children and adolescents, with many of them assessed in emergency departments each year. Most children recover fast, with full resolution of symptoms as headache, dizziness or fatigue.
- Trial name
- SHIPP (NCT05964764)
- Where
- 16 sites in Norway, Sweden
- Volunteers
- 5,300 people
- Sponsor
- Halmstad County Hospital
Traumatic Brain Injury
Ketogenic Diet & Functional Recovery in Moderate to Severe Traumatic Brain Injury
Traumatic Brain Injury (TBI) represents a significant public health risk in the United States leaving many survivors with significant long term cognitive deficits and at risk for neurodegenerative diseases.
- Trial name
- NCT04530032
- Testing
- ketogenic/modified Atkins diet, Standard diet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Loma Linda University
Traumatic Brain Injury, Pain
Characterization & Treatment of Chronic Pain After Moderate to Severe TBI
This is a five year multi-site, cross sectional, observational study designed to examine chronic pain and pain treatment after moderate to severe TBI.
- Trial name
- NCT03739307
- Where
- 13 sites in United States
- Volunteers
- 3,805 people
- Sponsor
- Craig Hospital
Traumatic Brain Injury
Long Term Effects of Erythropoietin in Patients With Moderate to Severe Traumatic Brain Injury
Traumatic brain injury is catastrophic event that commonly require treatment in an intensive care unit. Management is mainly supportive aiming at avoiding hypoxia, hypotension, hypoglycaemia and increased intracerebral pressure.
- Trial name
- NCT03061565
- Testing
- erythropoietin
- Where
- Australia
- Volunteers
- 356 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Head Injury
Effect of Rosuvastatin on Cytokines After Traumatic Brain Injury
The purpose of this study is to determine whether rosuvastatin could alter the immunological response after head injury by modulating TNF-alpha,IL6,IL-1.
- Trial name
- NCT00990028
- Testing
- Rosuvastatin
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Moderate to Severe Traumatic Brain Injury
Ante-hypophyseal Dysfunctions in Children Following Moderate to Severe Traumatic Brain Injuries
Annual incidence of severe traumatic brain injuries (TBI) varies from 180 to 300 out of 100.000. Mortality or severe sequelae risk is increased 8 fold after a TBI.
- Trial name
- Endoc-TC (NCT01250132)
- Testing
- Biological and behavioral explorations
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Hospices Civils de Lyon
Traumatic Brain Injury
MLC901 for Moderate to Severe Traumatic Brain Injury (Specified Drug Code)
Patients with a diagnosis of moderate to severe traumatic brain injury (TBI) will be enrolled. Subjects will be randomly assigned to receive either MLC901 (Specified Drug Code) or placebo capsules three times per day over 6…
- Trial name
- MLC901 (NCT04487275)
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Ali Amini Harandi
Brain Trauma
Magnetic Resonance (MR) Spectroscopy and Diffusion Tensor Imaging in Determining Brain Injury and Subsequent Clinical Outcome in Patients of Moderate Brain Trauma
The purpose of this study is to use magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) to assess for traumatic brain injury and determine if there is any correlation of these findings to clinical outcome.
- Trial name
- NCT00760903
- Testing
- Conventional MRI of the brain, MR spectroscopy (MRS), MR Diffusion Tensor Imaging (DTI)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Brain Injuries, Traumatic, Brain Injury Traumatic Moderate
A Prospective Outcome Study in Patients With Moderate to Severe Traumatic Brain Injury
Traumatic brain injury (TBI) is the leading cause of death, disability and cognitive impairment in young people worldwide. The majority of the traumatic deaths in developed countries results directly from lesions in the central…
- Conditions
- Brain Injuries, Traumatic, Brain Injury Traumatic Moderate, Brain Injury Traumatic Severe
- Trial name
- TBI-PRO (NCT03810222)
- Testing
- N/A (Observational Study)
- Where
- Italy
- Volunteers
- 225 people
- Sponsor
- FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
Traumatic Brain Injury
Virtual Reality in Rehabilitation of Executive Functions in Children With Mild or Moderate Traumatic Brain Injury
Traumatic brain injury (TBI) causes lifelong disability. Children with TBI often have difficulties in attention regulation and executive functions affecting their daily living.
- Trial name
- VREALFUN-TBI (NCT06127459)
- Testing
- Parental Guidance, Virtual Reality Game
- Where
- Finland
- Volunteers
- 44 people
- Sponsor
- Merja Nikula
TBI (Traumatic Brain Injury), Stroke Acute
The Multicenter Italian INCEPT (INfarto CErebrale Post-Traumatico) Study
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide (Ghajar, 2000). With an estimated annual incidence of up to 500 per 100,000 population and more than 200 hospital admissions per 100,000 admissions…
- Trial name
- NCT02430324
- Testing
- posttraumatic cerebral infarction
- Where
- Italy
- Volunteers
- 143 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia