Clinical trials: Brain Structure
Cerebral Palsy
Functional Electrical Stimulation (FES) for Upper Extremity Hemiplegia in Children With Cerebral Palsy
The proposed pilot study seeks to explore the effectiveness of Functional Electrical Stimulation (FES) to improve upper limb function in children and youth (aged 6 to 18 years) with hemiplegic cerebral palsy, as measured by the…
- Trial name
- NCT03016923
- Testing
- FES Therapy
- Volunteers
- 3 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Cerebral Palsy, Upper Extremity Paresis
Virtual Reality Mediated Upper Extremity rehabilitationPatients With Cerebral Palsy
Cerebral palsy (CP) refers to a group of permanent disorders that occur in the brain of the fetus or infant, which are non-progressive, cause movement and posture disorder along with activity limitation.
- Trial name
- NCT04529343
- Testing
- Virtual reality mediated upper extremity rehabilitation, Classical exercise therapy for upper extremities
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Parkinson's Disease
A Long-Term Extension Trial From of SPM 962 in Advanced Parkinson's Disease Patients
To investigate the safety of once-daily repeated transdermal administration of SPM 962 within a dose range of 4.5 to 36.0 mg/day (54-week treatment period) in Parkinson's disease (PD) patients treated concomitantly with L-dopa in…
- Trial name
- NCT01631825
- Testing
- SPM 962
- Where
- 8 sites in Japan
- Volunteers
- 321 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Refractory Epilepsy
Retrospective Evaluation of Perampanel in a French Neurology and Epileptology Department (Hospices Civil de Lyon)
Perampanel is a non-competitive antagonist of the AMPA ( 2-amino-3-(5-méthyl-3-hydroxy-1,2-oxazol-4-yl)) propanoïc acid receptors which was approved by the European Medicines Agency as adjunctive treatment for partial-onset…
- Trial name
- PERLYON (NCT02876289)
- Testing
- Perampanel
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Hospices Civils de Lyon
Dwarfism, Pituitary
Predictive Markers in Chinese Growth Hormone Deficiency (GHD) Children Treated With Saizen®
This is an open-label, prospective, multicentric, non-comparative, non-randomized Phase IV interventional study in which subjects pre-diagnosed with Growth Hormone Deficiency (GHD) were treated for 4 weeks with Saizen to compare…
- Trial name
- NCT01187550
- Testing
- Recombinant human growth hormone (r-hGH)
- Volunteers
- 214 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Migraine Headache
Clinical Study Examining Use of an Over-the-Counter Supplement for the Prevention of Menstrually-Associated Migraine Headache
The purpose of this trial is to study the use of soy isoflavones in the prevention of menstrually-associated migraines. Additionally, this trial may provide insight into the menstrual cycle and menstrually-related headaches in…
- Trial name
- NCT00203255
- Testing
- Soy Isoflavones
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Thomas Jefferson University
Visual Suppression, Amblyopia
Autostereoscopic Dynamic Near Vision Testing
This is an analysis of tests of near vision. Visual perception testing using a novel program on an interactive three dimensional electronic device: Autostereoscopic dynamic near games for monocular visual acuity, stereopsis and…
- Conditions
- Visual Suppression, Amblyopia, Color Vision Defects
- Trial name
- PDICheck (NCT04606355)
- Testing
- Visual Acuity, stereopsis, Color vision
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Alaska Blind Child Discovery
Friedreich Ataxia
Methylprednisolone Treatment of Friedreich Ataxia
This study will explore whether methylprednisolone treatment is safe, well-tolerated, and beneficial in patients that are diagnosed with Friedreich Ataxia (FRDA).
- Trial name
- NCT02424435
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Children's Hospital of Philadelphia
Seizures, Epilepsy
Investigating Epilepsy: Screening and Evaluation
Background: Epilepsy affects about 1 percent of the U.S. population. Most people with epilepsy respond well to medicine, but some do not.
- Conditions
- Seizures, Epilepsy, Epilepsy, Temporal Lobe, Partial Epilepsy
- Trial name
- NCT03478852
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy, Sensory Modulation Disorder
Sensory Modulation in Children With Epilepsy
Epilepsy is a neurological condition that can impact cognitive, motor, and behavioral skills, often leading to sensory modulation disorders (SMDs) in children.
- Trial name
- NCT06818344
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Brain Tumors
Working Memory Performance Among Childhood Brain Tumor Survivors
Children treated with radiation therapy for brain tumors are at risk for cognitive problems. These problems have typically been demonstrated on global cognitive measures including measures of intellectual functioning (IQ).
- Trial name
- NCT00693914
- Testing
- Series of tests/questionnaires
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Pediatric Growth Hormone Deficiency
A Study to Compare the Experiences of Taking Daily Growth Hormone Injections to Weekly Ngenla in Children With Low Levels of Growth Hormone
The purpose of this study is to learn about: how children stick to taking their injections their experience with the study medicines (Ngenla and daily growth hormone) prescribed to children with low levels of growth hormone.
- Trial name
- NCT06113952
- Testing
- Sharps bin to collect used needles/injections
- Sponsor
- Pfizer
GM2 Gangliosidoses, Tay-Sachs
Pharmacokinetics, Safety and Tolerability of Zavesca (Miglustat) in Patients With Infantile Onset Gangliosidosis: Single and Steady State Oral Doses
We want to see if Zavesca (or miglustat) is safe and can be tolerated by patients with acute infantile onset GM2 gangliosidosis - classical Tay-Sachs and infantile onset Sandhoff disease.
- Conditions
- GM2 Gangliosidoses, Tay-Sachs, Sandhoff Disease
- Trial name
- NCT00672022
- Testing
- Zavesca (Miglustat)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's National Research Institute
Drug Resistant Epilepsy
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy
Evaluation of the role of estimation of serum level of miRNAs223 and HMGB1in detection of patient with drug resistant epilepsy. Early detection of the prognosis might help in guiding patients for proper management and treatment…
- Trial name
- NCT05555537
- Testing
- MiRNA223 and High mobility group box1(HMGB1)
- Volunteers
- 90 people
- Sponsor
- Assiut University
Ventriculoperitoneal Shunt, Trans Fontanelle US
Insertion of Frontal Ventricular Catheter of VP Shunt in Congenital Hydrocephalus Guided by Trans Fontanelle Ultrasound
The Aim of This Study Is To Evaluate The Role Of Ultrasound In Decreasing Rate Of Proximal Obstruction In Frontal VP Shunt
- Conditions
- Ventriculoperitoneal Shunt, Trans Fontanelle US, Congenital Hydrocephalus
- Trial name
- NCT06664372
- Testing
- Trans fontanelle US Guided VP Shunt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Mucolipidosis Type IV
Safety and Efficacy of AAV9. hMCOLN1co For Patients With Mucolipidosis Type IV
Safety and Efficacy of AAV9.hMCOLN1co for patients with Mucolipidosis Type IV(MLIV): A Single-Center, Interventional, Open-Label, Single-Arm Clinical Study.
- Trial name
- AAV9-hMCOLN1 (NCT07398872)
- Testing
- AAV9.hMCOLN1co
- Where
- China
- Volunteers
- 1 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Cerebral Palsy
Robotic Exoskeleton Gait Training for Children With Cerebral Palsy
The goal of this clinical trial is to evaluate whether robotic-assisted gait training can improve motor function, walking capacity, joint flexibility, muscle structure, and psychological well-being in children aged 6 to 12 years…
- Trial name
- NCT07049523
- Testing
- Robotic-assisted gait training
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Hunan Normal University
Cerebral Palsy (CP), Intraventricular Hemorrhage Neonatal
Intelligent Physiological Monitoring to Predict Preterm Brain Injury
Cerebral palsy (CP) remains prevalent among very (28-31 weeks) and extremely (<28 weeks) preterm infants. Prematurity-related brain injuries (high-grade intraventricular haemorrhage, IVH or periventricular leukomalacia, PVL)…
- Conditions
- Cerebral Palsy (CP), Intraventricular Hemorrhage Neonatal, Periventricular Leukomalacia, Neurodevelopmental Delay
- Trial name
- AI4NICU (NCT07880431)
- Testing
- EEG, NIRS
- Where
- Ireland
- Volunteers
- 413 people
- Sponsor
- University College Cork
Pituitary Diseases
Clinical Characteristics and Analysis of Pituitary Complex and Rare Diseases
The goal of this observational study is to systematically describe the clinical characteristics and outcomes of patients with pituitary complex and rare diseases at Peking Union Medical College Hospital.
- Trial name
- NCT06435195
- Testing
- Surgical Removal, Biopsy
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Peking Union Medical College Hospital
Epilepsy
Safety and Tolerability of Intravenous Brivaracetam (Infusion or Bolus) as Adjunctive Antiepileptic Therapy
This is a multicenter, open-label, 4-arm, randomized, parallel-group study to evaluate safety and tolerability of Brivaracetam Intravenous (BRV iv) as adjunctive treatment for adults with epilepsy according to an initiation or a…
- Trial name
- NCT01405508
- Testing
- Brivaracetam tablets, Brivaracetam bolus, Brivaracetam infusion
- Where
- 17 sites in United States, Czechia and 2 more
- Volunteers
- 105 people
- Sponsor
- UCB Pharma
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