Clinical trials: Brain Trauma
Prematurity, Transfer Injury
Minimising the Adverse Physiological Effects of Transportation on the Premature Infant
Centralisation of neonatal intensive care has led to an increase in postnatal inter-hospital transfers within the first 72 hours of life.
- Conditions
- Prematurity, Transfer Injury, Brain Injuries, Intraventricular Hemorrhage
- Trial name
- TRiPs (NCT03754439)
- Testing
- Physiological changes to noise and vibration exposure
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Nottingham
Aplastic Anemia
Study of Fludarabine + Cyclophosphamide + TBI Conditioning Regimen for Double Units Cord Blood Transplantation(CBT)in Severe Aplastic Anemia(SAA)
Severe aplastic anemia is a fatal disease and patients without HLA matched siblings need alternative treatment option. Cord blood transplantation (CBT) has become an alternative treatment means in various diseases, but it has not…
- Trial name
- NCT00881933
- Testing
- Cyclophosphosphamide, TBI
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- The Korean Society of Pediatric Hematology Oncology
Hypoxic-Ischemic Encephalopathy, HIE
A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury
Infants with hypoxic-ischemic encephalopathy (HIE) are at high risk for neurodevelopmental impairment, despite current standards of care. Adjunctive treatments to promote brain repair are needed.
- Conditions
- Hypoxic-Ischemic Encephalopathy, HIE, Neurodevelopment, Infant Development
- Trial name
- NCT06429007
- Testing
- Metformin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston Children's Hospital
Brain Injuries,Traumatic, Outcome Assessment (Health Care)
Brain Trauma Outcomes in Nova Scotia Study
The goals of this study are to identify outcome indicators of optimal care for brain injury patients, including pre-hospital care, prompt delivery to neurosurgical care and access to early rehabilitation services.
- Conditions
- Brain Injuries,Traumatic, Outcome Assessment (Health Care), Craniocerebral Trauma, Emergency Medical Services
- Trial name
- BTOS (NCT01225692)
- Testing
- Head Injury Guideline
- Volunteers
- 52 people
- Sponsor
- Queen Elizabeth II Health Sciences Centre
Hemiplegia, Cerebral Palsy Spastic Hemiplegic
Arm More + Camp: An Implementation Study
Our primary aim is to evaluate the implementation cost of a full day modified constraint induced movement therapy camp for children with hemiparesis.
- Conditions
- Hemiplegia, Cerebral Palsy Spastic Hemiplegic, Acquired Brain Injury (Including Stroke)
- Trial name
- NCT07065916
- Testing
- Modified Constraint Induced Movement Therapy
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Post-Concussion Syndrome
Mild Traumatic Brain Injuries in Children: Predicting Behavioral and Emotional Deficits
The purpose of this study is to investigate the role of psychosocial factors in creating Persistent Post-concussive symptoms (PPCS).
- Trial name
- NCT02475044
- Testing
- Cognitive-Behavioral Therapy
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rabin Medical Center
Brain Injuries, Traumatic
Validation of the Scandinavian Guidelines for Minor and Moderate Head Trauma in Children
Head injuries are common among children and adolescents, with many of them assessed in emergency departments each year. Most children recover fast, with full resolution of symptoms as headache, dizziness or fatigue.
- Trial name
- SHIPP (NCT05964764)
- Where
- 16 sites in Norway, Sweden
- Volunteers
- 5,300 people
- Sponsor
- Halmstad County Hospital
Traumatic Brain Injury
Stem Cell Therapy in Traumatic Brain Injury
The purpose of this study was to study the effect of stem cell therapy on common symptoms in patients with Traumatic Brain Injury
- Trial name
- NCT02028104
- Testing
- Autologous bone marrow mononuclear cell transplantation
- Where
- India
- Sponsor
- Neurogen Brain and Spine Institute
Paediatric Brain Damage, Cerebral Palsy
Transcranial Direct Current Stimulation and Gamified Rehabilitation for Upper Limb Function in Pediatric Brain Damage
The goal of this clinical trial is to acknowledge the effects of transcranial direct current stimulation as an adjuvant with gaming rehabilitation for upper limb function rehabilitation in paediatric population with…
- Conditions
- Paediatric Brain Damage, Cerebral Palsy, Paediatric Stroke, Paediatric Traumatic Brain Injury
- Trial name
- NCT06214364
- Testing
- Active Transcranial Direct Current Stimulation
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Universidad Francisco de Vitoria
Pediatric Traumatic Brain Injury
Extradural Hematoma in Pediatrics After Acute Head Injury: Surgical and Clinical Outcome
Acute extradural hematoma (EDH) is a potentially life-threatening neurosurgical emergency in children, commonly resulting from traumatic head injury.
- Trial name
- NCT07696598
- Testing
- evacuation of hematoma
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Hypoxia-Ischemia, Brain
Transauricular Vagus Nerve Stimulation in Children
The goal of this clinical trial is to learn about brain waves during transauricular vagus nerve stimulation (taVNS) in healthy children.
- Trial name
- NCT06168071
- Testing
- taVNS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Persistent Concussion Symptoms
Study of an Exercise Program (STEP) for Youth With Concussion
To compare the efficacy of a sub-threshold aerobic exercise intervention provided with mobile health coaching (STEP-mhc) and a light stretching program (LS) to LS alone for 11-18 yo youth with persistent concussion symptoms.
- Trial name
- STEP (NCT02673112)
- Testing
- Subthreshold exercise (STEP) with mobile health coaching, Light stretching (LS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Seattle Children's Hospital
TBI (Traumatic Brain Injury), Stroke Acute
The Multicenter Italian INCEPT (INfarto CErebrale Post-Traumatico) Study
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide (Ghajar, 2000). With an estimated annual incidence of up to 500 per 100,000 population and more than 200 hospital admissions per 100,000 admissions…
- Trial name
- NCT02430324
- Testing
- posttraumatic cerebral infarction
- Where
- Italy
- Volunteers
- 143 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Craniocerebral Trauma, Hypothalamic-pituitary Disorders
Long-term Follow-up of Pituitary and Hypothalamic Dysfunction in Children Who Have Suffered Moderate to Severe Head Trauma Included in the ENDOC TC Cohort
The annual incidence of traumatic brain injury (TBI), all causes combined, varies between 180 and 300 per 100,000. TBI increases the risk of death or serious sequelae by a factor of 8.
- Conditions
- Craniocerebral Trauma, Hypothalamic-pituitary Disorders, Pediatric, Endocrinology
- Trial name
- ENDOC TC 2 (NCT07533435)
- Testing
- Telephone questionnaire
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury - UCSF
This hypothesis-generating feasibility study compares mTBI Patients and Controls using advanced MRI Applications.
- Trial name
- TBI-2 (NCT02141360)
- Testing
- MRI Diagnostic
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- GE Healthcare
Brain Injury, Seizures
Study of Bedside EEG to Evaluate Brain Injury in Premature Newborns
This study is evaluating whether a bedside brainwave monitor can be used to detect early brain injury in premature infants.
- Conditions
- Brain Injury, Seizures, Cerebral Palsy
- Trial name
- BrainZ (NCT00516334)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Patellar Dislocation, Knee Injuries
Blood Flow Restriction Training After Patellar INStability
This research study is designed to allow health care professionals and researchers to answer many questions about whether a new type of physical therapy called blood flow restriction training (called BFRT) will improve recovery…
- Conditions
- Patellar Dislocation, Knee Injuries, Leg Injury, Wounds and Injuries
- Trial name
- BRAINS (NCT04554212)
- Testing
- Blood Flow Restriction Training
- Where
- 4 sites in United States
- Volunteers
- 78 people
- Sponsor
- Caitlin Conley
Traumatic Brain Injury, Acquired Brain Injury
Venous and Cerebral Glucose Microdialysis in Neurocritical Care: Validation & Correlation
This study evaluates the validity of an intravascular continuous glucose monitoring microdialysis probe, and compares the values to routinely inserted cerebral glucose microdialysis to evaluate the hypothesised relationship…
- Conditions
- Traumatic Brain Injury, Acquired Brain Injury, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- NCT03246607
- Testing
- MicroEye & ContinuMon
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Dr Andrew Stevens
Neonatal Congenital Heart Disease
Magnetic Resonance Imaging (MRI) to Evaluate Brain Injury in Congenital Heart Disease
Infants with congenital heart disease (CHD) requiring surgery frequently have brain injury seen on magnetic resonance imaging (MRI).
- Trial name
- CHD Brain (NCT00932633)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Emory University
Child Abuse, Shaken Baby Syndrome
Prevention of Shaken Baby Syndrome
This research project seeks to implement an early intervention program that can be effective in the prevention of Shaken Baby Syndrome (SBS) and infant abuse.
- Trial name
- NCT00105963
- Testing
- Education about infant crying
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Harborview Injury Prevention and Research Center
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