Clinical trials: Bronchospasm
Exercise Induced Bronchospasm
A Study to Assess the Efficacy of Budesonide/Albuterol Metered-dose Inhaler (BDA MDI/PT027) on Exercise-induced Bronchoconstriction in Adults and Adolescents With Asthma
This is a multicenter, randomized, double-blind, single-dose, placebo-controlled, 2-period, crossover study to evaluate the efficacy and safety of budesonide/albuterol metered-dose inhaler (BDA MDI/PT027) as compared with a…
- Trial name
- TYREE (NCT04234464)
- Testing
- Budesonide/albuterol sulfate metered-dose inhaler 160/180 μg
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Bond Avillion 2 Development LP
Exercise Induced Asthma
A Prospective Study Measuring Exhaled Nitric Oxide in Exercise-Induced Asthma
Exercise induced bronchospasm (EIB), also known as exercise induced asthma (EIA) is a transient obstruction to airflow triggered by exertion.
- Trial name
- NCT01097954
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Winthrop University Hospital
Asthma, Exercise-Induced
Montelukast in Exercise-Induced Bronchospasm - 2004 (0476-275)
The purpose of this study is to determine the effect of an approved medication being studied in support of a new approach in the prevention of exercise-induced asthma (a worsening of asthma caused by exercise, also known as…
- Trial name
- NCT00090142
- Testing
- Comparator: Montelukast
- Volunteers
- 62 people
- Sponsor
- Organon and Co
Exercise Induced Bronchospasm, Athletes
Diagnosis of EIB in Young Elite Athletes (13-18 y)
The investigators recently observed airway inflammation and increased damage-associated molecular pattern (DAMP) level in sputum of children (age 11-12y) and adolescents (18-23y) from elite sport programs in Belgium with…
- Conditions
- Exercise Induced Bronchospasm, Athletes, Adolescent
- Trial name
- NCT03587675
- Testing
- EVH test
- Where
- Belgium
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Asthma, Exercise-Induced
Montelukast in Exercise-Induced Bronchospasm - 2003 (0476-270)
The purpose of this study is to determine the effect of an approved medication being studied in support of a new approach in the prevention of exercise-induced asthma (a worsening of asthma caused by exercise, also known as…
- Trial name
- NCT00092131
- Testing
- Comparator: Montelukast
- Volunteers
- 51 people
- Sponsor
- Organon and Co
Exercise-induced Bronchospasm
Comparison of Two Bronchodilator Inhalers in Adolescents and Adults With Exercise-Induced Asthma
This study was designed to examine the effectiveness of two bronchodilator inhalers in patients who have exercise-induced asthma.
- Trial name
- NCT00085774
- Testing
- albuterol aerosol by HFA MDI, albuterol aerosol by HFA BOI
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Bronchospasm; Bronchiolitis, Bronchospasm; Bronchitis
Efficacy and Safety Evaluation in Recurrent Wheezing Attacks
The study will be conducted in two hospitals of the same geographic area. It will be included children <3-years-old with recurrent wheezing attacks, confirmed by the review of the medical records, in the previous 12 months or a…
- Trial name
- MV130 (NCT01734811)
- Testing
- Biological vaccine
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Inmunotek S.L.
Asthma, Exercise Induced
Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm
This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role.
- Trial name
- NCT00710255
- Testing
- Hyperpnea challenge
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Vermont
Bronchitis Obstructive, Bronchiolitis; Obstruction
Comparing the Efficacy of Two Valved Holding Chambers in Acute Wheezing
The incidence of physician confirmed asthma is approximately 4-7% in children. An additional 5% of children suffer from infection-related bronchiolitis and obstructive bronchitis.
- Conditions
- Bronchitis Obstructive, Bronchiolitis; Obstruction, Bronchospasm; Bronchitis
- Trial name
- CHAMBER (NCT03900494)
- Testing
- VHC 1, VHC 2
- Where
- 4 sites in Finland
- Volunteers
- 80 people
- Sponsor
- Tampere University
Upper Respiratory Tract Infections, Perioperative Respiratory Complications
Interest of Lidocaine in Children with Upper Airway Infection Undergoing General Anesthesia
The goal of this clinical trial is to determine whether intravenous (IV) lidocaine reduces the incidence of perioperative respiratory complications (PRCs) in children with upper respiratory tract infections undergoing general…
- Trial name
- NCT06584461
- Testing
- Lidocaine (drug)
- Where
- Tunisia
- Volunteers
- 102 people
- Sponsor
- Tunis University
Bronchospasm
Bronchospasm During Anesthetic Induction: Study of Clinical Characteristics and Treatments Administered According to Etiology
Bronchospasm during anaesthesia is a rare but potentially life-threatening event. They are classically part of IgE-dependent anaphylaxis but can also occur as an independent clinical entity, triggered by inflammatory factors such…
- Trial name
- NCT05025709
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Central Hospital, Nancy, France
Asthma
Dose Response Study of Inhaled Ciclesonide (Glucocorticosteroid) to Patients With Persistent Asthma
To investigate the efficacy and safety of ciclesonide inhaled into the lungs in a range of doses in a new dry powder inhaler compared to ciclesonide inhaled into the lungs using a metered dose inhaler
- Trial name
- NCT00174746
- Testing
- AVE2635A
- Where
- United States
- Volunteers
- 1,145 people
- Sponsor
- Sanofi
Bronchospasm, Activity/Exercise Induced Bronchospasm
A Study Measuring Asthma Control In Pediatric And Adolescent Subjects Whose Asthma Is Worsened By Activity Or Exercise
During this study, your child will need to attend up to 5 office visits and maintain regular telephone contact with the clinic. Certain office visits will include physical exams, medical history review, exercise challenge test…
- Trial name
- NCT00118690
- Testing
- Fluticasone propionate/salmeterol
- Where
- 51 sites in United States
- Volunteers
- 227 people
- Sponsor
- GlaxoSmithKline
Asthma
Combivent vs. Salbutamol in Patients With Metacholine Induced Bronchospasm
The purpose of this study was to evaluate whether 2 puffs of fixed combination of aerosolized 120 mcg salbutamol sulphate (equivalent to 100 mcg of the base) + 20 mcg ipratropium bromide confers significant additional protection…
- Trial name
- NCT02182713
- Testing
- Salbutamol sulfate/Ipratropium bromide, Salbutamol
- Volunteers
- 30 people
- Sponsor
- Boehringer Ingelheim
Asthma, Airway Hyperresponsiveness
Bronchospasm Associated With High Nitric Oxide
Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.
- Trial name
- NCT00666510
- Where
- Brazil
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Bronchial Spasm, Respiratory Sounds
Efficacy of Nebulised Beclometasone in Viral Wheezing Prophylaxis
Inhaled steroids, in particular beclomethasone, are widely prescribed in Italy as symptomatic treatment of upper respiratory infections without evidence of efficacy.
- Conditions
- Bronchial Spasm, Respiratory Sounds, Respiratory Tract Infections
- Trial name
- ENBe (NCT01265342)
- Testing
- Beclomethasone
- Where
- 9 sites in Italy
- Volunteers
- 576 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Cystic Fibrosis, Bronchospasm
Exercise-Induced Bronchospasm in Cystic Fibrosis
Exercise is an important clinical feature in cystic fibrosis. Better exercise capacity has been associated with better patient outcomes and quality of life.
- Trial name
- NCT00806455
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Ohio State University
Healthy, Wheezing, Non Wheezing Acute Respiratory Episode
Measurement of Expiratory Flow Variability for the Detection of Bronchospasm in Infants Using the Ventica® Device by Revenio
Wheezing in infants and children less than 3 years of age children is a frequent feature that might be difficult to diagnose when only the caregivers reporting is available.
- Trial name
- VENTICA (NCT04702620)
- Testing
- Ventica® device from Revenio
- Where
- France
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
A Study of a New Asthma Medicine in Asthmatics Whose Asthma Worsens With Exercise
The primary objective of this study is to demonstrate that the combination of inhaled fluticasone furoate/vilanterol (100 mcg/25 mcg) once daily provides superior protection throughout the day against bronchoconstriction induced…
- Trial name
- NCT01435902
- Testing
- Fluticasone Furoate/Vilanterol Inhalation Powder, Fluticasone Propionate Inhalation Powder
- Sponsor
- GlaxoSmithKline
Asthma, Wheezing
Swiss Paediatric Airway Cohort
The Swiss Paediatric Airway Cohort (SPAC) is a national, prospective clinical cohort of children and adolescents who visit physicians in Switzerland for recurrent wheeze, cough, and exercise- or sleep-related respiratory…
- Conditions
- Asthma, Wheezing, Cough, Exercise Induced Bronchospasm
- Trial name
- SPAC (NCT03505216)
- Where
- 12 sites in Austria, Switzerland
- Volunteers
- 6,000 people
- Sponsor
- University of Bern