Clinical trials: C-REACTIVE PROTEIN
Respiratory Infection, Respiratory Infections in Children
Impact of the Use of CRP on the Prescription of Antibiotics in General Practitioners
Respiratory infections, including episodes of coughing with fever, are the main cause of outpatient antibiotic prescription, while a minority of them are linked to bacterial infections requiring antibiotic.
- Trial name
- VIP (NCT03540706)
- Testing
- Care with C-reactive protein assay in micro method
- Where
- 14 sites in France
- Volunteers
- 406 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
COVID-19 Pneumonia, ARDS
The Effect of Tocilizumab on Procalcitonin and Other Biochemical and Clinical Markers in the Setting of COVID-19 Pneumonia
This study aims to establish whether tocilizumab has any significant effect on procalcitonin levels on patients diagnosed with COVID-19 pneumonia requiring intensive care admission.
- Trial name
- NCT05035589
- Testing
- Tocilizumab
- Where
- Malta
- Volunteers
- 100 people
- Sponsor
- Sciberras, Stephen M.D.
Vascular Formation
Effect of Regular Exercise on Vascular Function and Cardiovascular Risk in a Sedentary Work Force
This study will evaluate the effects of NHLBI's employee exercise program, Keep the Beat, on blood vessel function. Damage to blood vessels can cause narrowing of the vessels, resulting in reduced blood flow to parts of the body…
- Trial name
- NCT00246883
- Testing
- Exercise
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lower Respiratory Tract Infection (LRTI), Pneumonia
Optimising Antibiotic Use for Paediatric Lower Respiratory Tract Infections in Africa
Lower respiratory tract infections (LRTIs) remain a leading cause of hospitalisation and death among young children in Africa. Although viral infections account for a substantial proportion of LRTIs, antibiotics are frequently…
- Conditions
- Lower Respiratory Tract Infection (LRTI), Pneumonia, Bronchopneumonia, Bronchiolitis
- Trial name
- BEACON (NCT07841691)
- Testing
- CRP- and PREPARE-guided Antibiotic Prescription
- Where
- South Africa
- Volunteers
- 400 people
- Sponsor
- University of Witwatersrand, South Africa
Infection
Impact of Clinical Guidance & Point-of-care CRP in Children: the ARON Project
Impact of clinical guidance \& point-of-care CRP test in children: the ARON project Trial Design: multicentre, cluster-randomized, parallel group pragmatic trial Trial Participants and setting: Children aged 6 months to 12 years…
- Trial name
- ARON (NCT04470518)
- Testing
- diagnostic algorithm
- Where
- Belgium
- Volunteers
- 6,750 people
- Sponsor
- KU Leuven
Neonatal Sepsis
Salivary C- Reactive Protein, Mean Platelet Volume and Neutrophil Lymphocyte Ratio as Diagnostic Markers for Neonatal Sepsis
To evaluate reliability of salivary C-reactive protein ,mean platelet volume , neutrophil -lymphocyte ratio , and platelet lymphocyte ratio in diagnosis of neonatal sepsis
- Trial name
- NCT04800445
- Testing
- Salivary CRP
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Respiratory Tract Diseases
Impact of C-reactive Protein Micromethod Testing in Primary Care on Antibiotics Delivery in Patients With Upper or Lower Respiratory Tract Infections
The project is a pragmatic approach to primary care. The main objective is to evaluate the impact of making a CRP measurement device available in primary care general practices on antibiotic prescribing for upper respiratory…
- Trial name
- ICARE (NCT07632651)
- Testing
- Quick test
- Where
- France
- Volunteers
- 140 people
- Sponsor
- MSPU des 3 Provinces
Septic Shock, Nonchemotherapy Drug-induced Neutropenia
Russian Clinical Trial of Mesenchymal Cells in Patients With Septic Shock and Severe Neutropenia
Septic shock remains a significant clinical problem associated with high rates of mortality among neutropenic patient despite antimicrobial therapy and supportive care.
- Conditions
- Septic Shock, Nonchemotherapy Drug-induced Neutropenia, Neutropenia After Chemotherapy in Oncohematological Patients, Neutropenia in Patients With Aplastic Anemia
- Trial name
- NCT01849237
- Testing
- Mesenchymal stromal cells, Standard therapy of septic shock
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- National Research Center for Hematology, Russia
Infections, Cancer
Procalcitonin as a Marker of Infection in Cancer Patients
Infections pose a serious threat to cancer patients in chemotherapy. Prompt diagnosis and treatment is of paramount importance as infections may be life-threatening in immune-compromised individuals.
- Conditions
- Infections, Cancer, Procalcitonin, C Reactive Protein
- Trial name
- NCT01227109
- Where
- 2 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Herlev Hospital
Obesity, Metabolic Syndrome
The Predictive Role of Preoperative Pentraxin-3 (PTX3) in Metabolic and Inflammatory Outcomes After Roux-en-Y Gastric Bypass
This study evaluated the prognostic value of preoperative pentraxin-3 (PTX3) levels in predicting weight loss, inflammatory resolution (CRP, IL-6), and metabolic improvements (HOMA-IR) following Roux-en-Y gastric bypass in…
- Conditions
- Obesity, Metabolic Syndrome, Insulin Resistance, Inflammation
- Trial name
- PTX3-BYPASS (NCT07241741)
- Testing
- Biomarker Stratification by PTX3
- Volunteers
- 23 people
- Sponsor
- Istanbul University
Juvenile Idiopathic Arthritis
Pharmacokinetics, Efficacy and Safety of Olokizumab In Patients With Juvenile Idiopathic Arthritis
The primary objective of this study is to evaluate the pharmacokinetics (PK) of olokizumab (OKZ) in patients with polyarticular juvenile idiopathic arthritis aged >2 and <18 years in two doses (64 mg or 48 mg every 4 weeks)…
- Trial name
- NCT07517575
- Testing
- OKZ q4w
- Where
- 14 sites in Russia
- Volunteers
- 71 people
- Sponsor
- R-Pharm International, LLC
Hyperreactive Airway
Evaluating the Capacity of High-sensitivity Serum CRP Levels to Predict Bronchial Hyper Responsiveness in School Age Children
Background: Bronchial hyper responsiveness (BHR) assessed by methacholine challenge test (MCT) may aid in the diagnosis of asthma, while negative MCT can help to exclude the diagnosis.
- Trial name
- NCT01963585
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Temporomandibular Joint Disorders
Evaluation of C-reactive Protein Level in the Group of Patient With Pain Form of Temporomandibular Joint Dysfunction
Temporomandibular joints dysfunction is a functional disorder concern with the abnormal functioning of the muscles of the stomatognathic system, temporomandibular joints involved in the dynamic movements of the jaw and…
- Trial name
- NCT03065608
- Volunteers
- 72 people
- Sponsor
- Jagiellonian University
Inguinal Hernia, Indirect, Children, Only
Inflammatory Stress Response in Pediatric Inguinal Hernia Repair
Today there are various surgical techniques for inguinal hernia. In this study, investigators want to compare the ''PIRS'' operating technique laparoscopy and modified "Marcy" operating technique with open inguinal access.
- Conditions
- Inguinal Hernia, Indirect, Children, Only, Inflammatory Response, Surgery
- Trial name
- NCT03203343
- Testing
- Operation - PIRS, Operation - MARCY
- Where
- Croatia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital of Split
Acute Febrile Illness, Use of Antimicrobial Agents
Comparison of Rates of Antimicrobial Use in Febrile Patients With or Without the Use of C-reactive Protein Blood Test
In Health Posts of rural areas operated by the Government of Nepal, there are limitations of tests to differentiate between bacterial and viral infections.
- Conditions
- Acute Febrile Illness, Use of Antimicrobial Agents, C-reactive Protein Level
- Trial name
- CREATIB (NCT05292508)
- Testing
- C-reactive Protein Rapid Diagnostic Test
- Where
- Nepal
- Volunteers
- 924 people
- Sponsor
- Patan Academy of Health Sciences
Antibiotic Prescribing for Acute Respiratory-tract Infections
Effect of CRP and SAA Point-of-care Testing on Antibiotic Prescribing for Acute Respiratory-tract Infections
The study was a practical, cluster-randomized controlled trial to evaluate the impact of CRP and SAA point-of-care testing (CRP\&SAA POCT) on antibiotic prescribing in patients with acute respiratory-tract infections (ARI) at…
- Trial name
- NCT06568432
- Testing
- CRP+SAA POCT
- Where
- China
- Volunteers
- 35,108 people
- Sponsor
- Huazhong University of Science and Technology
Obstructive Sleep Apnea
Biomarkers in Obstructive Sleep Apnea Surgery
Recent years have witnessed major advances in the understanding of the hormonal, metabolic, and biochemical changes that occur in obstructive sleep apnea (OSA).
- Trial name
- NCT00507078
- Testing
- Surgical treatment for OSA
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Acute Appendicitis
Diagnostic Importance of the C-reactive Protein From Blood and Saliva in Children With Acute Appendicitis
Diagnosing acute appendicitis in children is still a challenge even for experienced clinicians. Failure to recognize this acute condition can result in perforation, with consequent peritonitis, or misdiagnosis can result in…
- Trial name
- NCT06051825
- Testing
- Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels
- Volunteers
- 100 people
- Sponsor
- University Hospital of Split
Acute Hydrocarbon Toxicity
Evaluation of the Role of Poisoning Severity Score, Serum Procalcitonin and C-reactive Protein in Acute Hydrocarbon Intoxicated Cases Admitted to the Poison Control Center Ain Shams University Hospitals
Hydrocarbons are a primary energy source in modern society. They are present in many common household and occupational products, including motor fuels, paint thinners, cleaning agents, lotions, and industrial solvents.
- Trial name
- NCT06151301
- Testing
- serum procalcitonin, C-reactive protein
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Acute Respiratory Tract Infections
FebriDx DISRUPT Acute Respiratory Infection Trial in Acute Respiratory Infection: An Evaluation of FebriDx® POC Test
The aim of this study is to determine performance characteristics of the FebriDx test in predicting viral or bacterial infection etiology among febrile (observed or reported) patients presenting the emergency department, urgent…
- Trial name
- NCT02018198
- Testing
- FebriDx
- Where
- 20 sites in United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Rapid Pathogen Screening