Clinical trials: CPAP Ventilation
Intubation Complication, PreTerm Birth
NIPPV Versus Bi-level Nasal Continuous Positive Airway Pressure Following Extubation
Mechanical ventilation is important in the care of preterm infants with respiratory failure, but may be associated with lung injury. Efforts are needed to avoid or minimize the use of mechanical ventilation.
- Trial name
- NCT02842190
- Testing
- NIPPV
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Respiratory Distress Syndrome
Early CPAP in Respiratory Distress Syndrome
The purpose of this study is to establish if a strategy of EBCPAP application in a subgroup of VLBWI, 800 to 1500g birthweight, decreases the need for mechanical ventilation in this group, without affecting mortality.
- Trial name
- NCT00368680
- Testing
- Early Bubble CPAP
- Where
- 14 sites in Argentina, Chile and 3 more
- Volunteers
- 256 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Premature Birth
Changes in Respiratory Effort in Preterm Infants
Continuous Positive Airway Pressure (CPAP) is used to treat preterm infants with an immature respiratory center and having respiratory distress. CPAP requires intensive care monitoring and special qualified staff.
- Trial name
- NCT02014493
- Testing
- High Flow Nasal Cannulae (HFNC), Continuous Positive Airway Pressure (CPAP)
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- St. Olavs Hospital
Respiratory Distress Syndrome
Effects of Flow Magnitude on Cardiorespiratory Stability During Nasal High Flow Therapy in Preterm Infants
Premature babies often need help breathing for a longer period of time. Traditionally, this is done with a breathing aid called NCPAP (nasal continuous positive airway pressure).
- Trial name
- MASTER (NCT05908227)
- Testing
- NHF high, NHF low, NCPAP
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 150 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Infant, Premature, Diseases, Respiratory Distress Syndrome
Functional Residual Capacity During Different Levels of High-flow in Preterm Infants
Although there is a widespread use of HighFlow therapy around the world, there is still uncertainty about the most appropriate initial HighFlow level after nasal continuous positive airway pressure therapy.
- Trial name
- FunkFlow (NCT05237622)
- Testing
- High Flow
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Infant, Newborn, Respiratory Distress Syndrome
Early Surfactant to Reduce Use of Mechanical Breathing in Low Birth Weight Infants
Mechanical ventilation (MV) of preterm infants with respiratory distress syndrome (RDS) is associated with lung injury and nosocomial infection.
- Conditions
- Infant, Newborn, Respiratory Distress Syndrome, Respiratory Insufficiency
- Trial name
- Surfactant 2 (NCT00005774)
- Testing
- Early surfactant, Standard practice
- Where
- 13 sites in United States
- Volunteers
- 61 people
- Sponsor
- NICHD Neonatal Research Network
Respiratory Distress Syndrome
Comparing Bubble and Ventilator Nasal CPAP in Preterm Infants
There are various methods to generate the pressure needed for Nasal CPAP. Some neonatal intensive care units (NICU) use an underwater bubbling system and others use a ventilator to generate the pressure.
- Trial name
- NCT02003846
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Maimonides Medical Center
Preterm Infant
NHFOV vs NIPPV vs nCPAP in Preterm Infants With Respiratory Distress Syndrome
This will be a prospective, multi-center, three-arms,parallel, randomized, controlled trial with a superiority design,conducted in China.
- Trial name
- NCT03842462
- Testing
- nCPAP, NIPPV, NHFOV
- Where
- 8 sites in China
- Volunteers
- 684 people
- Sponsor
- Jiulongpo No.1 People's Hospital
Premature Birth, Respiratory Distress Syndrome, Newborn
Non-invasive Neurally Adjusted Ventilator Assist or Continuous Positive Airway Pressure in Preterm Infants
Strategies to prevent lung injury, facilitate lung development, and to support the preterm infant's capacity to breathe are decisive.
- Trial name
- NCT04333563
- Testing
- CPAP, NIV NAVA
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- St. Olavs Hospital
Acute Respiratory Failure
High Flow Nasal Cannulas in Children
Non-invasive Continuous Positive Airway Pressure (nCPAP) is widely recognized as an efficient respiratory support in infants with mild to moderate Acute Hypoxemic Respiratory Failure (AHRF).
- Trial name
- HFNC (NCT03689686)
- Testing
- Noninvasive Respiratory Support
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Respiratory Distress Syndrome (RDS)
Comparison of Continuous Positive Airway Pressure (CPAP) and Non-Invasive Positive Pressure Ventilation (NIPPV) in Preterm Newborns With Respiratory Distress Syndrome.
Primary objective: to evaluate safety and efficacy of two different non-invasive respiratory support modalities in preterm neonatal patients with respiratory distress syndrome.
- Trial name
- NC3 (NCT06966752)
- Testing
- NIPPV, CPAP
- Where
- Lithuania
- Volunteers
- 150 people
- Sponsor
- Vilnius University
Respiratory Distress Syndrome, Newborn
Diaphragm Electrical Activity of Preterm Infants on nCPAP Versus NIHFV
Preterm babies have immature lungs and frequent pauses in their breathing which often necessitates breathing support. Nasal Continuous Positive Airway Pressure (nCPAP) is one of the most commonly used tools, but does not always…
- Trial name
- NCT02267018
- Testing
- Drager VN500 Ventilator
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Respiratory Distress Syndrome (RDS), Infant, Premature, Diseases
FiO2 Delivered With Neonatal bCPAP
Continuous positive airway pressure (CPAP) is the mainstay of treatment recommended for preterm infants with respiratory distress syndrome in all resource contexts.
- Conditions
- Respiratory Distress Syndrome (RDS), Infant, Premature, Diseases, Infant, Newborn, Diseases
- Trial name
- NCT06615427
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Transient Tachypnea of the Newborn
nHFOV Versus nCPAP in Transient Tachypnea of the Newborn
In this prospective, randomised clinical trial the investigators aim to assess if nasal high frequency oscillatory ventilation (nHFOV) could be used as the primary modality of respiratory support in late preterm and term infants…
- Trial name
- NCT03006354
- Testing
- nHFOV, nCPAP
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Sleep Apnea, Obstructive
Heated Humidified High Flow Nasal Cannula for Children With Obstructive Sleep Apnea
The purpose of this study is to determine whether heated humidified high flow nasal cannula (HHHFNC) is effective as a treatment of obstructive sleep apnea syndrome (OSAS) compared to continues positive airway pressure (CPAP)…
- Trial name
- NCT02515409
- Testing
- HHHFNC, CPAP
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Neonates
Utility of Spontaneous Breathing Trial (SBT) Using ET-CPAP, in Predicting Extubation Failure in Neonates
Intubation and ventilation are lifesaving interventions in the neonatal intensive care unit (ICU), especially among preterm, low birth weight babies. However, timely extubation is also necessary.
- Trial name
- NCT03091387
- Testing
- Spontaneous Breathing Test
- Volunteers
- 110 people
- Sponsor
- Aga Khan University
Respiratory Distress Syndrome, Newborn, Medical Device Discomfort
Patient Comfort During High Flow Nasal Cannula Versus Nasal Continuous Airway Pressure (CPAP)
Preterm children are at increased risk for developing lung disease due to immature lungs. Non-invasive ventilation (NIV) support is increasingly used as treatment.
- Trial name
- NCT01526226
- Testing
- Respiratory support HFNC, Respiratory support NCPAP
- Where
- Norway
- Volunteers
- 24 people
- Sponsor
- University Hospital of North Norway
Continuous Positive Airway Pressure
Effect of Continuous Positive Airway Pressure Delivered by Two Different Modalities on Breathing Pattern in Preterm Infants
In this study, the investigators want to observe how continuous positive airway pressure delivered by two different modalities affects breathing pattern in small preterm infants.
- Trial name
- NCT01326975
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Respiratory Distress Syndrome, Newborn
Comparison of Methods of Weaning From Nasal CPAP in Preterm Infants: A Randomized Controlled Trial
This study aimed to determine the efficacy of different NCPAP weaning strategies in pre-term infants presenting with respiratory distress, and ultimately establishing the best method to withdraw from NCPAP.
- Trial name
- NCT07009366
- Testing
- Sudden weaning of NCPAP, Gradual weaning with increasing the time off NCPAP, Pressure weaning of NCPAP
- Where
- Pakistan
- Volunteers
- 75 people
- Sponsor
- RESnTEC, Institute of Research
Respiratory Distress Syndrome, Hyaline Membrane Disease
Weaning Preterm Neonates From Nasal Continuous Positive Airway Pressure
There is little data published concerning the best approach to nasal continuous positive airway pressure (nCPAP) weaning. Potential complications associated with prolonged nCPAP therapy include gastric distension, nasal…
- Conditions
- Respiratory Distress Syndrome, Hyaline Membrane Disease, Preterm Infants, Premature Infants
- Trial name
- NCT01093495
- Testing
- CPAP, Nasal Cannula
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University