Clinical trials: CRP
Community-acquired Pneumonia
Trial of Respiratory Infections in Children for Enhanced Diagnostics
The overall aim of the TREND study is to improve the differential diagnosis of bacterial and viral etiology in children below 5 years of age with clinical community acquired pneumonia.
- Trial name
- TREND (NCT03233516)
- Where
- Sweden
- Volunteers
- 376 people
- Sponsor
- Karolinska Institutet
Simulated Pediatric CRP Ventilation
Simulation-based Comparative Study on Efficiency of Ventilation During Paediatric Cardiopulmonary Resuscitation
The aim of this study is to gather data to support beginning the pediatric cardiopulmonary resuscitation (CPR) with 5 initial breaths.
- Trial name
- PEDIVENT (NCT05345704)
- Testing
- cardiopulmonary resuscitation (CPR)
- Where
- Czechia
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Brno University Hospital
Infections, Cancer
Procalcitonin as a Marker of Infection in Cancer Patients
Infections pose a serious threat to cancer patients in chemotherapy. Prompt diagnosis and treatment is of paramount importance as infections may be life-threatening in immune-compromised individuals.
- Conditions
- Infections, Cancer, Procalcitonin, C Reactive Protein
- Trial name
- NCT01227109
- Where
- 2 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- Herlev Hospital
Obesity, Insulin Resistance
Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity
Background: About 40 percent of adults and 20 percent of adolescents in the U.S. have a body mass index over 30 kg/m2. Being overweight may lead to a state of low-level inflammation. This may cause health problems.
- Conditions
- Obesity, Insulin Resistance, Inflammation
- Trial name
- NCT05017571
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infection
Impact of Clinical Guidance & Point-of-care CRP in Children: the ARON Project
Impact of clinical guidance \& point-of-care CRP test in children: the ARON project Trial Design: multicentre, cluster-randomized, parallel group pragmatic trial Trial Participants and setting: Children aged 6 months to 12 years…
- Trial name
- ARON (NCT04470518)
- Testing
- diagnostic algorithm
- Where
- Belgium
- Volunteers
- 6,750 people
- Sponsor
- KU Leuven
Obesity, Metabolically Benign
Adiponectin, Leptin, h-CRP Values in Obese Children - Important Markers for Metabolic Syndrome?
Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C reactive protein (CRP) play an important role. This study aimed to investigate the relationship between markers of adiposity like leptin, adiponectin…
- Trial name
- ChildObes (NCT03354676)
- Testing
- MetS+, MetS-
- Volunteers
- 122 people
- Sponsor
- Alexandru Florin Rogobete
Gestational Diabetes Mellitus in Second Trimester of Pregnancy
Evaluation of Serum Pentraxin 3 and High Sensitive CRP in Female Patients With Gestational Diabetes Mellitus in Second Trimester of Pregnancy
1. To assess the value of serum Pentraxin-3 and high sensitive CRP in females with normal pregnancy and females with gestational diabetes mellitus in second trimester of pregnancy. 2.
- Trial name
- NCT05846191
- Testing
- serum pentraxin 3 and high sensitive CRP
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Febrile Neutropenia (FN), Pediatric Cancer
Early Discontinuation of Antibiotics in Paediatric High-risk Febrile Neutropenia
The goal of this clinical trial is to evaluate whether stopping antibiotic treatment early is safe in paediatric patients with cancer who develop high-risk febrile neutropenia but show good clinical evolution and low biomarker…
- Conditions
- Febrile Neutropenia (FN), Pediatric Cancer, Hematologic Malignancies, Solid Tumors
- Trial name
- E-STOP2 (NCT07590648)
- Testing
- Early Discontinuation of Antibiotics, Standard Antibiotic Continuation Strategy
- Where
- 4 sites in Spain
- Volunteers
- 136 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Atherosclerosis, Type 2 Diabetes
High-sensitivity C-reactive Protein and United Kingdom Prospective Diabetes Study (UKPDS) Risk Score in Type 2 Diabetes
The UKPDS risk score is recommended to assess global risk for future coronary heart disease (CHD) events in primary prevention. Recently, high-sensitivity C-reactive protein (hsCRP) has emerged as a strong independent risk factor…
- Trial name
- NCT01099865
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Korea University
Anastomotic Leakage in Colon Surgery
Predictive Value of Procalcitonin, CRP, Drain Fluid Culture, Il-6 and Tnf-α in Anastomotic Leakage
Evaluating predictive value of serum procalcitonin, C-Reactive Protein, drain IL-6 and TNF-alpha for anastomotic leakage in post-operative period.
- Trial name
- NCT02361918
- Testing
- Colon surgery
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Hyperreactive Airway
Evaluating the Capacity of High-sensitivity Serum CRP Levels to Predict Bronchial Hyper Responsiveness in School Age Children
Background: Bronchial hyper responsiveness (BHR) assessed by methacholine challenge test (MCT) may aid in the diagnosis of asthma, while negative MCT can help to exclude the diagnosis.
- Trial name
- NCT01963585
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Periodontal Disease, Diabetes Mellitus, Type 2
Serum Hs-CRP in Periodontitis Patients With or Without Diabetes
the aim of this study was to assess serum levels of high sensitivity c reactive protein in periodontitis patients with and without type 2 diabetes in a trial to analyze its prognostic effect following non-surgical periodontal…
- Trial name
- NCT03908606
- Testing
- Scaling and root planing
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sepsis Bacterial, Ebola Virus Disease
Piloting Clinical Bacteriology in the Ebola Virus Disease Care Response
Despite access to experimental Ebola Virus Disease (EVD)-specific treatments, about 30% of patients still die in the Ebola Treatment Centers (ETC) in DRC.
- Conditions
- Sepsis Bacterial, Ebola Virus Disease, Bloodstream Infection
- Trial name
- Bact_EVD (NCT04250168)
- Where
- 2 sites in Democratic Republic of the Congo
- Volunteers
- 43 people
- Sponsor
- Institute of Tropical Medicine, Belgium
COVID-19 Pneumonia, ARDS
The Effect of Tocilizumab on Procalcitonin and Other Biochemical and Clinical Markers in the Setting of COVID-19 Pneumonia
This study aims to establish whether tocilizumab has any significant effect on procalcitonin levels on patients diagnosed with COVID-19 pneumonia requiring intensive care admission.
- Trial name
- NCT05035589
- Testing
- Tocilizumab
- Where
- Malta
- Volunteers
- 100 people
- Sponsor
- Sciberras, Stephen M.D.
Acute Respiratory Infection
Implementation of CRP Point of Care Testing in Primary Care to Improve Antibiotic Targeting in Respiratory Illness (ICAT)
The proposed study will monitor and evaluate a quality improvement project - the introduction of commercially available lateral flow CRP tests with international regulatory approval, as a routine care service to improve the…
- Trial name
- ICAT (NCT03855215)
- Testing
- ACTIM CRP Rapid Test (Medix, Biochemica)
- Where
- Vietnam
- Volunteers
- 2,606 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Septic Arthritis
The Predictive Role of C-reactive Protein to Albumin Ratio (CAR) in the Treatment of Septic Arthritis in Young Chlidren
Purpose: C-reactive protein to albumin ratio (CAR) has emerged as a novel marker of inflammation. However, almost no research has evaluated the role of CAR in septic arthritis (SA).
- Trial name
- NCT06241365
- Volunteers
- 82 people
- Sponsor
- wangxiaodong
Type 2 Diabetes Mellitus With Periodontal Complication, Inflammation
Taking Out All Teeth and Replacing Them With Dentures That Rest on Implants in People With Type 2 Diabetes
Gum disease and type 2 diabetes are common chronic diseases that affect each other. Diabetes is increasing, especially in Pakistan. People with diabetes have a greater risk for gum disease.
- Conditions
- Type 2 Diabetes Mellitus With Periodontal Complication, Inflammation, Dental Implant Failed
- Trial name
- NCT01774942
- Testing
- Procedure/Surgery
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Cardiovascular Disease
High Dose and Low Dose of Atorvastatin in Patients With Unstable Angina and NSTEMI (Non ST Elevation MI)
The aim of this study is to compare the effect of high dose and low dose of Atorvastatin in reduction level of C-reactive protein (CRP) in patients with unstable angina and NSTEMI (Non ST Elevation MI) attending Shahid Mohammadi…
- Trial name
- NCT01306565
- Testing
- Low dose Atorvastatin, High dose atorvastatin
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Hormozgan University of Medical Sciences
Recurrent Pericarditis
Therapy Management in Patients Treated With Anakinra Due to Recurrent Pericarditis
To determine the utility of serial cardiac magnetic resonance (CMR) imaging for guidance of therapy management in patients treated with anakinra due to recurrent pericarditis (RP), compared with c-reactive protein (CRP) assay…
- Trial name
- NCT06071156
- Testing
- Anakinra
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliero, Universitaria Ospedali Riuniti
Vitamin D Deficiency
Effect of Vitamin D Supplementation on Health of Low Birth Weight Infants
The purpose of this study is to determine whether a weekly supplement of vitamin D to low birth weight term infants will reduce their mortality and hospital admissions and improve their immunity.
- Trial name
- DIVIDS (NCT00415402)
- Testing
- Vitamin D3
- Where
- India
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Delhi University