Clinical trials: Cachexia, open to volunteers
Acute Malnutrition in Childhood, Acute Malnutrition, Severe
Reduced Dosage and/or Visitation Protocol for the Treatment of Acute Malnutrition in Kenya
Severe acute malnutrition (SAM) places children at significant risk of mortality. Outpatient treatment programs are effective but there is a need to increase treatment coverage and reduce costs of treatment.
- Conditions
- Acute Malnutrition in Childhood, Acute Malnutrition, Severe, Acute Malnutrition, Moderate, Wasting
- Trial name
- RSWITCH (NCT07420062)
- Testing
- WHO-reduced, WHO-full, Kenya-IMAM
- Where
- Kenya
- Volunteers
- 2,274 people
- Sponsor
- International Food Policy Research Institute
Oncology Patients Receiving Chemotherapy, Cachexia-Anorexia Syndrome
Olanzapine in the Prevention and Treatment of Anorexia-Cachexia Syndrome in Patients Receiving Neoadjuvant/Preoperative Chemotherapy
The goal of this clinical trial is to learn if olanzapine works to prevent and treat anorexia-cachexia syndrome and appetite loss in cancer patients.
- Conditions
- Oncology Patients Receiving Chemotherapy, Cachexia-Anorexia Syndrome, Oncology
- Trial name
- NCT07633236
- Testing
- OLANZapine 2.5 MG
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Acute Malnutrition, Severe, Malnutrition, Child
Expanding Coverage of Severe Acute Malnutrition (SAM) Treatment in Kenya
Child wasting is a type of malnutrition which occurs when a child becomes too thin. This medical condition increases the risk of becoming sick or dying.
- Conditions
- Acute Malnutrition, Severe, Malnutrition, Child, Wasting
- Trial name
- R-SWITCH (NCT06441305)
- Testing
- SWITCH intervention package
- Where
- Kenya
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Malnutrition in Children, Children Exposed to HIV
A Trial Testing a Two-way SMS Platform to Recognize and Prevent Wasting Among HIV-infected and HIV-exposed Uninfected Children in Kenya
The goal of this study is to test if a two-way text-message (SMS) maternally administered malnutrition monitoring system (MAMMS) that delivers infant and young child feeding (IYCF) education and supports caregivers in monitoring…
- Trial name
- MAMMS IYCF R33 (NCT06842732)
- Testing
- Maternal Administered Malnutrition Monitoring System - Infant and Young Child Feeding (MAMMS IYCF) intervention, Standard of Care (SOC)
- Where
- 2 sites in Kenya
- Volunteers
- 776 people, healthy volunteers welcome
- Sponsor
- University of Washington
Neurodevelopment, Child Growth
Building Opportunities for Nurturing Care to Enhance Child Development in Eastern and Southern Africa
The goal of this randomized controlled trial is to adapt and test a package of interventions to provide nurturing care for children aged 0-2 years in three countries (Botswana, Kenya, Zimbabwe).
- Trial name
- BONDS (NCT07430826)
- Testing
- Friendship Bench, Infant and Young Child Feeding (IYCF) Curriculum, Play-Based Curriculum
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- University of Washington
Duchenne Muscular Dystrophy
Safety and Efficacy of KER-065 in Participants With Duchenne Muscular Dystrophy
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and efficacy of KER-065 administered to adult and pediatric ambulatory and nonambulatory male participants with…
- Trial name
- NCT07704099
- Testing
- KER-065
- Where
- 4 sites in Georgia, New Zealand
- Volunteers
- 36 people
- Sponsor
- Keros Therapeutics, Inc.
Duchenne Muscular Dystrophy With Mutations Amenable to PBGENE-DMD
PBGENE-DMD Phase 1/2a Safety and Preliminary Efficacy Study in Duchenne Muscular Dystrophy (FUNCTION-DMD)
The purpose of this Phase 1/2a trial is to evaluate the safety, tolerability, and preliminary efficacy of PBGENE-DMD in patients with DMD harboring mutations amenable to excision of exons 45-55.
- Trial name
- NCT07429240
- Testing
- PBGENE-DMD (IV)
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Precision BioSciences, Inc.
Acute Malnutrition, Severe, Malnutrition, Child
Increasing the Coverage of Severe Acute Malnutrition (SAM) Treatment in Ethiopia
The R-SWITCH intervention aims to address the low coverage of treatment for severe wasting (SAM) by leveraging existing community groups to deliver an integrated package focused on prevention, screening, referral, and treatment…
- Conditions
- Acute Malnutrition, Severe, Malnutrition, Child, Wasting
- Trial name
- R-SWITCH (NCT06380504)
- Testing
- R-SWITCH integrated intervention package
- Where
- Ethiopia
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Malnutrition, Infant, Malnutrition
Hospital-Based Prospective Cohort of Malnutrition Under 6-Month Study (HOSPIC-6-Study)
This study is a hospital-based, prospective, multicentre cohort study (the HOSPIC-6 Study) that will follow infants under 6 months of age who are admitted to pediatric or perinatology wards with acute malnutrition, diagnosed…
- Trial name
- HOSPIC-6 (NCT07831343)
- Testing
- Not applicable- observational study
- Where
- 16 sites in Indonesia
- Volunteers
- 1,780 people
- Sponsor
- Universitas Indonesia
Diarrhea, Wasting
Lactoferrin and Lysozyme Supplementation for Long-term Diarrhea Sequelae
Children in low- and middle-income countries who are hospitalized for diarrhea and also have malnutrition are at high risk for illness and death in the 6 months period following treatment for diarrhoea despite receiving current…
- Conditions
- Diarrhea, Wasting, Malnutrition, Child
- Trial name
- NCT05519254
- Testing
- Lactoferrin, Lysozyme, Lactoferrin + Lysozyme
- Where
- 4 sites in Kenya
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Washington
Nutrition, Growth
Impact of Diet and Nutrition on Growth and Development in Young Children
The association between nutrition in early life and its long-term health consequences has long been known. However, there is a scarcity of scientific evidence on how nutritional status affects child growth and development in…
- Conditions
- Nutrition, Growth, Development, Stunting
- Trial name
- DIGEST (NCT06018636)
- Where
- Pakistan
- Volunteers
- 832 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Undernutrition
Effectiveness of Small-Quantity vs Medium-Quantity Lipid-Based Nutrient Supplements for Prevention of Undernutrition in Young Children
Nutrition is essential for a child's growth, brain development, and protection from disease. While breastmilk provides the best nutrition for young infants, children older than six months may not get all the nutrients they need…
- Trial name
- NCT07451951
- Testing
- Medium-quantity lipid-based nutrient supplement (MQ-LNS), Small-quantity lipid-based nutrient supplement (SQ-LNS)
- Where
- 2 sites in Pakistan
- Volunteers
- 1,568 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Moderate Acute Malnutrition (MAM), Undernutrition
Effectiveness of Positive Deviance/Hearth in Treating Uncomplicated Moderate Acute Malnutrition in Children 6-59 Months in Mymensingh Division, Bangladesh
The goal of this clinical trial (cluster randomized controlled trial) is to learn whether a Positive Deviance/Hearth (PDH) intervention can effectively treat moderate acute malnutrition (MAM) and reduce relapse compared to…
- Conditions
- Moderate Acute Malnutrition (MAM), Undernutrition, Wasting
- Trial name
- PD/Hearth MAM (NCT07591064)
- Testing
- PD/Hearth is a behavioral change program that teaches caregivers how to cook and feed their children. A nutrient-dense meal using local ingredients will be fed to children during Hearth sessions., Standard of Care (Investigator Selected)
- Where
- Bangladesh
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- World Vision US