Clinical trials: Cancer Progression
Parkinson Disease
Rock Steady Boxing vs. Sensory Attention Focused Exercise
This study evaluates the effect on Rock Steady Boxing (RSB) and PD SAFEx on Parkinson's disease.
- Trial name
- NCT03618901
- Testing
- Rock Steady Boxing, PD SAFEx
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sun Life Financial Movement Disorders Research and Rehabilitation Centre
Multiple Myeloma
Cyclophosphamide With Biochemical Progression During Lenalidomide-Dexamethasone Treatment for Relapsed/Refractory Multiple Myeloma (MM)
This study evaluates the efficacy of the addiction of Cyclophosphamide to Revlimid-low dose dexamethasone (Rd) in relapsed/refractory Multiple Myeloma patients, who experienced a biochemical progression, without CRAB, during Rd…
- Trial name
- NCT02206503
- Testing
- Cyclophosphamide, Lenalidomide, Dexamethasone
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Fondazione EMN Italy Onlus
Kidney, Polycystic
HALT Progression of Polycystic Kidney Disease Study A
The efficacy of interruption of the renin-angiotensin-aldosterone system (RAAS) on the progression of cystic disease and on the decline in renal function in autosomal dominant kidney disease (ADPKD) will be assessed in two…
- Trial name
- HALT PKD A (NCT00283686)
- Testing
- Lisinopril, Telmisartan, Standard Blood Pressure Control
- Where
- 7 sites in United States
- Volunteers
- 558 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Blood And Marrow Transplantation, Leukemia
Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies
The goal of this clinical research study is to learn if it is safe and feasible to transplant changed cord blood for patients with leukemia or lymphoma. Researchers also want to learn if this can help to control the disease.
- Conditions
- Blood And Marrow Transplantation, Leukemia, Lymphoma, Transplantation Infection
- Trial name
- NCT01471067
- Testing
- Melphalan, Fludarabine, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- M.D. Anderson Cancer Center
Type 1 Diabetes
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
This is a Phase 2b, investigator- and participant-blinded, placebo-controlled, parallel-arm study to evaluate the efficacy, safety and tolerability of SAB 142 in patients with Stage 3 New Onset of Type 1 Diabetes (NOT1D).
- Trial name
- SAFEGUARD (NCT07187531)
- Testing
- High Dose SAB-142, Low Dose SAB-142
- Where
- 68 sites in United States, Australia and 13 more
- Volunteers
- 159 people
- Sponsor
- SAb Biotherapeutics, Inc.
Acute Lymphoblastic Leukemia (ALL) in Complete Remission, Acute Myeloid Leukemia (AML) in Remission
Comparing Post-Transplant Cyclophosphamide As GVHD Prophylaxis to Standard of Care for Acute Leukemia Patients
This randomized clinical trial will evaluate two approaches of GvHD prophylaxis; the standard of care GVHD prophylaxis regimen (methotrexate/calcineurin inhibitors) and post-transplant cyclophosphamide with calcineurin inhibitors…
- Trial name
- PTCy-PMAT (NCT04314219)
- Testing
- Cyclophosphamide 50mg, Methotrexate
- Where
- Saudi Arabia
- Volunteers
- 264 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Parkinson's Disease
The Effects of Mindfulness-based Cognitive Therapy in People With Parkinson's Disease
Parkinson's disease (PD) is a debilitating neurodegenerative disorder occurring in 7 million patients worldwide. PD is caused by progressive loss of nigro-striatal dopamine cells, which causes motor symptoms such as slowness of…
- Trial name
- MIND-PD (NCT05779137)
- Testing
- MBCT
- Where
- Netherlands
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Hutchinson-Gilford Progeria Syndrome
A Study Observing Disease Progression in a Patient With Hutchinson-Gilford Progeria Syndrome (HGPS)
This study is a prospective, non-interventional, single-patient observational study following one patient with Hutchinson-Gilford Progeria Syndrome (HGPS), a rare disease that causes rapid, premature aging, over a 3-year period…
- Trial name
- progeria (NCT07839351)
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- Bundang CHA Hospital
Cluster Headache, Disease Course
Long-term Prognosis of Cluster Headache: a Retrospective Cohort Study
Cluster headache is a syndrome characterized by disabling headache and accompanying autonomic symptoms. Despite cluster headache is called "suicide headache", its natural history has not been well investigated.
- Trial name
- NCT02895256
- Testing
- Any treatment for cluster headache
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Samsung Medical Center
Idiopathic Scoliosis
Scoliosis-specific Exercises for Mild Idiopathic Scoliosis
Idiopathic scoliosis is the most common spinal deformity in children and adolescents with an estimated prevalence of 3%. About one tenth of the children with scoliosis develop a deformity that requires treatment with brace or…
- Trial name
- NCT05138393
- Testing
- Active self-corrective exercises, Observation
- Where
- 2 sites in Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Myopia
Eye Exercise, Transcutaneous Electrical Nerve Stimulation on Prevention of Myopia Progression
In Taiwan, the increasing prevalence of myopia shows a decline with age. Myopia has become a serious ocular problem in children because high myopia may lead to retinal damage, cataract and glaucoma.
- Trial name
- NCT04017234
- Testing
- frequency following response, eye exercise, and transcutaneous
- Where
- Taiwan
- Volunteers
- 27 people
- Sponsor
- China Medical University Hospital
Effect of Drugs, Progression
Famitinib Plus Camrelizumab & Famitinib Alone & Famitinib Plus Ifosfamide in Advanced Osteosarcoma
Results of previous study showed high objective response but short-term activity of anti-angiogenesis tyrosine kinase inhibitors in advanced osteosarcoma.
- Conditions
- Effect of Drugs, Progression, Pediatric Cancer
- Trial name
- NCT04044378
- Testing
- Famitinib, Ifosfamide, Camrelizumab
- Where
- China
- Sponsor
- Peking University People's Hospital
Crohn Disease (CD), Ulcerative Colitis (UC)
IBD Biomarker Discovery and Validation Platform
The goal of this observational study is to establish a multicenter prospective clinical and biospecimen platform for biomarker discovery and validation in inflammatory bowel disease, including Crohn's disease and ulcerative…
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD)
- Trial name
- IBD-BIOP (NCT07686406)
- Where
- 2 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Prostate Cancer Metastatic Disease, PET / CT
The Prognostic Value of PET/CT for Tumor Progression in Patients With Metastatic Hormone-sensitive Prostate Cancer
Investigators retrospectively collected data from consecutive patients treated at the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, from October 2020 to March 2024.
- Trial name
- NCT06915714
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Sun Yat-sen University
Myopia, Refractive Errors
Dual-Action Lenses for Slowing Myopia in Children and Teens: A Randomized, Double-Blind Trial
This is a single-center, randomized, double-blind, controlled study to test whether a new type of eyeglass lens - a "dual-action" lens that combines two technologies (multiple defocus zones and dot diffusion) - can slow the…
- Trial name
- NCT07854457
- Testing
- Dual-Action Myopia-Control Spectacle Lens, Stellest Myopia-Control Spectacle Lens（Highly Aspherical Lenslet Target / HALT Lens）
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Usher Syndrome, Type 2A, Retinitis Pigmentosa 39
Rate of Progression in USH2A-related Retinal Degeneration
The overall goal of this project funded by the Foundation Fighting Blindness is to characterize the natural history of disease progression in patients with USH2A related retinal degeneration associated with congenital hearing…
- Trial name
- RUSH2A (NCT03146078)
- Where
- 14 sites in United States, Canada and 4 more
- Volunteers
- 127 people
- Sponsor
- Jaeb Center for Health Research
Alport Syndrome
Urinary Biomarkers of the Progression of Alport Kidney Disease
The purpose of the study is to determine if there are certain laboratory tests that can be performed to detect substances or features in a child's urine that can be used to measure the progress of Alport kidney disease and the…
- Trial name
- NCT01705132
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Minnesota
Type 1 Diabetes Mellitus
An Innovative Approach Towards Understanding and Arresting Type 1 Diabetes (INNODIA)
INNODIA is a global consortium linking 26 academic institutions, 4 industrial partners, a small to medium enterprise (SME), and 2 patient organisations, bringing their knowledge and experience together with one common goal: "To…
- Trial name
- INNODIA (NCT03936634)
- Where
- 19 sites in Austria, Belgium and 11 more
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Rheumatic Heart Disease
GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial
The goal of this clinical trial is to determine if twice daily oral penicillin prophylaxis is non-inferior to monthly IM penicillin prophylaxis in preventing latent Rheumatic Heart Disease Progression in children between the ages…
- Trial name
- NCT05693545
- Testing
- phenoxymethyl penicillin, intramuscular benzathine penicillin G (BPG) prophylaxis
- Where
- Uganda
- Volunteers
- 1,004 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Scoliosis
Study of the Surgical Treatment of Early Onset Scoliosis Using a Non-invasive Growing Rod
It is current practice for children who have surgery for early onset scoliosis (EOS) to be treated with insertion of extendable implants known as growth rod systems.
- Trial name
- NCT01362881
- Where
- 2 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- Ellipse Technologies, Inc.