Clinical trials: Cancer-Related Condition
Cancer-related Fatigue
Real-world Clinical Benefit Evaluation in Breast Cancer Patients With Pharmaceutical Interventions for Cancer-related Fatigue
This retrospective study is to collect and analyze the data from medical records within the period that breast cancer patient is receiving NHI-covered CRF treatment.
- Trial name
- NCT05428527
- Where
- 9 sites in Taiwan
- Volunteers
- 261 people
- Sponsor
- National Defense Medical Center, Taiwan
Lymphoma
Combination Chemotherapy in Treating Patients With AIDS-Related Hodgkin's Disease
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003114
- Testing
- filgrastim, cyclophosphamide, etoposide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Case Comprehensive Cancer Center
Graft Versus Host Disease, Leukemia
Alemtuzumab, Busulfan, and Cyclophosphamide Followed By a Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer
RATIONALE: Monoclonal antibodies, such as alemtuzumab, can find cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells.
- Conditions
- Graft Versus Host Disease, Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases
- Trial name
- NCT00555048
- Testing
- alemtuzumab, busulfan, cyclophosphamide
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Fred Hutchinson Cancer Center
Little Cigars and Cigarillos (LCC) Use
Little Cigar and Cigarillo Warnings for Youth
This study explores the effect of the little cigars and cigarillos (LCC) warnings on youth who currently use, have ever used, or are susceptible to using LCCs.
- Trial name
- NCT06413797
- Testing
- FDA warnings + Image, FDA Warnings Text-Only, Surgeon General Text-Only Warnings
- Where
- United States
- Volunteers
- 928 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Lymphoma
Combination Chemotherapy in Treating Pediatric Patients With Advanced-Stage Large Cell Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Giving the drugs in different doses may kill more cancer cells.
- Trial name
- NCT00002618
- Testing
- filgrastim, cytarabine, doxorubicin hydrochloride
- Where
- 10 sites in United States, Puerto Rico and 1 more
- Volunteers
- 242 people
- Sponsor
- Children's Oncology Group
Neurofibromatosis 1, Social Skills
Pilot Randomized Control Trial of Telehealth Group for Improving Peer Relationships (PEERS) in NF1
This is a pilot randomized control trial of the UCLA PEERS protocol delivered via Telehealth with teens with neurofibromatosis type 1 whose parents report that they have difficulty making and keeping friends.
- Trial name
- NCT04860362
- Testing
- PEERS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Milwaukee
Diffuse Large B Cell Lymphoma
Lenalidomide Based Immunotherapy in the Treatment of DLBCL
This study is to evaluate the efficacy related molecular biomarker of Lenalidomide plus RCHOP or RICE in the treatment of de novo or Refractory and Relapsed DLBCL patients
- Trial name
- NCT03715296
- Testing
- Lenalidomide 25mg
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ruijin Hospital
Neuroblastoma
Allogeneic Stem Cell Transplantation for Advanced Neuroblastoma Using MHC Mismatched Related Donors
Allogeneic stem cell transplantation has been explored for patients with high risk neuroblastoma. Results have been mixed, with only small series and case reports.
- Trial name
- STALLO (NCT01462396)
- Testing
- CD34+ cells selected with the Miltenyi Clinimacs machine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Children's Mercy Hospital Kansas City
Myelodysplastic Syndrome, Acute Myeloid Leukemia
Phase I Dose-Escalation Trial of Clofarabine Followed by Escalating Doses of Fractionated Cyclophosphamide in Children With Relapsed or Refractory Acute Leukemias
This is a Phase I study designed to determine the MTD and assess the toxicity associated with clofarabine followed by fractionated cyclophosphamide in patients > 1 year of age or < 21 years of age with relapsed or refractory…
- Conditions
- Myelodysplastic Syndrome, Acute Myeloid Leukemia, Myeloproliferative Disorders, Acute Lymphocytic Leukemia
- Trial name
- POE07-01 (NCT00852709)
- Testing
- Clofarabine, Cyclophosphamide
- Where
- 7 sites in United States, Canada
- Volunteers
- 35 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Cancer Therapy-related Cardiovascular Toxicity, Childhood Cancer
Early Diagnosis and Cardiovascular Risk Stratification in Children Exposed to Cancer Therapies
The goal of this prospective interventional study is to improve the detection of subclinical chronic Cancer Therapy-Related Cardiovascular Toxicity (CTRCT) and evaluate the added value of advanced cardioechography…
- Conditions
- Cancer Therapy-related Cardiovascular Toxicity, Childhood Cancer, Chemotherapeutic Toxicity, Radiotherapy Side Effect
- Trial name
- CTRCT-pedia (NCT07408362)
- Testing
- Ergospirometry
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
AIDS-related Kaposi Sarcoma, Recurrent Kaposi Sarcoma
Halofuginone Hydrobromide in Treating Patients With HIV-Related Kaposi's Sarcoma
This phase II trial studies how well halofuginone hydrobromide works in treating patients with human immunodeficiency virus (HIV)-related Kaposi's sarcoma.
- Trial name
- NCT00064142
- Testing
- halofuginone hydrobromide, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Acute Myeloid Leukemia, Myelodysplastic Syndromes
A Pilot Study to Evaluate the Feasibility of Post-Hematopoietic Stem Cell Transplant Prophylaxis With Decitabine Combined With Filgrastim for Children and Young Adults With AML, MDS and Related Myeloid Malignancies
The purpose of this study is to examine if it is feasible to administer decitabine and filgrastim after allogenic hematopoietic stem cell transplant (HCT) in children and young adults with myelodysplastic syndrome, acute myeloid…
- Conditions
- Acute Myeloid Leukemia, Myelodysplastic Syndromes, Myeloid Malignancies, MDS
- Trial name
- MORE (NCT05796570)
- Testing
- Decitabine, Filgrastim
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Franziska Wachter
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome
This phase III trial compares hematopoietic (stem) cell transplantation (HCT) using mismatched related donors (haploidentical [haplo]) versus matched unrelated donors (MUD) in treating children, adolescents, and young adults with…
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Mixed Phenotype Acute Leukemia, Myelodysplastic Syndrome
- Trial name
- NCT05457556
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Busulfan
- Where
- 63 sites in United States, Australia and 1 more
- Volunteers
- 66 people
- Sponsor
- Children's Oncology Group
Leukemia, Children
Jacobson's Progressive Muscle Relaxation Technique on Children With Leukemia Undergoing Chemotherapy.
The goal of this clinical trial is to determine the effect of Jacobson's progressive muscle relaxation technique on anxiety and fatigue among children with leukemia undergoing chemotherapy.
- Conditions
- Leukemia, Children, Fatigue Related to Cancer Treatment, Anxiety
- Trial name
- JPMRT (NCT06631196)
- Testing
- Jacobson's PMRT
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Pregnancy Related, Cancer
Compliant Analysis of Patient Samples and Data
Patients of scientific interest who have provided a commercial sample to LabCorp or one of its' affiliates will have their de-identified remnant samples and/or data used for research and development.
- Conditions
- Pregnancy Related, Cancer, Infectious Disease
- Trial name
- NCT04364503
- Testing
- Multiple interventions depending on diagnostic test being run.
- Where
- 9 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Sequenom, Inc.
Cancer, Side Effect of Drug
Radiopharmaceuticals Analysis for Detailed Insights And INternational Tracking of Safety
Little is known about cancer therapy-related radiopharmaceuticals drugs safety. Here the investigators use VigiBase (http://www.vigiaccess.org/), the World Health Organization (WHO) database of individual safety case reports, to…
- Trial name
- RADIANTS (NCT06483685)
- Testing
- Radiopharmaceuticals drugs
- Where
- France
- Volunteers
- 500,000 people
- Sponsor
- University Hospital, Caen
Drug Toxicity
Real World Asparaginase Therapy Toxicity
This research study is being done to learn more about the short term and long term side effects of treatment with asparaginase drugs, which are commonly used in acute lymphoblastic leukemia (ALL) or acute lymphoblastic lymphoma…
- Trial name
- NCT07008027
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- St. Jude Children's Research Hospital
Bacteremia, Neoplasms
Taurolidine Lock Solution in the Prevention of Catheter Related Bacteremia
Children with cancer need a long term tunnelled central venous catheter (TCVC) for the entire duration of their treatment. TCVCs are locked with heparin when not in use.
- Trial name
- NCT00735813
- Testing
- Taurolock, Heparin
- Where
- Denmark
- Volunteers
- 129 people
- Sponsor
- Aarhus University Hospital
Osteosarcoma, Nephrotoxicity
Preventing Nephrotoxicity and Ototoxicity From Osteosarcoma Therapy
Osteosarcoma is the most common type of bone cancer in children, adolescents and young adults. Treatment with surgery and a combination of three conventional chemotherapy drugs can cure nearly two-thirds patients with…
- Conditions
- Osteosarcoma, Nephrotoxicity, Ototoxicity
- Trial name
- NCT01848457
- Testing
- Pantoprazole, High-dose methotrexate infusion duration
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospital of Philadelphia
Pediatric Cancers, Hematologic Malignancies
Follow-Up Evaluation for Gene-Therapy-Related Delayed Adverse Events After Participation in Pediatric Oncology Branch Clinical Trials
Background: Gene therapy involves changing the genes inside the body s cells to stop disease. It is very closely regulated. People who have had this therapy may have problems months or even years later.
- Conditions
- Pediatric Cancers, Hematologic Malignancies, Solid Tumors
- Trial name
- NCT02315599
- Testing
- anti-CD19 CAR
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Cancer Institute (NCI)