Clinical trials: Cardiac Death
Brain Death, Heart Failure
Intravenous Thyroxine for Heart-Eligible Organ Donors
This randomized controlled trial will evaluate whether intravenous thyroxine infusion given to brain-dead organ donors who are eligible to donate hearts for 12 hours will result in more hearts transplanted than saline placebo
- Trial name
- NCT04415658
- Testing
- Thyroxine, Saline
- Where
- 14 sites in United States
- Volunteers
- 838 people
- Sponsor
- Washington University School of Medicine
Congenital Heart Disease, Coronary Artery Anomaly
European Prospective Registry on Anomalous Aortic Origin of the Coronary Arteries
Anomalous aortic origin of a coronary artery (AAOCA) is a group of rare congenital heart defects with various clinical presentations.
- Conditions
- Congenital Heart Disease, Coronary Artery Anomaly, Sudden Cardiac Death, Surgical Procedure, Unspecified
- Trial name
- EUROAAOCA (NCT06089902)
- Testing
- unroofing or other surgery if needed
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Padova
ICD Malfunction, Sudden Cardiac Death
S-ICD Electrode Registry
The subcutaneous implantable cardioverter defibrillator (S-ICD) is established in the prevention of sudden cardiac death, but recently a defect of the electrode's Sense-B component was reported in some patients.
- Trial name
- NCT05713708
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Universitätsklinikum Köln
Sudden Cardiac Death, Sudden Cardiac Arrest
Low QRS Voltages in Young Healthy Individuals and Athletes
There is some limited evidence that reduced size of electrical complexes/traces of the heart on the electrocardiogram (ECG) may be associated with scarring in the heart muscle, which may predispose to serious life-threatening…
- Conditions
- Sudden Cardiac Death, Sudden Cardiac Arrest, Sudden Cardiac Death Due to Cardiac Arrhythmia, Arrhythmogenic Right Ventricular Cardiomyopathy
- Trial name
- NCT05799833
- Testing
- Cardiovascular magnetic resonance scan - 3T scanner (Siemens Vida)
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Arrhythmias, Cardiac, Children, Only
Mobile Electrocardiogram Monitoring for Detecting Arrhythmias in Children
The objective of this project is to evaluate the capability of a specific mobile electrocardiogram monitoring of detecting arrhythmic events in children with history of palpitation and or syncope.
- Conditions
- Arrhythmias, Cardiac, Children, Only, Congenital Heart Disease, Sudden Cardiac Death
- Trial name
- NCT05140343
- Testing
- KARDIA Mobile ECG Monitoring (KMCM)
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Centro Medico Teknon
Death, Sudden, Cardiac, Perfusion Index
Is the Perfusion Index an Accurate Predictor of Return of Spontaneus Circulation in Out-of-hospital Cardiac Arrest
The purpose of this pilot feasibility study is to evaluate the ability of the Perfusion Index to predict the return to spontaneous circulation of the out-of-hospital cardiac arrest patient during cardiopulmonary resuscitation.
- Conditions
- Death, Sudden, Cardiac, Perfusion Index, Return of Spontaneous Circulation
- Trial name
- NCT05383885
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Tetralogy of Fallot, Ventricular Tachycardia
Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses in Repaired Tetralogy of Fallot
Individuals with repaired Tetralogy of Fallot (rTOF) remain at risk for sudden cardiac death from ventricular tachycardia (VT). Transcatheter pulmonary valve replacement (TPVR) indications continue to broaden, yet its capability…
- Conditions
- Tetralogy of Fallot, Ventricular Tachycardia, Sudden Cardiac Death
- Trial name
- NCT05236153
- Testing
- Electroanatomic substrate mapping
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston Children's Hospital
Sudden Cardiac Death
REgiStry in Chinese yoUng pEople With Sudden Cardiac Death
The number of sudden cardiac death is up to 540,000 every year in China. Inherited cardiovascular disease is a common cause of sudden cardiac death in young people, and diseases often have the characteristics of family…
- Trial name
- RESCUE-SCD (NCT05713240)
- Where
- China
- Volunteers
- 450 people
- Sponsor
- China National Center for Cardiovascular Diseases
Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome
Hearts in Rhythm Organization (HiRO)National Registry and Bio Bank
The Hearts in Rhythm Organization (HiRO) is a national network of Canadian researchers/clinicians, working towards a better understanding of the rare genetic causes of sudden cardiac death (SCD).
- Conditions
- Sudden Cardiac Arrest, Sudden Arrhythmic Death Syndrome, Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), Long QT Syndrome (LQTS)
- Trial name
- HiRO (NCT04189822)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University of British Columbia
Heart Failure, Systolic, Sudden Cardiac Death
Prediction of Mortality After CIED Implantation (PM-CIED)
The study aims to develop and validate predictive models for the mortality of patients receiving CIED (including CRT and ICD) implantation.
- Trial name
- PM-CIED (NCT05396313)
- Testing
- CRT/ICD
- Where
- China
- Volunteers
- 1,618 people
- Sponsor
- Shanghai Zhongshan Hospital
ICD, Arrythmia
Genome-Wide Association Study With the Aim of Implantable Cardioverter Defibrillator Implantation Genophenotypic Risk Stratification
This clinical study will be conducted with funding from European Innovation Council(EIC) after approval of the fund grant and is part of our organization's European Pathfinder Project(Ref…
- Conditions
- ICD, Arrythmia, Sudden Cardiac Death
- Trial name
- ICDGPSS (NCT05582252)
- Testing
- Non-Invasive saliva sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Heart Attack, Stroke
ACS Registry - A Non-interventional Study to Estimate the Rates of Outcomes in ACS Patients in Moscow
Cardiovascular diseases (CVD) are currently the leading cause of death in industrialized countries and are expected to become the leading cause of death in emerging countries by 20201.
- Conditions
- Heart Attack, Stroke, Cardiovascular Death
- Trial name
- NCT03654157
- Where
- 27 sites in Russia
- Volunteers
- 1,576 people
- Sponsor
- AstraZeneca
Duct Dependent Lesions, Necrotising Enterocolitis
Enteral Feeding in Infants With Duct Dependant Lesions.
This is a multicenter randomised controlled trial to assess whether standardised enteral feeding in newborns with duct dependenty congenital heart disease decreases the risk of necrotising enterocolitis (NEC).
- Conditions
- Duct Dependent Lesions, Necrotising Enterocolitis, Death, Growth
- Trial name
- CARDIOFEED (NCT05117164)
- Testing
- enteral feeding as per predefined protocol
- Where
- 2 sites in Poland
- Volunteers
- 384 people
- Sponsor
- Princess Anna Mazowiecka Hospital, Warsaw, Poland
Cardiac Arrest, Sudden Death, Cardiac
Use of Public Access Defibrillators by Untrained Bystanders
Survival from out-of-hospital cardiac arrest is time critical and diminishes rapidly without appropriate intervention. Bystander CPR at least doubles the chances of survival and the additional use of a public access defibrillator…
- Trial name
- NCT03230773
- Testing
- Defibrillator model
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Sudden Cardiac Death, Implantable Defibrillator User
S-ICD French Cohort Study (HONEST)
Implantable cardioverter-defibrillators have been proven to be effective in the prevention of sudden cardiac death in high-risk patients.
- Trial name
- HONEST (NCT05302115)
- Testing
- S-ICD
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Paris Sudden Death Expertise Center
Heart Failure, Ventricular Dysfunction
Austrian Wearable Cardioverter Defibrillator Registry
Background: The wearable cardioverter defibrillator (WCD) is an established treatment option for patients at high risk for ventricular tachycardia / ventricular fibrillation (VT/VF), either in whom this risk may only be…
- Conditions
- Heart Failure, Ventricular Dysfunction, Sudden Death, Sudden Cardiac Arrest
- Trial name
- NCT02816047
- Testing
- Registry
- Where
- Austria
- Volunteers
- 450 people
- Sponsor
- Medical University of Graz
Maternal Death, Cardiac Arrest
Assessing a New Proforma for Maternal Cardiac Arrest
During the Multidisciplinary Obstetric and Midwifery Simulation (MOMS) course, groups of delegates manage simulated clinical emergencies, whilst the remaining delegates observe the scenario via a video link.
- Conditions
- Maternal Death, Cardiac Arrest, Heart Arrest
- Trial name
- NCT04260386
- Testing
- Non-Interventional
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic Right Ventricular Dysplasia
South Asian Arrhythmogenic Cardiomyopathy Registry
Arrhythmogenic Cardiomyopathy (ACM) is increasingly identified as an important cause of cardiac morbidity and mortality, especially of SCD, in a younger population.
- Conditions
- Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic Right Ventricular Dysplasia, Arrhythmogenic Ventricular Cardiomyopathy, Arrhythmogenic Cardiomyopathy
- Trial name
- NCT04895540
- Testing
- ECG, Echocardiography, Cardiac MRI
- Where
- 3 sites in United States, India
- Volunteers
- 100 people
- Sponsor
- Sheri Kashmir Institute of Medical Sciences
Sudden Cardiac Death, Congenital Heart Disease
Sudden Cardiac Death in Systemic Right Ventricle
In complete transposition of the great arteries (TGA) with previous atrial switch repair, and congenitally corrected transposition of the great arteries (ccTGA), the morphological right ventricle and its tricuspid valve continue…
- Conditions
- Sudden Cardiac Death, Congenital Heart Disease, Transposition of Great Vessels
- Trial name
- STARSII (NCT03833843)
- Testing
- imaging
- Where
- France
- Volunteers
- 1,240 people
- Sponsor
- European Georges Pompidou Hospital
Cardiovascular Diseases, Heart Diseases
Epidemiology of Long QTand Asian Sudden Death in Sleep
To conduct a cross-sectional epidemiologic study of the determinants of prolonged heart rate corrected QT interval (QTc) among 300 men and 300 woman in the population with the highest known risk of SUDS: Southeast Asian refugees…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Arrhythmia, Death, Sudden, Cardiac
- Trial name
- NCT00005367
- Sponsor
- Utah State University