Clinical trials: Cardiac Defects
Congenital Heart Disease, Desaturation of Blood
Evaluation of VITLS Compared to Traditional Inpatient Monitoring in Cardiac Shunt-Dependent Children
We are seeing how well a remote monitoring device that looks like a sticker placed on the chest, under the arm can monitor a child's vital signs including oxygen levels compared to the way that we usually get these measurements.
- Trial name
- NCT05526768
- Testing
- VITLS Device
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Baylor College of Medicine
Turner Syndrome, Short Stature
Vosoritide for Short Stature in Turner Syndrome
Turner syndrome (TS) is characterized by a missing whole or part of the second sex chromosome in a phenotypic female, resulting in short stature due to haploinsufficiency of the short-stature homeobox-containing (SHOX) gene.
- Trial name
- NCT05849389
- Testing
- Vosoritide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Roopa Kanakatti Shankar, MBBS, MS
Atrial Septal Defect
Cera™ ASD Occluder Post-Market Clinical Follow-Up Study
The objective of this post-market study is to: collect real-word clinical data and confirm the long-time safety and performance of the Lifetech Cera™ ASD Occluder identify previously unknown side-effects
- Trial name
- NCT06849635
- Where
- 6 sites in Poland
- Volunteers
- 139 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Transposition of Great Vessels
Influence of Timing of Switch Operation in Transposition of Great Arteries
Transposition of great vessels are usually corrected by an arterial switch operation. This operation is often done during the first week of life as surgical delays lead to deconditioned left ventricle.
- Trial name
- NCT05160116
- Where
- Belgium
- Volunteers
- 151 people
- Sponsor
- Brugmann University Hospital
Heart Defects, Congenital
Genetic and Nutritional Causes of Heart Birth Defects
Each year in the United States, thousands of babies are born with heart defects. Women who take folic acid during pregnancy have a lower risk of giving birth to infants with heart defects, but the reason for this remains unknown.
- Trial name
- NCT00368732
- Where
- United States
- Volunteers
- 1,610 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
22Q11.2 Deletion Syndrome
Open-Label Study of ZYN002 Administered as a Transdermal Gel to Children and Adolescents With 22q11.2 Deletion Syndrome (INSPIRE)
To evaluate the safety and tolerability of ZYN002 administered as a transdermal gel formulation, for up to 38 weeks, in participants ages 4 to <18 years, in the treatment of 22q.11.2 Deletion syndrome (22qDS).
- Trial name
- INSPIRE (NCT05149898)
- Testing
- ZYN002
- Where
- 3 sites in United States, Australia
- Volunteers
- 20 people
- Sponsor
- Harmony Biosciences Management, Inc.
Congenital Heart Defect, Hypoplastic Left Heart Syndrome
Physical Activity Promotion in Children and Adolescents With Single Ventricle Physiology (MedBike)
Single ventricular (SV) heart was a uniformly fatal condition before the advances in surgical treatment in 1980. In the present era, 5-year survival rate with SV is 75%, with some centers, including the Stollery Children's…
- Conditions
- Congenital Heart Defect, Hypoplastic Left Heart Syndrome, Physical Activity
- Trial name
- MedBike (NCT04056416)
- Testing
- MedBIKE
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- University of Alberta
Congenital Heart Disease, Pregnancy Complications
Fetal Growth and Pregnancy Complications Among Women With Heart Disease
An increasing proportion of women with heart disease now go through pregnancy and childbirth. More knowledge about the risk of complications and adverse outcomes for the mother and the baby is needed to guide clinical care in…
- Conditions
- Congenital Heart Disease, Pregnancy Complications, Arrhythmias, Cardiac, Hypertension in Pregnancy
- Trial name
- PreCor (NCT03657823)
- Where
- Norway
- Volunteers
- 800 people
- Sponsor
- Oslo University Hospital
Single-ventricle, Infant Conditions
PK/PD of Digoxin in Infants With SVHD
The primary participant will be an infant with single ventricle heart disease. This is a research study to learn more about how the medication digoxin, which is routinely prescribed to infants and children with heart disease in…
- Conditions
- Single-ventricle, Infant Conditions, Infant, Newborn, Diseases, Infant, Premature, Diseases
- Trial name
- Digoxin R01 (NCT06613477)
- Testing
- PK/PD Model Based Dosing of Digoxin in Infants with Single Ventricle Heart Disease
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Tetralogy of Fallot
Early Right Ventricular Function After Repair Of Tetralogy Of Fallot , An Evidence Based Study.
This study aims to assessing right ventricular function early after surgical repair of tetralogy of Fallot and identifying the risk factors associated with development of RV dysfunction.
- Trial name
- NCT03470064
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Atrial Septal Defect
A Prospective Randomized Multicenter Trial of the Guidewire for Echo-guided Interventions
Prospective randomized multicenter trial of about 100 subjects enrolled in 3-5 centers. Patients will be randomized to two groups in equal proportion (50 in each).
- Trial name
- NCT04096924
- Testing
- Guidewire for echo-guided interventions, Cook lunderquist guidewire
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Ventricular Septal Defects, Persistent Common Atrioventricular Canal
Optimal Timing for Repair of Left to Right Shunt Lesions
The purpose of this study is to determine the optimal timing for repair of left-to-right shunt lesions such as ventricular septal defects and atrioventricular canals.
- Trial name
- NCT00229827
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Healthcare of Atlanta
Complex Congenital Heart Defect
Neurodevelopment in Infants With Complex Congenital Heart Defects
The primary goal of this study is to systematically describe early neurodevelopment using a complementary set of observational and neurophysiological measures that may predict cognitive and motor delays earlier than currently…
- Trial name
- NCT03104751
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Congenital Heart Defects, Hypoplastic Left Heart Syndrome
Cerebral Perfusion During Neonatal Cardiac Surgery
Neonates with a congenital heart defect are often in need of early cardiac surgery. In complex congenital heart defects, cardiopulmonary bypass is usually employed, with or without deep hypothermic circulatory arrest (DHCA).
- Conditions
- Congenital Heart Defects, Hypoplastic Left Heart Syndrome, Aortic Coarctation
- Trial name
- NCT01032876
- Testing
- Deep Hypothermic Circulatory Arrest, Antegrade Cerebral Perfusion
- Where
- Netherlands
- Volunteers
- 37 people
- Sponsor
- UMC Utrecht
Turner Syndrome
Social Cognition and Turner Syndrome
Monocentric multidisciplinary study (psychologists, endocrinologists, psychiatrists, and molecular biologists) to characterize social cognition in adolescents with Turner syndrome (TS).
- Trial name
- COGNITUR (NCT01687842)
- Testing
- Evaluation of 45,X Turner syndrome patients
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
RASopathy, Costello Syndrome
Prevalence and Characterization of Pain in RASopathies
RASopathies are a group of syndromes caused by variants in genes belonging to the RAS/MAPK pathway. Pain is a neglected topic in RASopathies but it is frequently complained by affected individuals.
- Conditions
- RASopathy, Costello Syndrome, Cardio-Facio-Cutaneous Syndrome, Noonan Syndrome
- Trial name
- 3717 (NCT06355622)
- Testing
- Characterization of pain
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Kidney Injury, Congenital Heart Disease
Acute Kidney Injury After Cardiac Surgery on CPB
The purpose of this retrospective study is to determine the incidence and severity of acute kidney injuries (AKI) after heart surgery on cardiopulmonary bypass (CPB) in the pediatric intensive care unit (PICU) in Lausanne…
- Conditions
- Acute Kidney Injury, Congenital Heart Disease, Surgery, CBP
- Trial name
- NCT03513718
- Where
- Switzerland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Congenital Heart Defect
Signs and Symptoms Associated With Molecular Defects in Genetically Inherited Heart Disease
Genetically inherited heart diseases (familial cardiopathies) are conditions affecting the heart passed on to family members by abnormalities in genetic information.
- Trial name
- NCT00027196
- Where
- United States
- Volunteers
- 9,999,999 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Transition, Congenital Heart Defect
The Transitioning Rural Adolescents to Adult Care Study
Approximately 1 in 10 teenagers lives with a chronic health condition that will require ongoing care as they enter adulthood. Birth defects of the heart, also known as congenital heart disease (CHD) are more common than any other…
- Trial name
- TRAAC (NCT04090827)
- Testing
- Nurse-led transition intervention and access to the iHeartChange website
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- University of Alberta
Velocardiofacial Syndrome, Williams Syndrome
The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome
The purpose of this study is to investigate the Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome (VCFS), Williams Syndrome (WS)and Fragile X Syndrome Characterization, Treatment and Examining the Connection to…
- Conditions
- Velocardiofacial Syndrome, Williams Syndrome, Fragile X Syndrome
- Trial name
- VCFS (NCT00768820)
- Testing
- methylphenidate, fluoxetin, risperidone
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- The Chaim Sheba Medical Center
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