Clinical trials: Cardiac Defects
Congenital Heart Disease, Pregnancy Complications
Fetal Growth and Pregnancy Complications Among Women With Heart Disease
An increasing proportion of women with heart disease now go through pregnancy and childbirth. More knowledge about the risk of complications and adverse outcomes for the mother and the baby is needed to guide clinical care in…
- Conditions
- Congenital Heart Disease, Pregnancy Complications, Arrhythmias, Cardiac, Hypertension in Pregnancy
- Trial name
- PreCor (NCT03657823)
- Where
- Norway
- Volunteers
- 800 people
- Sponsor
- Oslo University Hospital
Atrial Septal Defect (ASD)
A Novel Echocardiography-Guided Strategy for Percutateous Closure of Atrial Septal Defect Assisted by PannaWire
Atrial septal defect (ASD) is a common congenital heart disease, and percutaneous interventional therapy is the main and effective treatment.
- Trial name
- PANNA-ASD (NCT07054541)
- Testing
- Ultrasound-guided intervention with assistance of specialized instruments, fluoroscopy-guided intervention
- Where
- China
- Volunteers
- 666 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Preterm Birth, Pediatric Cancer
eHealth as an Aid for Facilitating and Supporting Self-management in Families With Long-term Childhood Illness
The overall aim is twofold: 1) to stretch the borderline regarding the present knowledge of clinical and economic cost-effectiveness of eHealth as an aid for facilitating and supporting self-management in families with long-term…
- Conditions
- Preterm Birth, Pediatric Cancer, Hirschsprung Disease, Congenital Malformation
- Trial name
- eChildHealth (NCT04150120)
- Testing
- e-health device with application, Mobile phone text messaging, early detection of cerebral palsy using a mobile phone application
- Where
- 7 sites in Denmark, Ethiopia and 1 more
- Volunteers
- 720 people
- Sponsor
- Lund University
22q11.2 Deletion Syndrome
Understanding of Psychotic Disorders in Children With 22q11.2DS
The study PremiCeS22 will investigate the prodromal signals at the onset of psychotic disorders of children with 22q11.2 deletion syndrome
- Trial name
- PremiCeS22 (NCT04639388)
- Testing
- neuropsychological testing, questionnaires and experimental tasks
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Noonan Syndrome, LEOPARD Syndrome
Hormonal Sensitivity in Patients With Noonan and LEOPARD Syndromes
Noonan and LEOPARD syndromes share, with variable severity, different clinical traits, notably craniofacial manifestations, cardiopathies, short stature, and juvenile cancers.
- Trial name
- NOLEO (NCT02486731)
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Chylothorax
Chylothorax Following Heart Surgery
The purpose of this study is to determine at risk populations for certain congenital heart defects or certain operative procedures and to define the associated morbidity secondary to chylothorax - prolonged chest tube drainage…
- Trial name
- NCT00215098
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Children's Healthcare of Atlanta
Congenital Heart Disease
"Critical State" Early Warning Score After CHD Surgery and Rapid Response Team
By establishing a warning scoring tool for the early \"critical state\" after congenital heart disease surgery, the multidisciplinary rapid response team is proactively activated, forming an integrated treatment model of…
- Trial name
- NCT06578312
- Where
- China
- Volunteers
- 4,115 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Defects, Congenital, Rehabilitation
Development and Improvement of Home Rehabilitation Scheme for Preschool Children With Congenital Heart Disease After Operation
This part of the study focuses on understanding the home rehabilitation situation for preschool children with congenital heart disease after operation.
- Conditions
- Heart Defects, Congenital, Rehabilitation, Preschool Child, Qualitative Research
- Trial name
- NCT07055334
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wei XIA, PhD
Congenital Heart Disease
Perioperative Outcome of Congenital Heart Disease Surgery in Childhood
Congenital heart disease is the most common congenital malformation in the world with high morbidity and mortality. However, there is no data to assess the perioperative outcome of congenital heart disease surgery among Chinese…
- Trial name
- NCT04093011
- Testing
- Congenital Heart Disease Surgery
- Where
- China
- Volunteers
- 6,500 people
- Sponsor
- Nanjing Medical University
Sepsis, Congenital Heart Disease
Study of Hemodynamics of Neonates by Echocardiography and USCOM
The purpose of this study is to evaluate the hemodynamic values of neonates that are healthy and those with various congenital heart diseases and sepsis by using echocardiography and USCOM.
- Trial name
- HNEU (NCT01045252)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangdong Provincial People's Hospital
Patent Ductus Arteriosus
IV Acetaminophen and Patent Ductus Arteriosus
This is a randomized controlled trial to evaluate the efficacy of IV acetaminophen versus IV ibuprofen in closing a hemodynamically significant patent ductus arteriosus in preterm infants.
- Trial name
- NCT03008876
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Premature Infant, Patent Ductus Arteriosus
Non-Invasive Detection of Tissue Oxygen Deprivation in Premature Infants With Patent Ductus Arteriosus.
The proposed research evaluates tissue oxygenation (StO2) as measured by resonance raman spectroscopy (RRS) in premature infants with and without patent ductus arteriosus (PDA).
- Conditions
- Premature Infant, Patent Ductus Arteriosus, Hemodynamic Instability
- Trial name
- NCT03277768
- Testing
- Resonance Raman Spectroscopy (RRS)
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Florida
Congenital Heart Disease
Digital Health Nudging in Adolescents With Congenital Heart Disease
In adolescents with congenital heart disease physical activity level is reduced which is why promotion to a more active lifestyle with an age-appropriate and modern intervention is needed.
- Trial name
- NCT04933786
- Testing
- Digital Health Nudging
- Where
- Germany
- Volunteers
- 97 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Congenital Heart Disease, Fontan
Effects of Pulmonary Vasodilation Upon VA Coupling in Fontan Patients
The study involves documenting the effects of inhaled nitric oxide upon ventricular-arterial coupling in patients with congenital heart disease and passive pulmonary blood flow.
- Trial name
- NCT01607983
- Testing
- inhaled nitric oxide
- Where
- United States
- Sponsor
- University of California, San Francisco
Congenital Heart Disease
Enhanced Physical Activity Support in Congenital Heart Disease Clinical Care
Our cluster randomized controlled trial of a novel clinical practice change will IMPACT the physical activity (PA) of children living with congenital heart defects (CHD) through our Innovative and pragmatic approach to…
- Trial name
- PAToolKit (NCT03435354)
- Testing
- Physical activity counselling
- Where
- 3 sites in Canada
- Volunteers
- 155 people
- Sponsor
- Children's Hospital of Eastern Ontario
Pulmonary Hypertension, Congenital Heart Disease
Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
This study looks to develop a multi-scale computational model of Pulmonary Hypertension, this clinical model will be calibrated using longitudinal, retrospectively and prospectively acquired human clinical data.
- Conditions
- Pulmonary Hypertension, Congenital Heart Disease, Pediatric Congenital Heart Disease
- Trial name
- NCT03564522
- Testing
- cardiac catheterization, Cardiac MRI
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
Patent Foramen Ovale
Internal Microstructure of Patent Foramen Ovale Related to Stroke
This study aims to (1) investigate the internal microstructure of patent foramen ovale related to cryptogenic stroke, transient ischemic attack or migraine and determine the effectiveness of transcatheter closure in these…
- Trial name
- IMPORT (NCT04686253)
- Testing
- not appliable
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- China National Center for Cardiovascular Diseases
Congenital Heart Disease, Ischemia-reperfusion Injury
Pediatric Remote Ischemic Pre-conditioning Prior to Complex Cardiac Surgery
In 2012, infants having surgery for congenital heart disease have a high survival. The investigators are now focused on improving how sick these infants become after surgery (short term outcomes) and their later neurodevelopment…
- Trial name
- PREP (NCT01739088)
- Testing
- Remote ischemic pre-conditioning stimulus.
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- University of Alberta
Congenital Heart Disease, Aortic Valve Stenosis
Effect of Fetal Aortic Valvuloplasty on Outcomes
In one of the most severe congenital heart defects, hypoplastic left heart syndrome (HLHS), the left ventricle is underdeveloped and the prognosis is worse than in most other heart defects.
- Conditions
- Congenital Heart Disease, Aortic Valve Stenosis, Fetal Cardiac Disorder, Hypoplastic Left Heart Syndrome
- Trial name
- FASSprosp (NCT05386173)
- Testing
- Fetal aortic balloon dilatation
- Where
- 13 sites in United States, Austria and 6 more
- Volunteers
- 200 people
- Sponsor
- Queen Silvia Children's Hospital, Gothenburg, Sweden
Coarctation of the Aorta, Tetralogy of Fallot
Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic Resonance
The purpose of this study is to determine whether patients with repaired congenital heart disease show differences in size or function of their heart atria compared to normal controls and depending on the nature of their heart…
- Conditions
- Coarctation of the Aorta, Tetralogy of Fallot, Transposition of the Great Arteries
- Trial name
- NCT02161471
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
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