Clinical trials: Cardiac Defects
Turner Syndrome
Quantitative Liver Functions in Turner Syndrome With and Without Hormone Replacement Therapy
Several studies have demonstrated that Turner Syndrome patients have elevated liver enzymes readily suppressible by a short course of HRT.
- Trial name
- NCT00825617
- Testing
- Hormone replacement therapy
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Arrhythmia, Congenital Heart Defect
Evaluation and Treatment of Heart Disease in Patients Not Participating in Research
There is an important need to maintain clinical skills, provide quality training and expertise, and provide an environment that stimulates ideas for clinical research.
- Conditions
- Arrhythmia, Congenital Heart Defect, Heart Disease
- Trial name
- NCT00001460
- Testing
- inpatient evaluation and management
- Where
- United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Disease Congenital
Genomic Basis of Neurodevelopmental and Brain Outcomes in Congenital Heart Disease (CHD Brain and Genes)
Approximately 400 Congenital heart disease patients will participate in the research study which will include one or more research visits for neurodevelopmental testing, brain MRI, and collection of medical history including…
- Trial name
- NCT03070197
- Testing
- Exposure of interest: Brain MRI, Exposure of interest: neurodevelopmental assessments
- Where
- 8 sites in United States
- Volunteers
- 196 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Congenital Heart Disease
Inhaled NO as an Anti-inflammatory and Anti-reperfusion Agent in Infants and Children Undergoing Cardiopulmonary Bypass
Each year, there are over 400,000 cardiac surgical operations performed in the United States; of which 10,000 are performed on children.
- Trial name
- NCT00585013
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine
Mitochondrial Diseases, Barth Syndrome
An Intermediate Size Expanded Access Protocol of Elamipretide
Choosing to participate in an expanded access program is an important personal decision. Talk with your doctor to learn more about this program.
- Trial name
- NCT04689360
- Testing
- elamipretide
- Sponsor
- Stealth BioTherapeutics Inc.
Postoperative Chylothorax, Congenital Heart Disease
Propranolol Treatment for Postoperative Chylothorax
Postoperative chylothorax is a serious complication after open heart surgery for pediatric patients with congenital heart disease (CHD).
- Conditions
- Postoperative Chylothorax, Congenital Heart Disease, Open Heart Surgery, Chylothorax
- Trial name
- NCT06833320
- Testing
- Propranolol Hydrochloride
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- June Wu
Velocardiofacial Syndrome, Williams Syndrome
The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome
The purpose of this study is to investigate the Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome (VCFS), Williams Syndrome (WS)and Fragile X Syndrome Characterization, Treatment and Examining the Connection to…
- Conditions
- Velocardiofacial Syndrome, Williams Syndrome, Fragile X Syndrome
- Trial name
- VCFS (NCT00768820)
- Testing
- methylphenidate, fluoxetin, risperidone
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- The Chaim Sheba Medical Center
Hypoplastic Left Heart Syndrome (HLHS)
Umbilical Cord Blood Collection and Processing for Hypoplastic Left Heart Syndrome Patients
Cell-based cardiac regeneration has been the focus of acquired, adult heart disease for many years. However, congenital heart disease with severe structural abnormalities may also be reasonable targets for cell-based therapies.
- Trial name
- NCT01856049
- Testing
- Collection of umbilical cord blood
- Where
- 2 sites in United States
- Volunteers
- 464 people
- Sponsor
- Mayo Clinic
Congenital Heart Disease
HFNC vs NIPPV Following Extubation
This study has the goal to determine the best method of respiratory support following extubation after cardiac surgery (CS). After cardiac surgery for Congenital Heart Disease (CHD), patients remain intubated until the cardiac…
- Trial name
- NCT05869825
- Testing
- High Flow Nasal Canula following extubation, Non-Invasive Positive Pressure Ventilation following extubation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Emory University
Heart Defects, Congenital
Transcatheter Versus Surgical Closure of Ventricular Septal Defect: A Comparative Study
The aim of this study is to compare Safety, efiicacy and clinical effects of surgical versus transcatheter closure of ventricular septal defect (VSD ).
- Trial name
- NCT05306483
- Testing
- Ventricular septal defect closure surgery, Ventricular septal defect closure catheter
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Congenital Heart Disease, Pulmonary Hypertension
MRI and Computational Simulation Cardiology Study
The purpose of this study is to (1) quantify cardiovascular anatomy and physiology using magnetic resonance imaging under both resting and exercise conditions in patients who have congenital heart disease and in age-matched…
- Trial name
- NCT03149341
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Stanford University
Alagille Syndrome, Progressive Familial Intrahepatic Cholestasis
Validation of the Itch Reported Outcome (ItchRO) Diaries in Pediatric Cholestatic Liver Disease
The purpose of the study is to validate the ItchRO instrument (a clinical outcome assessment measure of itching) prior to the analysis of longitudinal treatment effect data being generated in ongoing clinical trials.
- Trial name
- NCT02131623
- Where
- 5 sites in United States, Canada
- Volunteers
- 23 people
- Sponsor
- Mirum Pharmaceuticals, Inc.
Hypoplastic Left Heart Syndrome, Heart Defects, Congenital
Safety of Autologous Cord Blood Cells in HLHS Patients During Norwood Heart Surgery
This study aims to evaluate the safety and feasibility of coronary infusion of autologous placental cord blood mononuclear cells during the Norwood heart operation in newborn hypoplastic left heart syndrome (HLHS) patients.
- Conditions
- Hypoplastic Left Heart Syndrome, Heart Defects, Congenital, Pediatric Disorder
- Trial name
- NCT03431480
- Testing
- Autologous Human Placental Cord Blood Mononuclear Cells
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Murdoch Childrens Research Institute
Congenital Heart Disease in Children
Family Centred Early Intervention of Infants With Congenital Heart Disease
In this study the investigators aim to test the feasibility for therapists and acceptability to parents of an early motor intervention for infants with congenital heart disease (CHD) after open heart surgery.
- Trial name
- NCT04666857
- Testing
- early motor intervention
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- University Children's Hospital, Zurich
Congenital Heart Disease, Executive Dysfunction
Learning by Heart: The Effectiveness of an EF Training Program for Pre-schoolers With Critical CHD
Advances in prenatal and neonatal care have improved outcomes in children with critical congenital heart disease (CCHD). With the increase in survival, neurocognitive problems such as executive functioning (EF) impairments have…
- Trial name
- LbH (NCT06267430)
- Testing
- Kleuter Extra training program
- Where
- 3 sites in Netherlands
- Volunteers
- 103 people
- Sponsor
- Erasmus Medical Center
Tetralogy of Fallot, Lymphatic
Lymphatic Magnetic Resonance Imaging Abnormalities in Children With Tetralogy of Fallot: A Case-Control Study
This study examines subclinical lymphatic abnormalities in Tetralogy of Fallot patients, utilizing lymphatic magnetic resonance and near-infrared fluorescence imaging.
- Trial name
- NCT06097377
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Congenital Heart Diseases
Ulinastatin Injection in in Pediatric Patients Undergoing Open Heart Surgery
1. Explore the efficacy of Ulinastatin use in improving post-operative pulmonary insufficiency and safety in pediatric patients undergoing scheduled CPB open heart surgery to treat Complex Congenital Heart Disease 2.
- Trial name
- NCT02527811
- Testing
- Ulinastatin
- Where
- 5 sites in China
- Volunteers
- 450 people
- Sponsor
- Techpool Bio-Pharma Co., Ltd.
Univentricular Heart
Prospective Evaluation of Univentricular Hearts
Univentricular heart defects are among the most complex congenital malformations. The treatment of these patients usually includes 3 operations and accompanying diagnostics, some of which are invasive, within the first 3 to 4…
- Trial name
- NCT05620030
- Testing
- Univentricular Heart
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Congenital Heart Disease
A Comprehensive Registry Study of the Whole Life Cycle of Patients With CHD
This observational study aims to collect data on the prevalence, intervention, and prognosis of congenital heart disease (CHD) in Chinese patients across their entire lifecycle.
- Trial name
- NCT06611787
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Congenital Heart Defect
Start-to-Sport - Home-based Exercise for Adolescents and Adults With Congenital Heart Disease
Almost 1% of all baby's is born with a heart defect (CHD) and most of them survive. Even though outcomes are good, they need lifelong follow-up because of a higher risk for cardiovascular diseases.
- Trial name
- S2S-ACHD (NCT02240147)
- Testing
- home-based exercise training
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- KU Leuven